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Towards a natural classification of Astrosphaeriella-like species;introducing Astrosphaeriellaceae and Pseudoastrosphaeriellaceae *** Astrosphaeriellopsis,***.

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Fungal Diversity 2015年第5期74卷 143-197页

作者： Rungtiwa Phookamsak Chada Norphanphoun Kazuaki Tanaka Dong-Qin Dai Zong-Long Luo Jian-Kui Liu Hong-Yan Su Darbhe J.Bhat Ali H.Bahkali Peter E.Mortimer Jian-Chu Xu Kevin D.Hyde Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanChina World Agroforestry centre East Asia NodeHeilongtanKunming 650201People’s Republic of China School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Center of Excellence in Fungal Research and School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Formerly Department of Botany Goa UniversityGoaIndia No.128/1-J Azad Housing SocietyCurcaGoa 403108India Guizhou Key Laboratory of Agricultural Biotechnology GuizhouAcademy of Agricultural SciencesGuiyangGuizhouChina College of Agriculture&Biology Dali UniversityDali 671003YunnanPeople’s Republic of China Faculty of Agriculture and Life Sciences Hirosaki University3 Bunkyo-choHirosakiAomori 036-8561Japan Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box:2455Riyadh 1145Saudi Arabia CAS Key Laboratory of Genome Sciences and Information Beijing Institute of GenomicsChinese Academy of SciencesNo.1 Beichen West RoadChaoyang DistrictBeijing 100101People’s Republic of China

Astrosphaeriella sensu lato is a common genus occurring on bamboo,palms and stout *** of Astrosphaeriella have been collected from various countries in tropical,subtropical or temperate *** Asia,species have been collected in Brunei,China,Indonesia,Japan,Philippines and *** have been several morphological studies on Astrosphaeriella,but molecular work and phylogenetic analyses are generally *** included in Astrosphaeriella were characterized in three main groups 1)typical Astrosphaeriella species(sensu stricto)having carbonaceous,erumpent,conical ascostromata 2)atypical Astrosphaeriella species(sensu lato)having immersed,coriaceous ascostromata with short to long papilla and 3)lophiostoma-like species having immersed ascostromata with slit-like *** of the latter Astrosphaeriella species,having slit-like openings,have been transferred to Fissuroma and Rimora in *** this study five type specimens of Astrosphaeriella were loaned from herbaria worldwide and re-examined and are re-described and *** of Astrosphaeriella were also made in Thailand and morphologically *** cultures were obtained from single spores and used in molecular *** asexual morph was induced on sterile bamboo pieces placed on water *** analyses of combined LSU,SSU and TEF1 sequence data of astrosphaeriella-like species using Bayesian,Maximum parsimony(MP)and Randomized Accelerated Maximum Likelihood(RAxML)analyses were carried *** analyses show that species of Astrosphaeriella can be distinguished in at least three *** of Astrosphaeriella sensu stricto with erumpent,carbonaceous ascostromata,form a strongly supported clade with Pteridiospora species and a new family,Astrosphaeriellaceae,is introduced to accommodate these *** genera are revised and Astrosphaeriella bambusae,***,***,***,*** and Pteridiospora chiangraiensis

关键词： Asexual morph Bamboo Palm Pseudoastrosphaeriella Phylogeny Pleosporales Taxonomy

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Characterization of Endophytic Microorganisms of Rice(Oryza sativa L.)Potentials for Blast Disease Biocontrol and Plant Growth Promoting Agents

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Phyton-International Journal of Experimental Botany 2023年第11期92卷 3021-3041页

