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Self-confocal NIR-II fluorescence microscopy for multifunctional in vivo imaging

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Journal of Innovative Optical Health Sciences 2024年第1期17卷 105-119页

作者： Jing Zhou Tianxiang Wu Runze Chen Liang Zhu Hequn Zhang Yifei Li Liying Chen Jun Qian State Key Laboratory of modern Optical Instrumentations Centre for Optical and Electromagnetic ResearchCollege of Optical Science and EngineeringInternational Research Center for Advanced PhotonicsZhejiang UniversityHangzhou 310058P.R.China Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cell and Regenerative Medicine Zhejiang UniversityHangzhou 310058P.R.China College of Biomedical Engineering and Instrument Science Interdisciplinary Institute of Neuroscience and Technology(ZIINT)Zhejiang UniversityHangzhou 310027P.R.China

Fluorescence imaging in the second near-infrared window(NIR-II,900–1880 nm)with less scattering background in biological tissues has been combined with the confocal microscopic system for achieving deep in vivo imaging with high spatial ***,the traditional NIR-IIfluorescence confocal microscope with separate excitation focus and detection pinhole makes it possess low confocal e±ciency,as well as di±cultly to *** types of upgraded NIR-IIfluorescence confocal microscopes,sharing the same pinhole by excitation and emission focus,leading to higher confocal e±ciency,are built in this *** type is-ber-pinhole-based confocal microscope applicable to CW laser *** is constructed forfluorescence intensity imaging with large depth,high stabilization and low cost,which could replace multiphotonfluorescence microscopy in some applications(e.g.,cerebrovascular and hepatocellular imaging).The other type is air-pinhole-based confocal microscope applicable to femtosecond(fs)laser *** can be employed not only for NIR-IIfluorescence intensity imaging,but also for multi-channelfluorescence lifetime imaging to recognize different structures with similarfluorescence ***,it can be facilely combined with multiphotonfluorescence microscopy.A single fs pulsed laser is utilized to achieve up-conversion(visible multiphotonfluorescence)and down-conversion(NIR-II one-photonfluorescence)excitation simultaneously,extending imaging spectral channels,and thus facilitates multi-structure and multi-functional observation.

关键词： Self-confocal fiber-pinhole air-pinhole multi-channe fluorescence lifetime imaging multi-color imaging

Metal-Organic Framework-Derived Metallic Carbon with Record High Radon Gas Capture Performance

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CCS Chemistry 2024年第7期6卷 1789-1797页

作者： Shicheng Gong Yi Tao Lixi Chen Qiuting Xu Junhao Lu Fuyin Ma Xia Wang Guodong Li Jun Wan Guoxun Ji Linfeng He Xiaohui Yu Duo Zhang Xuhui Sun Zhifang Chai Shuao Wang State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences(RAD-X)and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhou 215123 Institute of Functional Nano&Soft Materials Laboratory(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and DevicesJiangsu Key Laboratory of Advanced Negative Carbon TechnologiesSoochow UniversitySuzhou 215123 School of Environment and Material Engineering Yantai UniversityYantai 264005 Xi’an Research Institute of Hi-Technology Hong Qing TownXi’an 710025 Shanghai Institute of Measurement and Testing Technology Shanghai 201203 Engineering Institute of Advanced Manufacturing and modern Equipment Technology Jiangsu UniversityZhenjiang 212013

Developing efficient adsorbents for radon(Rn)capture from the ambient environment is of paramount importance for public ***,it poses a great challenge due to the chemical inertness and extremely low molar concentration of Rn in ***,we report a zeolite imidazolate frameworkderived metallic carbon adsorbent(Zn@NPC)with record high Rn removal performance under ambient *** one-step pyrolysis,the prepared Zn@NPC possesses pores with a preference for Rn and atomically dispersed Zn sites,achieving a high Rn removal efficiency that doubles in adsorption coefficient(9.47 L·g^(−1))and triples in adsorption kinetic coefficient(20.25 mL·g^(−1)·min^(−1))over the benchmark Rn adsorbent coconut activated *** functional theory calculations elucidate the important role of the metal polarization effect,which cooperates with the pore size confinement effect to boost the overall Rn adsorption *** work launches a promising alternative for practical Rn capture.

