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Single-molecule tracking in living microbial cells

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Biophysics Reports 2025年第01期11卷 1-11页

作者： Xiaomin Chen Qianhong Guo Jiexin Guan Lu Zhang Ting Jiang Liping Xie Jun Fan Institute of fundamental and frontier sciences University of Electronic Science and Technology of China School of Life sciences and Engineering Southwest University of Science and Technology School of Life sciences and Technology University of Electronic Science and Technology of China Yangtze Delta Region Institute (Huzhou) University of Electronic Science and Technology of China

Some microbes are referred to as model organisms because they are easy to study in the laboratory and hold the ability to retain their characteristics during DNA replication, DNA transcription, and other fundamental processes. Studying these microbes in living cells via single-molecule imaging allows us to better understand these processes at highly improved spatiotemporal resolution. Single particle tracking photoactivated localization microscopy(sptPALM) is a robust tool for detecting the positions and motions of individual molecules with tens of nanometers of spatial and millisecond temporal resolution in vivo, providing insights into intricate intracellular environments that traditional ensemble methods cannot. With this approach, the fluorophores are photoactivated stochastically, a series of images are recorded, and the positions of fluorophores are identified in these images, and ultimately the locations are linked together to yield trajectories of individual molecules. Quantitative kinetic and spatial information, such as reaction rates, diffusion coefficients, and localization maps, can be obtained by further analysis. Here, we present a single-molecule tracking protocol that includes sample preparation,data acquisition and brief data processing. This protocol will enable researchers to directly unveil molecular and cellular mechanisms underlying the essential biological processes.

关键词： Single-molecule tracking PALM Diffusion coefficients Trajectory Living microbial cells

Unlocking the stable interface in aqueous zinc-ion battery with multifunctional xylose-based electrolyte additives

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Journal of Energy Chemistry 2025年第1期100卷 770-778页

作者： Xiaoqin Li Jian Xiang Lu Qiu Xiaohan Chen Yinkun Zhao Yujue Wang Qu Yue Taotao Gao Wenlong Liu Dan Xiao Zhaoyu Jin Panpan Li Institute for Advanced Study Chengdu UniversityChengdu 610106SichuanChina School of Mechanical Engineering Chengdu UniversityChengdu 610106SichuanChina College of Food and Biological Engineering Chengdu UniversityChengdu 610106SichuanChina Institute of fundamental and frontier sciences University of Electronic Science and Technology of ChinaChengdu 611731SichuanChina College of Materials Science and Engineering Sichuan UniversityChengdu 610065SichuanChina

The growth of dendrites and the side reactions occurring at the Zn anode pose significant challenges to the commercialization of aqueous Zn-ion batteries(AZIBs). These challenges arise from the inherent conflict between mass transfer and electrochemical kinetics. In this study, we propose the use of a multifunctional electrolyte additive based on the xylose(Xylo) molecule to address these issues by modulating the solvation structure and electrode/electrolyte interface, thereby stabilizing the Zn anode. The introduction of the additive alters the solvation structure, creating steric hindrance that impedes charge transfer and then reduces electrochemical kinetics. Furthermore, in-situ analyses demonstrate that the reconstructed electrode/electrolyte interface facilitates stable and rapid Zn^(2+)ion migration and suppresses corrosion and hydrogen evolution reactions. As a result, symmetric cells incorporating the Xylo additive exhibit significantly enhanced reversibility during the Zn plating/stripping process, with an impressively long lifespan of up to 1986 h, compared to cells using pure ZnSO4electrolyte. When combined with a polyaniline cathode, the full cells demonstrate improved capacity and long-term cyclic stability. This work offers an effective direction for improving the stability of Zn anode via electrolyte design, as well as highperformance AZIBs.

关键词： Aqueous Zn-ion battery Electrolyte additive Solvation structure Electrode/electrolyte interface Zn anode

Operando and reversible manipulation of Pt electrocatalytic properties through its substrate phase transition

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Science China Chemistry 2025年

作者： Hongfei Liu Yi Xie Changzheng Wu Institute of fundamental and frontier sciences University of Electronic Science and Technology of China Key Laboratory of Precision and Intelligent Chemistry School of Chemistry and Materials ScienceCollaborative Innovation Center of Chemistry for Energy Materials (iChEM)and CAS Center for Excellence in NanoscienceUniversity of Science and Technology of China Institute of Energy Hefei Comprehensive National Science Center

The lattice strain is considered critical for determining the catalytic activity of metal catalysts such as Pt. However, the dynamic manipulation of Pt lattice strain under reaction conditions to directly examine its catalytic effect has not been achieved. In this study, we realized the reversible manipulation of Pt electrocatalytic properties under electrochemical conditions by tuning the Pt lattice strain with the temperature-controlled Martensite-Austenite phase transition of the shape memory NiTi alloy *** enabled establishing a straightforward relationship between the strain-induced electronic structure transformation and electrocatalytic activity leaping. The binding strength between Pt and surface oxygen species was confirmed as the critical factor that dominated the hydrogen evolution and the oxygen reduction activities. In contrast, the oxygen evolution activity was barely affected by NiTi substrate phase transition.