作者： Shugufta Parveen Fayaz A.Mohiddin M.Ashraf Bhat Zahoor Ahmed Baba Fehim Jeelani M.Anwar Bhat Sajad Un Nabi Burhan Hamid Saba Bandey Farhanaz Rasool Zakir Amin Ibrahim Al-Ashkar Muhammad Adnan Ayman El Sabagh Division of Plant Pathology Faculty of AgricultureSher-e-Kashmir University of Agricultural Sciences and Technology of KashmirWaduraIndia Mountain Research centre for Field Crops SKUAST-KashmirKhudwaniIndia Division of Genetics and Plant Breeding Faculty of AgricultureSher-e-Kashmir University of Agricultural Sciences and Technology of KashmirWaduraIndia Division of Microbiology Faculty of AgricultureSher-e-Kashmir University of Agricultural Sciences and Technology of KashmirWaduraIndia Division of Statistics Faculty of AgricultureSher-e-Kashmir University of Agricultural Sciences and Technology of KashmirWaduraIndia Division of Agronomy Faculty of AgricultureSher-e-Kashmir University of Agricultural Sciences and Technology of KashmirWaduraIndia Indian Council of Agricultural Research-Central institute of Temperate Horticulture(ICAR-CITH) Old AirportRangrethSrinagarIndia Division of Plant Pathology Faculty of HorticultureSher-e-Kashmir University of Agricultural Sciences and Technology of KashmirShalimarIndia Directorate of Extension Sher-e-Kashmir University of Agricultural Sciences and Technology of KashmirShalimarIndia Department of Plant Production College of Food and Agriculture SciencesKing Saud UniversityRiyadhSaudi Arabia College of Food Agricultural and Environmental SciencesThe Ohio State UniversityColumbusOHUSA Department of Agronomy Faculty of AgricultureUniversity of KafrelsheikhKafrelsheikhEgypt

One hundred twenty-five endophytic microorganisms were isolated from the roots,stems,and leaves of four prominent rice cultivars growing in temperate *** potential to combat rice blast disease and promote plant growth was *** dual culture tests highlighted the strong antagonistic activity of five fungal(ranging from 89%–70%)and five bacterial(72%–61%)*** examination focused on volatile compounds produced by selected isolates to counter the blast *** these,the highest chitinase(13.76μg mL−1)and siderophore(56.64%),was exhibited by Aspergillus flavus,and the highest HCN production was shown by Stenotrophomonas maltophilia(36.15μM mL−1).In terms of growth promotion traits,Aspergillus flavus and Enterobacter cloacae excelled in activities viz,phosphorous solubilization,ammonia production,auxin and gibberellic acid production,and nitrogen *** Identity of these endophytes was confirmed through molecular analysis as Trichoderma afroharzianum,Trichoderma harzianum,Penicillium rubens,Aspergillus flavus,Stenotrophomonas rhizophila,Stenotrophomonas maltophilia,Bacillus cereus,Enterobacter cloacae,and Bacillus *** greenhouse conditions,the highest disease control was shown by isolate Bacillus licheniformis and *** with an inhibition of 79%,followed by ***(77%)and ***(73%).The overall results of this study showed that Bacillus licheniformis and Stenotrophomonas rhizophila have great potential to be used as bio-stimulant and biocontrol agents to manage rice blast disease.

关键词： Endophytes phylogeny antagonistic activity Pyricularia phytohormones

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Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children

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四川生理科学杂志 2022年第12期44卷 2223-2223页

