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Targeting the motor cortex to restore walking after incomplete spinal cord injury

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Neural Regeneration Research 2022年第7期17卷 1489-1490页

作者： Marina Martinez Département de Neurosciences Groupe de recherche sur la Signalisation Neurale et la Circuiterie and Centre Interdisciplinaire de Recherche sur le Cerveau au service de l’ApprentissageUniversitéde MontréalCIUSSS du Nord-de-l’Île-de-MontréalMontréalQCCanada

Spinal cord injury(SCI),second only to stroke,is the leading cause of *** ability to walk is often lost after SCI,reducing independence and quality of *** of walking is cited as a priority among persons with SCI of all degrees of severity,chronicity,or age at *** 70%of SCIs are anatomically incomplete,some neural connections relaying information to and from the brain are spared.

关键词： incomplete paralysis injury

Characterization of Extracts from the Bark of the Gabon Hazel Tree (Coula edulis baill) for Antioxidant,Antifungal and Anti-termite Products

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Journal of Renewable Materials 2021年第1期9卷 17-33页

作者： Christ Stone Arnaud Bopenga Bopenga Henri Meyo degboevi Kevin Candelier Prosper Edou Engonga Stéphane Dumarçay Marie France Thévenon Christine Gérardin Charbonnier Philippe Gérardin Universitéde Lorraine Institut National de Recherche pour l’Agriculturel’Alimentation et l’EnvironnementLaboratoire d’Etudes et de Recherche sur le Matériau BoisNancyFrance Universitéde Montpellier Centre de Coopération Internationale en Recherche Agronomique pour le Développement-Research Unit BiomassWoodEnergyBioproductsMontpellierFrance Multidisciplinary Laboratory of Sciences of Libreville Normal Superior SchoolLibrevilleGabon

Chemical composition of the bark extracts of Coula edulis was investigated to find potential antioxidant,anti-termite and antifungal compounds which can find useful applications in the fields of food,nutraceuticals,cosmetics or *** screening revealed the presence of several groups of active molecules such as alkaloids,polyphenols,flavonoids,saponins and sterols and/or terpenes in the different *** phenols,condensed tannins and flavonoids contents corroborated phytochemical *** chromatographymass spectrometry(GC-MS)analysis revealed compounds in dichloromethane extract different from those obtained with all the other *** and trans-9-octadecenoic acids,as well as stigmasterol andβ-sitosterol have been identified as the major compounds in the dichloromethane *** obtained with acetone and toluene/ethanol mixture(2/1,v/v)indicated the presence of few amounts of fatty acids and sugars,catechin in small amount and huge amounts of phenolic acids like gallic and ellagic *** radical 2,2-diphenyl-1-picrylhydrazyle(DPPH)and the cationic radical 2,2’-azinobis(3-ethylbenzothiazoline-6-sulfonic acid)(ABTS+)were used for evaluation of antioxidant properties of the different *** dichloromethane extracts had a very low antioxidant activity,while acetone and toluene/ethanol extracts presented EC50 values similar to those of catechin and BHT used as reference antioxidant *** of the different extracts of the bark of *** on fungal growth inhibition indicated better inhibition of the mycelium growth of brown rot fungi compared to white rot *** anti-termite activities were recorded with the aqueous extracts,while stronger activities were recorded with dichloromethane,acetone and toluene/ethanol extracts.

关键词： Antifungal antioxidant anti-termite Coula edulis baill extracts valorisation

One Step Regioselective Acylation of Polyphenolic Wood Extractive and Its Application for Wood Treatment

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Journal of Renewable Materials 2022年第6期10卷 1491-1503页

作者： Wissem Sahmim Georges Eid Febrina dellarose Boer Hubert Chapuis Philippe Gérardin Christine Gérardin-Charbonnier Universitéde Lorraine-Institut National de recherche Pour l’Agriculture L’Alimentation et L’Environnement(INRAE)Laboratoire d’Etudes et de Recherche sur le Matériau Bois(LERMAB)NancyFrance

This study evaluated the methods of grafting commercial catechin with fatty acids,namely capric acid(C10),lauric acid(C12),and myristic acid(C14)through *** of beech wood(Fagus sylvatica L.)were impregnated with catechin and modified catechin-fatty acids,separately,at a 5%concentration diluted in ethanol using vacuum pressure treatment and subjected to *** weight percentage gain before leaching(WPG),after leaching(WPGAL),and weight loss due to leaching(PL)were *** leached and unleached samples were tested against white-rot fungi(Trametes versicolor)in Petri-dishes for twelve *** show that samples treated with modified catechin-fatty acids provide improved resistance towards ***-C14 was found to be more promising,possibly due to its chain *** decay weight loss for samples treated with modified catechin-fatty acids does not differ significantly between the samples that leached and *** the antifungal properties of catechin,the treatment with catechin alone was insufficient to protect wood samples from ***,it is recommended to increase the concentration level of modified catechin to obtain a significant effect on the decay resistance.

