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Characteristics and trends in incidence of childhood cancer in Beijing,China,2000-2009

Chinese Journal of cancer research 2014年第3期26卷 285-292页

作者： Lei Yang Yannan Yuan Tingting Sun Huichao Li Ning Wang Key Laboratory of Carcinogenesis and Translational research (Ministry of Education) Beijing Office for Cancer Prevention and ControlPeking University Cancer Hospital & Institute

Objective： To investigate the characteristics and incidence trends of childhood cancer in Beijing, China, from 2000 to 2009. Methods： A total of 1,274 cases with childhood cancer in Beijing from 2000 to 2009 were included in the study. All rates were age-standardized using the direct method to the world standard population and expressed per million person-years. Incidence trends were characterized by calculating annual percent change （APC） usingJoinpoint Regression Program. Results： The crude incidence rate was 106.47 per million [age-standardized rate （ASR） 113.34] between 2000 and 2009 in Beijing with the most common diagnoses, leukemia （N=505, 39.64%, ASR 45.20）, followed by central nervous system （CNS） tumors （N=228, 17.90%, ASR 19.28） and lyrnphoma （N=91, 7.14%, ASR 6.97）. The incidence for all childhood cancers combined has increased during the study period, with an APC of 5.84% [95% confidence interval （95% CI）： 1.0-10.9] after adjusted by world population. The ASR of all combined cancers in boys showed a slight, but no significant increase, with an APC of 5.33 % （95 % CI： -0.6- 11.6）; for girls, the trends increased significantly, with an APC of 6.54% （95% CI： 1.5-11.8）. Conclusions： The incidence rate of childhood cancer in Beijing was higher than the average level of China and lower than that of western countries. The incidence trends of childhood cancer, especially leukemia among girls showed a significantly increase from 2000 to 2009. While among boys, no substantially change was seen during the observed time period. Some sex-specific trends by subcategories and trends of major cancers in different age groups by cancer site merit further investigation.

关键词： Childhood cancer incidence epidemiology Beijing

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Motion equations of hemispherical resonator and analysis of frequency split caused by slight mass non-uniformity

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Chinese Journal of Aeronautics 2020年第10期33卷 2660-2669页

作者： Yan HUO Shunqing REN Guoxing YI Changhong WANG Space control and Inertial Technology research centre Harbin Institute of TechnologyHarbin 150080China

The mass non-uniformity of hemispherical resonator is one of reasons for frequency split,and frequency split can cause gyroscope to ***,it is of great significance to analyze the relationship between mass non-uniformity and frequency split,which can provide a theoretical basis for mass balance of imperfect *** starting point of error mechanism analysis for gyroscope is the motion equations of ***,based on the Kirchhoff-Love hypothesis in the elastic thin shell theory,the geometric deformation equations of resonator are ***,the deformation energy equation of resonator is derived according to the vibration mode and relationship between the stress and strain of hemispherical thin ***,the kinetic energy equation of resonator is deduced by the Coriolis ***,the motion equations of resonator are established by the Lagrange mechanics *** theoretical values of precession factor and natural frequency are calculated by the motion equations,which are substantially consistent with the ones by the finite element method and practical measurement,the errors are within a reasonable ***,the varying trend of natural frequency with respect to the geometrical and physical parameters of resonator by the motion equations is consistent with that by the finite element *** above conclusions prove the correctness and rationality of motion ***,the motion equations of resonator with mass non-uniformity are established by the same modeling method in case of ignoring the input angular rate and damping,and the state equations with respect to the velocity and displacement of vibration system are derived,then twonatural frequencies are solved by the characteristic *** is concluded that one of reasons for frequency split is the 4 th harmonic of mass non-uniformity,and thus much attention should be paid to minimizing the 4 th harmonic of mass non-uniformity in the course o

关键词： Hemispherical resonator Lagrange mechanics principle Theory of elastic thin shell Motion equations Mass non-uniformity Frequency split

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Annual report on status of cancer in China, 2011

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Chinese Journal of cancer research 2015年第1期27卷 2-12页

作者： Wanqing Chen Rongshou Zheng Hongmei Zeng Siwei Zhang Jie He National Office for cancer Prevention and control National Cancer Center

