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Global Wheat Head Detection(GWHD)Dataset:A Large and Diverse Dataset of High-Resolution RGB-Labelled Images to Develop and Benchmark Wheat Head Detection Methods

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Plant Phenomics 2020年第1期2卷 243-254页

作者： Etienne David Simon Madec Pouria Sadeghi-Tehran Helge Aasen Bangyou Zheng Shouyang Liu Norbert Kirchgessner Goro Ishikawa Koichi Nagasawa Minhajul A.Badhon Curtis Pozniak Benoit de Solan Andreas Hund Scott C.Chapman Frédéric Baret Ian Stavness Wei Guo Arvalis Institut du végétal3 Rue Joseph et Marie Hackin75116 ParisFrance UMR1114 EMMAH INRAECentre PACABâtiment ClimatDomaine Saint-Paul228 Route de l’AérodromeCS 4050984914 Avignon CedexFrance Plant Sciences Department Rothamsted ResearchHarpendenUK Institute of Agricultural Sciences ETH ZurichUniversitätstrasse 28092 ZurichSwitzerland CSIRO Agriculture and Food Queensland Biosciences Precinct306 Carmody RoadSt Lucia4067 QLDAustralia Plant Phenomics Research Center Nanjing Agricultural UniversityNanjingChina Institute of Crop Science National Agriculture and Food Research OrganizationJapan Hokkaido Agricultural Research Center National Agriculture and Food Research OrganizationJapan Department of Computer Science University of SaskatchewanCanada Department of Plant Sciences University of SaskatchewanCanada School of Food and Agricultural Sciences The University of QueenslandGatton4343 QLDAustralia Graduate School of Agricultural and Life Sciences The University of Tokyo1-1-1 Midori-choNishitokyo CityTokyoJapan

The detection of wheat heads in plant images is an important task for estimating pertinent wheat traits including head population density and head characteristics such as health,size,maturity stage,and the presence of *** studies have developed methods for wheat head detection from high-resolution RGB imagery based on machine learning ***,these methods have generally been calibrated and validated on limited *** variability in observational conditions,genotypic differences,development stages,and head orientation makes wheat head detection a challenge for computer ***,possible blurring due to motion or wind and overlap between heads for dense populations make this task even more *** a joint international collaborative effort,we have built a large,diverse,and well-labelled dataset of wheat images,called the Global Wheat Head Detection(GWHD)*** contains 4700 high-resolution RGB images and 190000 labelled wheat heads collected from several countries around the world at different growth stages with a wide range of *** for image acquisition,associating minimum metadata to respect FAIR principles,and consistent head labelling methods are proposed when developing new head detection *** GWHD dataset is publicly available at http://***/and aimed at developing and benchmarking methods for wheat head detection.

关键词： Wheat wheat maturity

Road Surface Condition and Monitoring system Utilizing Motorcycle(ROCOM)—system Development,Validation and Field Test

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Journal of Traffic and Transportation Engineering 2018年第6期6卷 282-291页

作者： Muhammad Marizwan Abdul Manan Muhammad Ruhaizat Abd Ghani Road Safety Engineering and Environment Research centre Malaysian Institute of Road Safety Research(MIROS)Lot 125-135Jalan TKS 1Taman Kajang SentralKajangSelangorMalaysia

Motorcycles are the riskiest mode of travel in Malaysia,however motorcycles are also very sensitive to the road surface ***,by taking advantage of this,a system of software applications that analyses motorcycle motion and mapped out risky road sections was developed,*** system consists of three major components,*** Data Logger app,which utilizes a smart phone to collect acceleration data,ROCOM Risk Mapping app,which is a web-based application,and ROCOM Visual Tracking,which is a stand along *** is able to detect adverse acceleration( >2g)or vibration on the road surface similar to the High Accuracy GPS Data Logging for Vehicle Testing(VBOX).Risk mapping validation along a section of the motorcycle lane along Federal Route 2 shows that not only ROCOM have the similar risk-mapping pattern,but its route tracking capability on the map is far superior that the *** pilot and field test results showed that ROCOM works best when mounting the smartphone on the motorcycle handle bar or basket,and it can detect various road anomalies with successful detection rate of 62%,with high detection rate when passing through uneven road surfaces.

