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Computers, Materials & Continua 2020年第10期65卷 865-878页

作者： Fuquan Huang Zijun Liu Tinghuang Wang Haitai Zhang Tony Yip Shenzhen Power Utility Co. Ltd.Shenzhen518000China Shandong Kehui Electric Power Automation Co. Ltd.Zibo255000China Kehui International ltd. Studio 206Mill Studio Business CentreCrane MeadWareHertsSG129PYUK

In order to quickly and accurately locate the fault location of the distribution network and increase the stability of the distribution network,a fault recovery method based on multi-objective optimization algorithm is *** optimization of the power distribution network fault system based on multiagent technology realizes fast recovery of multi-objective fault,solve the problem of network learning and parameter adjustment in the later stage of particle swarm optimization algorithm falling into the local extreme value dilemma,and realize the multi-dimensional nonlinear optimization of the main grid and the auxiliary *** system proposed in this study takes power distribution network as the goal,applies fuzzy probability algorithm,simplifies the calculation process,avoids local extreme value,and finally realizes the energy balance between each power *** results show that the Multi-Agent Technology enjoys priority in restoring important load,shortening the recovery time of power grid balance,and reducing the overall line loss rate of power ***,the power grid fault self-healing system can improve the safety and stability of the important power grid,and reduce the economic loss rate of the whole power grid.

关键词： Multi agent technology power distribution network fault self-healing

Efficacy and safety of human umbilical cord-derived mesenchymal stem cells in the treatment of refractory immune thrombocytopenia:a prospective,single arm,phase I trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2250-2259页

作者： Yunfei Chen Yanmei Xu Ying Chi Ting Sun Yuchen Gao Xueqing Dou Zhibo Han Feng Xue Huiyuan Li Wei Liu Xiaofan Liu Huan Dong Rongfeng Fu Mankai Ju Xinyue Dai Wentian Wang Yueshen Ma Zhen Song Jundong Gu Wei Gong Renchi Yang Lei Zhang State Key Laboratory of Experimental Hematology National Clinical Research Centre for Blood DiseasesHaihe Laboratory of Cell EcosystemTianjin Key Laboratory of Gene Therapy for Blood DiseasesCAMS Key Laboratory of Gene Therapy for Blood DiseasesInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China Tianjin Institutes of Health Science Tianjin 301600China National Clinical Research Center for Hematologic Diseases Jiangsu Institute of HematologyThe First Affiliated Hospital of Soochow UniversitySuzhou 215006China National Engineering Research centre of Cell Products Tianjin Key Laboratory of Engineering Technologies for Cell PharmaceuticalAmCellGene Engineering Co.LtdTianjin 300457China School of Population Medicine and Public Health Chinese Academy of Medical Sciences and Peking Union Medical College100730 BeijingChina

Patients with refractory immune thrombocytopenia(ITP)frequently encounter substantial bleeding risks and demonstrate limited responsiveness to existing *** cord-derived mesenchymal stem cells(UC-MSCs)present a promising alternative,capitalizing on their low immunogenicity and potent immunomodulatory effects for treating diverse autoimmune *** prospective phase I trial enrolled eighteen eligible patients to explore the safety and efficacy of UC-MSCs in treating refractory *** research design included administering UC-MSCs at escalating doses of 0.5×10^(6)cells/kg,1.0×10^(6)cells/kg,and 2.0×10^(6)cells/kg weekly for four consecutive weeks across three cohorts during the dose-escalation phase,followed by a dose of 2.0×10^(6)cells/kg weekly for the dose-expansion *** events,platelet counts,and changes in peripheral blood immunity were monitored and recorded throughout the administration and follow-up ***,12(with an addition of three patients in the 2.0×10^(6)cells/kg group due to dose-limiting toxicity)and six patients were enrolled in the dose-escalation and dose-expansion phase,*** patients(13/18,72.2%)experienced one or more treatment emergent adverse *** adverse events occurred in four patients(4/18,22.2%),including gastrointestinal hemorrhage(2/4),profuse menstruation(1/4),and acute myocardial infarction(1/4).The response rates were 41.7%in the dose-escalation phase(5/12,two received 1.0×10^(6)cells/kg per week,and three received 2.0×10^(6)cells/kg per week)and 50.0%(3/6)in the dose-expansion *** overall response rate was 44.4%(8/18)among all enrolled *** sum up,UC-MSCs are effective and well tolerated in treating refractory ITP(*** ID:NCT04014166).

