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Reply to “Beyond microbial carbon use efficiency”

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National Science Review 2024年第4期11卷 35-37页

作者： Feng Tao Johannes Lehmann Ying-Ping Wang Lifen Jiang Bernhard Ahrens Kostiantyn Viatkin Stefano Manzoni Benjamin Z.Houlton Yuanyuan Huang Xiaomeng Huang Yiqi Luo Department of Ecology and Evolutionary Biology Cornell University Soil and Crop sciences Section School of Integrative Plant ScienceCornell University CSIRO Environment Max Planck Institute for Biogeochemistry Department of Physical Geography and Bolin Centre for Climate research Stockholm University Department of Global Development Cornell University Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Department of Earth System Science Ministry of Education Key Laboratory for Earth System Modelling Institute for Global Change Studies Tsinghua University

In their commentary, Xiao et al.[1]cautioned that the conclusions on the critical role of microbial carbon use efficiency (CUE) in global soil organic carbon (SOC) storage in the paper by Tao et al.[2] might be too *** claimed that Tao et al.’s study lacked mechanistic consideration of SOC formation and excluded important data *** et al. brought up important points,which can be largely reconciled with our findings by understanding the differences in expressing processes in empirical studies and in models.

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机械敏感蛋白PC1调控破骨细胞及骨吸收的作用机制

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Science Bulletin 2024年第12期69卷 1964-1979页

作者：黄梅周静璇李潇骁刘冉姜洋子陈开璇焦玉睿尹欣刘玲孙宇晨王维山肖业苏甜郭奇黄燕杨觅魏婕 L.Darryl Quarles 肖洲生曾超罗湘杭雷光华李长俊 Department of Endocrinology Endocrinology Research CenterXiangya HospitalCentral South UniversityChangsha 410008China Hunan Key Laboratory of Joint Degeneration and Injury Changsha 410008China Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment Ministry of EducationXiangya HospitalCentral South UniversityChangsha 410008China School of Biomedical sciences Institute for Tissue Engineering and Regenerative MedicineFaculty of MedicineThe Chinese University of Hong KongHong Kong 999077China Key Laboratory for Regenerative Medicine Ministry of EducationSchool of Biomedical SciencesFaculty of MedicineThe Chinese University of Hong KongHong Kong 999077China Center for Neuromusculoskeletal Restorative Medicine(CNRM) The Chinese University of Hong KongHong Kong 999077China Department of Orthopaedics The First Affiliated Hospital of Shihezi UniversityShihezi 832061China Department of Orthopaedics Xiangya HospitalCentral South UniversityChangsha 410008China Department of Epidemiology and Health Statistics Xiangya School of Public HealthCentral South UniversityChangsha 410008China Department of Medicine University of Tennessee Health Science CenterMemphis 38163USA National Clinical research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China Laboratory Animal Center Xiangya HospitalCentral South UniversityChangsha 410008China

Mechanical loading is required for bone homeostasis,but the underlying mechanism is still *** previous studies revealed that the mechanical protein polycystin-1(PC1,encoded by Pkd1)is critical for bone ***,the role of PC1 in bone resorption is ***,we found that PC1directly regulates osteoclastogenesis and bone *** conditional deletion of Pkd1 in the osteoclast lineage resulted in a reduced number of osteoclasts,decreased bone resorption,and increased bone mass.A cohort study of 32,500 patients further revealed that autosomal dominant polycystic kidney disease,which is mainly caused by loss-of-function mutation of the PKD1 gene,is associated with a lower risk of hip fracture than those with other chronic kidney ***,mice with osteoclastspecific knockout of Pkd1 showed complete resistance to unloading-induced bone loss.A mechanistic study revealed that PC1 facilitated TAZ nuclear translocation via the C-terminal tail-TAZ complex and that conditional deletion of Taz in the osteoclast lineage resulted in reduced osteoclastogenesis and increased bone *** regulation of the PC1-TAZ axis alleviated unloading-and estrogen deficiency-induced bone ***,the PC1-TAZ axis may be a potential therapeutic target for osteoclast-related osteoporosis.