关键词： Road surface condition mobile and web-based application visual tracking data validation

Bisphosphonate-based hydrogel mediates biomimetic negative feedback regulation of osteoclastic activity to promote bone regeneration

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Bioactive Materials 2022年第7期7卷 9-22页

作者： Zhuo Li Haixing Wang Kunyu Zhang Boguang Yang Xian Xie Zhengmeng Yang Lingchi Kong Peng Shi Yuan Zhang Yi-Ping Ho Zhi-Yong Zhang Gang Li Liming Bian Department of Biomedical Engineering The Chinese University of Hong KongSha TinNew Territories999077Hong KongChina Department of Orthopaedic and Traumatology The Chinese University of Hong KongSha TinNew Territories999077Hong KongChina Department of Materials Science and Engineering Johns Hopkins UniversityBaltimoreMD21218USA Department of Orthopaedic Surgery Affiliated Sixth People’s HospitalShanghai Jiao Tong UniversityShanghai200233China School of Biomedical Sciences and Engineering South China University of TechnologyGuangzhou510006China Translational Research centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University Guangdong Province Engineering Research Center for Biomedical EngineeringState Key Laboratory of Respiratory DiseaseThe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou CityGuangdong Province510150China National Engineering Research Center for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhou510006China Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education South China University of TechnologyGuangzhou510006China

The intricate dynamic feedback mechanisms involved in bone homeostasis provide valuable inspiration for the design of smart biomaterial scaffolds to enhance in situ bone *** this work,we assembled a biomimetic hyaluronic acid nanocomposite hydrogel(HA-BP hydrogel)by coordination bonds with bisphosphonates(BPs),which are antiosteoclastic *** HA-BP hydrogel exhibited expedited release of the loaded BP in response to an acidic *** in vitro studies showed that the HA-BP hydrogel inhibits mature osteoclastic differentiation of macrophage-like RAW264.7 cells via the released ***,the HA-BP hydrogel can support the initial differentiation of primary macrophages to preosteoclasts,which are considered essential during bone regeneration,whereas further differentiation to mature osteoclasts is effectively inhibited by the HA-BP hydrogel via the released *** in vivo evaluation showed that the HA-BP hydrogel can enhance the in situ regeneration of *** work demonstrates a promising strategy to design biomimetic biomaterial scaffolds capable of regulating bone homeostasis to promote bone regeneration.

关键词： Bisphosphonate Hydrogel Tissue engineering Bone regeneration

Simple calculator to estimate the medical cost of diabetes in sub-Saharan Africa

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World Journal of Diabetes 2015年第16期6卷 1312-1322页

作者： Koffi Alouki Hélène Delisle Stéphane Besancon Naby Baldé Assa Sidibé-Traoré Joseph Drabo Francois Djrolo Jean-Claude Mbanya Serge Halimi Department of Nutrition Faculty of MedicineUniversity of MontrealDowntown Station Santé-Diabète (NGO) Mali Chapter Endocrinology Department Donka Teaching Hospital Internal Medicine Department Bamako University Hospital Internal Medicine Department Ouagadougou University Hospital Endocrinology Department National University Health Centre Department of Internal Medicine and Specialties Faculty of Medicine and Biomedical SciencesUniversity of Yaoundé I University Joseph Fourier and University Hospital centre

AIM: To design a medical cost calculator and show that diabetes care is beyond reach of the majority particularlypatients with ***: Out-of-pocket expenditures of patients for medical treatment of type-2 diabetes were estimated based on price data collected in Benin,Burkina Faso,Guinea and Mali. A detailed protocol for realistic medical care of diabetes and its complications in the African context was defined. Care components were based on existing guidelines,published data and clinical experience. Prices were obtained in public and private health facilities. The cost calculator used Excel. The cost for basic management of uncomplicated diabetes was calculated per person and per year. Incremental costs were also computed per annum for chronic complications and per episode for acute complications. RESULTS: Wide variations of estimated care costs were observed among countries and between the public and private healthcare system. The minimum estimated cost for the treatment of uncomplicated diabetes(in the public sector) would amount to 21%-34% of the country's gross national income per capita,26%-47% in the presence of retinopathy,and above 70% for nephropathy,the most expensive complication. CONCLUSION: The study provided objective evidence for the exorbitant medical cost of diabetes considering that no medical insurance is available in the study countries. Although the calculator only estimates the cost of inaction,it is innovative and of interest for several stakeholders.

