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台北结核病患者治疗转归:与中断治疗2个月和死亡相关的因素

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国际结核病与肺部疾病杂志 2010年第2期5卷 105-111页

作者： C-Y.Chiang J-J.Lee M-C.Yu K-T.Luh 徐汉成(译) 王雪静(校) International Union Against tuberculosis and Lung Disease Paris France division of Chest Medicine Department of Internal Medicine Buddhist Tzu Chi General Hospital Tzu Chi University Hualien Taiwan tuberculosis Association Taipei 不详

背景:2003年在台湾台北市所有登记治疗的肺结核患者目的:调查研究与中断治疗至少2个月和死亡相关的危险因素方法:由就诊病历来确定肺结核患者的治疗转归。结果:在登记的1 127例肺结核患者中,824例(73.1%)治疗成功,189例(16.8%)死亡,65例... 详细信息

背景:2003年在台湾台北市所有登记治疗的肺结核患者目的:调查研究与中断治疗至少2个月和死亡相关的危险因素方法:由就诊病历来确定肺结核患者的治疗转归。结果:在登记的1 127例肺结核患者中,824例(73.1%)治疗成功,189例(16.8%)死亡,65例(5.8%)中断治疗,17例(1.5%)已治疗15个月仍在继续治疗,32例(2.8%)治疗失败。与治疗中断显著相关的唯一因素是在开始抗结核治疗后去了其他医疗机构。结核病患者的标化死亡比率为8.7(95%可信区间为7.5～10.0)。与其他患者相比,死亡患者中与其死亡显著相关的因素有:年龄(调整风险比为1.06,95%可信区间为1.05～1.08)、未做痰培养或结果未知(调整风险比为2.07,95%可信区间为1.47～2.92)、合并呼吸系统疾病(调整风险比为1.68,95%可信区间为1.24～2.27),合并感染性疾病(调整风险比为2.80,95%可信区间为2.07～3.78),合并肾脏疾病(调整风险比为2.58,95%可信区间为1.82～3.66)或合并癌症(调整风险比为3.31,95%可信区间为2.35～4.65)。结论:到其他医疗机构就诊是与中断治疗至少2个月相关的因素。高死亡比例是由于年龄大和合并症。

关键词：死亡丢失、结核、转归

一个病例系列:越南胡志明市WHO标准复治方案治疗耐多药结核病人初步结果

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国际结核病与肺部疾病杂志 2001年第3期 137-139页

作者： N. T. N. Lan M. F. lademarco N. J. Binkin L. B. Tung H. T. Quy N. V. Co 张本 Pham Ngoc Thach tuberculosis and Lung Diseases Center Ho Chi Minh City Vietnam division of tuberculosis Elimination National Center for HIV STD and TB Prevention Centers for Disease Control and Prevention Atlanta Georgia USA National Institute of tuberculosis and Respiratory Diseases Hanoi Vietnam

阐述耐多药结核病人(MDR-TB),即至少对异烟肼和利福平耐药,初治后复发或失败后接受WHO推荐的标准复治方案病人转归的有关资料很少。在这一病例系列中,我们检查了常规样本,42例已记录为MDR-TB并已接受WHO标准复治方案(2SHRZE/1HRZE/5H_3R... 详细信息

阐述耐多药结核病人(MDR-TB),即至少对异烟肼和利福平耐药,初治后复发或失败后接受WHO推荐的标准复治方案病人转归的有关资料很少。在这一病例系列中,我们检查了常规样本,42例已记录为MDR-TB并已接受WHO标准复治方案(2SHRZE/1HRZE/5H_3R_3E_3)的复发或失败病人的治疗结果。一例病人在治疗的最后一个月内死亡;其余41例病人完成复治方案。42例病人中,14例(33％)完成治疗时痰涂片阴性。MDR-TB用WHO复治方案治愈的病人比例与结核病无化疗的时代结果相似。

关键词：耐多药结核病复发和失败病例复治方案

Viral hepatitis prevalence in patients with active and latent tuberculosis

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World Journal of Gastroenterology 2015年第29期21卷 8920-8926页

作者： Hesam Ahmadi Nooredinvand David W Connell Mahmoud Asgheddi Mohammed Abdullah Marie O'Donoghue Louise Campbell Melissa I Wickremasinghe Ajit Lalvani Onn Min Kon Shahid A Khan Hepatology and Gastroenterology Section Division of Diabetes Endocrinology and MetabolismDepartment of MedicineImperial College London tuberculosis Service St Mary’s HospitalImperial College Healthcare NHS Trust Liver Unit St Mary’s HospitalImperial College London