Objective： The National Central cancer Registry （NCCR） collected population-based cancer registration data in 20l 1 from all cancer registries. National cancer incidence and mortality were compiled and cancer incident new cases and cancer deaths were estimated. Methods： In 2014, there were 234 cancer registries submitted cancer incidence and deaths occurred in 2011. All datasets were checked and evaluated based on the criteria of data quality from NCCR. Total 177 registries＇ data were qualified and compiled for cancer statistics in 2011. The pooled data were stratified by area （urban/rural）, gender, age group （0, 1-4, 5-9, 10-14...85＋） and cancer type. cancer incident cases and deaths were estimated using age-specific rates and national population in 2011. All incidence and death rates are age-standardized to the 2000 Chinese standard population and Segi＇s population expressed per 100,000 persons. Results： All 177 cancer registries （77 in urban and 100 in rural areas） covered 175,310,169 populations （98,341,507 in urban and 76,968,662 in rural areas）. The morphology verified cases （MV%） accounting for 70.14% and 2.44% of incident cases were identified through death certifications only （DCO%） with mortality to incidence ratio of 0.63. The estimates of new cancer incident cases and cancer deaths were 3,372,175 and 2,113,048 in 2011, respectively. The incidence rate was 250.28/100,000 （males 277.77/100,000, females 221.37/100,000）, and the age-standardized incidence rates by Chinese standard population （ASIRC） and by world standard population （ASIRW） were 186.34/100,000 and 182.76/100,000 with the cumulative incidence rate （0-74 years old） of 21.20%. The cancer incidence and ASIRC in urban areas were 261.38/100,000 and 189.89/100,000 compared to 238.60/100,000 and 182.10/100,000 in rural areas, respectively. The cancer mortality was 156.83/100,000 （194.88/100,000 in males and 116.81/100,000 in females）, the age-standardized mortality rates by Chinese standard populatio

关键词： cancer registry incidence mortality epidemiology China

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Population-based cancer incidence analysis in Beijing, 2008-2012

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Chinese Journal of cancer research 2015年第1期27卷 13-21页

Objective： To analyze the incidence of cancer during 2008-2012 in Beijing, China, and compare the cancer spectrum with that during 1998-1999. Methods： Data from the Beijing cancer Registry （BCR）, which covered 12 million residents and 16 administrative regions in Beijing, were checked and evaluated on basis of the criteria of data quality from the National Central cancer Registry （NCCR） of China. Incidences were calculated stratified by cancer type, sex, areas （urban/rural）, and age. The Chinese census population in 1982 and the world Segi＇s population were used for calculating the age-standardized incidences. Results： A total of 177,101 new cancer cases were diagnosed in Beijing between 2008 and 2012. The crude incidence rate （CR） of all cancers was 282.64/100,000 （290.71/100,000 in males and 274.45/100,000 in females）. The age-standardized rates by Chinese standard population （ASR-China） and by world standard population （ASR-world） were 124.46/100,000 and 161.18/100,000, respectivel）a Female breast cancer was the most common cancer, followed by lung cancer, colorectal cancer, liver cancer, and stomach cancer, with the CR of 59.87/100,000, 59.21/100,000, 32.49/100,000, 19.81/100,000 and 17.96/100,000, respectively. In urban areas, female breast cancer （68.50/100,000） was still the most common cancer, followed by lung cancer （61.23/100,000）, colorectal cancer （37.23/100,000）, prostate cancer （20.49/100,000） and stomach cancer （20.07/100,000）. In rural areas, lung cancer （55.94/100,000） was the most common cancer, followed by female breast cancer （45.87/100,000）, colorectal cancer （24.77/100,000）, liver cancer （20.68/100,000） and stomach cancer （14.52/100,000）. Great changes of the cancer spectrum were found from the period of 1998-1999 to the period of2011-2012 in Beijing. Conclusions： The cancer burden in Beijing was heavier than the national average level. cancer prevention and control strategies, especially for lung, colorectal, prostate and female thyroid cancer

关键词： cancer registry incidence epidemiology Beijing

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Printing perovskite and graphene parallel structure-based optical-mechanical sensors for human-machine interaction

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Science China Technological Sciences 2025年

作者： Sisi CHEN Jiemin ZHANG Nan CHENG Wenbo LI Jing LIU Hongfei XIE Jie ZHANG Yueying CHENG Xiaotong ZHAO Meng SU Yanlin SONG Key Laboratory of Green Printing CAS Research/Education Center for Excellence in Molecular Sciences Institute of ChemistryChinese Academy of Sciences (ICCAS) University of Chinese Academy of Sciences Weiyang College Tsinghua University Department of Cardiovascular Surgery First Medical Center PLA General Hospital AECC Beijing Institute of Aeronautical Materials Beijing Institute of Graphene Technology Beijing Engineering research centre of Graphene Application School of Integrated Circuit & Beijing National research Center for Information Science and Technology (BNRist) Tsinghua University