关键词： Diabetes Non-communicable diseases Africa Advocacy Cost-of-illness

Taming Reactive Oxygen Species:Mitochondria-Targeting Aggregation-Induced Emission Luminogen for Neuron Protection via Photosensitization-Triggered Autophagy

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CCS Chemistry 2022年第7期4卷 2249-2257页

作者： Chao Chen Ruoyao Zhang Jianyu Zhang Yufan Zhang Haoke Zhang Zaiyu Wang Xiaolin Huang Sijie Chen Ryan T.K.Kwok Jacky W.Y.Lam Dan Ding Ben Zhong Tang Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionInstitute for Advanced StudyState Key Laboratory of Molecular NanoscienceDivision of Life ScienceDepartment of Chemical and Biological EngineeringThe Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong 999077 State Key Laboratory ofMedicinal Chemical Biology Key Laboratory of Bioactive MaterialsMinistry of EducationCollege of Life SciencesNankai UniversityTianjin 300071 Ming Wai Lau centre for Reparative Medicine Karolinska InstitutetHong Kong 999077 Center for Aggregation-Induced Emission SCUT-HKUST Joint Research InstituteState Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhou 510640 Shenzhen Institute of Aggregate Science and Technology School of Science and EngineeringThe Chinese University of Hong KongShenzhen 518172 AIE Institute Guangzhou Development DistrictHuangpuGuangzhou 510530

Oxidative damage to cells leads to accumulated harmful wastes,which in turn aggravate the imbalance of reactive oxygen species(ROS)and related ***,provoking the cellular defense system against severe oxidation and maintaining ROS homeostasis are ***,we designed and synthesized a powerful mitochondria-targeting aggregation-induced emission photosensitizer(named DTCSPY)by maximal restriction of heat *** is demonstrated that taming ROS generation within mitochondria through photosensitization-triggered autophagy via DTCSPY achieved a better neuroprotective effect against oxidative damages than Nacety-L-cysteine and vitamin *** work not only provides a new way to design high-performance photosensitizers by regulating the photophysical property,but also verifies the concept that taming ROS can be used for cell protection against destructive oxidation,thereby displaying broad prospects for alleviating oxidation-related diseases and promoting cell-based therapy.

关键词： aggregation-induced emission mitochondrial targeting photosensitizer reactive oxygen species neuron protection

Identifying contextual determinants of problems in tuberculosis care provision in South Africa: a theory-generating case study

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Infectious Diseases of Poverty 2021年第3期10卷 82-94页

作者： Jamie Murdoch Robyn Curran Andre Jvan Rensburg Ajibola Awotiwon Audry Dube Max Bachmann Inge Petersen Lara Fairall School of Health Sciences University of East AngliaNorwich NR47TJUK. University of Cape Town Lung Institute Knowledge Translation UnitUniversity of Cape TownMowbray 7700South Africa centre for Rural Health University of KwaZulu NatalDurbanSouth Africa Norwich Medical School University of East AngliaNorwich NR47TJUK. King's Global Health Institute King's College LondonLondon SE19NHUK. Knowledge Translation Unit Department of MedicineUniversity of Cape Town Lung InstituteUniversity of Cape TownMowbray 7700South Africa.

Background:Despite progress towards End TB Strategy targets for reducing tuberculosis(TB)incidence and deaths by 2035,South Africa remains among the top ten high-burden tuberculosis countries globally.A large challenge lies in how policies to improve detection,diagnosis and treatment completion interact with social and structural drivers *** understanding and theoretical development of the contextual determinants of problems inTB care is required for developing effective *** article reports findings from the pre-implementation phase of a study ofTB care in South Africa,contributing to HeAlth system StrEngThening in Sub-Saharan Africa(ASSET)-a five-year research programme developing and evaluating health system strengthening interventions in sub-Saharan *** study aimed to develop hypothetical propositions regarding contextual determinants of problems inTB care to inform intervention development to reduce TB deaths and incidence whilst ensuring the delivery of quality integrated,person-centred ***:Theory-building case study design using the Context and Implementation of Complex Interventions(CICI)framework to identify contextual determinants of problems in TB *** February and November 2019,we used mixed methods in six public-sector primary healthcare facilities and one public-sector hospital serving impoverished urban and rural communities in the Amajuba District of KwaZulu-Natal Province,South *** data included stakeholder interviews,observations and documentary *** data included routine data on sputum testing andTB *** were inductively analysed and mapped onto the seven CICI contextual ***:Delayed diagnosis was caused by interactions between fragmented healthcare provision;limited resources;verticalised care;poorTB screening,sputum collection and *** nurse responsible forTB care,with limited integration ofTB with other conditions,and policy focused o