AIM: To assess the prevalence of hepatitis B virus(HBV) and hepatitis C virus(HCV) infection and association with drug induced liver injury(DILI) in patients undergoing anti-tuberculosis(TB) ***: Four hundred and twenty nine patients with newly diagnosed TB- either active disease or latent infection- who were due to commence antiTB therapy between September 2008 and May 2011 were included. These patients were prospectively tested for serological markers of HBV, HCV and human immunodeficiency virus(HIV) infections- hepatitis B core antigen(HBc Ag), hepatitis B surface antigen(HBs Ag), hepatitis B e antigen, Ig G and Ig M antibody to HBc Ag(anti-HBc), HCV Ig G antibody and HIV antibody using a combination of enzyme-linked immunosorbent assay, Western blot assay and polymerase chain reaction techniques. Patients were reviewed at least monthly during the TB treatment initiation phase. Liver function tests were measured prior to commencement of antiTB therapy and 2-4 wk later. Liver function tests were also performed at any time the patient had significant nausea, vomiting, rash, or felt non-specifically unwell. Fisher's exact test was used to measure significance in comparisons of proportions between groups. A P value of less than 0.05 was considered statistically ***: Of the 429 patients, 270(62.9%) had active TB disease and 159(37.1%) had latent TB infection. 61(14.2%) patients had isolated anti-HBc positivity, 11(2.6%) were also HBs Ag positive and 7(1.6%) were HCV-antibody positive. 16/270 patients with active TB disease compared to 2/159 patients with latent TB infection had markers of chronic viral hepatitis(HBs Ag or HCV antibody positive; P = 0.023). Similarly the proportion of HBs Ag positive patients were significantly greater in the active vs latent TB infection group(10/43 vs 1/29, P = 0.04). The prevalence of chronic HBV or HCV was significantly higher than the estimated United Kingdom prevalence of 0.3% for each. We found no ass

关键词： Epidemiology Hepatitis B Hepatitis C tuberculosis Drug induced liver injury

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非中心化治疗结核病:转型期间病人的随访

国际结核病与肺部疾病杂志 2003年第1期 20-24页

作者： Th.Arnadottir B.Phongosa P.Chittamany H.Soukaseum 邹级谦 Directrate of Health Division of Infectious Disease ControlReykjaviklceland National tuberculosis Program Ministry of HealthVientiane Laos

背景:老挝,Vientiane自治区。目的:为了说明和评价标准化登记制度的实施及在该自治区实行非中心化期间的报告程序。标准化的目的是为获得完整的及可靠的病人发现和治疗结果的信息。设计:对病人发现和治疗结果的季报资料进行评价,并且用... 详细信息

背景:老挝,Vientiane自治区。目的:为了说明和评价标准化登记制度的实施及在该自治区实行非中心化期间的报告程序。标准化的目的是为获得完整的及可靠的病人发现和治疗结果的信息。设计:对病人发现和治疗结果的季报资料进行评价,并且用病人个人记录资料与督导员的记录作比较。结果:自1994—1998年,病人发现有所增加。治疗成功率提高,从26.8％(95％CI 21.5—44.0)提高到74.6％(95％CI 69.9—79.3)。在选择自服药的长程治疗或直接面视下的短程治疗时,1998年登记的病人中97％接受后者。随着非中心化的实施,由于‘迁出’病人的比例较高(16.4％,95％CI11.5—21.3),治疗结果的评价不甚完善。经干预后这个比例下降到2.3％(95％CI 0.7—3.9)。1998年,在国家结核病中心诊断并居住在该区的涂阳病人中,约40％是‘迁移’或‘转诊’到该区。68例中,除3例外均能到区综合医院治疗,大多数没有延误。登记和报告相当正确。在评价期结束时,只有一部分实施非中心化和在病人掌握方面显然仍存在一些问题。结论:为了对该工作给予评价,并有助于正确地分析存在的问题,在非中心化服务时建立信息流动的管理程序是很重要的。

关键词：非中心化转诊督导迁移结核病

Adverse drug reactions of first-line antitubercular drugs:A retrospective study on characteristics,management,factors,and impacts

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Asian Pacific Journal of Tropical Medicine 2024年第10期17卷 456-464页

