检索结果-南通市图书馆

Autism spectrum disorder:difficulties in diagnosis and microRNA biomarkers

Neural Regeneration Research 2025年第10期20卷 2776-2786页

作者： Bridget Martinez Philip V.Peplow department of Pharmacology University of Nevada-RenoRenoNVUSA department of Medicine University of Nevada-RenoRenoNVUSA department of Anatomy University of OtagoDunedinNew Zealand

We performed a PubMed search for microRNAs in autism spectrum disorder that could serve as diagnostic biomarkers in patients and selected 17 articles published from January 2008 to December 2023,of which 4 studies were performed with whole blood,4 with blood plasma,5 with blood serum,1 with serum neural cell adhesion molecule L1-captured extracellular vesicles,1 with blood cells,and 2 with peripheral blood mononuclear *** of the studies involved children and the study cohorts were largely *** of the studies had performed microRNA sequencing or quantitative polymerase chain reaction assays to measure microRNA *** five studies had used real-time polymerase chain reaction assay to validate microRNA expression in autism spectrum disorder subjects compared to *** microRNAs that were validated in these studies may be considered as potential candidate biomarkers for autism spectrum disorder and include miR-500a-5p,-197-5p,-424-5p,-664a-3p,-365a-3p,-619-5p,-664a-3p,-3135a,-328-3p,and-500a-5p in blood plasma and miR-151a-3p,-181b-5p,-320a,-328,-433,-489,-572,-663a,-101-3p,-106b-5p,-19b-3p,-195-5p,and-130a-3p in blood serum of children,and miR-15b-5p and-6126 in whole blood of *** important limitations were identified in the studies reviewed,and need to be taken into account in future *** studies are warranted with children and adults having different levels of autism spectrum disorder severity and consideration should be given to using animal models of autism spectrum disorder to investigate the effects of suppressing or overexpressing specific microRNAs as a novel therapy.

关键词： autism spectrum disorder biomarker blood cells blood plasma blood serum diagnosis microRNA peripheral blood mononuclear cells serum neural cell adhesion molecule L1-captured extracellular vesicles whole blood

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Growth, Metabolism and Yield of Rice Cultivated in Soils Amended with Fly Ash and Cyanobacteria and Metal Loads in Plant Parts

引用

Rice science 2016年第1期23卷 22-32页

作者： Rabindra N.PADHY Nabakishore NAYAK Rajesh R.DASH-MOHINI Shakti RATH Rajani K.SAHU department of botany and Biotechnology Buxi Jagabandhu Bidyadhar Autonomous College central Research Laboratory Institute of Medical Sciences & Sum HospitalSiksha ‘O' Anusandhan University

Soil amendment with fly ash（FA） and combined supplementation with N_2-fixing cyanobacteria masses as biofertilizer were done in field experiments with rice. Amendments with FA levels, 0, 0.5, 1.0, 2.0, 4.0, 8.0 and 10.0 kg/m2, caused increase in growth and yield of rice up to 8.0 kg/m2, monitored with several parameters. Pigment contents and enzyme activities of leaves were enhanced by FA, with the maximum level of FA at 10.0 kg/m2. Protein content of rice seeds was the highest in plants grown at FA level 4.0 kg/m2. Basic soil properties, p H value, percentage of silt, percentage of clay, water-holding capacity, electrical conductivity, cation exchange capacity, and organic carbon content increased due to the FA amendment. Parallel supplementation of FA amended plots with 1.0 kg/m2 N_2-fixing cyanobacteria mass caused further significant increments of the most soil properties, and rice growth and yield parameters. 1000-grain weight of rice plants grown at FA level 4.0 kg/m2 along with cyanobacteria supplementation was the maximum. Cyanobacteria supplementation caused increase of important basic properties of soil including the total N-content. Estimations of elemental content in soils and plant parts（root and seed） were done by the atomic absorption spectrophotometry. Accumulations of K, P, Fe and several plant micronutrients（Mn, Ni, Co, Zn and Cu） and toxic elements（Pb, Cr and Cd） increased in soils and plant parts as a function of the FA gradation, but Na content remained almost unchanged in soils and seeds. Supplementation of cyanobacteria had ameliorating effect on toxic metal contents of soils and plant parts. The FA level 4.0 kg/m2, with 1.0 kg/m2 cyanobacteria mass supplementation, could be taken ideal, since there would be recharging of the soil with essential micronutrients as well as toxic chemicals in comparative lesser proportions, and cyanobacteria mass would cause lessening toxic metal loads with usual N_2-fixation.