关键词： doses immunity treatment

Improving antioxidant activities of water-soluble lignin-carbohydrate complex isolated from wheat stalk through prolonging ball-milling pretreatment and homogeneous extraction

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Journal of Bioresources and Bioproducts 2024年第1期9卷 113-125页

作者： Di Xie Zhulan Liu Yunfeng Cao Sheng-I Yang Chen Su Mi Li Jiangsu Co-innovation Center for Efficient Processing and Utilization of Forest Products Nanjing Forestry UniversityNanjing 210037China International Innovation Center for Forest Chemicals and Materials Nanjing Forestry UniversityNanjing 210037China Center for Renewable Carbon School of Natural ResourcesUniversity of TennesseeKnoxvilleTN 37996USA Shandong Huatai Paper Co. Ltd.Dongying 257000China School of Natural Resources University of TennesseeKnoxvilleTN 37996USA Key Lab of Biomass Energy and Material Institute of Chemical Industry of Forest ProductsChinese Academy of ForestryJiangsu ProvinceNanjing 210042China

Water-soluble lignin-carbohydrate complex(LCC)rich in polysaccharides exhibits benign in vitro antioxidant activities and distinguishes high biocompatibility from lignin-rich LCC and ***,the antioxidant activity of water-soluble LCCs remains to be improved and its structure-antioxidant relationship is still ***,structurally diversified water-soluble LCCs were isolated under different ball-milling pretreatment durations(4,6,8 h),extraction pathways(ho-mogeneous and heterogeneous),and isolation routines(water extracts and residues after water extraction).Their structures were characterized by wet chemistry,chromatography and *** activities were evaluated by ferric reducing antioxidant power and 1,1-diphenyl-2-picrylhydrazyl radicals scavenging rate(RDPPH).Results show that altering ball-milling duration and isolation procedures cause varied structures and antioxidant activities of the water-soluble ***,prolonging ball-milling duration to 8 hours and homogeneous extrac-tion can enhance their antioxidant activity through releasing more phenolic structures and pro-moting the extraction of high-molecular-weight LCCs via reducing mass-transfer resistance,*** a result,the RDPPH of water-soluble LCCs reaches up to 97.35%,which is associated with the arabinan content with statistical significance(P<0.05).This study provides new insights into the structure-antioxidation relationship of herbaceous LCC as potential antioxidants.

关键词： LCC Homogeneous extraction Ball-milling Structure-antioxidation relationship Wheat straw

Poisson rectangular pulse(PRP)model establishment based on uncertainty analysis of urban residential water consumption patterns

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Environmental Science and Ecotechnology 2024年第2期18卷 53-59页

作者： Jiaxin Zhang Dragan Savic Qiang Xu Kuo Liu Zhimin Qiang Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100085China University of Chinese Academy of Sciences Beijing100049China KWR Water Research Institute Nieuwegein3430BBthe Netherlands centre for Water Systems University of ExeterExeterEX44QFUnited Kingdom Faculty of Civil Engineering University of Belgrade11000BelgradeSerbia Beijing Waterworks Group Co.ltd Beijing100031China

The commonly used Poisson rectangular pulse(PRP)model,employed for simulating high-resolution residential water consumption patterns(RWCPs),relies on calibration via medium-resolution RWCPs obtained from practical *** introduces inevitable uncertainty stemming from the measured RWCPs,which consequently impacts the precision of model *** we enhance the accuracy of the PRP model by addressing the uncertainty of *** established a critical sampling size of 2000 household water consumption patterns(HWCPs)with a data logging interval(DLI)of 15 min to attain dependable *** Genetic Algorithm calibration,the optimal values of the PRP model's parameters were determined:pulse frequency lλ=91 d^(-1),mean of pulse intensity E(I)=0.346 m^(3) h^(-1),standard deviation of pulse intensity STD(I)=0.292 m^(3) h^(-1),mean of pulse duration E(D)=40 s,and standard deviation of pulse duration STD(D)=55 ***,validation was conducted at both HWCP and RWCP *** recommend a sampling size of2000 HWCPs and a DLI of30 min for PRP model calibration to balance simulation precision and practical *** study significantly advances the theoretical foundation and real-world application of the PRP model,enhancing its role in urban water supply system management.

