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Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles Méryl-Farelle Oye Mintsa Mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond Martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada département de Médecine Facultéde MédecineUniversitéLavalQuebecQCCanada département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal dOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

decoding the nexus:branched-chain amino acids and their connection with sleep,circadian rhythms,and cardiometabolic health

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Neural Regeneration Research 2025年第5期20卷 1350-1363页

作者： Hui Li Laurent Seugnet department of Neurology Xijing HospitalXi’anShaanxi ProvinceChina centre de recherche en Neurosciences de Lyon Integrated Physiology of the Brain Arousal Systems(WAKING)UniversitéClaude Bernard Lyon 1INSERM U1028CNRS UMR 5292BronFrance

The sleep-wake cycle stands as an integrative process essential for sustaining optimal brain function and,either directly or indirectly,overall body health,encompassing metabolic and cardiovascular *** the heightened metabolic activity of the brain,there exists a considerable demand for nutrients in comparison to other *** these,the branched-chain amino acids,comprising leucine,isoleucine,and valine,display distinctive significance,from their contribution to protein structure to their involvement in overall metabolism,especially in cerebral *** the first amino acids that are released into circulation post-food intake,branched-chain amino acids assume a pivotal role in the regulation of protein synthesis,modulating insulin secretion and the amino acid sensing pathway of target of ***-chain amino acids are key players in influencing the brain's uptake of monoamine precursors,competing for a shared *** their involvement in protein synthesis,these amino acids contribute to the metabolic cycles ofγ-aminobutyric acid and glutamate,as well as energy ***,they impact GABAergic neurons and the excitation/inhibition *** rhythmicity of branchedchain amino acids in plasma concentrations,observed over a 24-hour cycle and conserved in rodent models,is under circadian clock *** mechanisms underlying those rhythms and the physiological consequences of their disruption are not fully *** sleep,obesity,diabetes,and cardiovascular diseases can elevate branched-chain amino acid concentrations or modify their oscillatory *** mechanisms driving these effects are currently the focal point of ongoing research efforts,since normalizing branched-chain amino acid levels has the ability to alleviate the severity of these *** this context,the drosophila model,though underutilized,holds promise in shedding new light on these *** findings indicate its po

关键词： branched-chain amino acids cardiovascular health circadian clock drosophila insulin metabolism sleep γ-aminobutyric acid

Enteric parasites prevalence at Saint Camille Medical centre in Ouagadougou,Burkina Faso

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Asian Pacific Journal of Tropical Medicine 2011年第5期4卷 401-403页

作者： Simplice damintoti Karou drissa Sanou djeneba Ouermi Salvatore Pignatelli Virginio Pietra Remy Moret Jean Baptiste Nikiema Jacques Simpore centre de recherche Biomoleculaire Pietro Annigoni(CERBA) OuagadougouBurkina Faso Ecole Superieure des Techniques Biologiques et Alimentaires(RSTBA-UL) Universite de LomeTogo Unite de Formation et de recherche en Sciences de la Vie et de la Terre(UFR/SVT) Universite de OuagadougouBurkina Faso centre medical saint Camille de Ouagadougou Burkina Faso

Objective:To assess the prevalence of parasitic infections among patients attending Saint Camille Medical centre and to estimate co-parasitic infections ***:From January to december 2009,stool samples were collected from 11 728 persons,aged from five months to 72 years and suffering from *** macroscopic description,the stools were examined by light microscopy to search for the presence of ***:From the 11 728 analyzed stools,6 154(52.47%) were infected with at least one *** frequently encountered were:Giardia intestinalis(43.47%),Entamoeba histolytica/Entamoeba dispar(30.74%) and Trichomonas irUestinalis(21.72%),while Hymenolepis nana(2.25%) was the most common ***-infections occurred in 22.34%*** the multi-infected samples,dual and triple infections accounted for 71.18%and 20.00%,*** irUestinalis for protozoan and Hymenolepis nana for helminths were the most implicated ***: This study confirms that intestinal parasites are still a public health problem in Burkina *** reduce the incidence of parasitic infections,it is necessary to promote the education of people so that they practice the rules of individual and collective hygiene.

关键词： Gastroenteritis Giardia intestinalis Hymenolepis nana Helminths Burkina Faso

Efficiency of HAART in the prevention of mother to children HIV-1 transmission at Saint Camille medical centre in Burkina Faso,West Africa

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Asian Pacific Journal of Tropical Medicine 2012年第12期5卷 991-994页

作者： Laure Stella Ghoma Linguissi Cyrille Bisseye Tani Sagna Bolni Marius Nagalo djeneba Ouermi Florencia W djigma Salvatore Pignatelli Joseph d Sia Virginio Pietra Remy Moret Jean Baptiste Nikiema Jacques Simpore centre de recherche Biomoleculaire Pietro Annigoni(CERBA)/LABIOGENE UFR/SVTUniversite de OuagadougouBurkina Faso department de Biologie Unirersite des Sciences et Techniques de Masuku(USTM) FrancerilleGabon centre Medical Saint Camille OuagadougouBurkina Faso

