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Stepping up after spinal cord injury:negotiating an obstacle during walking

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Neural Regeneration Research 2025年第7期20卷 1919-1929页

作者： Alain Frigon Charly G.Lecomte department of Pharmacology-Physiology Faculty of Medicine and Health SciencesUniversitéde SherbrookeCentre de recherche du Centre Hospitalier Universitaire de SherbrookeSherbrookeQCCanada

Every day walking consists of frequent voluntary modifications in the gait pattern to negotiate *** spinal cord injury,stepping over an obstacle becomes *** over an obstacle requires sensorimotor transformations in several structures of the brain,including the parietal cortex,premotor cortex,and motor *** information and planning are transformed into motor commands,which are sent from the motor cortex to spinal neuronal circuits to alter limb trajectory,coordinate the limbs,and maintain *** spinal cord injury,bidirectional communication between the brain and spinal cord is disrupted and animals,including humans,fail to voluntarily modify limb trajectory to step over an ***,in this review,we discuss the neuromechanical control of stepping over an obstacle,why it fails after spinal cord injury,and how it recovers to a certain extent.

关键词： biomechanics locomotion neurophysiology obstacle negotiation spinal cord injury

Bimetallic Single‑Atom Catalysts for Water Splitting

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Nano-Micro Letters 2025年第1期17卷 1-45页

作者： Megha A.deshmukh Aristides Bakandritsos Radek Zbořil Nanotechnology centre Centre for Energy and Environmental TechnologiesVŠB–Technical University of Ostrava17.listopadu 2172/1570800 Ostrava‑PorubaCzech Republic Regional centre of Advanced Technologies and Materials Czech Advanced Technology and Research Institute(CATRIN)Palacky University OlomoucŠlechtitelů241/2778371 Olomouc–HoliceCzech Republic

Green hydrogen from water splitting has emerged as a critical energy vector with the potential to spearhead the global transition to a fossil fuel-independent *** field of catalysis has been revolutionized by single-atom catalysts(SACs),which exhibit unique and intricate interactions between atomically dispersed metal atoms and their ***,bimetallic SACs(bimSACs)have garnered significant attention for leveraging the synergistic functions of two metal ions coordinated on appropriately designed *** offer an avenue for rich metal–metal and metal–support cooperativity,potentially addressing current limitations of SACs in effectively furnishing transformations which involve synchronous proton–electron exchanges,substrate activation with reversible redox cycles,simultaneous multi-electron transfer,regulation of spin states,tuning of electronic properties,and cyclic transition states with low activation *** review aims to encapsulate the growing advancements in bimSACs,with an emphasis on their pivotal role in hydrogen generation via water *** subsequently delve into advanced experimental methodologies for the elaborate characterization of SACs,elucidate their electronic properties,and discuss their local coordination ***,we present comprehensive discussion on the deployment of bimSACs in both hydrogen evolution reaction and oxygen evolution reaction,the two half-reactions of the water electrolysis process.

关键词： Single-atom catalysts Single-atom dimers Hydrogen evolution Oxygen evolution Water splitting

The role of refocusing in dynamic X-wave formation during femtosecond laser filamentation in water

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Chinese Optics Letters 2010年第2期8卷 244-247页

作者：徐俊杰徐晗熊辉程亚徐至展刘伟伟陈瑞良 State Key Laboratory of High Field Laser Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of Sciences Key Laboratory of Opto-Electronic Information Science and Technology centre d'optique Photonique er Laser(COPL)and Departement de Physiquede Genie Physique et d'OptiqueUniversite LavalQuebec

With the evolution of a laser pulse in water, the formation of a nonlinear X wave during femtosecond filamentation is investigated based on numerical simulations. In particular, we analyze the far-field angularly resolved spectra obtained for different temporal portions of the ultrashort pulse during its propagation. Our result shows that the refocusing of ultrashort pulse leads to the formation of dynamic X wave which essentially manifests itself as conical emission.