关键词： Tuberculosis Health systems strengthening Primary healthcare Person-centred care Context

A decision aid for the port placement problem in robot-assisted hysterectomy

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Laparoscopic, Endoscopic and Robotic Surgery 2023年第2期6卷 43-56页

作者： Mohammad R.Maddah Jean-Marc Classe Isabelle Jaffre Keith A.Watson Katherine S.Lin Damien Chablat Cedric Dumas Caroline G.L.Cao Department of Biomedical Industrialand Human Factors EngineeringWright State University3640 Colonel Glenn HwyDaytonOHUSA Department of Automatique Productique et InformatiqueIMT Atlantique4 Rue Alfred KastlerNantesFrance Laboratoire des Sciences Du Numerique de Nantes(LS2N) 2 Chemin de La Houssini?ereNantesFrance centre Rene Gauducheau ICO Institut de Cancerologie de L'Ouest BD Professeur Jacques MonodSaint-HerblainFrance Brethen Center for Surgical Advancement in Robotics and Minimally Invasive Surgery Miami Valley HospitalOne Wyoming StreetDaytonOHUSA Department of Computer Science IMT AtlantiqueTechnopole Brest-IroiseBrestFrance Laboratoire des Sciences et Techniques de L'information de La Communication et de La Connaissance(Lab-STICC) Technopole Brest-IroiseBrestFrance Future Industries Institute STEMUniversity of South AustraliaMawson Lakes BlvdMawson LakesAustralia

Objective:In robot-assisted minimally invasive surgery,proper port positioning ensures that surgical tools have adequate access to the surgical site and avoids mid-surgery collisions of robotic *** date,several guidelines have been proposed for more accurate port ***,challenges remain due to variations in patient morphology,anatomy,and,in particular,organ displacement due to insuf-flation in certain laparoscopic *** objective of this study was to design and develop a de-cision aid for optimal port placement in robot-assisted hysterectomy that accounts for patient variability and organ displacement due to ***:Three components were constructed:a robot model,a patient-specific model,and an opti-mization *** three components were integrated,and the system was verified using four different patients who underwent robotic *** verified,two expert surgeons were asked to evaluate the decision aid for face and construct validity.A usability test was conducted using a torso phantom with target organs located in three different *** expert surgeons performed a simulated hysterectomy task with and without the decision aid to evaluate performance and ***:The optimization algorithm was sensitive to individual differences in anatomy in the four *** surgeons successfully established face and construct *** test results showed a 28%-40% reduction in time to task completion with the optimized ports compared to expert-determined port locations without using the decision ***:The decision aid,based on an individualized patient-specific model,robot model,and optimization algorithm,was shown to be effective at addressing the challenges of displaced organs due to insufflation in robot-assisted *** face and construct validity of the decision aid was established by expert surgeons,while efficiency gains in task performance were demonstrated experim

关键词： Optimization Planning tool Patient model Robotic hysterectomy

多囊卵巢综合征妇女体外受精时子宫动脉血流与卵巢肾素血管紧张素系统

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世界核心医学期刊文摘（妇产科学分册） 2006年第4期2卷 19-19页

作者： Vrtanik-Bokal E. Meden-Vrtovec H. Verdenik I. 朱磊 Department of Obstetrics and Gynaecology University Medical Centre Ljubljanalajmerjeva 3 SI-1000 Ljubljana Slovenia