关键词： radon removal metal-organic frameworks microporous carbon synergistic effect dynamic adsorption

Hepatitis C virus infection in children in the era of directacting antiviral

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World Journal of Gastroenterology 2018年第24期24卷 2555-2566页

作者： Malgorzata Pawlowska Malgorzata Sobolewska-Pilarczyk Krzysztof Domagalski Department of Paediatric Infectious Diseases and Hepatology Faculty of MedicineCollegium MedicumNicolaus Copernicus University centre for modern interdisciplinary technologies Nicolaus Copernicus University

Hepatitis C virus(HCV) infection remains an important global health problem with chronic infection affecting approximately 11 million children worldwide. The emergence of direct-acting antiviral(DAA) therapies and the development of non-invasive methods for the determination of liver fibrosis will significantly improve the management of paediatric patients with chronic HCV infection in subsequent years. For paediatric patients, a new era of highly effective DAA agents is beginning, and the first results of available clinical trials are very promising. In this era, the identification and monitoring of patients continues to be an important issue. The availability of non-invasive serological and imaging methods to measure hepatic fibrosis enables the identification of patients with significant or advanced liver fibrosis stages. This article summarizes the current data on the epidemiology and progress of research aimed to evaluate the new therapies and non-invasive methods for liver injury in paediatric patients with chronic hepatitis C.

关键词： biomarkers of liver injury adolescents epidemiology direct-acting antiviral Hepatitis C virus non-invasive methods children

CRISPR,CAR-T,and NK:Current applications and future perspectives

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Genes & Diseases 2024年第4期11卷 246-257页

作者： Mohadeseh Khoshandam Hossein Soltaninejad Amir Ali Hamidieh Saman Hosseinkhani Department of Reproductive Biology Academic Center for EducationCultureand Research(ACECR)Qom branch***Iran National Institute of Genetic Engineering and Biotechnology(NIGEB) Tehran 14965/161Iran Department of stem cells technology and Tissue Regeneration Faculty of Interdisciplinary Science and TechnologiesTarbiat Modares UniversityTehran 15614Iran Pediatric Cell Therapy and Gene Therapy Research Center GeneCell&Tissue Research InstituteTehran University of Medical SciencesTehran ***Iran Department of Biochemistry Faculty of Biological SciencesTarbiat Modares UniversityTehran 15614Iran

Chimeric antigen receptor T(CAR-T)cell therapy represents a breakthrough in personalized cancer *** this regard,synthetic receptors comprised of antigen recognition domains,signaling,and stimulatory domains are used to reprogram T-cells to target tum or cells and destroy *** the success of this approach in refractory B-cell malignancies,the optimal potency of CAR T-cell therapy for many other cancers,particularly solid tumors,has not been *** killer cells are powerful cytotoxic lymphocytes specialized in recognizing and dispensing the tumor cells in coordination with other anti-tumor immunity *** on these studies,many investigations are focused on the accurate designing of CAR T-cells with clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)system or other novel gene editing tools that can induce hereditary changes with or without the presence of a double-stranded break into the *** methodologies can be specifically focused on negative controllers of T-cells,induce modifications to a particular gene,and produce reproducible,safe,and powerful allogeneic CAR T-cells for on-demand cancer *** improvement of the CRISPR/Cas9 innovation offers an adaptable and proficient gene-editing capability in activating different pathways to help natural killer cells interact with novel CARs to particularly target tumor *** achievements and future challenges of combining next-generation CRISPR-Cas9 gene editing tools to optimize CAR T-cell and natural killer cell treatment for future clinical trials toward the foundation of modern cancer treatments have been assessed inthis review.