关键词： soil property cyanobacteria fly ash growth heavy metal rice toxic element yield

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Interaction of major facilitator superfamily domain containing 2A with the blood-brain barrier

引用

Neural Regeneration Research 2025年第8期20卷 2133-2152页

作者： Yilun Ma Taiwei Dong Fei Luan Juanjuan Yang Feng Miao Peifeng Wei College of Pharmacy and First Clinical Medical College Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina National Drug Clinical Trial Agency The Second Affiliated Hospital of Shaanxi University of Chinese Medicine/Xixian New District Central HospitalXi′anShaanxi ProvinceChina

The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the blood-brain barrier remain poorly *** major facilitator superfamily domain containing 2A has been identified as a key regulator of blood-brain barrier *** plays a critical role in promoting and maintaining the formation and functional stability of the blood-brain barrier,in addition to the transport of lipids,such as docosahexaenoic acid,across the blood-brain ***,an increasing number of studies have suggested that major facilitator superfamily domain containing 2A is involved in the molecular mechanisms of blood-brain barrier dysfunction in a variety of neurological diseases;however,little is known regarding the mechanisms by which major facilitator superfamily domain containing 2A affects the blood-brain *** paper provides a comprehensive and systematic review of the close relationship between major facilitator superfamily domain containing 2A proteins and the blood-brain barrier,including their basic structures and functions,cross-linking between major facilitator superfamily domain containing 2A and the blood-brain barrier,and the in-depth studies on lipid transport and the regulation of blood-brain barrier *** comprehensive systematic review contributes to an in-depth understanding of the important role of major facilitator superfamily domain containing 2A proteins in maintaining the structure and function of the blood-brain barrier and the research progress to *** will not only help to elucidate the pathogenesis of neurological diseases,improve the accuracy of laboratory diagnosis,and optimize clinical treatment strategies,but it may also play an important role in prognostic *** addition,the effects of major facilitator superfamily domain containing 2A on blood-brain barrier lea

关键词： blood-brain barrier(BBB) caveolin-1 central nervous system docosahexaenoic acid endothelial cells lysophosphatidylcholine major facilitator superfamily domain containing 2A(MFSD2A) transcytosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ascomycota has a faster evolutionary rate and higher species diversity than Basidiomycota

引用

Science China(Life Sciences) 2010年第10期53卷 1163-1169,1263-1270页

作者： Lumbsch H. THORSTEN department of botany The Field Museum

Differences in rates of nucleotide or amino acid substitutions among major groups of organisms are repeatedly found and well documented. A growing body of evidence suggests a link between the rate of neutral molecular change within populations and the evolution of species diversity. More than 98% of terrestrial fungi belong to the phyla Ascomycota or Basidiomycota. The former is considerably richer in number of species than the latter. We obtained DNA sequences of 21 protein-coding genes from the lichenized fungus Rhizoplaca chrysoleuca and used them together with sequences from GenBank for subsequent analyses. Three datasets were used to test rate discrepancies between Ascomycota and Basidiomycota and that within Ascomycota: (i) 13 taxa including 105 protein-coding genes, (ii) nine taxa including 21 protein-coding genes, and (iii) nuclear LSU rDNA of 299 fungal species. Based on analyses of the 105 protein-coding genes and nuclear LSU rDNA datasets, we found that the evolutionary rate was higher in Ascomycota than in Basidiomycota. The differences in substitution rates between Ascomycota and Basidiomycota were significant. Within Ascomycota, the species-rich Sordariomycetes has the fastest evolutionary rate, while Leotiomycetes has the slowest. Our results indicate that the main contribution to the higher substitution rates in Ascomycota does not come from mutualism, ecological conditions, sterility, metabolic rate or shorter generation time, but is possibly caused by the founder effect. This is another example of the correlation between species number and evolutionary rates, which is consistent with the hypothesis that the founder effect is responsible for accelerated substitution rates in diverse clades.

关键词： evolutionary rate amino acid substitution nucleotide substitution fungal evolution species diversity founder effect

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A modified Murashige and Skoog media for efficient multipleshoot induction in G. arborea Roxb.

引用

Journal of Forestry Research 2014年第3期25卷 557-564页

作者： Shilpa S. Madke Konglanth J. Cherian Rupesh S. Badere department of botany Hislop College department of botany RTM Nagpur University M. J. Phuley Educational Campus

This paper reports on the effect of various micropropagation factors of Gmelina arborea Roxb. through multiple shoot induction. Factors like the source and age of explants, plant growth regulators （PGRs）, media composition, and carbon source affected multiple shoot-ing in the present study. Among all the explants used, only shoot tips derived from one, two, and three week old seedlings could form multiple shoots. Besides, the formation of multiple shoots depended on the con-centration and combination of PGRs. Among all the PGRs, BAP （6-benzylaminopurine） alone gave the highest regeneration efficiency. Simi-larly, IBA （Indole-3-butyric acid） was the most efficient PGR in inducing root formation in the microshoots. Media composition and carbon source also affected the regeneration efficiency. MS （Murashige and Skoog medium） proved to be the best media for regeneration followed by B5, SH （Schenk and Hilderbrandt medium） and WPM （Woody plant medium） in that order. Similarly, among sugars, only sucrose and glucose sup-ported induction of microshoots. Based on this study we recommend the use of glucose in place of sucrose in MS medium for maximum regenera-tion efficiency.