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Flexible artificial vision computing system based on FeOx optomemristor for speech recognition

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Journal of Semiconductors 2025年第1期46卷 225-232页

作者： Jie Li Yue Xin Bai Sun Dengshun Gu Changrong Liao Xiaofang Hu Lidan Wang Shukai Duan Guangdong Zhou College of Artificial Intelligence Southwest UniversityChongqing 400715China frontier Institute of Science and Technology X’ian Jiaotong UniversityXi’an 710049China School of Electronic Information and Electrical Engineering Chongqing University of Arts and SciencesChongqing 402160China

With the advancement of artificial intelligence,optic in-sensing reservoir computing based on emerging semiconductor devices is high desirable for real-time analog signal ***,we disclose a flexible optomemristor based on C_(27)H_(30)O_(15)/FeOx heterostructure that presents a highly sensitive to the light stimuli and artificial optic synaptic features such as short-and long-term plasticity(STP and LTP),enabling the developed optomemristor to implement complex analogy signal processing through building a real-physical dynamic-based in-sensing reservoir computing algorithm and yielding an accuracy of 94.88%for speech *** charge trapping and detrapping mediated by the optic active layer of C_(27)H_(30)O_(15) that is extracted from the lotus flower is response for the positive photoconductance memory in the prepared *** work provides a feasible organic−inorganic heterostructure as well as an optic in-sensing vision computing for an advanced optic computing system in future complex signal processing.

关键词： reservoir computing flexible optomemristor analogy signal processing optic computing

Isolation and single-molecule magnetism of neutral rare-earth(III) sandwich complexes supported by compact aromatic rings

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Science China Chemistry 2025年

作者： Ming Liu Yan-Cong Chen Jieyu Zheng Xiao-Han Peng Ming-Liang Tong Akseli Mansikkam?ki Fu-Sheng Guo Institute of fundamental and frontier sciences University of Electronic Science and Technology of China Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education School of Chemistry Institute of Green Chemistry and Molecular Engineering (IGCME) Guangdong Basic Research Center of Excellence (GBRCE) for Functional Molecular EngineeringSun Yat-sen University NMR Research Unit University of Oulu

Over the past few decades,various types of metal-sandwich structures have been synthesized and reported,which significantly advanced organometallic chemistry and contributed to numerous ***,charge-neutral rare-earth（III） sandwich structures based on compact aromatic ligands still remained unexplored due to the challenges in their ***,the immense potential of this type of structure in building high-performance single-molecule magnets （SMMs） has compelled us to overcome these synthetic ***,we aimed to isolate such complexes in a general formula of[（Ring1）REIII（Ring2）].[（CE4B）t4Me2NREIII(Cpi Pr5)](3-RE,RE=Y,Dy;（C4B）Et4Me2N=1-（N,N-dimethylamino）-2,3,4,5-tetraethylborolyl;Cpi Pr5=pentaisopropylcyclopentadienyl) were successfully obtained via the salt-metathesis reaction of the precursor[REIII(CpiPr5)（BH4）2-（THF）]（,RE=Y,Dy;THF=tetrahydrofuran） and the new aminoborolide ligand[Na2（C4B）Et4Me2N1-RE（THF）2]2（2）,which represent the first neutral rare-earth（III）-sandwich complexes ligated by compact aromatic *** complexes 3-RE were characterized by single-crystal X-ray diffraction,elemental analysis,UV-Vis-NIR and *** 3-Y was studied by NMR *** and dynamic magnetic properties of 3-Dy were investigated by SQUID magnetometry,showing a high anisotropy barrier of 785（12） cm-1and open hysteresis loops up to 12 *** bonding of nitrogen to dysprosium（III） near the equatorial plane lowers the anisotropy,and a bulkier ligand in the future should be able to avoid *** work not only demonstrates that such type of neutral rare-earth（III）-sandwich complexes is totally synthetically feasible,but also paves the way for the development of high-performance SMMs.