关键词： Acoustic waves Computer simulation Light propagation Ultrashort pulses

Nonlinear increase,invisibility,and sign inversion of a localized fs-laser-induced refractive index change in crystals and glasses

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Light(Science & Applications) 2020年第1期9卷 1398-1409页

作者： Jerome Lapointe Jean-Philippe Berube Yannick Ledemi Albert dupont Vincent Fortin Younes Messaddeq Real Vallee centre d’optique Photonique et Laser2375 Rue de la TerrasseUniversite LavalG1V 0A6 QuebecQCCanada

Multiphoton absorption via ultrafast laser focusing is the only technology that allows a three-dimensional structural modification of transparent ***,the magnitude of the refractive index change is rather limited,preventing the technology from being a tool of choice for the manufacture of compact photonic integrated *** propose to address this issue by employing a femtosecond-laser-induced electronic band-gap shift(FLIBGS),which has an exponential impact on the refractive index change for propagating wavelengths approaching the material electronic resonance,as predicted by the Kramers–Kronig *** by theoretical calculations,based on a modified Sellmeier equation,the Tauc law,and waveguide bend loss calculations,we experimentally show that several applications could take advantage of this ***,we demonstrate waveguide bends down to a submillimeter radius,which is of great interest for higher-density integration of fs-laser-written quantum and photonic *** also demonstrate that the refractive index contrast can be switched from negative to positive,allowing direct waveguide inscription in ***,the effect of the FLIBGS can compensate for the fs-laser-induced negative refractive index change,resulting in a zero refractive index change at specific wavelengths,paving the way for new invisibility applications.

关键词： waveguide millimeter refractive

Photobiomodulation:a novel approach to promote trans-differentiation of adipose-derived stem cells into neuronal-like cells

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Neural Regeneration Research 2025年第2期20卷 598-608页

作者： daniella da Silva Madeleen Jansen van Rensburg Anine Crous Heidi Abrahamse Laser Research centre Faculty of Health SciencesUniversity of JohannesburgDoornfonteinJohannesburgSouth Africa

Photobiomodulation,originally used red and near-infrared lasers,can alter cellular *** has been demonstrated that the visible spectrum at 451-540 nm does not necessarily increase cell proliferation,near-infrared light promotes adipose stem cell proliferation and affects adipose stem cell migration,which is necessary for the cells homing to the site of *** this in vitro study,we explored the potential of adipose-derived stem cells to differentiate into neurons for future translational regenerative treatments in neurodegenerative disorders and brain *** investigated the effects of various biological and chemical inducers on trans-differentiation and evaluated the impact of photobiomodulation using 825 nm near-infrared and 525 nm green laser light at 5 J/*** adipose-derived stem cells can be used in autologous grafting and photobiomodulation has been shown to have biostimulatory *** findings reveal that adipose-derived stem cells can indeed trans-differentiate into neuronal cells when exposed to inducers,with pre-induced cells exhibiting higher rates of proliferation and trans-differentiation compared with the control ***,green laser light stimulation led to notable morphological changes indicative of enhanced trans-differentiation,while near-infrared photobiomodulation notably increased the expression of neuronal *** biochemical analysis and enzyme-linked immunosorbent assays,we observed marked improvements in viability,proliferation,membrane permeability,and mitochondrial membrane potential,as well as increased protein levels of neuron-specific enolase and ciliary neurotrophic ***,our results demonstrate the efficacy of photobiomodulation in enhancing the trans-differentiation ability of adipose-derived stem cells,offering promising prospects for their use in regenerative medicine for neurodegenerative disorders and brain injuries.

关键词： differentiation inducers green photobiomodulation immortalized adipose-derived stem cell near-infrared photobiomodulation neurodegenerative disease neurogenesis photobiomodulation trans-differentiation

Insights from a proteomic atlas of human Alzheimer's disease brain tissue

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Neural Regeneration Research 2025年第3期20卷 799-800页

作者： Tomas Kavanagh Eleanor drummond Brain and Mind centre and School of Medical Sciences University of SydneyCamperdownNSWAustralia

There is an urgent need to identify new drug targets for Alzheimer's disease(Ad). While new immunotherapies show promise, clinical benefit appears low, and side effects are high. A greater understanding of the disease mechanisms driving Ad is an essential factor that will facilitate the identification of new, effective drug targets.