作者： Danyel Lee Laboratory of Human Genetics of Infectious Diseases Necker Branch INSERM U1163 Paris France Paris City University Imagine Institute Paris France Laboratory of Virology and Infectious Disease The Rockefeller University New York NY USA St. Giles Laboratory of Human Genetics of Infectious Diseases Rockefeller Branch The Rockefeller University New York NY USA Department of Cancer Biology Lerner Research Institute Cleveland Clinic Cleveland OH USA Human Evolutionary Genetics Unit Institut Pasteur Paris City University CNRS UMR 2000 Paris France Doctoral College Sorbonne University Paris France Laboratory of Immunology Lyon Sud Hospital Lyon France Pediatric Intensive Care Department Hospital Sant Joan de Déu Barcelona Spain Kids Corona Platform Barcelona Spain Center for Biomedical Network Research on Epidemiology and Public Health (CIBERESP) Instituto de Salud Carlos III Madrid Spain Department of Surgery and Surgical Specializations Faculty of Medicine and Health Sciences University of Barcelona Barcelona Spain Respiratory and Immunological Dysfunction in Pediatric Critically Ill Patients Institute of Recerca Sant Joan de Déu Barcelona Spain Bursa City Hospital Bursa Turkey Ankara City Hospital Yildirim Beyazit University Ankara Turkey Immunology and Rheumatology Division Department of Pediatrics University of Montreal CHU Sainte-Justine Montreal QC Canada Human Evolutionary Genetics Unit Institut Pasteur Paris City University CNRS UMR 2000 Paris France Center for Translational Research Institut Pasteur Paris City University Paris France Laboratory of Virology and Infectious Disease The Rockefeller University New York NY USA Department of Biochemistry and Center for RNA Science and Therapeutics Case Western Reserve University Cleveland OH USA Department of Surgery Weill Cornell Medical College New York NY USA Laboratory of Virology and Infectious Disease The Rockefeller University New York NY USA Department of Pediatrics School of Me

Multisystem inflammatory syndrome in children(MIS-C)is a rare and severe condition that follows benign *** report autosomal recessive deficiencies of OAS1,OAS2,or RNASEL in five unrelated children with *** cytosolic d... 详细信息

关键词： inflammatory children multisystem

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通过纯合子定位法确定的新的临床和分子类型的Unverricht-Lundborg病

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世界核心医学期刊文摘（神经病学分册） 2005年第8期1卷 16-16页

作者： Berkovic S.F. Mazarib A. Walid S. 郭俊 Epilepsy Research centre Neurosciences Building Repatriation Campus Heidelberg West Vic. 3081 Australia Dr.

Progressive myoclonus epilepsy (PME) has a number of causes,of which Unverrich t-Lundborg disease (ULD) is the most common. ULD has previously been mapped to a locus on chromosome 21 (EPM1). Subsequently, mutations in the cystatin B gene have been found in most cases. In the present work we identified an inbred Arab family with a clinical pattern compatible with ULD, but mutations in the cystati n B gene were absent. We sought to characterize the clinical and molecular featu res of the disorder. The family was studied by multiple field trips to their tow n to clarify details of the complex consanguineous relationships and to personal ly examine the *** was collected for subsequent molecular analyses from 2 1 individuals. A genome-wide screen was performed using 811 microsatellite mark ers. Homozygosity mapping was used to identify loci of interest. There were eigh t affected *** onset was at 7.3 ±1.5 years with myoclonic or t onic-clonic seizures. All had myoclonus that progressed in severity over time a nd seven had tonic-clonic seizures. Ataxia, in addition to myoclonus, occurred in all. Detailed cognitive assessment was not possible, but there was no signifi cant progressive dementia. There was intrafamily variation in severity; three re quired wheelchairs in adult life; the others could walk unaided. MRI, muscle and skin biopsies on one individual were unremarkable. We mapped the family to a 15 -megabase region at the pericentromeric region of chromosome 12 with a maximum lod score of 6.32. Although the phenotype of individual subjects was typical of ULD, the mean age of onset (7.3 years versus 11 years for ULD) was younger. The locus on chromosome 12 does not contain genes for any other form of PME, nor doe s it have genes known to be related to cystatin *** represents a new form of PME and we have designated the locus as EPM1B.