关键词： agroforestry micropropagation plant nutrition shoot tipexplant timber plant Verbenaceae

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

An arrow in the quiver: evaluating the performance of Hyptis suaveolens(L.) Poit. in different light levels

引用

Ecological Processes 2024年第2期13卷 130-147页

作者： Kanhaiya Shah Gyan Prakash Sharma R.Sagar department of Environmental Studies University of Delhi department of botany Banaras Hindu University

Background Hyptis suaveolens（L.） Poit.,native to the American tropics,is a pantropical annual plant and a major invasive species throughout *** was anticipated that the availability of sunlight,coupled with its superior reproductive potential,persistent propagule bank,and dispersal ability,could lead to an increase in the growth and spread of this invader,thus potentially impeding herbaceous growth and diversity in non-native *** its ecological fitness and competitive performance will be useful to manage the spread of *** in natural ecosystems that are facing a wide range of anthropogenic *** The present study is a three-tier *** the first tier,a field study was conducted to assess the patterns of *** abundance and herbaceous species diversity in response to light availability(sun,842-1072μmol m-2s-1and shade 253-341 μmol m-2S-1) in the tropical dry deciduous ecosystems in the Vindhyan highlands,***,the impact of *** abundance on the resident native and non-native species abundance and diversity was also *** the second tier,a randomized common garden experiment was conducted to understand the trait fitness of *** in sun(940 μmol m-2s-1) and shade(300 μmol m-2s-1) *** the third tier,a plant growth chamber experiment with high-light(940 μmol m-2s-1) and low-light(300 μmol m-2s-1)treatments was done to learn how *** partitions its biomass between aboveground and belowground plant *** The field study indicated that the sunlit areas had a higher abundance of *** and a lower diversity of resident herbaceous species than the shaded *** common garden experiment showed that sun-dwelling *** individuals performed better in germinative,vegetative,eco-physiological,and reproductive traits than the shade-dwelling *** growth chamber experiment exhibited that plants grown in high-light environment had greater seed germi

关键词： Invasive species Native species Species diversity Life-history trait Oskar syndrome Plasticity index

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Effect of shifting cultivation and fallow on soil quality index in Mokokchung district,Nagaland,India

引用

Ecological Processes 2022年第1期11卷 561-576页

作者： Wati Temjen Maibam Romeo Singh Tali Ajungla department of botany Nagaland University798627 LumamiIndia Centre for Biodiversity Department of BotanyNagaland University798627 LumamiIndia

Background:Shifting cultivation is a major agriculture practice in the Nagaland state of *** study examines the effect of shifting cultivation and the length of the fallow period on soil quality index(SQI).Four sites were selected for the study,viz.,a shifting cultivation site(SCS),a 3-year-old fallow land(FL-3),a 7-year-old fallow land(FL-7),and a 12-year-old fallow land(FL-12).Soil parameters were recorded seasonally and SQI was calculated from the minimum data ***:With the increase in the fallow period,the values of conductivity,soil organic carbon,available nitrogen,available phosphorus,exchangeable potassium,moisture,clay,and cation exchange capacity of soil ***,soil pH and bulk density decreased with fallow *** additive SQI_(a)values were in the order SCS

关键词： Shifting cultivation Jhum Soil quality index Soil health Seasonal variation Nagaland India

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Differential degradation of crude oil (Bonny Light) by four Pseudomonas strains

引用

Journal of Environmental Sciences 2009年第2期21卷 243-248页

作者： Oluwafemi S.Obayori Sunday A.Adebusoye Adams O.Adewale Ganiyu O.Oyetibo Odunola O.Oluyemi Rashid A.Amokun Matthew O.Ilori department of Microbiology Lagos State University department of botany and Microbiology University of Lagos

