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Ceramic-on-ceramic vs ceramic-on-polyethylene,a comparative study with 10-year follow-up

World Journal of orthopedics 2021年第1期12卷 14-23页

作者： Justin van Loon Daniël Hoornenborg Harm M van der Vis Inger N Sierevelt Kim TM Opdam Gino MMJKerkhoffs Daniël Haverkamp Department of orthopedic surgery Xpert Orthopedie Amsterdam/SCORE(Specialized Center of Orthopedic Research and Education)Amsterdam 1101EAThe Netherlands Department of orthopedic surgery Amsterdam University Medical Centreslocation Academic Medical CenterAmsterdam 1105AZThe Netherlands Department of orthopedic surgery Spaarne GasthuisHoofddorp 2134TMThe Netherlands

BACKGROUND In press-fit total hip arthroplasty(THA)ceramic-on-ceramic(CoC)bearings are a potential for overcoming the wear that is seen in ceramic-on-polyethylene(CoPE)bearings,and can lead to wear-induced osteolysis,resulting in loosening of the ***,CoC bearings show disadvantages as well,such as squeaking sounds and being more fragile,which can cause ceramic head or liner *** comparative long-term studies are limited,the objective of this study was to determine the long-term difference in wear,identify potential predictive factors for wear,investigate radiological findings such as osteolysis,and evaluate clinical functioning and complications between these *** To determine 10-year differences in wear,predictive factors for wear,and investigate radiological findings and clinical functioning between CoC and *** This observational prospective single-center cohort study with a 10-year followup includes a documented series of elective *** outcome was wear measured by anteroposterior(AP)*** outcomes were potential predictive factors for wear,complications during follow-up,Harris hip score(HHS),and radiological findings such as presence of radiolucency,osteolysis,atrophy,and hypertrophy around the *** to the absence of wear in the CoC group,stratified analysis to identify risk factors for wear was only performed in the CoPE group by use of univariate linear regression *** was expressed as a change from baseline and the association with bearing type was assessed by use of multivariate linear regression analysis,adjusted for potential *** A total of 17 CoPE(63.0%)and 25 CoC(73.5%)cases were available for follow-up and showed a linear wear of respectively 0.130 mm/year(range 0.010;0.350)and 0.000 mm/year(range 0.000;0.005),which was significant(P<0.001)between both *** always occurred in the cranial *** inclination was the only predictive factor for polyethyl

关键词： Total hip arthroplasty Press-fit Bearing Ceramic-on-ceramic Ceramic-onpolyethylene Wear

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Effects of immune cells on mesenchymal stem cells during fracture healing

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World Journal of Stem Cells 2021年第11期13卷 1667-1695页

作者： Sabrina Ehnert Borna Relja Katharina Schmidt-Bleek Verena Fischer Anita Ignatius Caren Linnemann Helen Rinderknecht Markus Huber-Lang Miriam Kalbitz Tina Histing Andreas K Nussler Siegfried Weller Research Institute at the BG trauma center Tübingen Department of Trauma and Reconstructive SurgeryUniversity of TübingenTübingen 72076Germany Experimental Radiology Department of Radiology and Nuclear MedicineOttovon-Guericke UniversityMagdeburg 39120Germany Julius Wolff Institute and Berlin Institute of Health center of Regenerative Therapies Charité-University Medicine BerlinBerlin 13353Germany Institute of orthopedic Research and Biomechanics Ulm University Medical CenterUlm 89091Germany Institute for Clinical and Experimental trauma-Immunology(ITI) University Hospital UlmUlm 89091Germany Department of trauma and orthopedic surgery University Hospital Erlangen Friedrich-Alexander University Erlangen-Nürnberg(FAU)Erlangen 91054Germany

In vertebrates,bone is considered an osteoimmune system which encompasses functions of a locomotive organ,a mineral reservoir,a hormonal organ,a stem cell pool and a cradle for immune *** osteoimmune system is based on cooperatively acting bone and immune cells,cohabitating within the bone *** are highly interdependent,a fact that is confounded by shared progenitors,mediators,and signaling *** fracture healing requires the participation of all the precursors,immune and bone cells found in the osteoimmune *** evidence demonstrated that changes of the immune cell composition and function may negatively influence bone *** this review,first the interplay between different immune cell types and osteoprogenitor cells will be elaborated more *** separate paragraphs focus on the specific cell types,starting with the cells of the innate immune response followed by cells of the adaptive immune response,and the complement system as mediator between ***,a brief overview on the challenges of preclinical testing of immunebased therapeutic strategies to support fracture healing will be given.