关键词：纯合子定位法肌阵挛性癫痫蛋白酶抑制剂基因突变分子学皮肤活组织检查进行性痴呆基因座着丝粒共济失调

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Helicobacter pylori Virulence Genes cagA, babA2, and vacA Detection in Dyspeptic Patients from Burkina Faso

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American Journal of molecular Biology 2023年第3期13卷 141-155页

作者： Tegwinde Rebeca Compaore Kalifou Traore Nômawendé Ines Compaore Lassina Traore Sylvie Zida Serge Theophile Soubeiga Dinanibe Kambire Jean Claude R. P. Ouedraogo Aminata Dickel Sidibe Yasmine Astrid Sana Tani Sagna Wendkuuni Florencia Djigma Henri Gautier Ouedraogo Jacques Simpore Département Biomédical et Santee Publique Institut de Recherche en Sciences de la Santé (IRSS) Ouagadougou Burkina Faso centre de Recherche Biomoléculaire Pietro Annigoni (CERBA) Ouagadougou Burkina Faso Laboratoire de Biologie et de Génétique Moléculaire (LABIOGENE) Université Joseph KI-ZERBO Ouagadougou Burkina Faso Clinique El Fateh-Suka Service de médecine et de spécialités médicales Ouagadougou Burkina Faso Département de Médecine et de Pharmacopée Traditionnelle Institut de Recherche en Sciences de la Santé (IRSS) Ouagadougou Burkina Faso

The diverse clinical presentation of Helicobacter pylori (H. pylori) infection results from the interaction between bacterial virulence, host genetics, socio-demographic and environmental factors. This study aimed to characterize Helicobacter pylori virulence genes and the associated behavioral factors among dyspeptic patients in Burkina Faso. Two hundred and fifty (250) stool samples were collected from patients with dyspepsia seen at health centers in Ouagadougou, Burkina Faso. Bacterial deoxyribonucleic acid (DNA) was extracted using a commercial kit. Virulence genes were detected using conventional multiplex Polymerase Chain Reaction with specific primers. The overall prevalence of Helicobacter pylori of the 250 participants was 91.20%. CagA virulence gene was present among 20.19% of individuals, while babA2 and vacA were detected respectively among 9.65% and 67.54% of the population positive for Helicobacter pylori. Among vacA subtypes, vacAs1 was the most frequent, with 39.04%, followed by vacAi1 (19.74%), vacAi2 (17.54%), and vacAs2 with 10.96%. Regarding vacAm1 and vacAm2, they were less frequent at 6.14% each. “Handwashing three times or less per day” significantly increased the risk of having vacAi2 allele and H. pylori rRNA16s, with p-values of 0.013 and 0.020, respectively. The consumption of non-tap water increases the risk of carrying the cagA virulence gene. Additionally, H. pylori-positive patients living with more than four (4) people in their household had about two times the risk of having the vacAs1 allele. The present study shows the detection of Helicobacter pylori cagA, vacA subtypes, and babA2 by stool a PCR method in Burkina Faso. The strong association between sanitary habits and virulence factors depicts the composite interaction between ecological factors, gastric mucosa, and bacteria. Therefore, the synergic action of these factors should be considered when aiming for bacterial eradication and gastric pathology cure.

关键词： Helicobacter pylori Stool cagA babA2 vacA

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Cholangiocarcinoma and liver transplantation:What we know so far?

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World Journal of Gastrointestinal Pathophysiology 2021年第5期12卷 84-105页

作者： Ali Reza Safarpour Hassan Askari Farshid Ejtehadi Asaad Azarnezhad Ehsan Raeis-Abdollahi Amir Tajbakhsh Mohammad Foad Abazari Firoozeh Tarkesh Alireza Shamsaeefar Ramin Niknam Gholam Reza Sivandzadeh Kamran Bagheri Lankarani Fardad Ejtehadi Department of Gastroenterohepatology Research Center Shiraz University of Medical SciencesShiraz ***Iran The Princess Alexandra Hospital HNS Trust HarlowEssex CM201QXUnited Kingdom Liver and Digestive Research Center Research Institute for Health DevelopmentKurdistan University of Medical SciencesSanandaj ***Iran Department of Basic Medical Sciences Qom Medical BranchIslamic Azad UniversityQomIran Pharmaceutical Sciences Research Center Shiraz University of Medical SciencesShiraz ***Iran Research Center for Clinical Virology Tehran University of Medical SciencesTehran ***Iran Shiraz Organ Transplant Center Shiraz University of Medical SciencesShiraz ***Iran Health Policy Research centre Shiraz University of Medical SciencesShiraz ***Iran