Surgical robots are designed to provide enhanced precision and dexterity compared to manual surgical procedures,which mainly rely on multimodal sensing technologies for the surgeon to seamlessly operate the robotic arms and *** with single-mode sensors, optical and mechanical bi-modal sensors provide improved precision, enhanced safety,and robustness of human-machine interaction systems. Here, the template-guided and pneumatic printing technologies are combined to construct perovskite and graphene parallel structures with both optical and mechanical sensing capabilities. The printed uniformly crystallized perovskite microstructure exhibits fast and sensitive photoelectric response characteristics,enabling shadow recognition functionality. The combination of graphene and elastic rubber endows the great printability to prepare parallel structures near the perovskite arrays for force sensing capabilities. Thus, the printed perovskite and graphene structures possess non-contact optical sensing capabilities to detect hand position by recognizing shadows between the hand and the sensor, as well as contact mechanical sensing capabilities to detect touch force applied by the hand. It provides a synergistic platform for real-time and multidimensional feedback to improve human-machine interaction.

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cancer burden in China:trends,risk factors and prevention

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cancer Biology & Medicine 2020年第4期17卷 879-895页

作者： Dianqin Sun He Li Maomao Cao Siyi He Lin Lei Ji Peng Wanqing Chen Department of cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of cancer Prevention and control Shenzhen Center for Chronic Disease ControlShenzhen 518020China

As the most populous country in the world,China has made strides in health promotion in the past few *** the aging population,the burden of cancer in China continues to *** in risk factors for cancer,especially diet,obesity,diabetes,and air pollution,continue to fuel the shift of cancer transition in *** burden of upper gastrointestinal cancer in China is decreasing,but still *** rising burden of colorectal,prostate,and breast cancers is also *** cancer became the top cause of cancer-related deaths,together with smoking as the most important contributor to cancer *** Chinese government has taken several approaches to control cancer and cancer-related risk *** achievements have been made,but some challenges *** China 2030 is ambitious and depicts a bright vision of the future for cancer control in *** decrease in the cancer burden in China will require cross-sector collaboration and coordinated efforts on primary and secondary preventions by governments,public health organizations,and *** this review,we describe the trends of cancer burden and discuss cancer-related risk factors in China,identifying strategies to reduce the burden of cancer in China.

关键词： cancer burden time trends risk factor prevention China

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Development of a PCR methodology to distinguish species members of Culex vishnui subgroup （Diptera： Culicidae）, based on DNA Barcodes

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Insect Science 2017年第2期24卷 336-340页

作者： N. Pradeep Kumar A. R. Rajavel P. Jambulingam Vector control research centre Field Station (ICMR) Kottayam Kerala India Vector control research centre (ICMR) Indira Nagar Puducherry India

Dear Editor, ＂DNA Barcoding＂ has emerged as a very efficient tool for species identification of diverse group of animals and plants （Stoeckle ＆ Hebert, 2008）. This methodology was proposed as a universal approach... 详细信息

关键词： PCR方法双翅目条形码 DNA 蚊科库蚊物种

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Population-level economic burden of lung cancer in China:Provisional prevalence-based estimations,2017-2030

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Chinese Journal of cancer research 2021年第1期33卷 79-92页

作者： Chengcheng Liu Jufang Shi Hong Wang Xinxin Yan Le Wang Jiansong Ren Mark Parascandola Wanqing Chen Alin Dai Office of cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Tobacco control research Branch Division of Cancer Control and Population Sciences/National Cancer InstituteBethesdaMD 20852USA

Objective:Population-level economic burden is essential for prioritizing healthcare resources and healthcare budget making in the ***,little is known about the economic burden of lung cancer in ***:A prevalence-based approach was adopted to estimate the economic burden of lung cancer,including direct expenditure(medical and non-medical)and indirect cost(disability and premature death).Data on direct expenditure and work-loss days per patient in each year post-diagnosis were obtained from two primary *** parameters were obtained from literatures and official *** were conducted based on varying *** expenditure data were reported in United States dollars(USD)using 2017 value(exchange rate:1 USD=6.760 CNY),with the discount rate of 3%.Results:The total economic burden of lung cancer was estimated to be 25,069 million USD in China in 2017(0.121%of gross domestic productivity,GDP).The estimated direct expenditure was 11,098 million USD,up to1.43%of total healthcare expenditure for China,covering 10,303 million USD and 795 million USD for medical and non-medical expenditure,*** estimated indirect cost was 13,971 million,including 1,517 million USD due to disability and 12,454 million USD due to premature *** current assumptions,the projected total economic burden would increase to 30.1 billion USD,40.4 billion USD,and 53.4 billion USD in 2020,2025,and 2030,accounting for 0.121%,0.131%,and 0.146%of China's GDP,***,if China meets the United Nation sustainable development goal of reducing premature death from non-communicable diseases by one-third by 2030,the total economic burden in 2030 would be 31.9 billion USD,0.087%of China's ***:The economic burden of lung cancer in China in 2017 is substantial and more likely to increase significantly in the *** makers need to take urgent actions in budget making for health *** economic burden could be alleviate

