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Acquired sensorineural hearing loss,oxidative stress,and microRNAs

Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru C.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British Columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science Core Collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P GC-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

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Development and validation of a novel questionnaire regarding vision screening among preschool teachers in Malaysia

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1102-1109页

作者： Shazrina Ariffin Saadah Mohamed Akhir Sumithira Narayanasamy Faculty of health Sciences Centre for Community Health Studies(ReaCH)Universiti Kebangsaan MalaysiaKuala Lumpur 50300Malaysia

AIM:To develop and evaluate the validity and reliability of a knowledge,attitude,and practice questionnaire related to vision screening(KAP-VST)among preschool teachers in ***:The questionnaire was developed through a literature review and discussions with *** and face validation were conducted by a panel of experts(n=10)and preschool teachers(n=10),respectively.A pilot study was conducted for construct validation(n=161)and test-retest reliability(n=60)of the newly developed ***:Based on the content and face validation,71 items were generated,and 68 items were selected after exploratory factor *** content validity index for items(I-CVI)score ranged from 0.8-1.0,and the content validity index for scale(S-CVI)/Ave was *** consistency was KR^(2)0=0.93 for knowledge,Cronbach’s alpha=0.758 for attitude,and Cronbach’s alpha=0.856 for ***:The KAP-VST is a valid and reliable instrument for assessing knowledge,attitude,and practice in relation to vision screening among preschool teachers in Malaysia.

关键词： validity reliability preschool teachers vision screening questionnaire

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Anti-inflammatory and anti-cancer potential of pterostilbene:A review

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Asian Pacific Journal of Tropical Biomedicine 2023年第12期13卷 497-506页

作者： Omchit Surien Siti Fathiah Masre Dayang Fredalina Basri Ahmad Rohi Ghazali centre for Toxicology and health Risk studies(CORE) Faculty of Health SciencesUniversiti Kebangsaan Malaysia50300Kuala LumpurMalaysia centre of Diagnostic Therapeutic&Investigative Studies(CODTIS)Faculty of Health SciencesUniversiti Kebangsaan Malaysia50300Kuala LumpurMalaysia

Pterostilbene is a natural compound that can be found in various food plants such as blueberries,grapes,and *** has also been reported to be extracted from Pterocarpus indicus,a tree species native to India and Southeast *** exhibits various pharmacological activities such as antioxidants,anti-proliferation,anti-microbial,and anti-inflammatory activities with favorable pharmacokinetic properties,such as high oral bioavailability and longer *** anti-inflammatory effect of pterostilbene has been reported to contribute to its therapeutic effects in many chronic inflammatory ***,pterostilbene has anti-cancer activity on various types of cancers due to its ability to induce cell cycle arrest and ***,in this review,we discuss the anti-inflammatory and anti-cancer activities of pterostilbene in preclinical studies.

关键词： Pterostilbene Anti-cancer NF-κB Anti-inflammation Natural product Pterocarpus indicus

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A Comprehensive Survey on Federated Learning Applications in Computational Mental healthcare

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 49-90页

作者： Vajratiya Vajrobol Geetika Jain Saxena Amit Pundir Sanjeev Singh Akshat Gaurav Savi Bansal Razaz Waheeb Attar Mosiur Rahman Brij B.Gupta Institute of Informatics and Communication University of DelhiDelhi110021India Maharaja Agrasen College University of DelhiDelhi110096India Computer Engineering Ronin InstituteMontclairNJ 07043USA Department of Research and Innovation Insights2TechinfoJaipur302001India University centre for Research and Development(UCRD) Chandigarh UniversityChandigarh140413India Management Department College of Business AdministrationPrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia CCRI&Department of Computer Science and Information Engineering Asia UniversityTaichung413Taiwan Symbiosis centre for Information Technology(SCIT) Symbiosis International UniversityPune411057India Center for Interdisciplinary Research University of Petroleum and Energy Studies(UPES)Dehradun248007India

Mental health is a significant issue worldwide,and the utilization of technology to assist mental health has seen a growing *** aims to alleviate the workload on healthcare professionals and aid *** applications have been developed to support the challenges in intelligent healthcare ***,because mental health data is sensitive,privacy concerns have *** learning has gotten some *** research reviews the studies on federated learning and mental health related to solving the issue of intelligent healthcare *** explores various dimensions of federated learning in mental health,such as datasets(their types and sources),applications categorized based on mental health symptoms,federated mental health frameworks,federated machine learning,federated deep learning,and the benefits of federated learning in mental health *** research conducts surveys to evaluate the current state of mental health applications,mainly focusing on the role of Federated Learning(FL)and related privacy and data security *** survey provides valuable insights into how these applications are emerging and evolving,specifically emphasizing FL’s impact.