关键词： trauma Bones Immune response Mesenchymal stem cells Fracture healing

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Vascular endothelial growth factor:a double-edged sword in the development of white matter lesions

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Neural Regeneration Research 2025年第1期20卷 191-192页

作者： Narek Manukjan Daniel Fulton Zubair Ahmed WMatthijs Blankesteijn Sébastien Foulquier Department of Pharmacology and Toxicology Maastricht UniversityMaastrichtThe Netherlands CARIM-School for Cardiovascular Diseases Maastricht UniversityMaastrichtThe Netherlands Neuroscience and Ophthalmology Institute of Inflammation and AgeingUniversity of BirminghamEdgbastonBirminghamUK Centre for trauma Sciences Research University of BirminghamEdgbastonBirminghamUK MHeNs-School for Mental Health and Neuroscience Maastricht UniversityMaastrichtThe Netherlands Department of Neurology Maastricht University Medical CenterMaastrichtThe Netherlands

As the population ages,the burden of age-related diseases becomes ***,over 55 million people suffer from dementia worldwide,with Alzheimer’s disease being the most common ***,it is becoming clearer that underlying vascular pathology such as cerebral small vessel disease(cSVD)may be a more detrimental cause for dementia(Cuadrado-Godia et al.,2018).It is estimated that 10%-30%of the elderly population and 35%-90%of all dementia patients exhibit signs of *** term cSVD refers to pathology affecting the small vessels of the brain,which can lead to lacunar cerebral infarcts,enlarged perivascular spaces,and cortical hemorrhages(Cuadrado-Godia et al.,2018).CSVD is often associated with cognitive decline,gait problems,and dementia(Cuadrado-Godia et al.,2018).

关键词： pathology becoming white

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Corrigendum to“Mitochondria-engine with self-regulation to restore degenerated intervertebral disc cells via bioenergetic robust hydrogel design”[***.40C(2024)1–18]

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Bioactive Materials 2024年第10期43卷 I0002-I0003页

作者： Juehan Wang Yulin Jiang Ce Zhu Zheng Liu Lin Qi Hong Ding Jing Wang Yong Huang Yubao Li Yueming Song Ganjun Feng Li Zhang Limin Liu Analytical&Testing center Department of Orthopedic Surgery and Orthopedic Research InstituteWest China HospitalSichuan UniversityChengdu610065China

The authors regret that in Fig.2Aa of the article,the images for TPUPPy and TPU-aa in the first column were mistakenly duplicated due to a formatting *** correct version of Fig.2 is provided below,along with the origi... 详细信息

关键词： fir restore mistake

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Recurrent aneurysmal bone cyst of talus resulted in tibiotalocalcaneal arthrodesis

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World Journal of Clinical Cases 2017年第9期5卷 364-367页

作者： Amir R Vosoughi Kamran Mozaffarian Mohammad A Erfani Bone and Joint Diseases Research center Department of Orthopedic SurgeryShiraz University of Medical Sciences

Aneurysmal bone cyst(ABC), a locally benign aggressive lytic lesion of either primary or secondary origin, seldom involves the talus. Herein, we present a 25-year-old man with recurrent ABC of the talus after curettage and bone grafting, which was managed by total resection followed by filling the defect using fibular graft and finally tibiotalocalcaneal arthrodesis due to articular surface involvement. At 18 mo postoperatively, no recurrence was detected. Arthrodesis might be a good option in cases with recurrent ABC of the talus especially with articular surface involvement.

关键词： Aneurysmal bone cyst Tibiotalocalcaneal arthrodesis Bone tumor Talus

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Outcome after early mobilization following hip reconstruction in children with developmental hip dysplasia and luxation

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World Journal of Pediatrics 2018年第2期14卷 176-183页

作者： Katharina Susanne Gather Eva von Stillfried Sebastien Hagmann Sebastian Müller Thomas Dreher center of Orthopaedic and trauma surgery/Spinal Cord Injury center Heidelberg University HospitalSchlierbacher Landstr.200a69118 HeidelbergGermany

Background Most orthopedic surgeons prefer spica cast immobilization in children for 4 to 12 weeks after surgical hip reconstruction in children with developmental hip *** challenging treatment may be associated with *** are lacking that focus on early mobilization without casting for postoperative care after hip *** Twenty-seven children(3.4±2.0 years),including 33 hips with developmental hip dysplasia(DDH)and dislocation of the hip(Tonnis grade 1 to 4),who underwent hip reconstruction(Dega acetabuloplasty,varisation-derotation osteotomy and facultative open reduction)were retrospectively included in this *** the patients were placed in an individual foam shell with 30 degrees of hip abduction,hip extension,and neutral *** mobilization physiotherapy was performed within the first few days after the surgery under epidural *** weight bearing was allowed after 3-4 *** children received a clinical examination and radiographic evaluation before and after surgical *** follow-up period was 12.3±2.9 *** On average,the postoperative acetabular index decreased significantly from 36.9 to 21.7 degrees and the center-edge angle increased from 9.9 to 28.6 *** hips had reached Tonnis grade 1 at the time of the last *** complications such as dislocation of the bone wedge,avascular necrosis of the acetabulum or femur,lack of non-union,or nerve injury,were *** In this cohort study,hip reconstruction was successful according to clinical and radiographic outcome param-eters after early mobilization without cast *** mobilization may be used as an alternative treatment option after hip reconstruction in DDH.