作者： Ai Ling Oh Mohd Makmor-Bakry Farida Islahudin Chuo Yew Ting Swee Kim Chan Siew Teck Tie Centre of Quality Management of Medicines Faculty of PharmacyUniversiti Kebangsaan MalaysiaKuala LumpurMalaysia Department of Pharmacy Sarawak General HospitalMinistry of Health MalaysiaKuchingSarawakMalaysia Faculty of Pharmacy Universitas AirlanggaSurabayaIndonesia Department of Sarawak State Health Ministry of Health MalaysiaKuchingSarawakMalaysia division of Respiratory Medicine Department of Internal MedicineSarawak General HospitalMinistry of Health MalaysiaKuchingSarawakMalaysia

Objective:To elucidate the characteristics,management strategies,risk factors,and clinical impacts associated with adverse drug reactions(ADRs)induced by first-line antitubercular drugs to enhance tuberculosis(TB)***:A retrospective cohort study was conducted by retrieving drug-susceptible TB records among adult patients who received TB treatment from 2018 to 2021 at 10 public health clinics in Sarawak,*** the initial TB treatment and occurrence of specific ADRs within the study period were *** analysis was performed to identify the risk factors associated with both overall ADRs and individual types of ***:Among 2953 cases,705(23.9%)developed *** reactions were the most prevalent(47.1%),followed by hepatotoxicity(32.8%)and gastrointestinal disturbances(29.8%).Six out of seven types of ADRs investigated occurred within the intensive phase,mostly manifesting at approximately 2 weeks of *** resulted in the majority(85.3%)of treatment discontinuations,while vision problems led to treatment modifications in half of the *** factors for all ADRs included age≥60 years,females,illicit drug use,and comorbidities such as HIV-positive,diabetes,and chronic liver *** consumption was independently associated with *** caused around one-third of interruptions exceeding 2 weeks(33.0%)and subsequently necessitated treatment restarts(34.5%).Conclusions:Understanding these various aspects contributes to improving the overall management of ADRs in TB *** ADR monitoring and reporting are essential to strengthen ADR management.

关键词： Adverse events Cutaneous reactions Hepatotoxicity Gastrointestinal disturbances Risk factors tuberculosis

miR-30b and miR-30c expression predicted response to tyrosine kinase inhibitors as first line treatment in non-small cell lung cancer

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Chinese Medical Journal 2013年第23期126卷 4435-4439页

作者： GU Yan-fei ZHANG Hui SU Dan MO Min-li SONG Pan ZHANG Fang ZHANG Shu-cai Department of Oncology Beijing Tuberculosis and Thoracic Tumor Research Institute/Beijing Chest Hospital Capital Medical University Beijing 101149 China Department of Pathology Beijing Tuberculosis and Thoracic Tumor Research Institute/Beijing Chest Hospital Capital Medical University Beijing 101149 China School of Life Sciences Tsinghua University Beijing 100084 China Beijing ACCB Biotech Ltd. Beijing 100094 China Zhejiang Provincial Key Laboratory of Applied Enzymology Yangtze Delta Region Institute of Tsinghua University Jiaxing Zhejiang 314006 China division of Life & Health Sciences Graduate School at ShenzhenTsinghua University Center for Biotech & Biomedicine

Background Aberrantly expressed microRNAs are a hallmark of cancer,and microRNA expression profiling is associated with tumor progression and response to chemotherapy,suggesting their potential application as prognostic and predictive *** role of microRNAs in lung cancer remains *** has been recently reported that epidermal growth factor receptor （EGFR） and hepatocyte growth factor receptor （MET） tyrosine kinase can regulate expression of specific microRNAs including miR-30b,miR-30c,miR-221,miR-222,miR-103 and miR-203,and induce tumorigenesis and gefitinib resistance in lung *** intend to study the role of miR-30b and miR-30c expression in predicting response to tyrosine kinase inhibitors （TKIs） in non-small cell lung cancer （NSCLC）.Methods We have therefore retrospectively examined expression of miR-30b miR-30c in 41 formalin fixed paraffin embedded tissue samples from NSCLC patients when TKIs were used as first line *** We found a significant correlation between expression of miR-30b and ***,miR-30b and miR-30c expression correlated with short-term ***-Meier analysis further revealed that the expression of miR-30b and miR-30c predicted progression free survival and the overall survival rate in the examined *** Our study identified miR-30b and miR-30c as useful prognostic predictors in NSCLC patients who underwent first line treatment with TKIs.

