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第十六届嗜铬细胞国际学术会议

作者： Stephen Bunn Shirley Douglas Fiona Carmen Dharshini Sreenivasan Danielle Tranter centre for neuroendocrinology and dept.of anatomy university of otago DunedinNew Zealand

＜正＞We have examined the effect of the cytokine IL-6 on the adrenal medullary chromaffin cell. Such an interaction has important implications for the bi-directional relationship believed to exist between the immune and neuroendocrine *** chromaffin cells,cultured on collagen-coated wells,were washed twice with a physiological salts solution and then

关键词： cytokine interleukin-6 receptor signalling gene expression

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8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases

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Acta Pharmaceutica Sinica B 2023年第5期13卷 2152-2175页

作者： Damijan Knez Daniel Diez-Iriepa Mourad Chioua Andrea Gottinger Milica Denic Fabien Chantegreil Florian Nachon Xavier Brazzolotto Anna Skrzypczak-Wiercioch Ane Meden Anja Pilar Janko Kos Simon akelj Jure Stojan Kinga Saat Julia Serrano Ana Patricia Fernández Aitana Sánchez-García Ricardo Martínez-Murillo Claudia Binda Francisco López-Muoz Stanislav Gobec JoséMarco-Contelles university of Ljubljana Faculty of PharmacyLjubljana 1000Slovenia Laboratory of Medicinal Chemistry(Institute of Organic Chemistry CSIC)Madrid 28006Spain Departamento de Química Orgánicay Química Inorgánica Alcaláde HenaresMadrid 28871Spain Department of Biology and Biotechnology University of PaviaPavia 27100Italy Département de Toxicologie et Risques Chimiques Institut de Recherche Biomédicale des ArméesParis 91220France Department of Animal anatomy and Preclinical Sciences University Centre of Veterinary Medicine JU-UAUniversity of Agriculture in KrakowKrakow 30-059Poland Institute of Biochemistry Faculty of MedicineUniversity of LjubljanaLjubljana 1000Slovenia Department of Pharmacodynamics Chair of PharmacodynamicsFaculty of PharmacyJagiellonian University Medical CollegeKrakow 30-688Poland Department of Translational Neurobiology Neurovascular Research GroupCajal Institute(CSIC)Madrid 28002Spain Biotechnology and Vegetal Biology Department Escuela Técnica Superior de Ingeniería AgronómicaAlimentaria y de BiosistemasUniversidad Politécnica de MadridMadrid 28040Spain Faculty of Health Camilo JoséCela University of Madrid(UCJC)Neuropsychopharmacology Unit“Hospital 12 de Octubre”Research InstituteMadrid 28692Spain

We describe the development of quinolylnitrones(QNs)as multifunctional ligands inhibiting cholinesterases(ChEs:acetylcholinesterase and butyrylcholinesterase—h BChE)and monoamine oxidases(hMAO-A/B)for the therapy of neurodegenerative *** identified QN 19,a simple,low molecular weight nitrone,that is readily synthesized from commercially available *** 19 has no typical pharmacophoric element to suggest ChE or MAO inhibition,yet unexpectedly showed potent inhibition of h BChE(IC50=1.06±0.31 nmol/L)and h MAO-B(IC_(50)=4.46±0.18μmol/L).The crystal structures of 19 with hBChE and hMAO-B provided the structural basis for potent binding,which was further studied by enzyme *** 19 acted as a free radical scavenger and biometal chelator,crossed the blood—brain barrier,was not cytotoxic,and showed neuroprotective properties in a 6-hydroxydopamine cell model of Parkinson's *** addition,in vivo studies showed the anti-amnesic effect of 19 in the scopolamine-induced mouse model of AD without adverse effects on motoric function and ***,chronic treatment of double transgenic APPswe-PS1δE9 mice with 19 reduced amyloid plaque load in the hippocampus and cortex of female mice,underscoring the disease-modifying effect of QN 19.

关键词： Quinolylnitrone Butyrylcholinesterase Monoamine oxidase B Alzheimer's disease Multifunctional ligands 6-Hydroxydopamine model Passive avoidance task Novel object recognition

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舞会药使用与冲动：基因和性格在中国人群的相关作用

舞会药使用与冲动：基因和性格在中国人群的相关作用

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第十届全国药物依赖性学术会议暨首届中美药物滥用和HIV/HCV共病专题研讨会

作者： Alfreda Stadlin Natalie J Loxton Ben KL Cheung School of Medical Science Genomics Research centre Griffith UniversityGold CoastAustralia dept.of anatomy Chinese University of Hong KongHong Kong dept.of Psychology university of Queensland Australia Substance Abuse Assessment Clinic Kwai Chung Hospital Hong Kong

The present study investigated the relationship between two biologically-based dimensions of impulsivity,"reward drive"and"rash impulsiveness",and the COMT and MAOA gene variants in Hong Kong Chinese club drug users.3... 详细信息

关键词： club drug use gene personality reward driven rash impulsiveness

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Aspects of syringeal mechanics in avian phonation

Aspects of syringeal mechanics in avian phonation

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23rd International Ornithological Congress

作者： Ole N.Larsen Franz Goller Johan L.van Leeuwen centre for Sound Communication SDU Odense Univ. DK-5230 Odense dept. of Biology Univ. of Utah Salt Lake City Utah 84112 USA dept. of Animal Sciences Wageningen Univ. NL-6709 PG Wageningen The Netherlands

＜正＞ The vocal organ of birds, the syrinx, is formed by modified cartilages of the trachea and/or bronchi and a number of muscles. The syrinx is relatively inaccessible. Although its anatomy, innervation, muscular control, and driving air flow are well described in some species, the biomechanics of phonation are still poorly understood. Recently, the use of very thin, flexible endoscopes has supported prior speculations on syringeal muscle mechanics, since abduction, adduction, rotation, and tensing of syringeal structures in response to

关键词： syrinx endoscopy biomechanics modelling

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