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Beyond neurodegeneration:engineering amyloids for biocatalysis

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Neural Regeneration Research 2025年第10期20卷 2915-2916页

作者： Andrea Bartolomé-Nafría Javier García-Pardo Salvador Ventura Institut de Biotecnologia i de Biomedicina(IBB)and departament de Bioquímica i Biologia Molecular Universitat Autònoma de BarcelonaBellaterraBarcelonaSpain Hospital Universitari Parc Taulí Institut d’Investigaciói InnovacióParc Taulí(I3PT-CERCA)Universitat Autònoma de BarcelonaSabadellSpain

Amyloid fibrils are highly organized protein or peptide aggregates,often characterized by a distinctive supramolecular cross-β-sheet *** formation and accumulation of these structures have been traditionally associated with neural or systemic human diseases,such as Alzheimer’s disease,Parkinson’s disease,type-2 diabetes,or amyotrophic lateral sclerosis(Wei et al.,2017;Wittung-Stafshede,2023).

关键词： structure amyloid

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The effect of landscape complexity and microclimate on the thermal tolerance of a pest insect

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Insect Science 2018年第5期25卷 905-915页

作者： Lucy Alford Kevin Tougeron Jean-Sebastien Pierre Francoise Burel Joan van Baaren UMR 6553 ECOBIO Centre National de la Recherche Scientitique Universite de Rennes I Rennes Cedex France departement de Sciences Biologiques Insfitut de Recherche en Biologie Vegetale Universite de Montreal Montreal QC Canada Universite Europeenne de Bretagne (UEB) Rennes France

Landscape changes are known to exacerbate the impacts of climate change. As such, understanding the combined effect of climate and landscape on agroecosystems is vital if we are to maintain the fimction of agroecosystems. This study aimed to elucidate the effects of agricultural landscape complexity on the microclimate and thermal tolerance of an aphid pest to better understand how landscape and climate may interact to affect the thermal tolerance of pest species within the context of global climate change. Meteo- rological data were measured at the landscape level, and cereal aphids （Sitobion avenae, Metopolophium dirhodum and Rhopalosiphum padi） sampled, from contrasting landscapes （simple and complex） in winter 2013/2014 and spring 2014 in cereal fields of Brittany, France. Aphids were returned to the laboratory and the effect of landscape of origin on aphid cold tolerance （as determined by CTmin） was investigated. Results revealed that local landscape complexity significantly affected microclimate, with simple homogenous landscapes being on average warmer, but with greater temperature variation. Landscape complexity was shown to impact aphid cold tolerance, with aphids from complex land- scapes being more cold tolerant than those from simple landscapes in both winter and spring, but with differences among species. This study highlights that future changes to land use could have implications for the thermal tolerance and adaptability of insects. Fur- thermore, not all insect species respond in a similar way to microhabitat and microclimate, which could disrupt important predator-prey relationships and the ecosystem service they provide.

关键词： agroecosystems biological control cereal aphids climate change coldtolerance landscape ecology

Antimicrobial,antiplasmodial,haemolytic and antioxidant activities of crude extracts from three selected Togolese medicinal plants

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Asian Pacific Journal of Tropical Medicine 2011年第10期4卷 808-813页

作者： Simplice D Karou Tchadjobo Tchacondo Lassina Ouattara Kokou Anani Aly Savadogo Amegnona Agbonon Mossaclok Ben Attaia Comlan de Souza Mohsen Sakly Jacques Simpore centre de recherche et de Formation sur les Plantes Medicinales(CERFOPLAM) Universite de LomeTogo centre de recherche Biomoleculaire Pietro Annigoni(CERBA/LABIOGenE) OuagadougouBurkina Faso centre de recherche en Sciences Biologiques Alimentaires et Nutritionnelles(CRSBAN)Universite de OuagadougouBurkina Faso Laboratoire de Biosurveillance de l'environnement Facultes des Sciences de BizerteUniversite 7 Novembre a CarthageTunisTunisie

Objective:To investigate the antioxidant,antimicrobial,antiplasmodial,acute toxicity and haemolytic activities of methanolic extracts of three *** analysis to determine the phenolic contents was also carried ***:The 2,2-diphenyl-1- picryl-hydrazyl（DPPH） free radical scavenging,NCCLS broth microdilution and Plasmodium Lactate dehydrogenase（pLDH） assays were used to determine antioxidant,antimicrobial and antiplasmodial activities,*** assay was conducted on A+ human red blood cells and acute toxicity on male Swiss albino *** were quantitatively determined using spectrophotometric ***:The DPPH assay yielded interesting antioxidant activities of methanolic extract of Parinari curatellifolia（***） and entada africana （***）(IC50 were 0.20±0.01μg/mL and 0.47±0.01μg/mL,respectively).This activity was highly correlated with phenolic contents of *** antimicrobial tests displayed minimal inhibitory concentrations（MICs） values ranging from 0.90 to 1.80 mg/mL for Serratia marcescens （***） the most susceptible bacterial *** value was 1.20 mg/mL for susceptible fungal strains including Mucor rouxi（***）,Fusarium oxyporum（***） and Rhizopus nigricans（***）.pLDH assay showed moderate antiplasmodial activity of Balanites aegyptiaca（***）(IC50= 24.56±3.45μg/mL),however this extract was highly haemolytic and toxic in mice(LD50= 625±128mg/kg).Conclusions:Our results support in part the use of the selected plants in the treatment of microbial *** addition the plant showed interesting antioxidant activity that could be useful in the management of oxidative stress.

