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China CDC weekly 2023年第18期5卷 391-396页

作者： Chunsheng Cai Yihong Li Ting Hu Rongwei Liang Kaibin Wang Congrui Guo Yan Li Meng Zhang Min Kang guangdong Field Epidemiology Training Program Guangzhou CityGuangdong ProvinceChina Zhongshan Center for disease control and prevention Zhongshan CityGuangdong ProvinceChina guangdong Provincial Center for disease control and prevention Guangzhou CityGuangdong ProvinceChina Huaiji County Center for disease control and prevention Zhaoqing CityGuangdong ProvinceChina Tianhe District Center for disease control and prevention Guangzhou CityGuangdong ProvinceChina Futian District Center for disease control and prevention Shenzhen CityGuangdong ProvinceChina

Summary What is already known about this topic?Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)reinfection by variants is being reported commonly and has caused waves of epidemic in many *** of dynamic zero policy,the SARSCoV-2 reinfection was less reported in *** is added by this report?SARS-CoV-2 reinfections were observed in guangdong province between December 2022 and January *** study estimated that the reinfection incidence was 50.0%for the original strain primary infections,35.2%for the Alpha or Delta variants,and 18.4%for the Omicron variant;The reinfection incidence within 3-6 months after primary infection by Omicron variant was 4.0%.Besides,96.2%reinfection cases were symptomatic while only 7.7%sought medical *** are the implications for public health practice?These findings suggest a reduced likelihood of an Omicron-driven epidemic resurgence in the short term but emphasize the importance of maintaining vigilant surveillance of emerging SARS-CoV-2 variants and conducting population-based antibody level surveys to inform response preparedness.

关键词： policy guangdong conducting

An Outbreak of Serogroup Y Meningococcal Meningitis in a Private Secondary Vocational School-Guangzhou City,guangdong province,China,2023

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China CDC weekly 2024年第12期6卷 242-246,I0005页

作者： Xiang Zeng Qing He Yilan Li Yong Zhou Xiaoping Shao Pei Hu Jian Liang Yudan Song Chao Ma Lijie Zhang Limei Sun Lei Luo Chinese Field Epidemiology Training Program Chinese Center for Disease Control and PreventionBeijingChina Zhuhai Center for disease control and prevention Zhuhai CityGuangdong ProvinceChina guangdong Center for disease control and prevention Guangzhou CityGuangdong ProvinceChina Guangzhou Center for disease control and prevention Guangzhou CityGuangdong ProvinceChina Institute of Public Health Guangzhou Medical University&Guangzhou Center for Disease Control and PreventionGuangzhou CityGuangdong ProvinceChina Department of the National Immunization Programme Chinese Center for Disease Control and PreventionBeijingChina

What is already known about this topic?The inclusion of meningococcal vaccines in the National Immunization Program(NIP)over several years has significantly reduced the incidence of meningococcal meningitis in China to historic ***,there has been a diversification of meningococcal serogroups,leading to a shift in dominant serogroups in China from serogroup A to serogroups C and B,accompanied by a rise in reports of serogroups Y and *** is added by this report?An outbreak of serogroup Y Neisseria meningitidis(Nm)in a secondary vocational school involved a single confirmed severe case and 24 individuals with laboratory-confirmed Nm *** investigation revealed that the outbreak was localized to the classroom of the confirmed *** close contact within a confined space was identified as a significant risk factor for Nm *** genotype sequence identified was type 1655(ST-1655),which is categorized under clonal complex 23(CC-23)and bears resemblance to 8 previously confirmed cases of serogroup Y meningococcal meningitis within guangdong *** suggests that serogroup Y infections continue to sporadically emerge and have become prevalent *** are the implications for public health practice?This outbreak underscores the critical need to enhance surveillance of meningococcal serogroups and population carrier,and advocate for vaccination with MenY-containing vaccines.