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Investigations of inelastic cross sections of H_(2)O molecule by He^(2+) and C^(6+) projectiles with energy range around the Bragg peak

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Nuclear Science and Techniques 2025年第2期36卷 141-154页

作者： Guo-Zhuang Li Cheng-Ye Sun Rui Cheng Yan-Shi Zhang Liang-Wen Chen Sheng Zhang Xin-Xia Li Lei Yang School of Nuclear Science and Technology University of South ChinaHengyang 421001China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Interdisciplinary Center for fundamental and frontier sciences Nanjing University of Science and TechnologyJiangyin 214443China Center for Basic Teaching and Experiment Nanjing University of Science and TechnologyJiangyin 214443China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China

Inelastic collisions are the dominant cause of energy loss in *** the energy range around the Bragg peak,single ionization(SI)and single-electron capture(SC)are the primary inelastic collisions that lead to energy *** study employs the classical trajectory Monte Carlo method to study the SI and SC processes of H_(2)O molecules using He^(2+) and C^(6+) projectiles in the energy range of 10 keV/u to 10 MeV/*** total cross sections,single differential cross sections,impact parameter dependence of SI and SC,and fragmentation cross sections were *** illustrate that the cross section for SI is the highest when the projectile energy is close to the Bragg peak *** the projectile energy is below the Bragg peak energy,the ionized electrons in the forward direction dominate,and the removal of electrons can be associated with large impact *** the projectile energy increases,the emission angle of the electrons gradually transitions from small angles(60°~120°)to large angles(60°~120°),and the removal of electrons is associated with small impact *** energy distributions of the ionized electron are similar when the projectile energy is equal to,below or above the Bragg peak *** fragmentation cross sections after SI and SC in the energy range around the Bragg peak were also estimated.

关键词： Classical trajectory Monte Carlo Heavy ion-water molecule collision Inelastic cross sections

Optimized inner ear organoids for efficient hair cell generation and ototoxicity response modeling

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Science China Life sciences 2025年

作者： Xuanhe Qin Liping Fu Chunying Li Xilin Tan Xiaolei Yin Institute for Regenerative Medicine State Key Laboratory of Cardiology and Medical Innovation CenterShanghai East HospitalFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji University

Hair cells in the mammalian cochlea are highly vulnerable to damage from drug toxicity,noise exposure,aging,and genetic mutations,with no capacity for *** in hair cell protection research has been limited by the scarcity of cochlear tissue and suitable in vitro ***,we present a novel one-step,self-organizing inner ear organoid system optimized with small molecules,which bypasses the need for multi-step expansion and forced differentiation *** approach efficiently generates hair cells and supporting cells that recapitulate the molecular,cellular,and structural characteristics of the inner ***-cell RNA sequencing revealed the diversity and fidelity of cell populations within the *** this platform,we validated the protective effects of candidate compounds against hair cell damage,highlighting its potential as a powerful tool for drug discovery and mechanistic studies of hair cell protection.

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Rational Design of Colloidal Core/Shell Quantum Dots for Optoelectronic Applications

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Journal of Electronic Science and Technology 2020年第2期18卷 105-118页

作者： Xiang-Long Huang Xin Tong Zhiming MWang Institute of fundamental and frontier sciences University of Electronic Science and Technology of China

Colloidal core/shell quantum dots(QDs) are promising for solar technologies because of their excellent optoelectronic properties including tunable light absorption/emission spectra, high photoluminescence quantum yield(PLQY), suppressed Auger recombination, efficient charge separation/transfer, and outstanding photo-/thermal-/chemical stability. In this review, engineered core/shell QDs with various types of band structures and corresponding device performance in luminescent solar concentrators(LSCs), light-emitting diodes(LEDs), solar-driven photoelectrochemical(PEC) devices, and QDs-sensitized solar cells(QDSCs) are summarized. In particular, the applications of interfacial layer engineering and eco-friendly, heavy metal-free core/shell QDs in optoelectronic devices are highlighted. Finally, strategies towards the developments and practical perspectives of core/shell QDs are briefly mentioned to offer guidelines for achieving prospective high-efficiency and long-term stable QD devices.

关键词： stability. quantum mentioned

Toward Next-Generation Heterogeneous Catalysts:Empowering Surface Reactivity Prediction with Machine Learning

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Engineering 2024年第8期39卷 25-44页

作者： Xinyan Liu Hong-Jie Peng Institute of fundamental and frontier sciences University of Electronic Science and Technology of ChinaChengdu 611731China

Heterogeneous catalysis remains at the core of various bulk chemical manufacturing and energy conversion processes,and its revolution necessitates the hunt for new materials with ideal catalytic activities and economic *** high-throughput screening presents a viable solution to this challenge,as machine learning(ML)has demonstrated its great potential in accelerating such processes by providing satisfactory estimations of surface reactivity with relatively low-cost *** review focuses on recent progress in applying ML in adsorption energy prediction,which predominantly quantifies the catalytic potential of a solid *** models that leverage inputs from different categories and exhibit various levels of complexity are classified and *** the end of the review,an outlook on the current challenges and future opportunities of ML-assisted catalyst screening is *** believe that this review summarizes major achievements in accelerating catalyst discovery through ML and can inspire researchers to further devise novel strategies to accelerate materials design and,ultimately,reshape the chemical industry and energy landscape.

关键词： Machine learning Heterogeneous catalysis Chemisorption Theoretical simulation Materials design High-throughput screening