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Self-cross-linked arrays enabled flexible mechanical sensors for monitoring the body tremor

npj Flexible Electronics 2020年第1期4卷 73-81页

作者： Xuewen Wang Wei Fu Guanhui Gao Mandeep Singh Mehay Lu Zheng Hong Wang Wu Zhao Kian Ping Loh Ting Zhang Wei Huang Zheng Liu Frontiers Science Center for Flexible Electronics(FSCFE)&Shaanxi Institute of Flexible Electronics(SIFE) Northwestern Polytechnical University127 West Youyi RoadXi’an 710072China MIIT Key Laboratory of Flexible Electronics(KLoFE) Northwestern Polytechnical University127 West Youyi RoadXi’an 710072China Department of Chemistry and centre for Advanced 2D Materials National University of Singapore3 Science Drive 3117543 SingaporeSingapore Paul-Drude-Institut für Festkörperelektronik LeibnizInstitut im Forschungsverbund BerlinHausvogteiplatz 5-7Berlin 10117Germany School of Materials Science and Engineering Nanyang Technological University50 Nanyang AvenueSingapore 640260Singapore Institute of Biomedical Materials and Engineering(IBME) Northwestern Polytechnical University127 West Youyi RoadXi’an 710072China School of Information Science and Technology Northwest UniversityXi’an 710069China i-Lab Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China centre for Micro-/Nano-electronics(NOVITAS) School of Electrical and Electronic EngineeringNanyang Technological UniversitySingapore 639798Singapore

Thin-film electronics played an important role in flexible healthcare sensor *** common status of their constituent blocks are solid film and network ***,the solid film could only sustain bend in a narrow range due to cracks,and the network structure decreased the sensitivity of flexion sensors due to the strong interactions between *** materials and technologies are urgently required for flexible sensing electronics,to produce the reliable data for assessment of the human ***,we report on a novel three-dimensional(3D)carbon nanorods array(CNA)that is characterized as vertically aligned nanorods and self-cross-linked *** also demonstrate the CNA-based flexible healthcare sensors in monitoring the Parkinsonian *** with two-dimensional(2D)carbon nanotube networks and solid thin films,such self-cross-linked geometries are highly resistant to crack and fragmentation under *** the meantime,it shows high sensitivity and good stability(~10,000 times)to detect the *** CNA-based flexible devices are capable of recording low-frequency vibrations(<6 Hz)and make it excellent to monitor the rest tremor of the human body,which is an initial symptom of Parkinson’s *** 3D self-cross-linked CNA film shows great potential in the fabrication of cost-effective and durable flexible sensors for early diagnosis of disease by monitoring the health-related rest tremors.

关键词： nanowires film network

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Non-viral vector mediated CKb11 with folic acid modification regulates macrophage polarization and DC maturation to elicit immune response against cancer

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Bioactive Materials 2021年第11期6卷 3678-3691页

作者： Wen Nie Ting Yu Xiaoxiao Liu Bilan Wang Tingting Li Yin Wu Xikun Zhou Lu Ma Yunfeng Lin Zhiyong Qian Xiang Gao Department of Neurosurgery1nd Institute of Neurosurgery State Key Laboratory of Biotherapy1nd Cancer CenterWest China HospitalWest China Medical SchoolSichuan University1nd Collaborative Innovation Center for BiotherapyChengdu610041PR China Department of Medical Oncology The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou310003China Department of Pathology1nd Laboratory of Pathology State Key Laboratory of BiotherapyWest China HospitalWest China School of MedicineSichuan UniversityChina Department of Radiation Oncology Cancer CenterAffiliated Hospital of Xuzhou Medical UniversityJiangsu Center for the Collaboration1nd Innovation of Cancer BiotherapyCancer InstituteXuzhou Medical UniversityXuzhou221000China Department of Pharmacy West China Second University Hospital of Sichuan UniversityChengdu610041China State Key Laboratory of Oral Diseases National Clinical Research Centre for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu610041China College of Biomedical Engineering Sichuan UniversityChengdu610041China