Four hydrocarbon degraders isolated from enriched oil- and asphalt-contaminated soils in Lagos, Nigeria, were tested for their petroleum degradation potentials. All the isolates were identified as species of Pseudomonas. Pseudomonas putida P 11 demonstrated a strong ability to degrade kerosene, gasoline, diesel, engine oil and crude oil while P. aeruginosa BB3 exhibited fair degradative ability on crude oil, gasoline, engine oil, anthracene and pyrene but weak on kerosene, diesel and dibenzothiophene. Pseudomonas putida WL2 and P. aeruginosa MVL1 grew on crude oil and all its cuts tested with the latter possessing similar polycyclic aromatic potentials as P11. All the strains grew logarithmically with 1-2 orders of magnitude and with generation time ranging significantly between 3.07 and 8.55 d at 0.05 level of confidence. Strains WL2 and MVL1 utilized the oil substrate best with more than 70% in 6 d experimental period, whereas the same feat was achieved by P11 in 12 d period. BB3 on the other hand degraded only 46% within 6 d. Interestingly, data obtained from gas chromatographic analysis of oil recovered from the culture fluids of MVL1 confirmed near-disappearance of major peaks （including aliphatics and aromatics） in the hydrocarbon mixture.

关键词： biodegradation crude oil hydrocarbons pollution Pseudomonas strains

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nitrogen in Relation to Photosynthetic Capacity and Accumulation of Osmoprotectant and Nutrients in Brassica Genotypes Grown Under Salt Stress

引用

Agricultural Sciences in China 2010年第5期9卷 671-680页

作者： Manzer H Siddiqui Firoz Mohammad M Nasir Khan Mohamed H Al-Whaibi Ali H A Bahkali department of botany & Microbiology College of Science King Saud University Plant Physiology Section Department of Botany Aligarh Muslim University

Different strategies of the application of nutrients are required to overcome the adverse effects of mustard （Brassica juncea L.） in response to NaCl stress. The objective of the present study was to determine if different added levels of nitrogen （N） in growth medium could alleviate the adverse effects of salt stress on photosynthetic capacity and accumulation of osmoprotectants and nutrients. 14 days mustard seedlings of salt-sensitive （cv. Chuutki） and salt-tolerant （cv. Radha） genotypes were fed with：（i） 0 mmol L^-1 NaCl ＋ 0 mg N kg^-1 sand （control）, （ii） 90 mmol L^-1 NaCl ＋ 30 mg N kg^-1 sand, （iii） 90 mmol L^-1 NaCl ＋60 mg N kg^-1 sand, （iv） 90 mmol L^-1 NaCl ＋90 mg N kg^-1 sand and （v） 90 mmol L^-1NaCl＋ 120 mg N kg^-1 sand. Under the condition of salinity stress, N application caused a significant ameliorative effect on both genotypes with respect to growth attributes [fresh weight （FW） and dry weight （DW）] and physio-biochemical parameters [percent water content （WC）, net photosynthetic rate （PN）, stomatal conductance （gs）, total chlorophyll （Ch1）, carbonic anhydrase （CA） activity and malondialdehyde （MDA）, nitrogen （N）, potassium （K） and sodium （Na） contents, and K/Na ratio] and yield attributes （number of pods/plant, seeds/pod and seed yield/plant）. The salt-tolerant genotype exhibited maximum value for growth, physio-biochemical and yield attributes at 60 mg N kg 1 sand than that of salt-sensitive genotype. These results suggest that application of N may ameliorate most of the attributes and prove to be a physiological remedy to increase the tolerance against the ill effects of salt stress in Brassicas.

关键词： Brassica juncea L. carbonic anhydrase activity malondialdehyde net photosynthetic rate osmoprotectants,salt stress

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Impacts of Coriaria nepalensis colonization on vegetation structure and regeneration dynamics in a mixed conifer forest of Indian central Himalaya

引用

Journal of Forestry Research 2019年第1期30卷 305-317页

作者： Nidhi Rani Mourya Kiran Bargali Surendra Singh Bargali department of botany DSB Campus Kumaun University

This study evaluated impacts of Coriaria nepalensis *** on soil characteristics,vegetation structure and composition,regeneration status and expected future compositional changes,biomass and carbon stock in tree species of a mixed conifer forest of central *** sites(1 ha each in an old landslide area)differing in Coriaria density(low:20 individuals ha^(-1);medium:120 ***^(-1);high:190 ***^(-1))were used to enumerate the tree species.A total of 9 tree species and 2830 individuals were recorded from the three study sites that represented a gradient of Coriaria *** of species varied from 3 to 7 and the individuals from 690 to 1270 per site with lowest numbers at low Coriaria density and highest at medium Coriaria *** number of seedlings increased with increasing Coriaria density,and the sites were unique in their seedling composition,indicating marked temporal *** wise regeneration analysis showed that regeneration was poor at the site with low Coriaria density and good at the high-density site where many species emerged as *** results indicate that the ameliorative effects of Coriaria in terms of soil buildup,and accumulation of nutrients and organic matter helped more species to colonize the *** facilitative ability of Coriaria can be used to restore degraded forest ecosystems of Indian central Himalaya.

关键词： Basal area Conifer Coriaria Density Facilitation Species richness

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：