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Associations between physical activity levels and ATPase inhibitory factor 1 concentrations in older adults

Journal of Sport and Health Science 2024年第3期13卷 409-418页

作者： Jérémy Raffin Yves Rolland Annelise Genoux Guillaume Combes Mikael Croyal Bertrand Perret Sophie Guyonnet Bruno Vellas laurent O.Martinez Philipe de Souto Barreto For the MAPT/DSA Group Institut du Vieillissement Gérontopôle de ToulouseCentre Hospitalo-Universitaire de ToulouseToulouse 31000France centre d'Epidémiologie et de recherche en Santédes Populations UnitéMixte de Recherche 1295Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse-III-Paul-SabatierToulouse 31000France limitAging Team Institut des Maladies Métaboliques et CardiovasculairesUnitéMixte de Recherche 1297Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse III-Paul SabatierToulouse 31432France service de Biochimie Pôle de biologieHôpital de PurpanCentre Hospitalo-Universitaire de ToulouseToulouse 31300France l'Institut du Thorax Institut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France BioCore US16Structure Fédérative de Recherche BonamyInstitut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France Plate-forme de spectrométrie de masse Centre de Recherche en Nutrition HumaineOuestNantes 44000France 不详

Background:Adenosine triphosphatase inhibitory factor 1(IF1)is a key protein involved in energy ***1 has been linked to various agerelated diseases,although its relationship with physical activity(PA)remains ***,the apolipoprotein A-I(apoA-I),a PA-modulated lipoprotein,could play a role in this relationship because it shares a binding site with IF1 on the cell-surface ATP *** examined here the associations between chronic PA and plasma IF1 concentrations among older adults,and we investigated whether apoA-I mediated these ***:In the present work,1096 healthy adults(63.8%females)aged 70 years and over who were involved in the Multidomain Alzheimer Prevention Trial study were ***1 plasma concentrations(square root of ng/ml)were measured at the 1-year visit of the Multidomain Alzheimer Prevention Trial,while PA levels(square root of metabolic equivalent task min/week)were assessed using questionnaires administered each year from baseline to the 3-year *** linear regressions were performed to investigate the associations between the first-year mean PA levels and IF1 *** analyses were conducted to examine whether apoA-I mediated these *** linear regressions were carried out to investigate whether the 1-year visit IF1 concentrations predicted subsequent changes in ***:Multiple linear regressions indicated that first-year mean PA levels were positively associated with IF1 concentrations(B=0.021;se=0.010;p=0.043).Mediation analyses revealed that about 37.7%of this relationship was mediated by apoA-I(B_(ab)=0.008;se=0.004;p=0.023).longitudinal investigations demonstrated that higher concentrations of IF1 at the 1-year visit predicted a faster decline in PA levels over the subsequent 2 years(time×IF1:B=0.148;se=0.066;p=0.025).Conclusion:This study demonstrates that regular PA is associated with plasma IF1 concentrations,and it suggests that apoA-I partly med

关键词： Aging Apolipoprotein Bioenergetics Exerkine Mitochondria

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development of nK cell-based cancer immunotherapies through receptor engineering

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Cellular & Molecular Immunology 2024年第4期21卷 315-331页

作者： Audrey Page nicolas Chuvin Jenny Valladeau-Guilemond Stéphane depil centre de recherche en Cancérologie de lyon UMR INSERM U1052 CNRS 5286Centre Léon BérardLyonFrance ErVimmune LyonFrance centre léon Bérard LyonFrance universitéClaude Bernard lyon 1 LyonFrance

natural killer(nK)cell-based immunotherapies are attracting increasing interest in the field of cancer *** clinical trials have shown promising outcomes,alongside satisfactory product efficacy and *** developments have greatly increased the therapeutic potential of nK cells by endowing them with enhanced recognition and cytotoxic *** review focuses on surface receptor engineering in nK cell therapy and discusses its impact,challenges,and future *** approaches are based on engineering with chimeric antigen receptors to allow nK cells to target specific tumor antigens independent of human leukocyte antigen *** approach has increased the precision and potency of nK-mediated recognition and elimination of cancer *** addition,engineering nK cells with T-cell receptors also mediates the recognition of intracellular epitopes,which broadens the range of target *** tumor peptide recognition by nK cells has also been improved by optimizing immunoglobulin constant fragment receptor expression and ***,engineered nK cells have an improved ability to recognize and destroy target cells coated with specific antibodies,thereby increasing their antibodydependent cellular *** ability of nK cell receptor engineering to promote the expansion,persistence,and infiltration of transferred cells in the tumor microenvironment has also been ***-based strategies for sustained nK cell functionality within the tumor environment have also been discussed,and these strategies providing perspectives to counteract tumor-induced ***,receptor engineering has led to significant advances in nK cell-based cancer *** technical challenges are addressed,these innovative treatments will likely reshape cancer immunotherapy.