Cholangiocarcinoma(CCA)is a type of cancer with increasing prevalence around the world that originates from cholangiocytes,the epithelial cells of the bile *** tumor begins insidiously and is distinguished by high grade neoplasm,poor outcome,and high risk for *** transplantation has become broadly accepted as a treatment option for *** transplantation is expected to play a crucial role as palliative and curative therapy for unresectable hilar CCA and intrahepatic *** purpose of this study was to determine which cases with CCA should be subjected to liver transplantation instead of resection,although reported post-transplant recurrence rate averages approximately 20%.This review also aims to highlight the molecular current frontiers of CCA and directions of liver transplantation for CCA.

关键词： Cholangiocarcinoma Liver transplantation Primary sclerosing cholangitis Neoadjuvant chemoradiotherapy

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医学是终极的个体化技术

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英国医学杂志中文版 2017年第7期20卷 418-418页

作者： Rebecca C Fitzgerald Peter Sasieni 胡俊 MRC Cancer Unit Hutchison-MRC Research Centre University ofCambridge Cambridge CB2 0XZ UK centre for Cancer Prevention Queen Mary University of LondonLondon UK 中华医学会组织部

现代医学将科学与交流、照护个体患者的艺术相结合。临床医生通过与患者交谈来确定最佳治疗方案一直是各种临床照护情境的中心环节。由于巨大的技术进步，二十一世纪医学的科学成分与艺术成分不相上下。在分子水平上展现肿瘤特点的技术... 详细信息

现代医学将科学与交流、照护个体患者的艺术相结合。临床医生通过与患者交谈来确定最佳治疗方案一直是各种临床照护情境的中心环节。由于巨大的技术进步，二十一世纪医学的科学成分与艺术成分不相上下。在分子水平上展现肿瘤特点的技术能力已经降低了治疗的副作用，提高了患者的生存率和生活质量。

关键词：个体化技术医学研究患者医疗卫生行业

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Current status and trends in forest genomics

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Forestry Research 2022年第1期2卷 99-120页

作者： Dulal Borthakur Victor Busov Xuan Hieu Cao Qingzhang Du Oliver Gailing Fikret Isik Jae-Heung Ko Chenghao Li Quanzi Li Shihui Niu Guanzheng Qu Thi Ha Giang Vu Xiao-Ru Wang Zhigang Wei Lin Zhang Hairong Wei Department of molecular Biosciences and Bioengineering University of Hawaii at Manoa1955 East-West RoadHonoluluHI 96822USA College of Forest Resources and Environmental Science Michigan Technological UniversityHoughtonMI 49931USA Forest Genetics and Forest Tree Breeding Faculty for Forest Sciences and Forest EcologyUniversity of GöttingenBüsgenweg 237077 GöttingenGermany National Engineering Research Center of Tree Breeding and Ecological Restoration College of Biological Sciences and TechnologyBeijing Forestry UniversityBeijing 100083P.R.China Cooperative Tree Improvement Program North Carolina State UniversityRaleighNC 27695USA Department of Plant&Environmental New Resources Kyung Hee University1732 Deogyeong-daeroYongin 17104Republic of Korea State Key Laboratory of Tree Genetics and Breeding Northeast Forestry UniversityHarbin 150040P.R.China State Key Laboratory of Tree Genetics and Breeding Chinese Academy of ForestryBeijing 100093P.R.China Department of Ecology and Environmental Science UmeåPlant Science CentreUmeåUniversityUmeå90187Sweden College of Life Sciences Heilongjiang UniversityHarbin 150080P.R.China Key Laboratory of Cultivation and Protection for Non-Wood Forest Trees Ministry of EducationCentral South University of Forestry and TechnologyChangsha 410004Hunan ProvinceP.R.China