关键词： Polycystin1 Osteoclastogenesis Bone resorption Mechanical stress

Managerial perspectives of scaling up robotic-assisted surgery in healthcare systems:A systematic literature review

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Laparoscopic, Endoscopic and Robotic Surgery 2024年第3期7卷 113-122页

作者： Ravichandran Anitha Komattu Chacko John Gnanadhas Jabarethina Sri Ramachandra Faculty of Management sciences Sri Ramachandra Institute of Higher Education and Research(Category-I Deemed to be University)ChennaiIndia

Objectives Robotic-assisted surgery(RAS)is a minimally invasive technique practiced in multiple *** training is essential for the acquisition of RAS *** cost of RAS is considered to be high,which makes it a burden for institutes and unaffordable for *** systematic literature review(SLR)focused on the various RAS training methods applied in different surgical specialties,as well as the cost elements of RAS,and was to summarize the opportunities and challenges associated with scaling up *** An SLR was carried out based on the Preferred Reporting Items for Systematic reviews and Meta-Analyses reporting *** PubMed,EBSCO,and Scopus databases were searched for reports from January 2018 through January ***-text reviews and research articles in the English language from Asia-Pacific countries were *** that outlined training and costs associated with RAS were *** The most common training system is the da Vinci *** simulation technique,which includes dry-lab,wet-lab,and virtual reality training,was found to be a common and important *** cost of RAS encompasses the installation and maintenance costs of the robotic system,the operation theatre rent,personnel cost,surgical instrument and material cost,and other miscellaneous *** synthesis of SLR revealed the challenges and opportunities regarding RAS training and *** The results of this SLR will help stakeholders such as decision-makers,influencers,and end users of RAS to understand the significance of training and cost in scaling up RAS from a managerial *** any healthcare innovation to reach a vast population,cost-effectiveness and standard training are crucial.

关键词： da Vinci system Healthcare Robotic-assisted surgery Robotic surgery Robotic training Robotic surgery cost

ROS Balance Autoregulating Core-Shell CeO_(2)@ZIF-8/Au Nanoplatform for Wound Repair

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Nano-Micro Letters 2024年第8期16卷 341-361页

作者： Xi Zhou Quan Zhou Zhaozhi He Yi Xiao Yan Liu Zhuohang Huang Yaoji Sun Jiawei Wang Zhengdong Zhao Xiaozhou Liu Bin Zhou Lei Ren Yu Sun Zhiwei Chen Xingcai Zhang The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province Research Center of Biomedical Engineering of XiamenDepartment of BiomaterialsCollege of MaterialsXiamen UniversityXiamen 361005People’s Republic of China Department of Electronic Science Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance ResearchSchool of Electronic Science and EngineeringXiamen UniversityXiamen 361005People’s Republic of China John A Paulson School of Engineering and Applied sciences Harvard UniversityCambridgeMA 02138USA Department of Otorhinolaryngology Union Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022People’s Republic of China NO.1 Middle School Affiliated to central China Normal University Wuhan 430223People’s Republic of China

Reactive oxygen species(ROS)plays important roles in living *** ROS is a double-edged sword,which can eliminate drug-resistant bacteria,but excessive levels can cause oxidative damage to cells.A core–shell nanozyme,Ce O_(2)@ZIF-8/Au,has been crafted,spontaneously activating both ROS generating and scavenging functions,achieving the multifaceted functions of eliminating bacteria,reducing inflammation,and promoting wound *** Au Nanoparticles(NPs)on the shell exhibit high-efficiency peroxidase-like activity,producing ROS to kill ***,the encapsulation of Ce O_(2) core within ZIF-8 provides a seal for temporarily limiting the superoxide dismutase and catalase-like activities of Ce O_(2) ***,as the ZIF-8 structure decomposes in the acidic microenvironment,the Ce O_(2) core is gradually released,exerting its ROS scavenging activity to eliminate excess ROS produced by the Au *** two functions automatically and continuously regulate the balance of ROS levels,ultimately achieving the function of killing bacteria,reducing inflammation,and promoting wound *** innovative ROS spontaneous regulators hold immense potential for revolutionizing the field of antibacterial agents and therapies.

关键词： Metal-organic framework(MOF) Reactive oxygen species(ROS) Cerium dioxide Au nanoparticles Wound healing

A new implementation of FLEXPART with Enviro-HIRLAM meteorological input,and a case study during a heavy air pollution event

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Big Earth Data 2024年第2期8卷 397-434页