关键词： Cancer CAR T-cell CRISPR Gene editing Immunotherapy NK cell

Reshaping the Cortical Connectivity Gradient by Long-Term Cognitive Training During Development

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Neuroscience Bulletin 2024年第1期40卷 50-64页

作者： Tianyong Xu Yunying Wu Yi Zhang Xi-Nian Zuo Feiyan Chen Changsong Zhou Bio-X Laboratory School of PhysicsZhejiang UniversityHangzhou 310027China Qiushi Academy for Advanced Studies Zhejiang UniversityHangzhou 310027China State Key Laboratory of modern Optical Instrumentation College of Optical Science and EngineeringZhejiang UniversityHangzhou 310027China State Key Laboratory of Cognitive Neuroscience and Learning Bejing Normal UniversityBeijing 100875China Developmental Population Neuroscience Research Center IDG/McGovern Institute for Brain ResearchBeijing Normal UniversityBeijing 100875China Zhejiang Province Key Laboratory of Quantum Technology and Devices Zhejiang UniversityHangzhou 310027China Department of Physics Centre for Nonlinear Studies and Beijing-Hong Kong-Singapore Joint Centre for Nonlinear and Complex Systems(Hong Kong)Institute of Computational and Theoretical StudiesHong Kong Baptist UniversityHong Kong 999077China

The organization of the brain follows a topologi-cal hierarchy that changes dynamically during ***,it remains unknown whether and how cognitive training administered over multiple years during develop-ment can modify this hierarchical *** measuring the brain and behavior of school children who had carried out abacus-based mental calculation(AMC)training for five years(starting from 7 years to 12 years old)in pre-training and post-training,we revealed the reshaping effect of long-term AMC intervention during development on the brain hierarchical *** observed the development-induced emergence of the default network,AMC training-promoted shifting,and regional changes in cortical ***,the training-induced gradient changes were located in visual and somatomotor areas in association with the visuospatial/motor-imagery *** found that gradient-based features can predict the math ability within *** findings provide novel insights into the dynamic nature of network recruitment impacted by long-term cognitive training during development.

关键词： Connectivity gradient Cognitive training Development Neural plasticity Abacus-based mental calculation

Nonlinear density wave and energy consumption investigation of traffic flow on a curved road

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Chinese Physics B 2017年第11期26卷 135-143页

作者：金智展程荣军葛红霞 Faculty of Maritime and Transportation Ningbo University Jiangsu Province Collaborative Innovation Center for modern Urban Traffic technologies National Traffic Management Engineering and Technology Research centre Ningbo University Sub-centre

A new car-following model is proposed based on the full velocity difference model（FVDM） taking the influence of the friction coefficient and the road curvature into account. Through the control theory, the stability conditions are obtained,and by using nonlinear analysis, the time-dependent Ginzburg-Landau（TDGL） equation and the modified Korteweg-de Vries（mKdV） equation are derived. Furthermore, the connection between TDGL and mKdV equations is also given. The numerical simulation is consistent with the theoretical analysis. The evolution of a traffic jam and the corresponding energy consumption are explored. The numerical results show that the control scheme is effective not only to suppress the traffic jam but also to reduce the energy consumption.

关键词： car-following model curved road energy consumption time-dependent Ginzburg-Landau(TDGL) equation

Role of microRNA dysregulation in childhood acute leukemias:Diagnostics,monitoring and therapeutics:A comprehensive review

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World Journal of Clinical Oncology 2020年第6期11卷 348-369页

作者： Joanna Szczepanek centre for modern interdisciplinary technologies Nicolaus Copernicus UniversityToruń 87100Poland

MicroRNAs(miRNAs)are short noncoding RNAs that regulate the expression of genes by sequence-specific binding to mRNA to either promote or block its translation;they can also act as tumor suppressors(e.g.,let-7b,miR-29a,miR-99,mir-100,miR-155,and miR-181)and/or oncogenes(e.g.,miR-29a,miR-125b,miR-143-p3,mir-155,miR-181,miR-183,miR-196b,and miR-223)in childhood acute leukemia(AL).Differentially expressed miRNAs are important factors associated with the initiation and progression of *** shown in many studies,they can be used as noninvasive diagnostic and prognostic biomarkers,which are useful in monitoring early stages of AL development or during therapy(e.g.,miR-125b,miR-146b,miR-181c,and miR-4786),accurate classification of different cellular or molecular AL subgroups(e.g.,let-7b,miR-98,miR-100,miR-128b,and miR-223),and identification and development of new therapeutic agents(e.g.,mir-10,miR-125b,miR-203,miR-210,miR-335).Specific miRNA patterns have also been described for commonly used AL therapy drugs(e.g.,miR-125b and miR-223 for doxorubicin,miR-335 and miR-1208 for prednisolone,and miR-203 for imatinib),uncovering miRNAs that are associated with treatment *** the current review,the role of miRNAs in the development,progression,and therapy monitoring of pediatric ALs will be presented and discussed.