关键词： nK cells Cell therapy Receptor engineering CAR

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energy and exergy analysis of a 20-MW grid-connected PV plant operating under harsh climatic conditions

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Clean energy 2024年第1期8卷 281-296页

作者： nouar Aoun Unitéde recherche en energies Renouvelables en Milieu Saharien URERMSCentre de Développement des Energies RenouvelablesCDER01000 AdrarAlgeria

large grid-connected photovoltaic(PV)plants are increasingly being installed around the world,including in harsh desert *** their performance can help improve the design and operation of PV *** study performed an energy and exergy analysis of a 20-MW grid-connected PV plant under desert climatic conditions in southern Algeria over a period of 1 *** PV plant was divided into two 10-MW *** analysis was performed using actual irradiation,power output,wind speed and ambient temperature *** annual average energy efficiency of the plant and subsystems was 10.82%,10.95%and 10.69%,*** radiation had the most significant impact(80%determination coefficient)on thermal exergy *** exergy efficiency of the plant was lower than the literature values,likely due to the harsh desert *** comprehensive energy and exergy analysis provides insights into the performance of large-scale PV plants in desert *** results can help guide the system design and operation improvements for such *** cleaning and cooling could improve performance.

关键词： photovoltaic grid-connected energy exergy analysis efficiency

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developing biophilic intermediate spaces for Arctic housing:Optimizing the thermal,visual,and energy performance

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Building Simulation 2024年第6期17卷 857-875页

作者： Tarlan Abazari AndréPotvin louis Gosselin Claude MH demers GRAP(Groupe de recherche en ambiance physiques) School of ArchitectureLaval UniversityQuébecCanada department of Mechanical engineering Faculty of Science and EngineeringLaval UniversityQuébecCanada

Connecting occupants to the outdoor environment and incorporating biophilic design principles are challenging in extreme Arctic climatic *** Arctic housing models do not provide efficient thermal and daylight transitions which are essential for the well-being and cultural needs of their *** address these challenges,this research develops free-running biophilic intermediate spaces,integrated into an existing Arctic housing *** simulation methods are employed to optimize the primary and secondary architectural design variables for 26 case studies of intermediate *** variables include volume,transparency ratio,and *** variables include materials and physical ***,Daylight Factor/Autonomy,and energy Use are evaluated as performance *** reveal that free-running intermediate spaces with 6 meters depth and a transparency ratio above 50%provide efficient indoor–outdoor transitions regarding thermal,visual,and energy *** architectural configurations contribute to an approximately 5%reduction in energy consumption within the housing unit compared to the *** side windows prevents the risk of overheating during the summer by reducing the average indoor temperature of intermediate spaces by 7°C but increases the overall energy *** a potential alternative to double-glazing,polycarbonate sheets enable efficient thermal performance by increasing the average indoor temperature of intermediate spaces by approximately 15°C during the cold Arctic *** polycarbonate sheets results in a 16.6%reduction in energy consumption compared to using double-glazing material in intermediate space,and a 26%reduction from the *** outcomes contribute to efficient indoor–outdoor connections and energy efficiency in Arctic housing.