Forests are not only the most predominant of the Earth's terrestrial ecosystems,but are also the core supply for essential products for human ***,global climate change and ongoing population explosion severely threatens the health of the forest ecosystem and aggravtes the deforestation and forest *** genomics has great potential of increasing forest productivity and adaptation to the changing *** the last two decades,the field of forest genomics has advanced quickly owing to the advent of multiple high-throughput sequencing technologies,single cell RNA-seq,clustered regularly interspaced short palindromic repeats(CRISPR)-mediated genome editing,and spatial transcriptomes,as well as bioinformatics analysis technologies,which have led to the generation of multidimensional,multilayered,and spatiotemporal gene expression *** technologies,together with basic technologies routinely used in plant biotechnology,enable us to tackle many important or unique issues in forest biology,and provide a panoramic view and an integrative elucidation of molecular regulatory mechanisms underlying phenotypic changes and *** this review,we recapitulated the advancement and current status of 12 research branches of forest genomics,and then provided future research directions and focuses for each ***,a shift from simple biotechnology-based research to advanced and integrative genomics research,and a setup for investigation and interpretation of many spatiotemporal development and differentiation issues in forest genomics have just begun to emerge.

关键词： forest routine biotechnology

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Limen,Non-Toxic Recombinant Plant Defensin and Its Effect against Pathogenic Yeast and Fungi

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Journal of Pharmacy and Pharmacology 2018年第11期6卷 945-955页

作者： Katerina Rehorova Jitka Viktorova Barbora Macuchova Tomas Vlcko Lucie Stankova Nikola Jelenova Ludmila Ohnoutkova Tomas Macek Department of Biochemistry and Microbiology University of Chemistry and TechnologyPragueTechnicka 516628Prague 6Czech Republic Department of Chemical Biology and Genetics Centre of the Region Hana for Biotechnological and Agricultural ResearchPalacky University OlomoucSlechtitelu 27Olomouc 78371Czech Republic

Limen is a small cysteine-rich peptide that was originally isolated from lima beans,and its activity against Micromycetes was *** expression of limen in both a prokaryotic and plant system was performed to demonstrate a wide selection of its activities with potential for further *** first limen was expressed in *** cells and after purification steps,its antimicrobial activity was tested on pathogenic *** showed that limen can significantly eliminate the growth of several pathogenic yeasts such as Candida albicans,while its hemolytic activity was not *** confirm limen’s activity in vivo,transformation of the barley Hordeum vulgare *** *** barley was obtained using Agrobacterium-mediated transformation and the production of limen peptide in plant tissues was verified by molecular *** barley plants were repeatedly exposed to Fusarium oxysporum *** resistance to the most important pathogen was followed using chlorophyll measurements as indicators of *** on the food safety aspect of the use of GM plants,cytotoxicity was followed in extracts from transgenic stressed *** or a lower cytotoxic effect was found on human keratinocytes and human embryonic kidney cells than extracts from the non-transformed plants.

关键词： Plant defensin recombinant production toxicity Candida Fusarium barley

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IPEX综合征的临床和分子学异常表现

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世界核心医学期刊文摘（儿科学分册） 2006年第5期2卷 11-11页

作者： Myers A.K. Perroni L. Costigan C. Reardon W 张振 National centre for Medical Genetics Our Lady's Hospital for Sick Children Crumlin Dublin 12 Ireland.Dr

IPEX (immunodysregulation, polyendocrinopathy, enteropathy, X linked syndrome) is a rare disorder which usually results in death in early infancy or childhood . Clinical awareness remains the cornerstone of diagnosis, and provided that the diagnosis is entertained, mutation analysis for FOXP3 gene mutations can be con firmatory. Two new patients in whom IPEX was diagnosed retrospectively are repor ted.

关键词： X综合征异常表现临床分子学回顾性诊断免疫功能失调 X染色体连锁内分泌病早期死亡

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