Objective:To evaluate efficiency of HAART in the prevention of mother to child HIV ***:A longitudinal study was conducted on 1 300 women attending the antenatal service at Saint Camille Medical centre from September 2010 to July *** HIV status of mothers was determined by rapid tests and *** results were confirmed by real-time *** was used to determine HIV status of children born from HIV-positive ***:Among 1 300 pregnant women tested for HIV,378 were *** were predominantly housewives(69.7%),and their mean age was(28.32±0.15) *** overall prevalence of HIV transmission from mother to child was 4.8%(18/378).This prevalence differed significantly from 0.0%(0/114) to 6.8%(18/264) in children born from mothers under HAART and those with mothers under New Prophylactic Protocol(ACT + 3TC + NVP),respectively(Pdren’s mortality rate during the medical follow up was 1.3%(5/378).Among 16 women with HIV dubious status by ELISA,the Real Time PCR confirmed 2/16(12.5%) as HIV positive. Conclusions:The protocol of prevention of mother to children HIV transmission(PMTCT) is *** rate of HIV vertical transmission is significantly *** diagnosis determined by PCR of children born from HIV- positive mother is necessary and recommended in the context of PMTCT in Burkina *** also found that PCR is an effective tool to confirm HIV status in pregnant women.

关键词： Pregnant Women Child HIV PCR dNA

decentralized observers for a class of large-scale singular systems via LMI

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International Journal of Intelligent Computing and Cybernetics 2013年第2期6卷 158-181页

作者： Mejda Mansouri Latifa Boutat-Baddas Mohamed darouach Hassani Messaoud Ecole Nationale d’Ingenieurs de Monastir MonastirTunisie and Centre de Recherche en AutomatiqueNancy-UniversiteIUT de LongwyCosnes et RomainFrance centre de recherche en Automatique de Nancy Nancy-UniversiteCosnes et RomainFrance Ecole Nationale d’Ingenieurs de Monastir MonastirTunisie

Purpose–The purpose of this paper is to propose a decentralized observer for large-scale singular ***/methodology/approach–In this paper,the authors investigate the problem of observers’design for large-scale singular *** proposed decentralized observer is based on a new parameterization of the generalized Sylvester equation *** considered system is partitioned into small-sizes interconnected subsystems with unknown ***–A decentralized observer based on new parameterization of generalized Sylvester *** performance of the proposed approach is illustrated by a numerical ***/value–The proposed approach unites the full-order,the reduced-order and the minimal order observer design for large-scale *** conditions of the existence of this observer are given in the linear matrix inequalities(LMI)form.

关键词： Systems theory design Control systems Large scale system decentralized observer Singular system Linear matrix inequalities

Associations between physical activity levels and ATPase inhibitory factor 1 concentrations in older adults

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Journal of Sport and Health Science 2024年第3期13卷 409-418页

作者： Jérémy Raffin Yves Rolland Annelise Genoux Guillaume Combes Mikael Croyal Bertrand Perret Sophie Guyonnet Bruno Vellas Laurent O.Martinez Philipe de Souto Barreto For the MAPT/dSA Group Institut du Vieillissement Gérontopôle de ToulouseCentre Hospitalo-Universitaire de ToulouseToulouse 31000France centre d'Epidémiologie et de recherche en Santédes Populations UnitéMixte de Recherche 1295Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse-III-Paul-SabatierToulouse 31000France LimitAging Team Institut des Maladies Métaboliques et CardiovasculairesUnitéMixte de Recherche 1297Institut National de la Santéet de la Recherche MédicaleUniversitéToulouse III-Paul SabatierToulouse 31432France Service de Biochimie Pôle de biologieHôpital de PurpanCentre Hospitalo-Universitaire de ToulouseToulouse 31300France L'Institut du Thorax Institut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France BioCore US16Structure Fédérative de Recherche BonamyInstitut National de la Santéet de la Recherche MédicaleCentre National de la Recherche ScientifiqueCentre Hospitalo-Universitaire de NantesNantes UniversitéNantes 44000France Plate-forme de spectrométrie de masse Centre de Recherche en Nutrition HumaineOuestNantes 44000France 不详

Background:Adenosine triphosphatase inhibitory factor 1(IF1)is a key protein involved in energy ***1 has been linked to various agerelated diseases,although its relationship with physical activity(PA)remains ***,the apolipoprotein A-I(apoA-I),a PA-modulated lipoprotein,could play a role in this relationship because it shares a binding site with IF1 on the cell-surface ATP *** examined here the associations between chronic PA and plasma IF1 concentrations among older adults,and we investigated whether apoA-I mediated these ***:In the present work,1096 healthy adults(63.8%females)aged 70 years and over who were involved in the Multidomain Alzheimer Prevention Trial study were ***1 plasma concentrations(square root of ng/mL)were measured at the 1-year visit of the Multidomain Alzheimer Prevention Trial,while PA levels(square root of metabolic equivalent task min/week)were assessed using questionnaires administered each year from baseline to the 3-year *** linear regressions were performed to investigate the associations between the first-year mean PA levels and IF1 *** analyses were conducted to examine whether apoA-I mediated these *** linear regressions were carried out to investigate whether the 1-year visit IF1 concentrations predicted subsequent changes in ***:Multiple linear regressions indicated that first-year mean PA levels were positively associated with IF1 concentrations(B=0.021;SE=0.010;p=0.043).Mediation analyses revealed that about 37.7%of this relationship was mediated by apoA-I(B_(ab)=0.008;SE=0.004;p=0.023).Longitudinal investigations demonstrated that higher concentrations of IF1 at the 1-year visit predicted a faster decline in PA levels over the subsequent 2 years(time×IF1:B=0.148;SE=0.066;p=0.025).Conclusion:This study demonstrates that regular PA is associated with plasma IF1 concentrations,and it suggests that apoA-I partly med

