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Photobiomodulation:a novel approach to promote trans-differentiation of adipose-derived stem cells into neuronal-like cells

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Neural Regeneration research 2025年第2期20卷 598-608页

作者： Daniella Da Silva Madeleen Jansen van Rensburg Anine Crous Heidi Abrahamse Laser research centre Faculty of Health SciencesUniversity of JohannesburgDoornfonteinJohannesburgSouth Africa

Photobiomodulation,originally used red and near-infrared lasers,can alter cellular *** has been demonstrated that the visible spectrum at 451-540 nm does not necessarily increase cell proliferation,near-infrared light promotes adipose stem cell proliferation and affects adipose stem cell migration,which is necessary for the cells homing to the site of *** this in vitro study,we explored the potential of adipose-derived stem cells to differentiate into neurons for future translational regenerative treatments in neurodegenerative disorders and brain *** investigated the effects of various biological and chemical inducers on trans-differentiation and evaluated the impact of photobiomodulation using 825 nm near-infrared and 525 nm green laser light at 5 J/*** adipose-derived stem cells can be used in autologous grafting and photobiomodulation has been shown to have biostimulatory *** findings reveal that adipose-derived stem cells can indeed trans-differentiate into neuronal cells when exposed to inducers,with pre-induced cells exhibiting higher rates of proliferation and trans-differentiation compared with the control ***,green laser light stimulation led to notable morphological changes indicative of enhanced trans-differentiation,while near-infrared photobiomodulation notably increased the expression of neuronal *** biochemical analysis and enzyme-linked immunosorbent assays,we observed marked improvements in viability,proliferation,membrane permeability,and mitochondrial membrane potential,as well as increased protein levels of neuron-specific enolase and ciliary neurotrophic ***,our results demonstrate the efficacy of photobiomodulation in enhancing the trans-differentiation ability of adipose-derived stem cells,offering promising prospects for their use in regenerative medicine for neurodegenerative disorders and brain injuries.

关键词： differentiation inducers green photobiomodulation immortalized adipose-derived stem cell near-infrared photobiomodulation neurodegenerative disease neurogenesis photobiomodulation trans-differentiation

Multisensory mechanisms of gait and balance in Parkinson’s disease:an integrative review

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Neural Regeneration research 2025年第1期20卷 82-92页

作者： Stiven Roytman Rebecca Paalanen Giulia Carli Uros Marusic Prabesh Kanel Teus van Laar Nico I.Bohnen Department of Radiology University of MichiganAnn ArborMIUSA Department of Neurology University of MichiganAnn ArborMIUSA Morris K.Udall Center of excellence for Parkinson’s Disease research University of MichiganAnn ArborMIUSA Institute for Kinesiology research Science and Research Centre KoperKoperSlovenia Department of Health Sciences Alma Mater Europaea–ECMMariborSlovenia Parkinson’s Foundation research Center of excellence University of MichiganAnn ArborMIUSA Department of Neurology University of GroningenUniversity Medical Center GroningenGroningenThe Netherlands Neurology Service and GRECC VA Ann Arbor Healthcare SystemAnn ArborMIUSA

Understanding the neural underpinning of human gait and balance is one of the most pertinent challenges for 21st-century translational neuroscience due to the profound impact that falls and mobility disturbances have on our aging *** and gait control does not happen automatically,as previously believed,but rather requires continuous involvement of central nervous *** effectively exert control over the body,the brain must integrate multiple streams of sensory information,including visual,vestibular,and somatosensory *** mechanisms which underpin the integration of these multisensory signals are the principal topic of the present *** multisensory integration theories focus on how failure of cognitive processes thought to be involved in multisensory integration leads to falls in older *** emphasis,however,has been placed on specific contributions of individual sensory modalities to multisensory integration processes and cross-modal interactions that occur between the sensory modalities in relation to gait and *** the present work,we review the contributions of somatosensory,visual,and vestibular modalities,along with their multisensory intersections to gait and balance in older adults and patients with Parkinson’s *** also review evidence of vestibular contributions to multisensory temporal binding windows,previously shown to be highly pertinent to fall risk in older ***,we relate multisensory vestibular mechanisms to potential neural substrates,both at the level of neurobiology(concerning positron emission tomography imaging)and at the level of electrophysiology(concerning electroencephalography).We hope that this integrative review,drawing influence across multiple subdisciplines of neuroscience,paves the way for novel research directions and therapeutic neuromodulatory approaches,to improve the lives of older adults and patients with neurodegenerative diseases.