作者： Benjamin Foreback Alexander Mahura Petri Clusius Carlton Xavier Metin Baykara Putian Zhou Tuomo Nieminen Victoria Sinclair Veli-Matti Kerminen Tom V.Kokkonen Simo Hakala Diego Aliaga Risto Makkonen Alexander Baklanov Roman Nuterman Men Xia Chenjie Hua Yongchun Liu Markku Kulmala Pauli Paasonen Michael Boy Aerosol and Haze Laboratory Beijing Advanced Innovation Center for Soft Matter Science and EngineeringBeijing University of Chemical TechnologyBeijingChina Institute for Atmospheric and Earth System research/Physics Faculty of ScienceUniversity of HelsinkiHelsinkiFinland Division of Nuclear Physics Department of PhysicsLund UniversityLundSweden Swedish Meteorological and Hydrological Institute(SMHI) Research DepartmentUnit of Meteorology/Environment and ClimateNorrköpingSweden Climate and Marine sciences Department Eurasia Institute of Earth SciencesIstanbul Technical UniversityIstanbulTurkey Department of Physics Faculty of ScienceUniversity of HelsinkiHelsinkiFinland Department of Meteorology(MISU)and Bolin Centre for Climate research Stockholm UniversityStockholmSweden Climate System research Unit Finnish Meteorological InstituteHelsinkiFinland Science and Innovation Department World Meteorological Organization(WMO)GenevaSwitzerland Niels Bohr Institute University of CopenhagenCopenhagenDenmark Joint International research Laboratory of Atmospheric and Earth System sciences School of Atmospheric SciencesNanjing UniversityNanjingChina School of Engineering Science Lappeenranta-Lahti University of Technology(LUT)LappeenrantaFinland Atmospheric Modelling Centre Lahti Lahti University CampusLahtiFinland

We integrated Enviro-HIRLAM(Environment-High Resolution Limited Area Model)meteorological output into FLEXPART(FLEXible PARTicle dispersion model).A FLEXPART simulation requires meteorological input from a numerical weather prediction(NWP)*** publicly available version of FLEXPART can utilize either ECMWF(European Centre for Medium-range Weather Forecasts)Integrated Forecast System(IFS)forecast or reanalysis NWP data,or NCEP(*** Center for Environmental Prediction)Global Forecast System(GFS)forecast or reanalysis NWP *** primary benefits of using Enviro-HIRLAM are that it runs at a higher resolution and accounts for aerosol effects in meteorological *** compared backward trajectories gener-ated with FLEXPART using Enviro-HIRLAM(both with and without aerosol effects)to trajectories generated using NCEP GFS and ECMWF IFS meteorological inputs,for a case study of a heavy haze event which occurred in Beijing,China in November *** found that results from FLEXPART were considerably different when using different meteorological *** aerosol effects were included in the NWP,there was a small but noticeable differ-ence in calculated ***,when looking at potential emission sensitivity instead of simply expressing trajectories as lines,additional information,which may have been missed when looking only at trajectories as lines,can be inferred.

关键词： Atmospheric and chemical transport modelling trajectory and particle dispersion modelling severe air pollution episode FLEXPART Enviro-HIRLAM

Transformed by Technology China is striving to meet global challenges by promoting international cooperation in sci-tech innovation

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ChinAfrica 2024年第8期16卷 31-33页

作者： TIAN JIETANG LUO LIPING MA SHUAN GU YAN LI YUJU Industrial Economics Department Development Research Centre of the State Council research Institute for Regional Economy and Ecological Development Hunan Academy of Social Sciences Specialised Committee on International Cooperation and Science and Technology Diplomacy Chinese Association for Science of Science and S&T Policy research Xi Jinping Economic Thought research Centre National Development and Reform Commission

In recent years,China has made remarkable technological progress in a number of *** this progress,it is crucial to rapidly transform technological results into productivity gains.

关键词： technological cooperation remarkable

research funding and citations in papers of Nobel Laureates in Physics, Chemistry and Medicine, 2019-2020

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Journal of Data and Information Science 2024年第2期9卷 56-80页

作者： Mario Coccia Saeed Roshani CNR-National research council of Italy IRCRES-CNRTurin Research Area of the CNRStrada delle Cacce73-10135-TurinItaly Arizona State University School of Complex Adaptive Systems1031 S.Palm WalkTempeAZ 85281-2701USA Allameh Tabataba’i University Department of Technology and Entrepreneurship ManagementDehkadeh-ye-OTehran***Iran

