检索结果-南通市图书馆

Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles Méryl-Farelle Oye Mintsa Mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond Martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de Médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

decoding the nexus:branched-chain amino acids and their connection with sleep,circadian rhythms,and cardiometabolic health

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1350-1363页

作者： Hui Li Laurent Seugnet department of Neurology Xijing HospitalXi’anShaanxi ProvinceChina centre de Recherche en Neurosciences de Lyon Integrated Physiology of the Brain Arousal Systems(WAKING)UniversitéClaude Bernard Lyon 1INSERM U1028CNRS UMR 5292BronFrance

The sleep-wake cycle stands as an integrative process essential for sustaining optimal brain function and,either directly or indirectly,overall body health,encompassing metabolic and cardiovascular *** the heightened metabolic activity of the brain,there exists a considerable demand for nutrients in comparison to other *** these,the branched-chain amino acids,comprising leucine,isoleucine,and valine,display distinctive significance,from their contribution to protein structure to their involvement in overall metabolism,especially in cerebral *** the first amino acids that are released into circulation post-food intake,branched-chain amino acids assume a pivotal role in the regulation of protein synthesis,modulating insulin secretion and the amino acid sensing pathway of target of ***-chain amino acids are key players in influencing the brain's uptake of monoamine precursors,competing for a shared *** their involvement in protein synthesis,these amino acids contribute to the metabolic cycles ofγ-aminobutyric acid and glutamate,as well as energy ***,they impact GABAergic neurons and the excitation/inhibition *** rhythmicity of branchedchain amino acids in plasma concentrations,observed over a 24-hour cycle and conserved in rodent models,is under circadian clock *** mechanisms underlying those rhythms and the physiological consequences of their disruption are not fully *** sleep,obesity,diabetes,and cardiovascular diseases can elevate branched-chain amino acid concentrations or modify their oscillatory *** mechanisms driving these effects are currently the focal point of ongoing research efforts,since normalizing branched-chain amino acid levels has the ability to alleviate the severity of these *** this context,the Drosophila model,though underutilized,holds promise in shedding new light on these *** findings indicate its po

关键词： branched-chain amino acids cardiovascular health circadian clock drosophila insulin metabolism sleep γ-aminobutyric acid

Novel small molecule TRVA242 targets neuromuscular junction in amyotrophic lateral sclerosis

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2020年第6期15卷 1041-1042页

作者： Poulomee Bose department of Neuroscience Centre Hospitalier Universitaire St. Justine Université de Montréal

Research over the past decade has enabled a deeper understanding of the pathophysiology of amyotrophic lateral sclerosis(ALS).While 10%of all ALS cases have been reported to be familial with a clear Mendelian inheritance,clinically,sporadic and familial forms of ALS cannot be distinguished(Robberecht and Philips,2013).Presently there are only two Food and Drug Administration approved treatment options for ALS-riluzole and radicava(also known as edavarone).Riluzole is mostly known to delay the onset of ventilator dependence and extends the life span by 2–3 months;edavarone on the other hand has been reported slow disease progression at all stages in ALS(Jaiswal,2019).However,given the multifaceted nature of ALS,there is an urgent need to identify more molecules with a strong therapeutic potential.

关键词： amyotrophic sclerosis mostly

Acute ulcerative jejunal diverticulitis:Case report of an uncommon entity

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第40期14卷 6265-6267页

作者： Wojciech Staszewicz Michel Christodoulou Stefania Proietti Nicolas demartines Service de Chirurgie Viscerale Centre Hospitalier Universitaire Vaudois Service de Radiologie Centre Hospitalier Universitaire Vaudois

Jejunal diverticulosis is a rare entity with variable clinical and anatomical *** reported incidence varies from 0.05% to 6%.Although there is no consensus on the management of asymptomatic jejunal diverticular disease,some complications are potentially life threatening and require early surgical *** report a case of an 88-year-old man investigated for acute abdominal pain with a high biological inflammatory *** of multiple giant jejunal diverticulum was discovered at abdominal computed tomography (CT).As a result of the clinical and biological signs of early peritonitis,an emergency surgical exploration was *** first jejunal loop showed clear signs of jejunal *** segmental jejunum resection with end-to-end anastomosis was *** report confirmed an ulcerative jejunal diverticulitis with imminent perforation and acute local *** patient made an excellent rapid postoperative *** diverticulum is rare but may cause serious *** should be considered a possible etiology of acute abdomen,especially in elderly patients with unusual *** CT is the diagnostic tool of *** best treatment is emergency surgical management.