关键词： aging balance encephalography functional magnetic resonance imaging gait multisensory integration Parkinson’s disease positron emission tomography somatosensory vestibular visual

Bimetallic Single‑Atom Catalysts for Water Splitting

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Nano-Micro Letters 2025年第1期17卷 1-45页

作者： Megha A.Deshmukh Aristides Bakandritsos Radek Zbořil Nanotechnology centre Centre for Energy and Environmental TechnologiesVŠB–Technical University of Ostrava17.listopadu 2172/1570800 Ostrava‑PorubaCzech Republic Regional centre of Advanced Technologies and Materials Czech Advanced Technology and Research Institute(CATRIN)Palacky University OlomoucŠlechtitelů241/2778371 Olomouc–HoliceCzech Republic

Green hydrogen from water splitting has emerged as a critical energy vector with the potential to spearhead the global transition to a fossil fuel-independent *** field of catalysis has been revolutionized by single-atom catalysts(SACs),which exhibit unique and intricate interactions between atomically dispersed metal atoms and their ***,bimetallic SACs(bimSACs)have garnered significant attention for leveraging the synergistic functions of two metal ions coordinated on appropriately designed *** offer an avenue for rich metal–metal and metal–support cooperativity,potentially addressing current limitations of SACs in effectively furnishing transformations which involve synchronous proton–electron exchanges,substrate activation with reversible redox cycles,simultaneous multi-electron transfer,regulation of spin states,tuning of electronic properties,and cyclic transition states with low activation *** review aims to encapsulate the growing advancements in bimSACs,with an emphasis on their pivotal role in hydrogen generation via water *** subsequently delve into advanced experimental methodologies for the elaborate characterization of SACs,elucidate their electronic properties,and discuss their local coordination ***,we present comprehensive discussion on the deployment of bimSACs in both hydrogen evolution reaction and oxygen evolution reaction,the two half-reactions of the water electrolysis process.

关键词： Single-atom catalysts Single-atom dimers Hydrogen evolution Oxygen evolution Water splitting

Pathotypes and Genetic Diversity of Chinese Collections of Elsinoě fawcettii Causing Citrus Scab

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Journal of Integrative Agriculture 2014年第6期13卷 1293-1302页

作者： HOU Xin HUANG Feng ZHANG Tian-yuan XU Jian-guo Hyde D Kevin LI Hong-ye Institute of Biotechnology Zhejiang University Zhejiang Citrus research Institute Institute of excellence in fungal research Mae Fah Luang University

Two scab diseases are currently recognized on citrus：citrus scab, caused by Elsino？ fawcettii, and sweet orange scab, caused by E. australis. Although these pathogens are economically important, there is no molecular data on these species in China. Here we use internal transcribed spacer sequence data to report on host-speciifcity and genetic relationships among 46 isolates collected from the main citrus varieties grown across China. All strains isolated were E. fawcettii. Based on pathogenicity testing on 9 different citrus species, isolates were divided into 11 pathotypes （SM, FBHR, SJCR, SPOJCR, SR, SOJG, SPOJC, SRGC, Lemon and two unnamed pathotypes）. SM is a new pathotype, and two isolates did not ift into any of the known pathotypes of E. fawcettii. Inter-simple sequence repeat （ISSR-PCR） assays separated the E. fawcettii isolates into 10 subgroups;the groupings basically corresponded to the pathogenicity test.

关键词： ElsinoYfawcettii genetic diversity ISSR pathotypes

Glia-to-neuron reprogramming to the rescue?

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Neural Regeneration research 2025年第5期20卷 1395-1396页

作者： Jack W.Hickmott Cindi M.Morshead Department of Surgery University of TorontoTorontoONCanada Donnelly centre for Cellular and Biomolecular research TorontoONCanada Institute of Biomedical Engineering University of TorontoTorontoONCanada The KITE research Institute Toronto Rehabilitation InstituteUniversity Health NetworkTorontoONCanada

Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative *** brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is powerful proof that cell fate can be *** exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates without first passing through a stem cell state.

关键词： programming passing proof

Epitypification:should we epitypify?

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第10期9卷 842-846页

作者： Kevin D. HYDE Ying ZHANG International fungal research and Development centre the Research Institute of Resource Insects Chinese Academy of Forestry Kunming 650224 China fungal research Group School of Science Mae Fah Luang University Tasud Muang Chiang Rai 5 7100 Thailand centre for research in fungal Diversity School of Biological Sciences University of Hong Kong Hong Kong China

Epitypification can solve many taxonomic problems and stabilize the understanding of species, genera, families or orders. The aim of this paper is to illustrate how to epitypify. A few examples where taxa have been epitypified are considered and the benefits and disadvantages of epitypification are discussed. We also outline some examples of taxa which need to be epitypifled with reasons.