Objective: To find whether plasma and follicular prorenin concentrations have any effect on the uterine arterial blood flow in women with polycystic ovarian syndrome (PCOS) compared to those with normal menstrual cycles (NMC). Study design: Controlled prospective clinical study involved 55 women undergoing in vitro fertilization: 24 with PCOS and 31with NMC. In both groups transvaginal colour Doppler assessment of uterine arterial blood flow was analysed on day 22 of the cycle, on the day of human chorionic gonadotrophin (HCG) administration and 36 h after HCG. Plasma and follicular (in the dominant follicle containing mature oocyte, and in the pooled follicles) prorenin and active renin, and serum estradiol and androstenedione concentrations were measured at these timepoints. The Student’s t-test and Pearson correlation were used for the statistical analysis. Results: The resistance index (RI) in the NMC group decreased from 0.84 ±0.05 on the day of HCG to 0.78±0.08 36 h after HCG (P < 0.05); in the PCOS group the RI did not decrease. Follicular prorenin concentrations in the dominant follicle and in the pooled follicles were lower in the PCOS than in the NMC group (20,210 ±10,831 μU/l, 16,753 ±8634 μU/l versus 42,637 ±35,400 μU/l, 33,067 ±26,200 μU/l; P < 0.05). Conclusions: Plasma prorenin concentrations do not affect vascular impedance to the uterine artery, but follicular prorenin do by newly formed low resistant vessels in the follicles.

关键词：多囊卵巢综合征体外受精子宫动脉血流卵泡液肾素原血清雌二醇正常月经周期成熟卵母细胞临床

Effects of urea plus nitrate pretreated rice straw and corn oil supplementation on fiber digestibility,nitrogen balance,rumen fermentation,microbiota and methane emissions in goats

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Journal of Animal Science and Biotechnology 2019年第2期10卷 491-500页

作者： Xiumin Zhang Rodolfo F.Medrano Min Wang Karen A.Beauchemin Zhiyuan Ma Rong Wang Jiangnan Wen Lukuyu A.Bernard Zhiliang Tan Key Laboratory for Agro-Ecological Processes in Subtropical Region National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125HunanChina University of the Chinese Academy of Sciences Beijing 100049China College of Veterinary Science and Medicine Central Luzon State UniversityScience City of Munoz3120 Nueva EcijaPhilippines College of Animal Science and Technology Hunan Agricultural UniversityChangsha 410128People’s Republic of China Agriculture and Agri-Food Canada Lethbridge Research and Development CentreLethbridgeAlberta T1J 4B1Canada International livestock Research Institute POB 30709Nairobi 00100Kenya.

Background: Urea pretreatment is an efficient strategy to improve fiber digestibility of low quality roughages for ruminants. Nitrate and oil are usually used to inhibit enteric methane(CH4) emissions from ruminants. The objective of this study was to examine the combined effects of urea plus nitrate pretreated rice straw and corn oil supplementation to the diet on nutrient digestibility, nitrogen(N) balance, CH4 emissions, ruminal fermentation characteristics and microbiota in goats. Nine female goats were used in a triple 3 × 3 Latin Square design(27 d periods). The treatments were: control(untreated rice straw, no added corn oil), rice straw pretreated with urea and nitrate(34 and 4.7 g/kg of rice straw on a dry matter [DM] basis, respectively, UN), and UN diet supplemented with corn oil(15 g/kg soybean and15 g/kg corn were replaced by 30 g/kg corn oil, DM basis, UNCO).Results: Compared with control, UN increased neutral detergent fiber(NDF) digestibility(P < 0.001) and copies of protozoa(P < 0.001) and R. albus(P < 0.05) in the rumen, but decreased N retention(-21.2%, P < 0.001), dissolved hydrogen concentration(-22.8%, P < 0.001), molar proportion of butyrate(-18.2%, P < 0.05),(acetate + butyrate) to propionate ratio(P < 0.05) and enteric CH4 emissions(-10.2%, P < 0.05). In comparison with UN, UNCO increased N retention(+34.9%, P < 0.001) and decreased copies of protozoa(P < 0.001) and methanogens(P < 0.001). Compared with control, UNCO increased NDF digestibility(+8.3%, P < 0.001), reduced ruminal dissolved CH4 concentration(-24.4%, P < 0.001) and enteric CH4 emissions(-12.6%, P < 0.05).Conclusions: A combination of rice straw pretreated with urea plus nitrate and corn oil supplementation of the diet improved fiber digestibility and lowered enteric CH4 emissions without negative effects on N retention. These strategies improved the utilization of rice straw by goats.

关键词： Dissolved hydrogen Methane Nitrate Oil Rumen fermentation Urea