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Interaction and Relationship Between Angiotensin ConvertingEnzyme Gene and Environmental Factors Predisposing toEssential Hypertension in MongolianPopulation of China

引用

Biomedical and Environmental Sciences 2004年第2期17卷 177-186页

作者： QUNXU YAN-HUAWANG WEI-JUNTONG MING-LIANGGU GANGWU BATUBUREN YONG-YUELIU JIANWANG YONG-SHANLI HUAFENG SHUANG-LIANBAI HAI-HUAPANG GUI-RONGHUANG MING-WUFANG YONG-HONGZHANG ZHENG-LAIWU CHANG-CHUNQIU NationalLaboratoryofMedicalMolecularBiology SchoolofBasicMedicinePekingCollegeInstituteofBasicMedicalSciencesChineseAcademyofMedicalSciencesBeijing100005China DepartmentofEpidemiology SchoolofBasicMedicinePekingUnionMedicalCollegeInstituteofBasicMedicalSciencesChineseAcademyofMedicalSciencesBeijing100005China DepartmentofEpidemiology PublicHealthSchoolHarbinMedicalUniversityHarbin150001HeilongjiangChina CenterforDiseaseControlandPreventionofTongliao Tongliao028000InnerMongoliaChina centerhospitaloftongliao Tongliao028000InnerMongoliaChina CenterforDiseaseControlandPreventionofKezuohouqi Kezuohouqi028100InnerMongoliaChina

Objective To investigate the association of specific functional gene ACE (I/D) variants of the renin-angiotensin system with essential hypertension (EH) and interaction between ACE (I/D) gene and risk factors for EH in a genetically homogenous Mongolia rural population of China. Methods Individuals (n=1099) were recruited from general population of Kezuohouqi Banner in Inner Mongolian Autonomous Region. Results The association was found between ACE genotype DD plus ID and EH, with an interaction between ACE genotype DD plus ID and cigarette smoking in an additive model. Cigarette smoking index and ACE gene showed a low exposure-gene (LEG) effect on EH, with interaction indices from 7.10 to 1.16. Interaction between ACE genotype DD plus ID and alcohol drinking on EH appeared an additive model. Alcohol drinking index and ACE gene showed a low exposure-gene (LEG) effect on EH, with interaction indices from 1.66 to 1.09. BMI and ACE gene showed a low exposure-gene (LEG) effect on EH, with interaction indices from 6.15 to 2.49. Interactions between ACE genotype and WHR on EH showed a multiplicative model. In a short, there was an interaction between ACE gene and cigarette smoking, alcohol drinking and BMI on EH, especially in a low dose-exposure effect Conclusion It is important for individuals who carry ACE D allele gene to prevent EH, and furthermore, to prevent and control coronary heart disease, in a view of population-based prevention.

关键词： Angiotensin-converting enzyme Hypertension Genetic Risk factors Interaction Exposure-gene effect

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