关键词： break Secondary guangdong

AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/PS1 mice

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Neural Regeneration Research 2025年第1期20卷 253-264页

作者： Zhengwei Hu Jing Yang Shuo Zhang Mengjie Li Chunyan Zuo Chengyuan Mao Zhongxian Zhang Mibo Tang Changhe Shi Yuming Xu Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Academy of Medical Sciences of Zhengzhou University ZhengzhouHenan ProvinceChina NHC Key Laboratory of prevention and treatment of Cerebrovascular diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Henan Key Laboratory of Cerebrovascular diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Institute of Neuroscience Zhengzhou UniversityZhengzhouHenan ProvinceChina Sino-British Research centre for Molecular Oncology National Centre for International Research in Cell and Gene TherapySchool of Basic Medical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Department of Gerontology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina

The E3 ubiquitin ligase,carboxyl terminus of heat shock protein 70(Hsp70)interacting protein(CHIP),also functions as a co-chaperone and plays a crucial role in the protein quality control *** this study,we aimed to investigate the neuroprotective effect of overexpressed CHIP on Alzheimer’s *** used an adeno-associated virus vector that can cross the blood-brain barrier to mediate CHIP overexpression in APP/PS1 mouse *** overexpression significantly ameliorated the performance of APP/PS1 mice in the Morris water maze and nest building tests,reduced amyloid-βplaques,and decreased the expression of both amyloid-βand phosphorylated *** also alleviated the concentration of microglia and astrocytes around *** APP/PS1 mice of a younger age,CHIP overexpression promoted an increase in ADAM10 expression and inhibitedβ-site APP cleaving enzyme 1,insulin degrading enzyme,and neprilysin *** of HSP70 and HSP40,which have functional relevance to CHIP,were also *** nuclei transcriptome sequencing in the hippocampus of CHIP overexpressed mice showed that the lysosomal pathway and oligodendrocyte-related biological processes were up-regulated,which may also reflect a potential mechanism for the neuroprotective effect of *** research shows that CHIP effectively reduces the behavior and pathological manifestations of APP/PS1 ***,overexpression of CHIP could be a beneficial approach for the treatment of Alzheimer’s disease.

关键词： adeno-associated virus Alzheimer’s disease APP/PS1 mice carboxyl terminus of Hsp70 interacting protein gene therapy

First Case Report of Cystic Echinococcosis Caused by G7 Genotype Echinococcus intermedius Confirmed by Genetic Sequencing—Southern China,December 2023

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China CDC weekly 2024年第23期6卷 558-562页

作者： De Wu Jiayi Zhang Jieling Wang Yangyang Zhao Lei Wang Qiang Mao Haisen Lin Gang Yao Guanting Zhang Xu Wang Chuizhao Xue Ying Wang Jingdiao Chen Parasitic disease prevention and control Institute Guangdong Center for Disease Control and PreventionGuangzhou CityGuangdong ProvinceChina Epidemic prevention and control Institute Zhuhai Center for Disease Control and PreventionZhuhai CityGuangdong ProvinceChina Department of prevention&Healthcare Zhuhai First People's HospitalZhuhai CityGuangdong ProvinceChina National Institute of Parasitic diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)ShanghaiChina

What is already known about this topic?Echinococcosis exhibits a global *** China,the primary endemic area is the northwest *** December 2023,we documented a case of echinococcosis in an individual lacking any travel or residential history in endemic *** is added by this report?This is the first laboratory-confirmed case of hepatic echinococcosis reported in guangdong province,associated with the G7 genotype of Echinococcus granulosus(***).The most probable mode of transmission is a local infection resulting from *** introduced from endemic *** are the implications for public health practice?As the circulation of agricultural products increases,it is essential to enhance the quarantine and management of livestock from epidemic areas to prevent and control the spread of echinococcosis to non-epidemic regions.