Purpose:The goal of this study is a comparative analysis of the relation between funding(a main driver for scientific research)and citations in papers of Nobel Laureates in physics,chemistry and medicine over 2019-2020 and the same relation in these research fields as a ***/methodology/approach:This study utilizes a power law model to explore the relationship between research funding and citations of related *** study here analyzes 3,539 recorded documents by Nobel Laureates in physics,chemistry and medicine and a broader dataset of 183,016 documents related to the fields of physics,medicine,and chemistry recorded in the Web of Science ***:Results reveal that in chemistry and medicine,funded researches published in papers of Nobel Laureates have higher citations than unfunded studies published in articles;vice versa high citations of Nobel Laureates in physics are for unfunded studies published in ***,when overall data of publications and citations in physics,chemistry and medicine are analyzed,all papers based on funded researches show higher citations than unfunded ***/value:Results clarify the driving role of research funding for science diffusion that are systematized in general properties:a)articles concerning funded researches receive more citations than(un)funded studies published in papers of physics,chemistry and medicine sciences,generating a high Matthew effect(a higher growth of citations with the increase in the number of papers);b)research funding increases the citations of articles in fields oriented to applied research(e.g.,chemistry and medicine)more than fields oriented towards basic research(e.g.,physics).Practical implications:The results here explain some characteristics of scientific development and diffusion,highlighting the critical role of research funding in fostering citations and the expansion of scientific *** finding can support decision-making of policymakers and R&D mana

关键词： research funding Citations Science diffusion Scientific change Science of Science Power-law distribution Basic research Applied research Matthew effect Nobel Laureates Nobel Prizes

Evolutionary Multi/Many-Objective Optimisation via Bilevel Decomposition

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IEEE/CAA Journal of Automatica Sinica 2024年第9期11卷 1973-1986页

作者： Shouyong Jiang Jinglei Guo Yong Wang Shengxiang Yang School of Automation Central South UniversityChangsha 410083China Department of Computing Science University of AberdeenAberdeen AB243FXUK School of Computer Science Central China Normal UniversityWuhan 430079China School of Computer Science and Informatics De Montfort UniversityLeicester LE19BHUK

Decomposition of a complex multi-objective optimisation problem(MOP)to multiple simple subMOPs,known as M2M for short,is an effective approach to multi-objective ***,M2M facilitates little communication/collaboration between subMOPs,which limits its use in complex optimisation *** paper extends the M2M framework to develop a unified algorithm for both multi-objective and manyobjective *** bilevel decomposition,an MOP is divided into multiple subMOPs at upper level,each of which is further divided into a number of single-objective subproblems at lower *** subMOPs are allowed to share some subproblems so that the knowledge gained from solving one subMOP can be transferred to another,and eventually to all the *** bilevel decomposition is readily combined with some new mating selection and population update strategies,leading to a high-performance algorithm that competes effectively against a number of state-of-the-arts studied in this paper for both multiand many-objective *** analysis and component analysis have been also carried out to further justify the proposed algorithm.

关键词： Bilevel decomposition evolutionary algorithm many-objective optimisation multi-objective optimisation

Population genomic data reveal low genetic diversity,divergence and local adaptation among threatened Reeves's Pheasant(Syrmaticus reevesii)

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Avian research 2024年第1期15卷 1-11页

作者： Qi Lu Pengcheng Wang Jiang Chang De Chen Shenghan Gao Jacob Hoglund Zhengwang Zhang Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering College of Life SciencesBeijing Normal UniversityBeijing100875China Jiangsu Key Laboratory for Biodiversity and Biotechnology College of Life SciencesNanjing Normal UniversityNanjing210023China State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing100012China State Key Laboratory of Microbial Resources Institute of MicrobiologyChinese Academy of SciencesBeijing100101China Department of Ecology and Genetics Animal EcologyUppsala UniversityUppsalaSweden

Population genomic data could provide valuable information for conservation efforts;however,limited studies have been conducted to investigate the genetic status of threatened ***’s Pheasant(Syrmaticus reevesii)is facing population decline,attributed to increases in habitat *** is a knowledge gap in understanding the genomic status and genetic basis underlying the local adaptation of this threatened ***,we used population genomic data to assess population structure,genetic diversity,inbreeding patterns,and genetic ***,we identified candidate genes linked with adaptation across the current distribution of Reeves’s *** present study assembled the first de novo genome sequence of Reeves’s Pheasant and annotated 19,458 *** also sequenced 30 individuals from three populations(Dabie Mountain,Shennongjia,Qinling Mountain)and found that there was clear population structure among those *** comparing with other threatened species,we found that Reeves’s Pheasants have low genetic *** of homozygosity suggest that the Shennongjia population has experienced serious *** demographic history results indicated that three populations experienced several declines during the glacial *** adaptative analysis among the populations identified 241 candidate genes under directional *** are involved in a large variety of processes,including the immune response and *** results suggest that the three populations should be considered as three different conservation *** current study provides genetic evidence for conserving the threatened Reeves’s Pheasant and provides genomic resources for global biodiversity management.

关键词： Conservation genetics Local adaptation Pheasant Whole-genome sequencing