关键词： Aging Apolipoprotein Bioenergetics Exerkine Mitochondria

In vitro antiplasmodial activity of crude extracts from Togolese medicinal plants

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Asian Pacific Journal of Tropical Medicine 2011年第2期4卷 129-132页

作者： Koffi Koudouvo Simplice d.Karou denise P.Ilboudo Kouami Kokou Kodjo Essien Kodjo Aklikokou Comlan de Souza Jacques Simpore Mensavi Gbeassor centre de recherche et de Formation sur les Plantes Medicinales(CERFOPLAM) Universite de LomeTogo Laboratoire de Botanique et d'Ecologie Vegetale Faculte des SciencesUniversite de LomeTogo centre de recherche Biomoleculaire Pietro Annigoni(CERBA) OuagadougouBurkina Faso

Objective:To investigate the antimalarial effect of a few plants in Togo folk medicine. Methods:After ethnobotanical survey,Opilia celtidifolia,Pavetta corymbosa（***） and Tamarindus indica（***） were selected for *** vitro antimalarial tests were performed on crude extracts against fresh clinical isolates of Plasmodium falciparum using the semi ***:different IC50,values of the extracts ranged from 2.042 to 100.000μg/mL. According to the results,the methanol extract of aerial part of *** followed by aqueous extract of fruit of *** were the most active(IC50 of 2.042 and 4.786μg/mL,respectively). Qualitative test revealed the presence of alkaloids in the leaves of *** that may be responsible for the activity of the ***:Our study provides scientific evidence for usage of plant in the folk medicine,and further studies are needed for identification and purification of the active principles.

关键词： Medicinal plants In vitro Screening Plasmodium falciparum

The High Light Response and Redox Control of Thylakoid FtsH Protease in Chlamydomonas reinhardtii

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Molecular Plant 2017年第1期10卷 99-114页

作者： Fei Wang Yafei Qi Alizee Malnoe Yves Choquet Francis-Andre Wollman Institut de Biologie Physico-Chimique Unite Mixte de Recherche 7141 Centre National de la Recherche Scientifique/Universite Pierre et Marie Curie Paris 75005 France

In Chlamydomonas reinhardtii, the major protease involved in the maintenance of photosynthetic machinery in thylakoid membranes, the FtsH protease, mostly forms large hetero-oligomers （-1 Mda） comprising FtsH1 and FtsH2 subunits, whatever the light intensity for growth. Upon high light exposure, the FtsH subunits display a shorter half-life, which is counterbalanced by an increase in FTSH1/2 mRNA levels, resulting in the modest upregulation of FtsH1/2 proteins. Furthermore, we found that high light increases the protease activity through a hitherto unnoticed redox-controlled reduction of intermolecular disulfide bridges. We iso- lated a Chlamydomonas FTSH1 promoter-deficient mutant, ftsh1-3, resulting from the insertion of a TOC1 transposon, in which the high light-induced upregulation of FTSH1 gene expression is largely lost. In ftsh1- 3, the abundance of FtsH1 and FtsH2 proteins are loosely coupled （decreased by 70% and 30%, respectively） with no formation of large and stable homo-oligomers. Using strains exhibiting different accumulation levels of the FtsH1 subunit after complementation of ftsh1-3, we demonstrate that high light tolerance is tightly correlated with the abundance of the FtsH protease. Thus, the response of Chlamydomonas to light stress involves higher levels of FtsH 1/2 subunits associated into large complexes with increased proteolytic activity.

关键词： chloroplast protease regulation of gene expression photoinhibition Chlamydomonas reinhardtii

Variation of CH_4 concentrations recorded in dunde ice core bubbles

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Chinese Science Bulletin 1999年第4期44卷 383-384页

作者： J. Chappellaz Laboratoire de Glaciologie et Geophysique de I'Environnement centre National de la recherche Scientifique

GREENHOUSE gases such as CH4 in the ancient atmospheric concentration can be reconstructed by extracting and analyzing the gases trapped in polar ice core bubbles. It is a new attempt to extract and analyze the CH4 concentration in dunde ice core for the study of mountain glacier. Samples were taken from the about 140-m ice core drilled in 1987 in dunde ice cap in Qilian Mountain. The ice core has been well preserved in cold room. 12 samples were taken from the upper 95 m, and cut to 15 cm in length and 5cm in diameter. CH4 concentrations were measured in CNRS Laboratory of Glaciology, Grenoble, France.

关键词： core Variation of CH4 concentrations recorded in dunde ice core bubbles CH