关键词： travel fir northwest

Community Incidence Estimates of Five Pathogens Based on Foodborne diseases Active Surveillance—China,2023

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China CDC weekly 2024年第24期6卷 574-579,I0002页

作者： Penghui Fan Haihong Han Jikai Liu Xiaochen Ma Ronghua Zhang Hong Liu Yijing Zhou Zunhua Chu Jian Wen Li Lin Weiwei Li Yunchang Guo NHC Key Laboratory of Food Safety Risk Assessment China National Center for Food Safety Risk AssessmentBeijingChina Beijing Center for disease prevention and control BeijingChina Zhejiang Provincial Center for disease control and prevention Hangzhou CityZhejiang ProvinceChina Shanghai Center for disease control and prevention ShanghaiChina Jiangsu Provincial Center for disease control and prevention Nanjing CityJiangsu ProvinceChina Shandong province Center for disease control and prevention Jinan CityShandong ProvinceChina guangdong province Center for disease control and prevention Guangzhou CityGuangdong ProvinceChina Sichuan province Center for disease control and prevention Chengdu CitySichuan ProvinceChina

What is already known about this topic?Foodborne diseases,representing significant food safety and public health challenges globally,are not welldocumented in terms of incidence,particularly for cases characterized by acute gastroenteritis(AGI)in *** is added by this report?This study developed a pyramid model to estimate the incidence of five pathogens,stratified by gender and *** estimated incidences per 100,000 people with 95%uncertainty intervals(UI)are as follows:Norovirus,3,188.28(95%UI:2,518.03,7,296.96);Salmonella spp.,1,295.59(95%UI:1,002.62,1,573.11);diarrheagenic ***(DEC),782.62(95%UI:651.19,932.05);Vibrio parahaemolyticus,404.06(95%UI:342.19,468.93);and Shigella spp.,26.73(95%UI:21.05,33.46).What are the implications for public health practice?This study elucidates the incidence rates across various gender and age groups,thereby identifying priority populations for targeted preventive interventions aimed at reducing disease *** insights are crucial for the development of public health policies and management of food safety risks.

关键词： acute diseases stratified

Epidemiological Features of Foodborne disease Outbreaks in Catering Service Facilities—China,2010–2020

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China CDC weekly 2023年第22期5卷 479-484页

作者： Donglei Lu Jikai Liu Hong Liu Yunchang Guo Yue Dai Junhua Liang Lili Chen Lizi Xu Ping Fu Ning Li Shanghai Municipal Center for disease control and prevention ShanghaiChina China National Center for Food Safety Risk Assessment BeijingChina Jiangsu Provincial Center for disease control and prevention Nanjing CityJiangsu ProvinceChina guangdong Provincial Center for disease control and prevention Guangzhou CityGuangdong ProvinceChina Zhejiang Provincial Center for disease control and prevention Hangzhou CityZhejiang ProvinceChina Anhui Provincial Center for disease control and prevention Hefei CityAnhui ProvinceChina

Introduction:In terms of food preparation settings,catering service facilities have been identified as locations with the highest incidence of foodborne disease outbreaks in *** 2010,the China National Center for Food Safety Risk Assessment has established the Foodborne disease Outbreak Surveillance System(FDOSS)to monitor foodborne disease ***,data from the FDOSS has provided a more accurate depiction of the epidemic characteristics of outbreaks within these ***:From 2010 to 2020,the FDOSS gathered data related to the prevalence of outbreaks,cases,hospitalizations,and deaths linked to foodborne disease outbreaks in catering service *** study examined the temporal and geographical distribution,pathogenic factors,and contributing variables of these outbreaks over the course of the ***:From 2010 to 2020,China’s catering service facilities reported 18,331 outbreaks,which resulted in 206,718 illnesses,68,561 hospitalizations,and 201 *** second and third quarters of the year accounted for 76.12%of the outbreaks and 72.93%of the *** primary pathogenic factors were pathogenic organisms,which caused 4,883(26.64%)outbreaks,94,047(45.50%)cases,32,170(46.92%)hospitalizations,and 21(10.45%)*** were 5,607(30.59%)outbreaks in restaurants,2,876(15.69%)outbreaks from street vendors,and 2,560(13.97%)outbreaks in employee canteens in ***:The implementation of relevant control methods,including health education and promotion,is critical for addressing foodborne diseases in catering service *** food safety training sessions for restaurant personnel and managers are essential to ensuring the effective management of these health risks.