关键词： Residential water consumption pattern Uncertainty analysis Poisson rectangular pulse model Model establishment

Work-function-induced interfacial electron redistribution of MoO_(2)/WO_(2) heterostructures for high-efficiency electrocatalytic hydrogen evolution reaction

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Rare Metals 2024年第2期43卷 489-499页

作者： Tong-Fei Li Jing Li Lu-Ping Zhang Jia-Wei Ke Meng-Xing Fan Li-Fang Zhang Cheng-Wei Deng Yi Sun Tao Qian Cheng-Lin Yan School of Chemistry and Chemical Engineering Nantong UniversityNantong226019China Jiangsu Key Laboratory of New Power Batteries Jiangsu Collaborative Innovation Centre of Biomedical Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing210023China Aerospace Hydrogen Energy Technology(Shanghai)Co.ltd. Shanghai201800China Key Laboratory of Core Technology of High Specific Energy Battery and Key Materials for Petroleum and Chemical Industry College of EnergySoochow UniversitySuzhou215006China Light Industry Institute of Electrochemical Power Sources Suzhou215006China

The engineering of the electronic configurations of active sites,together with the production of more accessible active sites through heterostructure design,has been established as a forceful methodology for boosting water electrolysis ***,a facile approach is developed to fabricate well-dispersed MoO_(2) and WO_(2) nanoparticles with abundant heterointerfaces entrapped in N,P-doped carbon nanofibers(referred to as MoO_(2)/WO_(2)@N,P-CNFs hereafter)as hydrogen evolution reaction(HER)electrocatalysts in alkaline and acidic *** spectroscopic analyses and theoretical findings manifest that the heterointerface formed by the work function modulation of MoO_(2)/WO_(2) triggers the spontaneous electron redistribution from MoO_(2)to WO_(2) and a built-in electric field,which is essential to promote water adsorption,optimize the H-intermediate adsorption energy,result in the enhanced charge transfer efficiency,and ultimately increase the intrinsic HER ***,the intimate confinement of MoO_(2)/WO_(2) heterostructures in the porous carbon substrate can restrain the active sites from unfavorable coarsening and detachment,thus ensuring facilitated HER kinetics and outstanding structural *** a result,MoO_(2)/WO_(2)@N,P-CNFs exhibit superior catalytic HER performance in acidic and basic solutions,requiring 118 and 95 mV overpotentials to achieve 10 mA·cm^(−2),respectively,surpassing a number of reported non-noble metal-based *** work provides guidelines for the rational design and construction of special metallic heterocomponents with optimized interfacial electronic structure for various electrochemical technologies.

关键词： Electrospinning MoO_(2)/WO_(2) heterostructure Work function Hydrogen evolution reaction

Targeting muscle to treat Charcot-Marie-Tooth disease

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Neural Regeneration Research 2024年第8期19卷 1653-1654页

作者： David Villarroel-Campos James N.Sleigh Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease centre UCL Queen Square Institute of NeurologyUniversity College LondonLondonUK UK Dementia Research Institute University College LondonLondonUK

Charcot-Marie-Tooth disease(CMT)is a hereditary peripheral neuropathy causing muscle weakness/wasting and sensory dysfunction predominantly in limb *** patients display gait abnormalities,foot deformities,loss of sens... 详细信息

关键词： Marie sensation neuropathy

Analysis of Osteoporosis Risk Factors in 148 Retired Employees Based on Physical Examination Results

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Proceedings of Anticancer Research 2024年第4期8卷 116-123页

作者： Sunhang Cao Zhengfeng Liu Guiyu Cheng Dongmei Zhai Peng Li Chunshui Huang Physical Examination and Rehabilitation centre Civil Aviation General HospitalBeijing 100123China Department of Vascular Surgery Civil Aviation General HospitalBeijing 100123China China TravelSky Holding Co.ltd. Beijing 101318China

Objective:To investigate and thoroughly understand the physical examination results of retired employees from a certain unit in Beijing,analyze their bone mineral density(BMD),and identify risk factors that may indicate *** provides a reference for the individualized prevention,identification,and control of osteoporosis among retired ***:The bone mineral density and potential factors of 148 retired employees from a unit in 2023 were analyzed and categorized into osteoporosis and non-osteoporosis *** factors from the physical examinations of the two groups were ***’s correlation analysis was used to determine the correlation between key factors and *** key factors were included in a regression analysis.A multivariate binary logistics regression was employed to identify risk factors indicative of ***:Correlation analysis revealed that gender,age,and ECG ST-segment length were significantly associated with *** analysis showed that for each additional year of age,the likelihood of developing osteoporosis increased by 1.058 times;females were 2.865 times more likely to develop osteoporosis compared to males;the longer the ECG ST-segment,the higher the likelihood of ***:Gender,age,and ECG ST-segment length are significantly associated with *** indicators can provide reference points for early identification,early intervention,and reducing the incidence of osteoporosis in clinical settings.

关键词： Osteoporosis Gender Age ECG ST-segment Correlation analysis

Research on photodarkening in rare earth doped fibers

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Journal of Rare Earths 2012年第11期30卷 1102-1105页

作者：成煜 State Key Laboratory of Optical Fibre and Cable Manufacture Technology R&D CentreYangtze Optical Fibre and Cable Company Ltd.