关键词： Antifungal catechin chemical modification fatty acids wood protection

Biomolecules of Interest Present in the Main Industrial Wood Species Used in Indonesia-A Review

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Journal of Renewable Materials 2021年第3期9卷 399-449页

作者： Resa Martha Mahdi Mubarok Wayan Darmawan Wasrin Syafii Stéphane Dumarcay Christine Gérardin Charbonnier Philippe Gérardin Universitéde Lorraine Institut National de Recherche pour l’Agriculturel’Alimentation et l’EnvironnementLaboratoire d'Etudes et de Recherche sur le Matériau BoisNancyFrance department of Forest Products Faculty of Forestry and EnvironmentInstitut Pertanian BogorBogor UniversityBogorIndonesia

As a tropical archipelagic country,Indonesia’s forests possess high biodiversity,including its wide variety of wood *** of biomolecules released from woody plant extracts has been gaining attractive interests since in the middle of 20th *** paper focuses on a literature review of the potential valorisation of biomolecules released from twenty wood species exploited in *** has revealed that depending on the natural origin of the wood species studied and harmonized with the ethnobotanical and ethnomedicinal knowledge,the extractives derived from the woody plants have given valuable heritages in the fields of medicines and *** families of the bioactive compounds found in the extracts mainly consisted of flavonoids,stilbenes,stilbenoids,lignans,tannins,simple phenols,terpenes,terpenoids,alkaloids,quinones,and *** addition,biological or pharmacological activities of the extracts/isolated phytochemicals were recorded to have antioxidant,antimicrobial,antifungal,anti-inflammatory,anti-diabetes,anti-dysentery,anticancer,analgesic,anti-malaria,and anti-Alzheimer *** from these remarkable characteristics of woody plant extractives,further studies concerning the valorisation of these extractives in the fields of nutraceutical,cosmetic,bio-control,bio-stimulation,and other advanced applications would be of interest.

关键词： Bark by-product bioactivity extractive Indonesia industry molecule valorization wood species

Effects of a sex ratio gradient on female mate-copying and choosiness in Drosophila melanogaster

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Current Zoology 2018年第2期64卷 251-258页

作者： Magdalena MONIER Sabine NOBEL Guillaume ISABEL Etienne DANCHIN UMR-5174 Laboratoire Evolution & Diversite Biologique (EDB) Centre National de la Recherche Scientifique (CNRS) Institut de Recherche pour le Developpement (IRD) Universite de Toulouse 118 route de NarbonneF-31062 Toulouse Cedex 9 France centre de recherches sur la Cognition Animale (CRCA) Centre de Biologie Integrative (CBI) Centre National de la Recherche Scientifique (CNRS) Universite de Toulouse 118 route de Narbonne F-31082 Toulouse Cedex 9 France

In many sexually reproducing species, individuals can gather information about potential mates by observing their mating success. This behavioral pattern, that we call mate-copying, was reported in the fruit fly Drosophila rnelanogaster where females choosing between 2 males of contrasting phenotypes can build a preference for males of the phenotype they previously saw being chosen by a demonstrator female. As sex ratio is known to affect mate choice, our goal was to test whether mate-copying is also affected by encountered sex ratios. Thus, we created a gradient of sex ratio during demonstrations of mate-copying experiments by changing the number of females observ- ing from a central arena 6 simultaneous demonstrations unfolding in 6 peripheral compartments of a hexagonal device. We also tested whether the sex ratio experienced by females during demon- strations affected their choosiness （male courtship duration and double courtship rate） in subse- quent mate-choice tests. Experimental male：female sex ratio during demonstrations did not affect mate-copying indices, but positively affected the proportion of both males courting the female during mate-choice tests, as well as male courtship duration, the latter potentially explaining the for- mer relationship. As expected, the sex ratio affected female choosiness positively, and Drosophila females seem to have evolved a mate-copying ability independently of sex ratio, and a capacity to adapt their choosiness to male availability. This suggests that, as in many animal species, individuals, especially females, can adapt their mate choice depending on the current sex ratio.