关键词： Service restaurant facilities

Exploration for the Priority of HIV Intervention:Modelling Health Impact and Cost-Effectiveness—Six Cities,Eastern China,2019-2028

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China CDC weekly 2024年第20期6卷 463-468,I0008-I0014页

作者： Youran Zhang Lili Wang Zhen Jiang Hongjing Yan Xiaoxia Liu Jing Gu Guoyong Wang Xiaosong Cheng Qiyan Leng Qisui Long Zimian Liang Jing Wang Liang Liang Yanchao Qiu Lin Chen Hang Hong School of Health Service Management Anhui Medical UniversityHefei CityAnhui ProvinceChina Division of prevention and intervention National Center for AIDS and STD Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Jiangsu Provincial Center for disease control and prevention Nanjing CityJiangsu ProvinceChina Zhenjiang Center for disease control and prevention Zhenjiang CityJiangsu ProvinceChina Wuxi Center for disease control and prevention Wuxi CityJiangsu ProvinceChina Shandong Provincial Center for disease control and prevention Jinan CityShandong ProvinceChina Yantai Center for disease control and prevention Yantai CityShandong ProvinceChina guangdong Provincial Center for disease control and prevention Guangzhou CityGuangdong ProvinceChina Foshan Center for disease control and prevention Foshan CityGuangdong ProvinceChina Hebei Provincial Center for disease control and prevention Shijiazhuang CityHebei ProvinceChina Shijiazhuang Center for disease control and prevention Shijiazhuang CityChina Zhejiang Provincial Center for disease control and prevention Hangzhou CityZhejiang ProvinceChina Ningbo Center for disease control and prevention Ningbo CityZhejiang ProvinceChina

Introduction:In order to enhance the effectiveness of resource allocation,regions must tailor their responses to their specific epidemiological and economic ***:Utilizing Spectrum software,we projected the cost-effectiveness of 10 chosen HIV interventions in six cities in eastern China from 2019 to *** assessed three scenarios—Base,Achievable,and Idealized—for each *** analysis included the projected number of HIV infections and deaths averted,as well as the incremental costeffectiveness ratios for each intervention in the six ***:In Shijiazhuang,Wuxi,Yantai,and Zhenjiang,cities with initially low antiretroviral therapy(ART)coverage,ART showed significant effectiveness,especially for ***,in Foshan and Ningbo,where ART coverage was notably high,oral pre-exposure prophylaxis(PrEP)for men who have sex with men(MSM)proved effective in the Idealized *** outreach,ART for males,and ART for females demonstrated cost-effectiveness across all six cities in both Achievable and Idealized scenarios at the predefined thresholds for each ***:Maintaining an appropriate coverage rate for outreach to MSM can lead to *** cities with low ART coverage,scaling up ART remains a crucial *** regions with high ART coverage,consideration may be given to the utilization of oral PrEP for MSM individuals,requiring budget allocation.