Samarium doped aluminosilicate fiber was fabricated by modified chemical vapor deposition （MCVD） process. The optical properties of this fiber were characterized by white light source and OSA. The photodarkening property of the fiber was measured by an Ar^＋ laser. The experiment results proved that the samarium doped aluminosilicate fiber had better photodarkening resistance than that of the samarium doped germanosilicate fiber. A brief explanation showed that the photodarkening loss could be reduced by changing the fiber core＇s material from germanosilicate to aluminosilicate. Samarium doped aluminosilicate fiber was very promising for the red fiber laser application.

关键词： fiber fabrication MCVD samarium photodarkening rare earths

A data-driven approach to RUL prediction of tools

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Advances in Manufacturing 2024年第1期12卷 6-18页

作者： Wei Li Liang-Chi Zhang Chu-Han Wu Yan Wang Zhen-Xiang Cui Chao Niu Department of Mechanical Engineering University College LondonLondonWC1E 7JEUK Shenzhen Key Laboratory of Cross-Scale Manufacturing Mechanics Southern University of Science and TechnologyShenzhen518055GuangdongPeople’s Republic of China SUSTech Institute for Manufacturing Innovation Southern University of Science and TechnologyShenzhen518055GuangdongPeople’s Republic of China Department of Mechanics and Aerospace Engineering Southern University of Science and TechnologyShenzhen518055GuangdongPeople’s Republic of China School of Mechanical and Manufacturing Engineering The University of New South WalesKensingtonNSW2052Australia Baoshan Iron&Steel Co. Ltd.Shanghai200941People’s Republic of China

An effective and reliable prediction of the remaining useful life(RUL)of a tool is important to a metal forming process because it can significantly reduce unexpected maintenance,avoid machine shutdowns and increase system *** study proposes a new data-driven approach to the RUL prediction for metal forming processes under multiple contact sliding *** data-driven approach took advantage of bidirectional long short-term memory(BLSTM)and convolutional neural networks(CNN).A pre-trained lightweight CNN-based network,WearNet,was re-trained to classify the wear states of workpiece surfaces with a high accuracy,then the classification results were passed into a BLSTM-based regression model as inputs for RUL *** experimental results demonstrated that this approach was able to predict the RUL values with a small error(below 5%)and a low root mean square error(RMSE)(around 1.5),which was more superior and robust than the other state-of-the-art methods.

关键词： Remaining useful life(RUL) Bidirectional long short-term memory(BLSTM) Data-driven approach Metal forming

Low-carbon design towards sustainable city development:Integrating glass space with natural greenery

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Science China(Technological Sciences) 2024年第9期67卷 2659-2674页

作者： CAO Shi-Jie ZHANG CunKuan WANG JunQi FENG ZhuangBo CHEN Gang HAGHIGHAT Fariborz School of Architecture Southeast UniversityNanjing 210096China Jiangsu Province Engineering Research Center of Urban Heat and Pollution Control Southeast UniversityNanjing 210096China Global centre for Clean Air Research Department of Civil and Environmental EngineeringFaculty of Engineering and Physical SciencesUniversity of SurreyGuildfordGU27XHUnited Kingdom The Third Construction Co. Ltd.of China Construction Eighth Engineering DivisionNanjing 210046China Energy and Environment Group Department of BuildingCivil and Environmental EngineeringConcordia UniversityMontrealH3G 1M8Canada

The rapid urban development has caused serious problems such as high energy consumption and carbon emissions,especially under the context of climate *** are particularly energy-intensive,generating about one third of global energyrelated carbon *** with active solutions(like mechanical systems),passive solutions offer the potential to balance energy consumption,thermal comfort,and ecological *** potential solution is the integration of green glass space(GGS)into passive building *** is a transitional building space with glass curtain walls that exhibit excellent insulation performance during ***,GGS is susceptible to overheating during summer,which limits its ***,this work proposes a strategy of integrating vertical greenery into GGS,leveraging the nature-based solution of greenery(i.e.,flourishes in summer and withers in winter)to address this seasonal challenge of *** results demonstrated that the strategic application of vertical greenery can effectively mitigate the overheating in GGS and improve comprehensive *** using full coverage of vertical greenery in a linear layout,the air temperature of GGS and cooling energy consumption were largely reduced by 8.02℃and 12.2%,respectively,while the carbon abatement was enhanced by up to 101.11 *** on a comprehensive evaluation of energy,economy,and environmental benefits,it is recommended to use a greenery configuration with 50%coverage in a vertical linear layout for *** integration of greenery into building design can mitigate adverse environmental impacts,reduce energy consumption,and contribute to the sustainable development of low-carbon cities.

关键词： low-carbon design green glass space vertical greenery greenery configuration carbon abatement