关键词： Jejunal diverticulum Diverticulitis Surgery Tomography

Microbial markers in colorectal cancer detection and/or prognosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2018年第22期24卷 2327-2347页

作者： Romain Villéger Amélie Lopès Julie Veziant Johan Gagnière Nicolas Barnich Elisabeth Billard delphine Boucher Mathilde Bonnet université Clermont Auvergne Research Biologics Sanofi R&D Chirurgie digestive Centre Hospitalier Universitaire université Clermont Auvergne Institut Universitaire de Technologie de Clermont-Ferrand

Colorectal cancer(CRC) is the second leading cause of cancer worldwide. CRC is still associated with a poor prognosis among patients with advanced disease. On the contrary, due to its slow progression from detectable precancerous lesions, the prognosis for patients with early stages of CRC is encouraging. While most robust methods are invasive and costly, actual patient-friendly screening methods for CRC suffer of lack of sensitivity and specificity. Therefore, the development of sensitive, non-invasive and cost-effective methods for CRC detection and prognosis are necessary for increasing the chances of a cure. Beyond its beneficial functions for the host, increasing evidence suggests that the intestinal microbiota is a key factor associated with carcinogenesis. Many clinical studies have reported a disruption in the gut microbiota balance and an alteration in the faecal metabolome of CRC patients, suggesting the potential use of a microbialbased test as a non-invasive diagnostic and/or prognostic tool for CRC screening. This review aims to discuss the microbial signatures associated with CRC known to date, including dysbiosis and faecal metabolome alterations, andthe potential use of microbial variation markers for noninvasive early diagnosis and/or prognostic assessment of CRC and advanced adenomas. We will finally discuss the possible use of these markers as predicators for treatment response and their limitations.

关键词： Colorectal cancer microbiota F.nucleatum Colibactin-producing E.coli prognostic markers diagnostic markers dysbiosis

Neurostimulation for fecal incontinence after correction of repair of imperforate anus

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2017年第3期5卷 124-127页

作者： Alexandre Bougie Nathalie McFadden Sandeep Mayer Michel Lebel Ghislain devroede Surgery department Centre Hospitalier Universitaire de SherbrookeFaculté de MédecineUniversité de Sherbrooke Medicine department NeurologyCentre Hospitalier Universitaire de SherbrookeFaculté de MédecineUniversité de Sherbrooke

We are reporting the case of a 32-year-old female who had suffered from fecal incontinence(FI). She was born with an imperforate anus and a recto-vaginal fistula; she underwent repair at 6 mo of age. At 29 years of age, she was still fecally incontinent despite extensive pelvic floor reeducation. A magnetic resonance imaging and an anal electromyography were performed. Because her symptoms were considered to be probably due to extra-sphincteric implantation of the neo-anus, a redo was performed of the recto-neo-anal intra-sphincteric anastomosis. A neurostimulator device was subsequently implanted for persistent incontinence. Solid and liquid FI resolved, and her quality of life improved markedly. Combining surgery to correct the position of the neo-anus within the anal sphincter complex and neurostimulation could thus become a new approach in cases of refractory FI for patients with imperforate anus as a newborn. Follow-up into adulthood after pediatric imperforate anus surgery should be recommended for adult patients with persistent FI.

关键词： Fecal incontinence Congenital malformation Neuromodulation Neurostimulation Imperforate anus

Calculation of CO_2, CH_4 and H_2S Solubilities in Aqueous Electrolyte Solution at High Pressure and High Temperature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Thermal Science 1997年第4期6卷 251-259页

作者： Carrier Hervé Suyu Ye Lagourette Bernard Alliez Jacques Xans Pierre Laboratoire Haute Pression Centre Universitaire de Recherche Scientifique Université de Pau Pau France

This paper reports an investigation into the characterisation of liquidaivapor electrolyte solutions at high pressure and high temperature. A procedure to enable calcuIations of methane, carbon dioxide and hydrogen sulphide solubilities in brines (0-6 m.) for temperature from 25 to 350℃ and for pressures from 1 to 1800 bar is presented. The model is based on Helgeson, Kirkham and Flowers modified equations of state (HKF) and on the semi-empirical interaction model introduced by Pitzer. HKF modified equations of state are used to calculate the reference fugacity of gas species, and the Pitzer ionic interaction model is used to calculate the activity coefficient of dissolved species (i.e. ionic or neutral).The efficiency of the combination of the two models is confirmed by several comparisons with data in the literature.