关键词： Eastern Ningbo Impact

Survey on Immunization Services for Children with Medical Conditions-China, 2022

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China CDC weekly 2023年第19期5卷 419-423页

作者： Yong Huang Yudan Song Junhong Li Yamin Wang Xiang Zeng Chao Ma Zundong Yin Guangzhou Municipal Center for disease control and prevention Guangzhou CityGuangdong ProvinceChina National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina Chinese Field Epidemiology Training Program Chinese Center for Disease Control and PreventionBeijingChina Zhuhai Municipal Center for disease control and prevention Zhuhai CityGuangdong ProvinceChina

Summary What is already known about this topic?Children with medical conditions frequently experience *** high-quality immunization services is crucial for enhancing vaccination coverage levels;nevertheless,the state of immunization service provision for children with medical conditions in China remains *** is added by this report?Immunization support for children with medical conditions in China demonstrates considerable variability and may be *** obstacles to the provision of immunization services include an absence of comprehensive vaccination recommendations and assessment guidelines for specific medical conditions,as well as inconsistencies among vaccine recommendations,package inserts,and expert consensus statements pertaining to the vaccination of children with medical *** are the implications for public health practice?The examination of provincial practices in providing immunization services for children with medical conditions,as well as understanding the barriers faced by National Immunization Program providers in administering vaccinations,can contribute to the improvement of immunization services for this population in China.

关键词： services Services children

First Imported Case of SARS-CoV-2 Omicron Subvariant BA.4-guangdong province,China,May 4,2022

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China CDC weekly 2022年第40期4卷 902-903页

作者： Qianfang Guo Changcheng Wu Aiping Deng Jingtao Liang Xiang Zhao Ruhan A Jiajun Liu Fangzhu Ouyang Jing Xu Shen Huang Yang Song Lirong Zou Xiaoling Deng Kai Nie Baisheng Li guangdong Provincial Center for disease control and prevention Guangzhou CityGuangdong ProvinceChina National Institute for Viral disease control and prevention Chinese Center for Disease Control and PreventionBeijingChina Foshan Center for disease control and prevention Foshan CityGuangdong ProvinceChina

On April 29,2022,a flight arrived at Baiyun International Airport,Guangzhou City,guangdong province,and departed from Amsterdam Schiphol Airport,*** the first test of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)nucleic acid at the Baiyun International Airport,all passengers were admitted to a quarantine hotel for a routine 14-day medical *** April 30,one of the passengers(a 20-year-old Chinese female)was reported positive for coronavirus disease 2019(COVID-19),and then a nasopharyngeal swab sample was immediately retested on May 1 and reported positive.

关键词： admitted guangdong routine

Effectiveness of COVID-19 Vaccination Against SARS-CoV-2 Omicron Variant Infection and Symptoms—China,December 2022–February 2023

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China CDC weekly 2023年第17期5卷 369-373,I0001-I0005页

作者： Di Fu Guanhao He Huanlong Li Haomin Tan Xiaohui Ji Ziqiang Lin Jianxiong Hu Tao Liu Jianpeng Xiao Xiaofeng Liang Wenjun Ma Department of Public Health and Preventive Medicine School of MedicineJinan UniversityGuangzhou CityGuangdong ProvinceChina disease control and prevention Institute Jinan UniversityGuangzhou CityGuangdong ProvinceChina Key Laboratory of Ministry of Education for Viral Pathogenesis&Infection prevention and control Jinan UniversityGuangzhou CityGuangdong ProvinceChina Fuyang District Center for disease control and prevention Hangzhou CityZhejiang Province guangdong Provincial Institute of Public Health Guangdong Provincial Center for Disease Control and PreventionGuangzhou CityGuangdong ProvinceChina

Summary What is already known about this topic?A considerable percentage of the population has received both primary and booster vaccinations,which could potentially provide protection against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron infections and related *** is added by this report?The self-reported infection rate,as determined from an online survey,reached its peak(15.5%)between December 19 and 21,2022,with an estimated 82.4%of individuals in China being infected as of February 7,*** the epidemic,the effectiveness of booster vaccinations against SARS-CoV-2 Omicron infection was found to be 49.0%within three months of vaccination and 37.9%between 3 and 6 months following ***,the vaccine effectiveness of the booster vaccination in relation to symptom prevention varied from 48.7%to 83.2%within three months and from 25.9%to 69.0%between 3 and 6 months post-booster vaccination.

关键词： vaccination prevention acute