关键词： Lung cancer cost of illness China population-level prevalence

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SEFormer:A Lightweight CNN-Transformer Based on Separable Multiscale Depthwise Convolution and Efficient Self-Attention for Rotating Machinery Fault Diagnosis

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Computers, Materials & Continua 2025年第1期82卷 1417-1437页

作者： Hongxing Wang Xilai Ju Hua Zhu Huafeng Li State Key Laboratory of Mechanics and control for Aerospace Structures Nanjing University of Aeronautics and AstronauticsNanjing210016China School of Computer Science and Engineering Nanyang Technological UniversitySingapore639798Singapore

Traditional data-driven fault diagnosis methods depend on expert experience to manually extract effective fault features of signals,which has certain ***,deep learning techniques have gained prominence as a central focus of research in the field of fault diagnosis by strong fault feature extraction ability and end-to-end fault diagnosis ***,utilizing the respective advantages of convolution neural network(CNN)and Transformer in local and global feature extraction,research on cooperating the two have demonstrated promise in the field of fault ***,the cross-channel convolution mechanism in CNN and the self-attention calculations in Transformer contribute to excessive complexity in the cooperative *** complexity results in high computational costs and limited industrial *** tackle the above challenges,this paper proposes a lightweight CNN-Transformer named as SEFormer for rotating machinery fault ***,a separable multiscale depthwise convolution block is designed to extract and integrate multiscale feature information from different channel dimensions of vibration ***,an efficient self-attention block is developed to capture critical fine-grained features of the signal from a global ***,experimental results on the planetary gearbox dataset and themotor roller bearing dataset prove that the proposed framework can balance the advantages of robustness,generalization and lightweight compared to recent state-of-the-art fault diagnosis models based on CNN and *** study presents a feasible strategy for developing a lightweight rotating machinery fault diagnosis framework aimed at economical deployment.

关键词： CNN-Transformer separable multiscale depthwise convolution efficient self-attention fault diagnosis

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Detecting circulating tumor material and digital pathology imaging during pancreatic cancer progression

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World Journal of Gastrointestinal Oncology 2017年第6期9卷 235-250页

作者： Radim Moravec Rao Divi Mukesh Verma Surveillance research Program Division of Cancer Control and Population SciencesNational Cancer InstituteNational Institutes of Health Methods and Technologies Branch Division of Cancer Control and Population SciencesNational Cancer InstituteNational Institutes of Health

Pancreatic cancer(PC) is a leading cause of cancerrelated death worldwide. Clinical symptoms typically present late when treatment options are limited and survival expectancy is very short. Metastatic mutations are heterogeneous and can accumulate up to twenty years before PC diagnosis. Given such genetic diversity, detecting and managing the complex states of disease progression may be limited to imaging modalities and markers present in circulation. Recent developments in digital pathology imaging show potential for early PC detection, making a differential diagnosis, and predicting treatment sensitivity leading to long-term survival in advanced stage patients. Despite large research efforts, the only serum marker currently approved for clinical use is CA 19-9. Utility of CA 19-9 has been shown to improve when it is used in combination with PC-specific markers. Efforts are being made to develop early-screening assays that can detect tumor-derived material, present in circulation, before metastasis takes a significant course. Detection of markers that identify circulating tumor cells and tumor-derived extracellular vesicles(EVs) in biofluid samples offers a promising non-invasive method for this purpose. Circulating tumor cells exhibit varying expression of epithelial and mesenchymal markers depending on the state of tumor differentiation. This offers a possibility for monitoring disease progression using minimally invasive procedures. EVs also offer the benefit of detecting molecular cargo of tumor origin and add the potential to detect circulating vesicle markers from tumors that lack invasive properties. This review integrates recent genetic insights of PC progression with developments in digitalpathology and early detection of tumor-derived circulating material.

关键词： Circulating tumor cells Digital pathology Early detection Exosomes Pancreatic cancer

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