关键词： Arctic housing intermediate spaces biophilic design positive thermal transitions daylight availability energy efficiency

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Immunobiodiversity:Conserved and specific immunity across land plants and beyond

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Molecular Plant 2024年第1期17卷 92-111页

作者： Baptiste Castel Karima El Mahboubi Christophe Jacquet Pierre-Marc delaux laboratoire de recherche en Sciences Végétales(lRSV) Universitéde ToulouseCNRSUPSToulouse INPCastanet-TolosanFrance

Angiosperms represent most plants that humans cultivate,grow,and ***,angiosperms are only one of five major land plant *** a whole lineage,plants also include algal *** these clades represent a tremendous genetic diversity that can be investigated to reveal the evolutionary history of any given *** this review,we describe the current model of the plant immune system,discuss its evolution based on the recent literature,and propose future directions for the *** angiosperms,plant–microbe interactions have been intensively studied,revealing essential cell surface and intracellular immune receptors,as well as metabolic and hormonal defense *** diversity at the genomic and functional levels demonstrates the conservation of these pathways across land plants,some of which are beyond *** basis of the conserved mechanisms,lineage-specific variations have occurred,leading to diversified reservoirs of immune *** rare cases,this diversity has been harnessed and successfully transferred to other species by integration of wild immune receptors or engineering of novel forms of receptors for improved resistance to *** propose that exploring further the diversity of immune mechanisms in the whole plant lineage will reveal completely novel sources of resistance to be deployed in crops.

关键词： evolution MPMI immunity plant evoMPMI symbiosis

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Hydrometallurgy two stage process for preparation of (nd,la,Ce)_(2)O_(3) from end-of-life niMH batteries

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Journal of Rare Earths 2024年第2期42卷 415-423,I0007页

作者： Karim Tanji Khalid Ouzaouit Mohamed Belghiti Isam lamsayety Hakim Faqir Intissar Benzakour centre de recherche REMInEX-Groupe MAnAGEM MarrakechMorocco

The present work aims to investigate the recovery of light rare earth elements(lREEs) oxides from end-oflife niMH batteries using a hydro metallurgical process followed by effective *** operational leaching parameters such as phosphoric acid concentration,temperature,and the solid-liquid ratio were first optimized by Box-Behnken *** results reveal that under optimum conditions([H_(3)PO_(4)]=2 mol/l,T=80℃,and S/l=1:10 g/ml) the leaching efficiencies of ni,Co reach 98.1% and99.3%.While la,Ce,and nd elements remain in the leaching residue as(la,Ce,nd)PO_(4) with yields of 98.2%,98.6%,and 99.6% for la,Ce,and nd,***,the(la,Ce,nd)PO_(4) is leached with HCl acid,then the rare earth oxalate was precipitated using oxalic acid at a pH of 1.8 and then the product was calcined at 800℃ for 2 h in order to synthesize the(nd,la,Ce)_(2)O_(3).The analysis using scanning electron microscopy(seM) coupled with energy dispersive X-ray spectroscopy(EDX) confirms the homogeneity of(nd,la,Ce)_(2)O_(3) particles that have two morphologies,i.e.,flower and sticks with a particle size between 3and 6 μ*** unit cell parameters of(nd,la,Ce)_(2)O_(3) were calculated after Rietveld refinement of the XRD patterns,in the space group of Fm-3m are a=b=c=0.57921 nm and the volume equal to 0.194322 nm^(3).

关键词： niMH batteries Hydrometallurgical process leaching Phosphoric acid Box-Behnken light rare earth oxides

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A study on wildfire impacts on greenhouse gas emissions and regional air quality in South of Orléans,France

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Journal of environmental Sciences 2024年第1期135卷 521-533页

作者： Chaoyang Xue Gisèle Krysztofiak Yangang Ren Min Cai Patrick Mercier Frédéric le Fur Corinne Robin Benoit Grosselin Véronique Daele Max RMcGillen Yujing Mu Valéry Catoire Abdelwahid Mellouki laboratoire de Physique et Chimie de l’environnement et de l’Espace(lPC2E) CNRS–UniversitéOrléans–CNES(UMR 7328)Orléans Cedex 245071France Institut de Combustion AérothermiqueRéactivitéEnvironnement(ICARE)CNRSOrléans Cedex 245071France Research centre for Eco-environmental Sciences Chinese Academy of SciencesBeijing 100085China lig’Air-Association de surveillance de la qualitéde l’air en région centre-Val de loire Saint-Cyr-en-Val 45590France Mohammed V university RabatMorocco