关键词： Alzheimer clinical driving

Intense broadband THz generation from femtosecond laser filamentation

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Chinese Optics Letters 2013年第1期11卷 25-30页

作者： Tie-Jun Wang Shuai Yuan Yanping Chen See Leang Chin centre d'optique Photonique et Laser (COPL) and Département de Physique de Génie Physique et D'Optique Université Laval Québec

Broadband and energetic terahertz （THz） pulses can be remotely generated in air through filamentation. We review such THz generation and detection in femtosecond Ti-sapphire laser induced remote filaments. New results are presented on the direct relationship between THz generation in a two color filament and induced N2 fluorescence through population trapping during molecular alignment and revival in air. This further supports the new technique of remote THz detection in air through the sensitive measurement of N2 fluorescence.

关键词： THz Intense broadband THz generation from femtosecond laser filamentation

Experimental Study for Effect of Multi-Site Spark Ignition on dedicated Hybrid Engine Performance under High dilution Condition

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Journal of Thermal Science 2025年第1期 254-267页

作者： YAN Bowen WATERS Benjamin HAINES Andrew MCGHEE Mike HU Tiegang dENG Wei PU Yongxian MA Tianyu Powertrain Engineering R&d Center Chongqing Changan Automobile Co.Ltd. Changan UK R&d centre Limited

In this study,a triple spark ignition scheme was first designed on a three-cylinder 1.5-L dedicated hybrid engine（dHE）.On this basis,the effect of different ignition modes on engine combustion and emission characteristics was studied,especially under high dilution *** results tested at 2000 r/min and 0.8 MPa BMEP（brake mean effective pressure） show that with highly increased in-cylinder flow intensity,using only passive prechamber（PPC） has a lower lean limit than that with single central spark plug（CSP）,thereby leading to slightly higher minimum fuel consumption and nitrogen oxides（NOx） *** side spark plugs（SSP）based on PPC can result in improved capability of lean limit extension and engine performance than ***,the improvement level is lower than that with triple spark plugs（TSP）.As the excess air ratio λincreases,the advantage of PPC and PPC with SSP in improving the combustion phasing compared with CSP gradually ***,the increasing tendency of their ignition delay and combustion duration is more *** added SSP based on PPC can effectively shorten the ignition delay of leaner mixture,but the combustion duration can be only slightly *** a result,under extremely lean condition,the advantage of PPC and PPC with SSP in terms of combustion characteristics over CSP becomes much *** contrast,the TSP ignition can achieve much shorter ignition delay and combustion duration simultaneously under this *** to the highest available dilution level,the TSP ignition achieves the lowest raw ***,it can also reduce the raw carbon monoxide（CO） and hydrocarbons（HC） emissions compared to CSP due to a more thorough combustion of the end gas *** on the excellent performance of TSP,the highest engine brake thermal efficiency（BTE） was further *** results show that with normal RON 92 fuel,the engine finally achieved 43.69% and 45.02% BTE under stochiometric mode with exhaust

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16.48% Efficient solution-processed CIGS solar cells with crystal growth and defects engineering enabled by Ag doping strategy

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Journal of Energy Chemistry 2025年第1期100卷 59-65页

作者： Mengyu Xu Shaocong Yan Ting Liang Jia Jia Shengjie Yuan dongxing Kou Zhengji Zhou Wenhui Zhou Yafang Qi Yuena Meng Litao Han Sixin Wu Key Laboratory for Special Functional Materials of MOE National & Local Joint Engineering Research Centre for High-efficiency Display and Lighting Technology School of Nanoscience and Materials Engineering Henan University

Solution-processed Cu（In,Ga）Se2（CIGS） solar cells suffer from serious carrier recombination and power conversion efficiency（PCE） loss because of the poor film properties and easy formation of ***, we propose Ag&Se co-selenization strategy to enhance the crystallization and passivate harmful defects of the CIGS films. The formation of Ag-Se phase during the selenization process enables the formation of large grains and suppresses the deep level defects. It is found that Ag doping can enlarge the depletion region width, lower the Urbach energy and prolong the carrier lifetime. As a result, a champion solution-processed CIGS solar cell presents a high efficiency of 16.48% with the highly improved opencircuit voltage（VOC） of 662 m V and fill factor（FF） of 75.8%. This work provides an efficient strategy to prepare high quality solution-processed CIGS films for high-performance CIGS solar cells.

关键词： CIGS solar cells Solution-processed method Ag doping Crystal growth defects engineering