The immunosuppressive tumor microenvironment(TME)of cancer strongly hinders the anti-tumor immune responses,thereby resulting in disappointing responses to *** and promotive traits of chemokines exerted on leukocytes have garnered interest in improving the efficiency of immunotherapy by increasing the infiltration of immune cells in the *** this study,a folic acid(FA)-modified gene delivery system based on the self-assembly of DOTAP,MPEG-PCL-MPEG,and FA-PEG-PCL-PEG-FA,namely F-PPPD,was developed to deliver plasmids encoding the immunostimulating chemokine *** delivery of plasmid CKb11(pCKb11)by F-PPPD nanoparticles resulted in the high secretion of CKb11 from tumor cells,which successfully activated T cells,suppressed the M2 polarization of macrophages,promoted the maturation of dendritic cells(DCs),facilitated the infiltration of natural killer(NK)cells and inhibited the infiltration of immunosuppressive cells in tumor *** of F-PPPD/pCKb11 also significantly suppressed the cancer *** study demonstrated a nanotechnology-enabled delivery of pCKb11,that remodeled the immunosuppressive TME,for cancer treatment.

关键词： Cancer Immunogene therapy CKb11 Nanocomposites Macrophages polarization

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Structural isomer and high-yield of Pt1Ag28 nanoduster via one-pot chemical wet method

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Nano Research 2019年第2期12卷 309-314页

作者： Xinzhang Lin Chao Liu Keju Sun Ren'an Wu Xuemei Fu Jiahui Huang Gold Catalysis Research centre State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China College of Environmental and Chemical Engineering Yanshan University Qinhuangdao 066004 China Laboratory of High-Resolution Mass Spectrometry Technologies Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China University of Chinese Academy of Sciences Beijing 100049 China

In order to understand the structure-property correlation and explore the application of metal nanoclusters, it is important and intriguing to determine their crystal structure and obtain high-yield. At the same time, this is also a challenge in nanoscience and technology. Here, we report the highly efficient synthesis of Pt1Ag28 nanocluster via one-pot chemical wet method. The crystal structure of Pt1Ag28 nanocluster was determined by X-ray crystallography to be a face centered cubic (FCC) kernel. This novel structure is the structural isomerization of Pt1Ag28 nanocluster reported before. This phenomenon is first discovered in the synthesis of alloy nanoclusters. In addition, Pt1Ag28 nanocluster has high yield and exhibits potential optics in the near infrared (NIR) fluorescent imaging. The time-dependent density functional theory (TD-DFT) calculation implied that the optical property of Pt1Ag28 was sensitive to its structure. This work provides a simple method to synthesize alloy nanoclusters with structural isomerization.

关键词： Pt1Ag28 nanocluster one-pot synthesis structural isomerization high yield strong fluorescenee

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Development of a Total Flavonoids Extract of Artemisia Rupestris *** nanotechnology and Its Antiviral Effect In Vitro

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Infectious Diseases Research 2020年第2期1卷 5-14页

作者： Hasimu Hamulati Su-Xiang Chen Zhen-Yi Gu Yu-Hua Sun Tao Wang The Xingjian Institute of Materia Medica Xinjiang Uygur Autonomous RegionUrumqiP.R.China830004 centre for Molecular Medicine and Innovative Therapeutics Murdoch UniversityPerth 6150Australia The College of Nursing and Health Zhengzhou UniversityZhengzhou450001China

Objective:We aimed to develop a novel Artemisia rupestris *** nano-encapsulation(AFN)preparation and evaulate its anti-hepatitis B virus(HBV)activityin ***:First,the AFN was prepared using polylactic-co-glycolic acid(PLGA).Then,after verification of the AFN,in vitro anti-virus assays were conducted by:(1)assessing the inhibitory effect of AFN on the secretion of hepatitis B surface antigens(HBsAg),hepatitis B e-antigens(HBeAg),and the replication of HBV DNAin HepG2.2.15 cells;(2)analyzing the influence of AFN on the activation rate of NF-κB positive cells;and(3)evaluating the effect of AFN on the function of glutathione peroxidase(GSH-PX)enzymes located onthe HepG2.2.15 cell ***:Compared to the original total flavonoids extract of Artemisia rupestris L.(withoutnano-encapsulation),AFN preparation under the maximum nontoxic concentration effectively inhibited the secretion of HBsAg,HBeAg,and HBV DNA from HepG2.2.15 *** the same time,AFN preparation promoted not only the activation rate of NF-κB positive cells,but also antiviral GSH-PX enzyme *** conclusion,nano-encapsulation of the flavonoids extract of Artemisia rupestris *** an enhanced anti-HBV effect in vitro compared to the original total flavonoids extract(without nanoencapsulation);therefore,nano-encapsulation has great potential for the development of a novel antiviral herbal medicine preparation with improved efficacy.