Wildfire events are increasing globally which may be partly associated with climate change,resulting in significant adverse impacts on local,regional air quality and global *** september 2020,a small wildfire(burned area:36.3 ha)event occurred in Souesmes(loiret-Cher,Sologne,France),and its plume spread out over 200 km on the following day as observed by the MODIS *** on measurements at a suburban site(~50 km northwest of the fire location)in Orléans and backward trajectory analysis,young wildfire plumes were *** increases in gaseous pollutants(CO,CH_(4),n_(2)O,VOCs,etc.)and particles(including black carbon)were found within the wildfire plumes,leading to a reduced air *** factors,defined as EF(X)=ΔX/ΔCO(where,X represents the target species),of various trace gases and black carbon within the young wildfire plumes were determined accordingly and compared with previous *** in the ambient ions(such as ammonium,sulfate,nitrate,chloride,and nitrite in the particle-and gasphase)and aerosol properties(e.g.,aerosol water content,aerosol p H)were also quantified and ***,we estimated the total carbon and climate-related species(e.g.,CO_(2),CH_(4),n_(2)O,and BC)emissions and compared them with fire emission *** biomass burning emission inventories have uncertainties in estimating small fire burned areas and *** instance,we found that the Global Fire Assimilation System(GFAS)may underestimate emissions(e.g.,CO)of this small wildfire while other inventories(GFED and FInn)showed significant *** that it is the first time to record wildfire plumes in this region,related atmospheric implications are presented and discussed.

关键词： Wildfire Air quality Emission factor Emission inventory VOlTAIRE supersite

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Analysis and Control of the Vehicle Roll Dynamics Using Sum of Squares Polynomial Approach

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Journal of Systems Science & Complexity 2024年

作者： IBen AMMAR Imen DOUMIATI Moustapha TAlJ Reine CHOKOR Abbas MACHMOUM Mohamed EseO-IREenA Institut de recherche en énergie électrique de nantes Atlantique IREENA UR 4642 37 Boulevard de l’Université-BP406 Sorbonne universités Université de Technologie de Compiègne CNRS Institut de recherche en énergie électrique de nantes Atlantique IREENA UR 4642 37 Boulevard de l’Université-BP 406

The safety of vehicle travel relies on good stability performance, making vehicle motion control a vital technology in vehicles. This paper focuses on investigating the impact of roll control on vehicle performance, particularly in terms of avoiding rollover and ensuring lateral stability. By introducing a feedback roll moment, the roll motion can be effectively controlled. The paper considers two roll reference generators: A static one aimed at zero roll, and a dynamic one based on the vehicle's lateral acceleration. The static roll reference generator enhances stability by employing a fixed reference, particularly beneficial during routine driving conditions. In contrast, the dynamic roll reference generator continually adapts the roll angle reference in response to real-time vehicle dynamics and driving conditions. These proposed reference generators can be paired with varying suspension systems — Static reference could be achieved using semi-active suspensions, while the dynamic one is integrated into advanced active suspension systems, offering heightened adaptability and *** address the roll control objectives, this paper proposes a novel sum of squares(SOS) integral polynomial tracking control. The proposed controller satisfies control bounds and considers control constraints during the design phase. The effectiveness and robustness of the proposed control scheme are evaluated through numerical simulations using a full vehicle nonlinear model in Matlab/Simulink. The results of these simulations are compared to super-twisting sliding mode and lyapunov-based controllers.

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Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles Méryl-Farelle Oye Mintsa Mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond Martine Saint-Pierre Clémence Rouxel line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated laboratory(nutrineuro FranceINAFCanada)QuebecQCCanada Axe endocrinologie et néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de Médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

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Rapid correction of chronic hyperglycemia and bone remodeling,warning against overdoing

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World Journal of Diabetes 2024年第9期15卷 1858-1861页

作者： Dured Dardari Beatrice segurens department of Diabetology Centre Hospitalier Sud FrancilienCorbeil Essonne 91100France universitéParis-Saclay CEACentre National de Recherche en Génomique Humaine(CNRGH)Evry CourcouronnesFrance

It is widely recognized that chronic hyperglycemia decreases bone quality,although little is known about the impact of the rapid correction of chronic hyperglycemia on the quality of bone *** spotlight article explore... 详细信息

关键词： Bone remodeling Chronic hyperglycemia Intensive hyperglycemia treatment Diabetes complication Rapid correction of hyperglycemia

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