关键词： Depression emotional recognition intelligent healthcare systems mental health federated learning stress detection sleep behaviour

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Upper ocean high resolution regional modeling of the Arabian Sea and Bay of Bengal

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Acta Oceanologica Sinica 2019年第5期38卷 32-50页

作者： Dwivedi Suneet Mishra Alok Kumar Srivastava Atul K Banerjee centre of Atmospheric and Ocean studies and M N Saha centre of Space studies University of Allahabad

In this paper, effort is made to demonstrate the quality of high-resolution regional ocean circulation model in realistically simulating the circulation and variability properties of the northern Indian Ocean(10°S–25°N,45°–100°E) covering the Arabian Sea(AS) and Bay of Bengal(BoB). The model run using the open boundary conditions is carried out at 10 km horizontal resolution and highest vertical resolution of 2 m in the upper *** surface and sub-surface structure of hydrographic variables(temperature and salinity) and currents is compared against the observations during 1998–2014(17 years). In particular, the seasonal variability of the sea surface temperature, sea surface salinity, and surface currents over the model domain is studied. The highresolution model's ability in correct estimation of the spatio-temporal mixed layer depth(MLD) variability of the AS and BoB is also shown. The lowest MLD values are observed during spring(March-April-May) and highest during winter(December-January-February) seasons. The maximum MLD in the AS(BoB) during December to February reaches 150 m (67 m). On the other hand, the minimum MLD in these regions during March-April-May becomes as low as 11–12 m. The influence of wind stress, net heat flux and freshwater flux on the seasonal variability of the MLD is discussed. The physical processes controlling the seasonal cycle of sea surface temperature are investigated by carrying out mixed layer heat budget analysis. It is found that air-sea fluxes play a dominant role in the seasonal evolution of sea surface temperature of the northern Indian Ocean and the contribution of horizontal advection, vertical entrainment and diffusion processes is small. The upper ocean zonal and meridional volume transport across different sections in the AS and BoB is also computed. The seasonal variability of the transports is studied in the context of monsoonal currents.

关键词： Indian Ocean modeling Arabian Sea and Bay of Bengal mixed layer depth transport

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Laser-assisted ablation and plasma formation of titanium explored by LIBS,QCM, optical microscopy and SEM analyses along with mechanical modifications under different pressures of Ar and Ne

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Plasma Science and Technology 2023年第3期25卷 181-192页

作者： Maryam RIAZ Shazia BASHIR Asma HAYAT Zarish NAZ centre for Advanced studies in Physics GC University Lahore

This study deals with the investigation of Nd:YAG laser-assisted ablation and plasma formation of Ti at irradiance of 0.85 GW cm-2 under Ar and Ne environment at various pressures ranging from 10-120 ***-induced breakdown spectroscopy is used to evaluate plasma parameters,whereas quartz crystal microbalance is used for ablation yield *** crater depth is evaluated by optical *** surface features are explored by scanning electron microscope(SEM) analysis and the micro-hardness is measured by a Vickers hardness *** is observed that the plasma parameters are higher in Ar than in Ne,and are strongly correlated with the ablation yield,ablation depth,surface features and hardness of laser-ablated *** parameters increase with increasing the pressure of environmental gases,attain their maxima at 40 Torr for Ar and at 60 Torr for ***,they show a decreasing trend up till a maximum pressure of 120 *** maximum value of the electron temperature(Te) is5480 K,number density(ne) is 1.46 × 1018 cm-3,ablation depth is 184 μm,ablation yield is3.9 × 1015 atoms/pulse and hardness is 300 HV in the case of Ar *** analysis reveals the growth of surface features,such as cones,ridges and pores,whose appearance is more distinct in Ar than Ne and is attributed to temperature,pressure and density gradients along with recoil pressure of the Ti plasma.

关键词： ablation plasma electron temperature electron density laser-induced breakdown spectroscopy surface structures

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Scarcity within Opulence:Water Management in the Karakoram Mountains Revisited

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Journal of Mountain Science 2011年第4期8卷 525-534页

作者： Hermann KREUTZMANN centre for Development studies Freie Universitaet Berlin

Water management in general and in the Indus Basin in particular is concerned with the energy-efficient transportation of hydrologically exploitable resources from the upper zone to climatically favourable areas where irrigation helps to supersede arid conditions for the cultivation of crops and watering of *** other words:Human intervention sets the stage for the allocation of water from a wider catchment area in a smaller habitat where this resource is *** on mountain irrigation practices is counteracted with developments in the forelands where different frame conditions prevail and peculiar development problems *** dealing with the importance of water from the mountain regions three dimensions have to be evaluated:1) natural factors and their validity for the environmental frame conditions and technological adaptation processes;2) social factors and their impact on culture,economy and equitability;3) institutional factors and their importance for sustainable growth and for the implementation of development *** the study of decentralized irrigation systems in high mountain regions of the Indus Basin a systems theoretical approach values the complexity of interrelationships between different systems *** activities in arid mountain regions are restricted by limiting ecological factors and are characterized by certain utilization and adaptive strategies.