关键词： competition Drosophila melanogaster experimental protocol mate-copying social learning sex ratio.

Associations between physical activity levels and ATPase inhibitory factor 1 concentrations in older adults

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Journal of Sport and Health Science 2024年第3期13卷 409-418页

作者： Jérémy Raffin Yves Rolland Annelise Genoux Guillaume Combes Mikael Croyal Bertrand Perret Sophie Guyonnet Bruno Vellas Laurent O.Martinez Philipe de Souto Barreto For the MAPT/DSA Group Institut du Vieillissement Gérontopôle de ToulouseCentre Hospitalo-Universitaire de ToulouseToulouse 31000France centre d'Epidémiologie et de recherche en Santédes Populations UnitéMixte de Recherche 1295Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse-III-Paul-SabatierToulouse 31000France LimitAging Team Institut des Maladies Métaboliques et CardiovasculairesUnitéMixte de Recherche 1297Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse III-Paul SabatierToulouse 31432France Service de Biochimie Pôle de biologieHôpital de PurpanCentre Hospitalo-Universitaire de ToulouseToulouse 31300France L'Institut du Thorax Institut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France BioCore US16Structure Fédérative de Recherche BonamyInstitut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France Plate-forme de spectrométrie de masse Centre de Recherche en Nutrition HumaineOuestNantes 44000France 不详

Background:Adenosine triphosphatase inhibitory factor 1(IF1)is a key protein involved in energy ***1 has been linked to various agerelated diseases,although its relationship with physical activity(PA)remains ***,the apolipoprotein A-I(apoA-I),a PA-modulated lipoprotein,could play a role in this relationship because it shares a binding site with IF1 on the cell-surface ATP *** examined here the associations between chronic PA and plasma IF1 concentrations among older adults,and we investigated whether apoA-I mediated these ***:In the present work,1096 healthy adults(63.8%females)aged 70 years and over who were involved in the Multidomain Alzheimer Prevention Trial study were ***1 plasma concentrations(square root of ng/mL)were measured at the 1-year visit of the Multidomain Alzheimer Prevention Trial,while PA levels(square root of metabolic equivalent task min/week)were assessed using questionnaires administered each year from baseline to the 3-year *** linear regressions were performed to investigate the associations between the first-year mean PA levels and IF1 *** analyses were conducted to examine whether apoA-I mediated these *** linear regressions were carried out to investigate whether the 1-year visit IF1 concentrations predicted subsequent changes in ***:Multiple linear regressions indicated that first-year mean PA levels were positively associated with IF1 concentrations(B=0.021;SE=0.010;p=0.043).Mediation analyses revealed that about 37.7%of this relationship was mediated by apoA-I(B_(ab)=0.008;SE=0.004;p=0.023).Longitudinal investigations demonstrated that higher concentrations of IF1 at the 1-year visit predicted a faster decline in PA levels over the subsequent 2 years(time×IF1:B=0.148;SE=0.066;p=0.025).Conclusion:This study demonstrates that regular PA is associated with plasma IF1 concentrations,and it suggests that apoA-I partly med

关键词： Aging Apolipoprotein Bioenergetics Exerkine Mitochondria

J’ai grandi dans l’Axe central de Beijing

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今日中国（法文版） 2022年第8期60卷 30-31页

作者： CAO JINGZHOU centre de recherche sur la culture de l’Axe central à l'Institut de recherche sur le développement urbain de Beijing

J’ai grandi à Beijing et j’ai vécu dans le lnitong(allée)de Majuan,à l’angle nord-est de la Cité interdite,et en face de la cour,il y avait le hutong de *** sortant à l’ouest,vous voyez la tour d'angle nord-... 详细信息

关键词： les angle Beijing

Effects of glutamine supplementation on gut barrier,glutathione content and acute phase response in malnourished rats during inflammatory shock

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World Journal of Gastroenterology 2007年第20期13卷 2833-2840页