关键词： Antioxidant Antimicrobial Phenolics Haemolytic

Conceptual design of irradiation device for silicon neutron transmutation doping around Es-Salam research reactor

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Nuclear Science and Techniques 2020年第4期31卷 69-78页

作者： M.Salhi B.Mohammedi S.Laouar M.Dougdag M.Touiza M.Abbaci M.Moughari centre de recherche Nucle′aire de Birine 17200 Ain OusseraAlgeria Institut Alge′rien de formation en Ge′nie Nucle′aire 16050 DrariaAlgerAlge′rie

Silicon neutron transmutation doping remains one of the most viable nuclear applications for research *** this kind of product involves an irradiation method capable of fulfilling the quality requirements of doping and alleviating the challenges related to the design and safety of the irradiation *** this paper,we propose an irradiation device prototype for neutron transmutation doping of silicon ingots with diameters of 2 to 3 *** on the Es-Salam research *** thermal hydraulic analysis of the proposed irradiation device was performed to determine the optimum conditions for *** effect of the mechanical vibrations induced by the circulation of coolant in the device was quantified via experimental measurements under different flow *** results show that the maximum temperature reached by the silicon ingots is below the temperature limit,effectively validating the design of the irradiation *** investigations are prospected to further optimize the design and the irradiation *** irradiation of silicon ingots with a large diameter will be considered.

关键词： Irradiation device prototype Es-Salam research reactor NTD-Si Irradiation temperature CFD method

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Early evolution of life cycles in embryophytes: A focus on the fossil evidence of gametophyte/sporophyte size and morphological complexity

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Journal of Systematics and Evolution 2011年第1期49卷 1-16页

作者： Philippe GERRIenNE Paul GONEZ palobotanique Palopalynologie et Micropalontologie Unit Department of Geology University of Liege

Embryophytes (land plants) are distinguished from their green algal ancestors by diplobiontic life cycles, that is, alternation of multicellular gametophytic and sporophytic generations. The bryophyte sporophyte is small and matrotrophic on the dominant gametophyte; extant vascular plants have an independent, dominant sporophyte and a reduced gametophyte. The elaboration of the diplobiontic life cycle in embryophytes has been thoroughly discussed within the context of the Antithetic and the Homologous Theories. The Antithetic Theory proposes a green algal ancestor with a gametophyte-dominant haplobiontic life cycle. The Homologous Theory suggests a green algal ancestor with alternation of isomorphic generations. The shifts that led from haplobiontic to diplobiontic life cycles and from gametophytic to sporophytic dominance are most probably related with terrestrial habitats. Cladistic studies strongly support the Antithetic Theory in repeatedly identifying charophycean green algae as the closest relatives of land plants. In recent years, exceptionally well-preserved axial gametophytes have been described from the Rhynie chert (Lower devonian, 410 Ma), and the complete life cycle of several Rhynie chert plants has been reconstructed. All show an alternation of more or less isomorphic generations, which is currently accepted as the plesiomorphic condition among all early polysporangiophytes, including basal tracheophytes. Here we review the existing evidence for early embryophyte gametophytes. We also discuss some recently discovered plants preserved as compression fossils and interpreted as gametophytes. All the fossil evidence supports the Antithetic Theory and indicates that the gametophytic generation/sporophytic generation size and complexity ratios show a gradual decrease along the land plant phylogenetic tree.

关键词： devonian early land plants embryophyte gametophyte life cycle sporophyte.

Immune therapies in pancreatic ductal adenocarcinoma: Where are we now?

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World Journal of Gastroenterology 2018年第20期24卷 2137-2151页

作者： Marc Hilmi Laurent Bartholin Cindy Neuzillet Service d'Oncologie Médicale H?pital Henri Mondor Assistance Publique-H?pitaux de Paris Université Paris Est Créteil Université de Lyon Université Claude Bernard Lyon 1 Inserm U1052 CNRS 5286Centre Léon Bérard Centre de Recherche en Cancérologie de Lyon

Pancreatic ductal adenocarcinoma(PDAC)is one of the deadliest cancers,mostly due to its resistance to *** these,checkpoint inhibitors(CPI)are inefficient when used as monotherapy,except in the case of a rare subset of tumors harboring microsatellite instability(des in the low immunogenicity and non-inflamed phenotype of *** abundant stroma generates a hypoxic microenvironment and drives the recruitment of immunosuppressive cells through cancerassociated-fibroblast activation and transforming growth factorβ*** strategies have recently been developed to overcome this immunosuppressive *** therapies involving CPI aim at increasing tumor immunogenicity and promoting the recruitment and activation of effector T *** studies are therefore exploring the association of CPI with vaccines,oncolytic viruses,MEK inhibitors,cytokine inhibitors,and hypoxia-and stroma-targeting *** T-cell transfer is also under ***,translational studies on tumor tissue and blood,prior to and during treatment may lead to the identification of biomarkers with predictive value for both clinical outcome and response to immunotherapy.