关键词： MiRNome MicroRNA Acute leukemia Acute myeloid leukemia Acute lymphoblastic leukemia Biomarker Classification Prognosis Drug resistance

Ultra-robust informational metasurfaces based on spatial coherence structures engineering

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Light(Science & Applications) 2024年第7期13卷 1310-1319页

作者： Leixin Liu Wenwei Liu Fei Wang Xiaofeng Peng Duk-Yong Choi Hua Cheng Yangjian Cai Shuqi Chen Shandong Provincial Engineering and Technical Center of Light Manipulations Collaborative Innovation Center of Light Manipulation and ApplicationsShandong Provincial Key Laboratory of Optics and Photonic DeviceSchool of Physics and ElectronicsShandong Normal UniversityJinan 250014China. The Key Laboratory of Weak Light Nonlinear Photonics Ministry of EducationSchool of PhysicsSchool of Materials Science and EngineeringSmart Sensing Interdisciplinary Science CenterNankai UniversityTianjin 300071China. School of Physical Science and Technology Soochow UniversitySuzhou 215006China. Laser Physics centre Research School of PhysicsAustralian National UniversityCanberraACT 2601Australia. The Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuanShanxi 030006China

Optical information transmission is vital in modern optics and photonics due to its concurrent and multi-dimensional nature,leading to tremendous applications such as optical microscopy,holography,and optical *** optical information transmission technologies suffer from bulky optical setup and information loss/crosstalk when meeting scatterers or obstacles in the light ***,we theoretically propose and experimentally realize the simultaneous manipulation of the coherence lengths and coherence structures of the light beams with the disordered *** ultra-robust optical information transmission and self-reconstruction can be realized by the generated partially coherent beam with modulated coherence structure even 93%of light is recklessly obstructed during light transmission,which brings new light to robust optical information transmission with a single *** method provides a generic principle for the generalized coherence manipulation on the photonic platform and displays a variety of functionalities advancing capabilities in optical information transmission such as meta-holography and imaging in disordered and perturbative media.

关键词： optics coherent holography

Investigation of microstructure modification of C-doped a-SiO_2/Si after Pb-ion irradiation

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Science China(Physics,Mechanics & Astronomy) 2012年第2期55卷 242-246页

作者： LIU ChunBao WEI KongFang YAO CunFeng WANG ZhiGuang JIN YunFan TOULEMONDE M Department of Physics Heze UniversityHeze 274015China Institute of modern Physics Chinese Academy of SciencesLanzhou 730000China centre for interdisciplinary Research with Heavy lons Caen 14070France

Thermally grown amorphous SiO2 （a-SiOz） films were implanted at room temperature （RT） with 100 keV C-ions to 5.0× 10^17 ions/cm2. These samples were irradiated at RT with 853 MeV Pb-ions to 1.0x 1012 and 5.0× 10^12 ions/cm2. Then the samples were investigated using Transmission Electron Microscopy （TEM） at RT. Significant microstructure modifications were observed in C-doped a-SiO2/Si samples after high energy Pb-ion irradiations, and the formation of new structures depended strongly on the Pb-ion irradiation fluences. For example, tracks in high density were observed in a 1.0× 10^12 Pb/cm2 irradiated and C-doped sample. Additionally, the length of tracks grows, and a large number of 8H-SiC nanocrystals can be seen in the film when irradiation fluence is increased to 5.0× 10^12 Pb/cm2. Possible modification processes of C-doped a-SiO2 under swift heavy ion irradiations are briefly discussed.

关键词： swift heavy ion irradiation C-doped SiO2 Transmission Electron Microscopy (TEM)