关键词： non-small cell lung cancer microRNA tyrosine kinase inhibitor epidermal growth factor receptor

ADRENOCORTICAL FUNCTION IN PULMONARY tuberculosis

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Chinese Medical Journal 1965年第6期

作者：朱松山华萝兰孙桐年 division of Pulmonary tuberculosis Shanghai Second Medical College Shanghai

Determinations of 24-hour urinary excretion of 17-ketosteroids in 114 patients suffering from pulmonary tuberculosis and of 17-hydroxycorticosteroids, in addition, in 77 of them were carried out. The amount of 17-ketosteroids excreted was subnormal in 53.8%, normal in 29.8% and greater than normal in 11.4%. 62.2% of the male and 52.5% of the female patients showed diminished urinary excretion of 17-ketosteroids. No correlation was found between the duration of the disease or the clinical form of pulmonary tuberculosis and the amount of 17-ketosteroids excreted. The more extensive the lesion, however, the lower was the amount of 17-ketosteroids excreted. The urinary excretion of 17-hydroxycorticosteroids in pulmonary tuberculosis was normal in amount (68.8%) or increased (24.7%). No apparent relationship existed between the duration, extent or clinical form of pulmonary tuberculosis and the amount of 17-hydroxycorticosteroids excreted. Basing on a general tendency of decreased excretion of 17-ketosteroids and of increased excretion of 17-hydroxycortieosteroids in pulmonary tuberculosis, we suggest the possibility that production of androgens rather than that of glucocorticoids of the adrenal cortex may be impaired in pulmonary tuberculosis. Consequently, urinary excretion of 17-ketosteroids or 17-hydroxyeortieosteroids alone cannot be relied upon for the estimation of adrenocortical function in tuberculosis. Owing to the fact that the extent of pulmonary tuberculosis appears to be more closely related with the amount of 17-ketosteroid excretion than that of 17-hydroxycorticosteroid excretion, the disturbance of androgens function might be of greater importance than that of glucocorticoids in pulmonary tuberculosis.

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A lipidomic concept in infectious diseases

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Asian Pacific Journal of Tropical Biomedicine 2017年第3期7卷 265-274页

作者： Khaled Mohamed Mohamed Koriem Department of Medical Physiology Medical Research Division National Research CentreDokki Cairo Egypt

Infectious diseases resemble a great threat to the human health according to World Health Organization where about 17% of all deaths(z9.2 million deaths) in 2013 recorded are related to infectious diseases. The pathogenic microorganisms such as bacteria, viruses,fungi and parasites are the principle causes of infectious diseases. Ebola, AIDS, dengue,hepatitis, malaria, tuberculosis and schistosomiasis are among 216 infectious diseases found where the immunity represents the first line defense in infection. Lipidomic includes examination of different biological lipids in the biological cell. The lipidomic research covers all aspects of individual lipid molecule including its structure, function,connection with other cell constituents such as protein, lipid, and metabolite in both health and disease conditions. Details of cell biology obtained from different pathogens(viruses, bacteria, and parasites) provide a great data on molecular structure of hostpathogen relation and consequently on infection process. The lipids here play a very important role in many processes involved in host-pathogen relations. The role of lipid in host-pathogen link includes many processes in(1) structural host constituents,(2) host recognition,(3) intracellular transferring, and(4) energy and resource homeostasis during pathogen duplication. There are many lipid phosphatases, kinases, and lipases molecules that greatly involved in these processes and controlling pathogen expression and infection progress. The cell lipid metabolism depends on an adequate energy stores that push the infection to be accelerated and disease symptoms to be appeared. Consequently, future lipidomics studies are the basic for detecting the lipid role in host-pathogen relations which help in therapy advances and biomarkers development.

关键词： Lipidomics Virus Bacteria Parasite Membrane trigger

Diagnostic and Therapeutic Strategies for Peritoneal tuberculosis: A Review

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Journal of Clinical and Translational Hepatology 2019年第2期7卷 140-148页

作者： David C.Wu Leon D.Averbukh George Y.Wu Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Peritoneal tuberculosis(PTB),although rarer than its pulmonary counterpart,is a serious health concern in regions of the world with high tuberculosis *** with baseline immunocompromise condition,whether acquired or medically induced,are at greatest risk for experiencing *** medical treatment of the condition is similar to that of the pulmonary disease,the generally immunocompromised state of those infected with PTB,along with a lack of highly sensitive and specific testing methods make early diagnosis *** review discusses the risks factors,clinical features,diagnostic methods,and treatment options for PTB.

关键词： Peritoneal tuberculosis tuberculosis Liver disease Human immunodeficiency virus