关键词： Colletotrichum GenBank Molecular phylogeny Taxonomy Typification

Molecular Analysis of Legume Nodule Development and Autoregulation

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Journal of Integrative Plant Biology 2010年第1期52卷 61-76页

作者： Brett J. Ferguson Arief Indrasumunar Satomi Hayashi Yu-Hsiang Lin Dugald E. Reid Peter M. Gresshoff ARC centre of excellence for Integrative Legume research The University of Queensland

Legumes are highly important food, feed and biofuel crops. With few exceptions, they can enter into an intricate symbiotic relationship with specific soil bacteria called rhizobia. This interaction results in the formation of a new root organ called the nodule in which the rhizobia convert atmospheric nitrogen gas into forms of nitrogen that are useable by the plant. The plant tightly controls the number of nodules it forms, via a complex root-to-shoot-to-root signaling loop called autoregulation of nodulation （AON）. This regulatory process involves peptide hormones, receptor kinases and small metabolites. Using modern genetic and genomic techniques, many of the components required for nodule formation and AON have now been isolated. This review addresses these recent findings, presents detailed models of the nodulation and AON processes, and identifies gaps in our understanding of these process that have yet to be fully explained.

关键词： Molecular Analysis of Legume Nodule Development and Autoregulation

Classical Ethylene Insensitive Mutants of the Arabidopsis EIN2 Orthologue Lack the Expected‘hypernodulation’ Response in Lotus japonicus

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Journal of Integrative Plant Biology 2013年第4期55卷 395-408页

作者： Pick Kuen Chan Bandana Biswas Peter M. Gresshoff Australian research Council (ARC) centre of excellence for Integrative Legume research The University of Queensland ARC centre of excellence for Integrative Legume research and School of Agriculture and Food Sciences The University of Queensland

Three independent ethylene insensitive mutants were selected from an EMS- mutagenized population of Lotus japonicus MG-20 （Miyakojima）. The mutants, called ＇Enigma＇, were mutated in the LjEIN2a gene from Lotus chromosome 1, sharing significant homology with Arabidopsis EIN2 （ethylene-insensitive2）. All three alleles showed classical ethylene insensitivity phenotypes （e.g., Triple Response）, but lacked the increased nodulation phenotype commonly associated with ethylene insensitivity. Indeed, all showed a marginal reduction in nodule number per plant, a phenotype that is enigmatic to sickle, an ethylene- insensitive EIN2 mutant in Medicago truncatula. In contrast to wild type, but similar to an ETRI-1 ethylene ethylene-insensitive transgenic of L. japonicus, enigma mutants formed nodules in between the protoxylem poles, demonstrating the influence of ethylene on radial positioning. Suppression of nodule numbers by nitrate and colonisation by mycorrhizal fungi in the enigma-1 mutant were indistin- guishable from the wild-type MG-20. However, reflecting endogenous ethylene feedback, the enigma-1 mutant released more than twice the wild-type amount of ethylene, enigma-1 had a moderate reduction in growth, greater root mass （and lateral root formation）, delayed flowering and ripening, smaller pods and seeds. Expression analysis of ethylene-regulated genes, such as ETR1, NRL1 （neverripe-like 1）, and ElL3 in shoots and roots of enigma-1 and MG-20 illustrated that the ethylene-insensitive mutation strongly affected transcriptional responses in the root. These mutants open the possibility that EIN2 in L. japonicus, a determinate nodulating legume, acts in a more complex fashion possibly through the presence of a duplicated copy of LjEIN2.

关键词： ABA development ethylene legume nodulation symbiosis.

Larvicidal activity of endocarp and seed crude extracts of Dracaena loureiri Gagnep against Aedes aegypti(L.) mosquito

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Asian Pacific Journal of Tropical Biomedicine 2017年第3期7卷 222-226页

作者： Damrongpan Thongwat Supaporn Lamlertthon Urat Pimolsri Nophawan Bunchu Department of Microbiology and Parasitology Faculty of Medical ScienceNaresuan UniversityPhitsanulokThailand centre of excellence in Medical Biotechnology Faculty of Medical ScienceNaresuan UniversityPhitsanulokThailand centre of excellence in fungal research Faculty of Medical ScienceNaresuan UniversityPhitsanulokThailand

Objective: To evaluate the larvicidal activity of the ethanolic and aqueous extracts of the endocarp and seeds of Dracaena loureiri(D. loureiri) against the dengue mosquito vector, Aedes ***: Bioassays were performed by exposing late third-stage to early fourth-stage larvae of Aedes aegypti to various concentrations of the extracts from D. loureiri. The larval mortality was observed after 24-and 48-h ***: The larvicidal bioassay in this study demonstrated that the ethanolic endocarp extract was the most effective with the LC50 value of 84.00 mg/L after 24 h exposure and< 50 mg/L after 48 h exposure. Extracts from the other parts of the plant were significantly less effective as a ***: The ethanolic endocarp extract of D. loureiri demonstrated effective larvicidal activity. It is an alternative source for developing a novel larvicide for controlling this mosquito species.

关键词： Aedes aegypti Dracaena loureiri Larvicide Plant extracts Crude extracts