关键词： vapor-liquid equilibria solubility electrolytes solutions high temperature high pressure

Chronic hepatitis C infection in a patient with bone marrow hypoplasia

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第26期14卷 4238-4240页

作者： S Bethlen K Chandrikakumari L de Leval JB Giot D Mukeba P Leonard F Frippiat C Meuris J delwaide M Moutschen centre Hospitalier universitaire de Liege Liege 4000Belgium Medical Student department of Infectious Diseases and Internal Medicine Centre Hospitalier Universitaire de LiegeLiege 4000Belgium department of Pathology Centre Hospitalier Universitaire de LiegeLiege 4000Belgium department of Gastroenterology and Hepatology Centre Hospitalier Universitaire de LiegeLiege 4000Belgium

Chronic hepatitis C virus(HCV) infection is associated with multifarious extra-hepatic manifestations;the most described and discussed being mixed cryoglob-ulinemia which is strongly related to B-cell lympho-proliferative disorders(LPDs).We present a case of chronic HCV infection and mixed cryoglobulinemia,with minimal liver *** case is a 53-year-old patient who was diagnosed as having bone marrow hypoplasia at the age of *** received several blood transfusions to normalize her *** the age of 31,she was diagnosed with rheumatoid ar-thritis on account of her diffuse joint pain and inflam-mation,elevated rheumatoid factor(RF) and Raynaud's *** years later,monoclonal gam-mopathy of IgG Lambda(one year later,changed to IgM Kappa) was detected during a routine examina-tion.A bone marrow biopsy showed hypoplasia,Kappa positive B-lymphocytes and low-grade malignant lym-phoma *** of the bone marrow aspirate was not *** treatment was initiated owing to herpoor bone marrow function and she is under regular follow-up.

关键词： Chronic hepatitis C infection Mixed cryoglobulinemia Prognosis

Physical and Cooking Characteristics of Six Cowpea Varieties Seeds Cultivated in Burkina Faso

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

American Journal of Plant Sciences 2022年第7期13卷 929-942页

作者： Karidiatou Traore Pingawindé Sawadogo Téyouré Benoit Joseph Batiéno Nerbéwendé Sawadogo Hamadou Zongo Saadon Leandre Poda Jean Baptiste de Salle Tignegré Tinga Jeremy Ouédraogo Mahamadou Sawadogo Institut de l’Environnement et de Recherches Agricoles (INERA) CNRST Ouagadougou Burkina Faso centre universitaire de tenkodogo Université Thomas SANKARA Tenkodogo Burkina Faso équipe Génétique et Amélioration des Plantes/Laboratoire Biosciences Ecole Doctorale Sciences et Technologies Université Joseph KI-ZERBO Ouagadougou Burkina Faso

Cowpea is essential in the diet in Burkina Faso. The information on their physical properties and cooking quality is important for consumer acceptance. This study has therefore been undertaken in order to fill the gap. Thus, six cowpea varieties were evaluated for their physical and cooking properties. The seeds had between 9% to 12% moisture. For physical proprieties, the result revealed that the variety Makoyin had the highest seed length (9.65 mm), the variety Gourgou recorded the highest seed width (7.08 mm), seed thickness (5.13 mm), and seed area (153.29 mm2), and 100-seeds weight (21.1 g). The lowest seed sizes were presented by the variety Teeksongo with values of 7.88 mm, 6.34 mm, 4.88 mm, 122.68 mm2, and 16.87 g for respectively the length, the width, the thickness, the area, and the 100-seeds weight. The variety Makoyin produces seed elliptical form and varieties Neerwaya, Gourgou, Yipoussi and Issa-sosso, and Teek-songo the seeds spherical form. For cooking proprieties, the highest value of the bulk density of the seeds was presented in the variety Teek-song (1.51 g/ml). The highest hydration and swelling capacity were observed in varieties Gourgou (0.22 g/seed and 0.24 ml/seed respectively) and Yipoussi (0.22 g/seed and 0.21 ml/seed respectively). The seed with large size, greater hydration, and swelling capacity is preferred by consumers and processors for food products. Varieties Makoyin, Neerwaya, Gourgou, Yipoussi, and Issa-sosso presented cooking time of unsoaked seeds equal to one hour (from 60 to 68 min) excepted Teek-songo which had 46 min. These cooking times are acceptable for consumers. Seed length, surface area, thickness, the weight of seeds, hydration capacity, and cooking time have been the most discriminating among the cowpea varieties studied.

关键词： Cowpea Varieties Physical Properties Cooking Properties Burkina Faso