作者： Liliana Belmonte Mose Co■ffier Florence le Pessot Olga Miralles-Barrachina Martine Hiron Antony leplingard Jean-Franois lemeland Bernadette Hecketsweiler Maryvonne Daveau Philippe Ducrotté Pierre Déchelotte Appareil Digestif Environnement Nutrition ADEN EA3234Institut Hospitalo-Universitaire de Recherche Biomédicale and Institut Fédératif de Recherches Multidisciplinaires sur les PeptidesFaculté de Médecine-PharmacieRouenFrance Service d’Anatomie Pathologique Centre Hospitalier UniversitaireRouenFrance INSERM unit 519 Institut Hospitalo-Universitaire de Recherche Biomédicale and Institut Fédératif de Recherches Multidisciplinaires sur les PeptidesFaculté de Médecine-PharmacieRouenFrance Groupe de recherche sur les Antimicrobiens et les Microorganismes GRAM EA2656Institut Hospitalo-Universitaire de Recherche Biomédicale and Institut Fédératif de Recherches Multidisciplinaires sur les PeptidesFaculté de Médecine-PharmacieRouenFrance

AIM: To evaluate the effect of glutamine on intestinal mucosa integrity,glutathione stores and acute phase response in protein-depleted rats during an inflammatory shock. METHODS: Plasma acute phase proteins (APP),jejunal APP mRNA levels,liver and jejunal glutathione concentrations were measured before and one,three and seven days after turpentine injection in 4 groups of control,protein-restricted,protein-restricted rats supplemented with glutamine or protein powder. Bacterial translocation in mesenteric lymph nodes and intestinal morphology were also assessed. RESULTS: Protein deprivation and turpentine injection significantly reduced jejunal villus height,and crypt depths. Mucosal glutathione concentration significantly decreased in protein-restricted rats. Before turpentine oil,glutamine supplementation restored villus heights and glutathione concentration (3.24 ± 1.05 vs 1.72 ± 0.46 μmol/g tissue,P level after turpentine oil but did not affect its plasma concentration. Bacterial translocation in protein-restricted rats was not prevented by glutamine or protein powder supplementation. CONCLUSION: Glutamine restored gut glutathione stores and villus heights in malnourished rats but had no preventive effect on bacterial translocation in our model.

关键词： Acute phase response Glutamine Glutathione Intestine Malnutrition

Cross-sectional associations between cortical thiclmess and physical activity in older adults with spontaneous memory complaints:The MAPT Study

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Journal of Sport and Health Science 2023年第3期12卷 324-332页

作者： Jérémy Raffin Yves Rolland Clara Fischer Jean-Francois Mangin Audrey Gabelle Bruno Vellas Philipe de Souto Barreto the MAPT/DSA Group Gérontopôle de Toulouse Institut du VieillissementCentre Hospitalo-Universitaire de ToulouseToulouse 31000France UniversitéPaul-Sabatier/Institut National de la Santéet de la recherche Médicale UnitéMixte de recherche 1027 Facultéde médecineUniversity of Toulouse ⅢToulouse 31000France centre pour l'Acquisition et le Traitement des Images Multicenter Neuroimaging Platform NeurospinUniversitéParis-SaclayGif sur Yvette 91191France Memory Resources and Research Center Montpellier University HospitalMontpellier 34295France Institut National de la Santéet de la recherche Médicale Unité1061 i-site Montpellier Universitéd'Excellence University of MontpellierMontpellier 34090France 不详

Background:Age-related changes in brain structure may constitute the starting point for cerebral function *** activity(PA)demonstrated favorable associations with total brain volume,but its relationship with cortical thickness(CT)remains *** investigated the cross-sectional associations between PA level and CT in community-dwelling people aged 70 years and ***:A total of 403 older adults aged 74.8±4.0 years(mean±SD)who underwent a baseline magnetic resonance imaging examination and who had data on PA and confounders were *** was assessed with a *** were categorized according to PA *** linear regressions were used to compare the brain CT(mm)of the inactive group(no PA at all)with 6 active groups(growing PA levels)in 34 regions of ***:Compared with inactive persons,people who achieved PA at a level of 1500-1999 metabolic equivalent task-min/week(i.e.,about6-7 h of brisk walking for exercise) and those who achieved it at 2000-2999 metabolic equivalent task-min/week(i.e.,8-11 h of brisk walking for exercise)had higher CT in the fusiform gyrus and the temporal ***,dose-response associations between PA and CT were found in the fusiform gyrus(B=0.011,SE=0.004,adj.p=0.035),the temporal pole(B=0.026,SE=0.009,adj.p=0.048),and the caudal middle frontal gyrus,the entorhinal,medial orbitofrontal,lateral occipital,and insular ***:This study demonstrates a positive association between PA level and CT in temporal areas such as the fusiform gyrus,a brain region often associated to Alzheimer’s disease in people aged 70 years and *** investigations focusing on PA type may help to fulfil remaining knowledge gaps in this field.

关键词： Alzheimer's disease Brain aging Cortical thickness Physical activity