关键词： Artemisia rupestris L. HBV PLGA Nanoparticle Traditional medicine

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Small interfering RNA for cancer treatment:overcoming hurdles in delivery

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Acta Pharmaceutica Sinica B 2020年第11期10卷 2075-2109页

作者： Nitin Bharat Charbe Nikhil D.Amnerkar B.Ramesh Murtaza M.Tambuwala Hamid A.Bakshi Alaa A.A.Aljabali Saurabh C.Khadse Rajendran Satheeshkumar Saurabh Satija Meenu Metha Dinesh Kumar Chellappan Garima Shrivastava Gaurav Gupta Poonam Negi Kamal Dua Flavia C.Zacconin Departamento de Quimica Orgánica Facultad de Química y de FarmaciaPontificia Universidad Católica de ChileSantiago 7820436Chile Sri Adichunchunagiri College of Pharmacy Sri Adichunchunagiri UniversityBG NagarKarnataka 571418India Adv V.R.Manohar Institute of Diploma in Pharmacy NagpurMaharashtra 441110India School of Pharmacy and Pharmaceutical Science Ulster UniversityColeraineNorthern Ireland BT521SAUK Faculty of Pharmacy Department of Pharmaceutics and Pharmaceutical TechnologyYarmouk UniversityIrbid 21163Jordan Department of Pharmaceutical Chemistry R.C.Patel Institute of Pharmaceutical Education and ResearchDist.DhuleMaharashtra 425405India Discipline of Pharmacy Graduate School of HealthUniversity of Technology SydneyNSW 2007Australia School of Pharmaceutical Sciences Lovely Professional UniversityPhagwara 144411 PunjabIndia Department of Life Sciences School of PharmacyInternational Medical UniversityBukit Jalil 57000Kuala LumpurMalaysia Department of Biochemical Engineering and Biotechnology Indian Institute of TechnologyDelhiNew Delhi 110016India School of Pharmacy Suresh Gyan Vihar UniversityJagatpuraJaipur 302017India School of Pharmaceutical Sciences Shoolini University of Biotechnology and Management SciencesSolan 173229India Priority Research centre for Healthy Lungs Hunter Medical Research Institute(HMRI)and School of Biomedical Sciences and PharmacyUniversity of NewcastleNSW 2308Australia Institute for Biological and Medical Engineering Schools of EngineeringMedicine and Biological SciencesPontificia Universidad Católica de ChileSantiago 4860Chile

In many ways,cancer cells are different from healthy cells.A lot of tactical nano-based drug delivery systems are based on the difference between cancer and healthy ***,nanotechnology-based delivery systems are the most promising tool to deliver DNA-based products to cancer *** review aims to highlight the latest development in the lipids and polymeric nanocarrier for siRNA delivery to the cancer *** also provides the necessary information about siRNA development and its mechanism of ***,this review gives us a clear picture of lipid and polymer-based drug delivery systems,which in the future could form the base to translate the basic siRNA biology into siRNA-based cancer therapies.

关键词： Small interfering RNA(siRNA) Nanomedicine Liposomes Micelles Cancer Polymer

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Radiation-Induced Synthesis of Polyvinylpyrrolidone （PVP） Nanogels

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Journal of Physical Science and Application 2016年第5期6卷 21-26页

作者： Adrian Alejandro Ges Naranjo HerlysViltres Cobas Danaydis Fonseca Rogdriguez Manuel Rapado Paneque Yuri Aguilera Corrales Higher Institute of Technologies and Applied Science Nuclear Development and Technological Applications Centre La Habana Cuba Center of Research in Applied Science and Technology Advanced Legaria-Unit Polytechnic National Institute Ciudad de Mexico Mexico Finlay Institute La Habana Cuba Center for Technological Applications and Nuclear Development La Habana Cuba

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