关键词： Drug therapy combination Immunology Hypoxia Checkpoint inhibitor Inflammation Pancreatic cancer Tumor-infiltrating lymphocyte Transforming growth factorβ Tumor microenvironment

Mapping common and glossy buckthorns (Frangula alnus and Rhamnus cathartica) using multi-date satellite imagery WorldView-3, GeoEye-1 and SPOT-7

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International Journal of Digital Earth 2023年第1期16卷 31-42页

作者： Fiston Nininahazwe Mathieu Varin Jerome Theau departement de Geomatique appliquee Universite de SherbrookeSherbrookeCanada centre d'enseignement et de recherche en foresterie(CERFO) QuebecCanada centre de la science de la biodiversite du Quebec MontrealCanada

Buckthorns(Glossy buckthorn,Frangula alnus and common buckthorn,Rhamnus cathartica)represent a threat to *** high competitivity lead to the replacement of native species and the inhibition of forest *** detection strategies are therefore necessary to limit invasive alien plant species’impacts,and remote sensing is one of the techniques for early invasion *** studies have used phenological remote sensing approaches to map buckthorn distribution from medium spatial resolution *** studies highlighted the difficulty of detecting buckthorns in low densities and in understory using this category of *** main objective of this study was to develop an approach using multi-date very high spatial resolution satellite imagery to map buckthorns in low densities and in the understory in the Québec city *** machine learning classifiers(Support Vector Machines,Random Forest and Extreme Gradient Boosting)were applied to WorldView-3,GeoEye-1 and SPOT-7 satellite *** Random Forest classifier performed well(Kappa=0.72).The SVM and XGBoost’s coefficient Kappa were 0.69 and 0.66,***,buckthorn distribution in understory was identified as the main limit to this approach,and LiDAR data could be used to improve buckthorn mapping in similar environments.

关键词： Invasive alien plant species remote sensing buckthorns multi-date satellite imagery machine learning

Axial Breakthrough in Ancient Greece. New Considerations： Plato, Confucius, and the Buddha

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Fudan Journal of the Humanities and Social Sciences 2016年第4期9卷 555-564页

作者： Luc Brisson Directeur de recherche Emerite au centre National de la recherche Scientifique 4 bis rued'Italie 65013 Paris France

Here I will examine the resemblances and similarities between Plato and two other personages, Confucius and the Buddha, who were his near-contempo- raries, and who enabled a breakthrough. The Platonic break with the world of bodies and the sphere of belief, in favor of a level of intelligible realities, the models of the sensible realities explained by mathematics and moved by the soul, explains the specificity of the Western world, in the field of science, politics, ethics, and even religion.

关键词： Plato Confucius The Buddha Intelligible realities Soul Mathematics - Politics

Acetic acid additive in NaNO_(3)aqueous electrolyte for long-lifespan Mg-air batteries

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Journal of Magnesium and Alloys 2024年第2期12卷 825-839页

作者： Yaqing Zhou Fan Sun Gunahua Lin Sandrine Zanna Antoine Seyeux Philippe Marcus Jolanta´Swiatowska Chimie parisTech-CNRS PSL UniversityInstitut de Recherche de Chimie Paris11 rue Pierre et Marie CurieParis 75005France

Mg-air batteries have attracted tremendous attention as a potential next-generation power source for portable electronics and e-transportation due to their remarkable high theoretical volumetric energy density,environmental sustainability,and ***,the fast hydrogen evolution reaction(HER)in NaCl-based aqueous electrolytes impairs the performance of Mg-air batteries and leads to poor specific capacity,low energy density,and low ***,the conventionally used NaCl solute was proposed to be replaced by NaNO_(3)and acetic acid additive as a corrosion inhibitor,therefore an electrolyte engineering for long-life time Mg-air batteries is *** resulting Mg-air batteries based on this optimized electrolyte demonstrate an improved discharge voltage reaching~1.8 V for initial 5 h at a current density of 0.5 mA/cm^(2) and significantly prolonged cells'operational lifetime to over 360 h,in contrast to only~17 h observed in NaCl electrolyte.X-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometry were employed to analyse the composition of surface film and scanning electron microscopy combined with transmission electron microscopy to clarify the morphology changes of the surface layer as a function of acetic acid *** thorough studies of chemical composition and morphology of corrosion products have allowed us to elucidate the working mechanism of Mg anode in this optimized electrolyte for Mg-air batteries.

关键词： Acetic acid additive in NaNO_(3)electrolyte Electrolyte engineering Corrosion surface film Surface characterization Hydrogen evolution

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