关键词： Irrigation Water management Institutions Development Hunza Valley Indus Basin Pakistan

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Dechlorination of chlorophenols by zero valent iron impregnated silica

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Journal of Environmental Sciences 2012年第4期24卷 765-773页

作者： Praveena Juliya Dorathiy Palanivelu Kandasamy centre for Environmental studies Anna UniversityChennai 600025India

Laboratory studies were conducted to find out the efficacy of uniquely prepared zero valent iron impregnated silica in transforming xenobiotic chlorophenols namely 4-chlorophenol, 2,4-dichlorophenol and 2,4,6-trichlorophenol. Continuous mode column experiments were performed to investigate the transformation of chlorophenols by varying pH, column height, flow rate and initial chlorophenol concentration. Reusability study of the zero valent iron impregnated silica was studied as well as the morphological changes and the chemical composition of the catalyst medium were also investigated. Dechlorination kinetic studies were conducted and the order of dechlorination of chlorophenols was found to be 2,4,6-trichlorophenol 〉 2,4-dichlorophenol 〉 4-chlorophenol. The optimum pH, column height and flow rate were found to be 7, 20 cm and 0.75 L/hr respectively for all chlorophenols in the reaction duration of 4 hr. Intermediates formed during dechlorination study were identified by gas chromatography-mass spectroscopy analysis. This method was applied to real pulp and paper wastewater and was found satisfactory.

关键词： zero valent iron silica chlorophenols dechlorination

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Benchmark Integral Cross Sections for Electron Impact Excitation of the n=2 States in Helium

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Plasma Science and Technology 2010年第3期12卷 348-352页

作者： M.HOSHINO H.KATO D.SUZUKI H.TANAKA I.BRAY D.V.FURSA S.J.BUCKMAN O.INGLFSSON M.J.BRUNGER Department of Physics Sophia University centre for Antimatter-Matter studies Curtin University of Technology centre for Antimatter-Matter studies Australian National University Department of Chemistry University of IcelandScience Institute centre for Antimatter-Matter studies Flinders University

In this paper, we present integral cross sections （ICS） for electron impact excitation of the n = 2 levels in helium in the impact energy range of 23.5 eV to 35 eV. The ICS of each final state, 2^3S, 2^1S, 2^3P and 2^1P, has been determined by integration of the angular differential cross sections （DCS） over all of 0° to 180°, where those DCS were obtained from both our previous experiments and the extrapolation using the convergent close coupling calculation. The present experimental ICS for the optically allowed 21P transition state are also compared with those obtained from the BE f-scaling method. Very good agreement between the experimental and BE f-scaled 21P ICSs is generally found in the measured impact energy region.

关键词： low energy electron impact electronic excitations helium

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Taking action on violence through research,policy,and practice

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Global health Research and Policy 2016年第1期1卷 44-52页

作者： Ilene Hyman Mandana Vahabi Annette Bailey Sejal Patel Sepali Guruge Karline Wilson-Mitchell Josephine Pui-Hing Wong Dalla Lana School of Public health University of TorontoTorontoCanada Daphne Cockwell School of Nursing TorontoCanada centre for Global health and health equity TorontoCanada Diverse and At Risk Population TorontoCanada Research Cluster Ryerson UniversityTorontoCanada centre for Global health and health equity Ryerson UniversityTorontoCanada Early Childhood studies TorontoCanada Urban health Daphne Cockwell School of NursingTorontoCanada Nursing centre for Research and Education on Violence Against Women and Children Ryerson UniversityTorontoCanada College of New Scholars Artists and ScientistsRoyal Society of CanadaTorontoCanada Department of health Sciences The Open University of Sri LankaTorontoCanada Midwifery Education Program TorontoCanada Daphne Cockwell School of Nursing Ryerson UniversityTorontoCanada Adjunct Professor Dalla Lana School of Public HealthOHTN-CIHR New InvestigatorTorontoCanada centre for Global health and health equity Ryerson UniversityTorontoCanada.

Background:Violence is a critical public health problem associated with compromised health and social suffering that are *** centre for Global health and health equity organized a forum in 2014 to identify:(1)priority issues related to violence affecting different population groups in Canada,and(2)strategies to take action on priority issues to reduce violence-related health inequities in *** this paper,we present findings from the roundtable discussions held at the Forum,offer insights on the socio-political implications of these findings,and provide recommendations for action to reduce violence through research,policy and ***:Over 60 academic researchers,health and social service agency staff,community advocates and graduate students attended the daylong Forum,which included presentations on structural violence,community violence,gender-based violence,and violence against marginalized *** notes taken at the roundtables were analyzed by the first author using a thematic analysis ***:The thematic analysis identified four thematic areas:1)structural violence perpetuates interpersonal violence-the historical,social,political and economic marginalization that contributes to personal and community violence.2)social norms of gender-based violence—the role of dominant social norms in perpetuating the practice of violence,especially towards women,children and older adults;3)violence prevention and mitigation programs—the need for policy and programming to address violence at the individual/interpersonal,community,and societal levels;and 4)research gaps—the need for comprehensive research evidence made up of systematic reviews,communitybased intervention and evaluation of implementation research to identify effective programming to address ***:The proceedings from the Global health and health equity Forum underscored the importance of recognizing violence as a public health issue that requires immedi

关键词： Structural violence Social policy Immigration Community services Neoliberalism

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