关键词： Dega acetabuloplasty Developmental hip dysplasia Early mobilization Spica cast Varisation-derotation osteotomy

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Spinous process plate fixation for cervical spinal fusion after spinal trauma:two case reports

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第9期14卷 855-858页

作者： Hiroki HIRABAYASHI Jun TAKAHASHI Hiroyuki HASHIDATE Nobuhide OGIHARA Keijiro MUKAIYAMA Shugo KURAISHI Masayuki SHIMIZU Hiroyuki NAKAGAWA Renzo MATSUE Hiroyuki KATO Department of orthopedic surgery Shinshu University School of Medicine

Posterior cervical fixation with various forms of instrumentation has been used for reconstruction in cases of traumatic disorders and degenerative or tumor-related dysfunction of the cervical spine. Recently, posterior plate and rod techniques using lateral mass screws or pedicle screws have been reported to show excellent fusion rates (Xu et al.,2010).

关键词：病例报告脊柱融合脊髓损伤颈椎椎弓根螺钉钢板功能障碍外伤性

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Decision aids can decrease decisional conflict in patients with hip or knee osteoarthritis: Randomized controlled trial

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World Journal of orthopedics 2021年第12期12卷 1026-1035页

作者： Lode A van Dijk Antonius MJS Vervest Dominique C Baas Rudolf W Poolman Daniel Haverkamp Department of orthopedic surgery Tergooi HospitalHilversum 1213 XZNoord-HollandNetherlands Department of orthopedic surgery Onze Lieve Vrouwe GasthuisAmsterdam 1091 ACNetherlands Department of orthopedic surgery Leiden University Medical CentreLeiden 2333 ZANetherlands Department of orthopedic surgery Xpert Orthopedie Amsterdam/SCORE(Specialized Center of Orthopedic Research and Education)Amsterdam 1101 EANetherlands

BACKGROUND The interest in shared decision making has increased considerably over the last couple of *** aids(DAs)can help in shared decision *** when there is more than one reasonable option and outcomes between treatments are *** To investigate if the use of DAs decreases decisional conflict in patients when choosing treatment for knee or hip osteoarthritis(OA).METHODS In this multi-center unblinded randomized controlled trial of patients with knee or hip OA were included from four secondary and tertiary referral ***-thirty-one patients who consulted an orthopedic surgeon for the first time with knee or hip OA were included between December 2014 and January *** the first consultation,patients were randomly assigned by a computer to the control group which was treated according to standard care,or to the intervention group which was treated with standard care and provided with a *** the first consultation,patients were asked to complete questionnaires about decisional conflict(DCS),satisfaction,anxiety(PASS-20),gained knowledge,stage of decision making and preferred ***-up was carried out after 26 wk and evaluated decisional conflict,satisfaction,anxiety,health outcomes(HOOS/KOOS),quality of life(EQ5D)and chosen *** After the first consultation,patients in the intervention group(mean DCS:25 out of 100,SD:13)had significantly(P value:0.00)less decisional conflict compared to patients in the control group(mean DCS:39 out of 100,SD 11).The mean satisfaction score for the given information(7.6 out of 10,SD:1.8 vs 8.6 out of 10,SD:1.1)(P value:0.00),mean satisfaction score with the physician(8.3 out of 10,SD:1.7 vs 8.9 out of 10,SD:0.9)(P value:0.01)and the mean knowledge score(3.3 out of 4,SD:0.9 vs 3.7 out of,SD:0.6)(P value:0.01)were all significantly higher in the intervention *** 26-wk follow-up,only 75 of 131 patients(57%)were available for *** sample is too

关键词： Decision aid Decisional conflict Shared decision making Anxiety Hip osteoarthritis Knee osteoarthritis

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Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development

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Bone Research 2024年第1期12卷 199-214页

作者： Laura J.Brylka Assil-Ramin Alimy Miriam E.A.Tschaffon-Müller Shan Jiang Tobias Malte Ballhause Anke Baranowsky Simon von Kroge Julian Delsmann Eva Pawlus Kian Eghbalian Klaus Püschel Astrid Schoppa Melanie Haffner-Luntzer David J.Beech Frank Timo Beil Michael Amling Johannes Keller Anita Ignatius Timur A.Yorgan Tim Rolvien Thorsten Schinke Department of Osteology and Biomechanics University Medical Center Hamburg-Eppendorf20246 HamburgGermany Department of trauma and orthopedic surgery University Medical Center Hamburg-Eppendorf20246 HamburgGermany Institute of orthopedic Research and Biomechanics University Medical Center UlmBadenWürttemberg89081 UlmGermany Department Legal Medicine University Medical Center Hamburg-Eppendorf20246 HamburgGermany Leeds Institute of Cardiovascular and Metabolic Medicine School of MedicineUniversity of LeedsLS29JT LeedsUK

Piezo proteins are mechanically activated ion channels,which are required for mechanosensing functions in a variety of cell *** we and others have previously demonstrated that the expression of Piezo1 in osteoblast lineage cells is essential for boneanabolic processes,there was only suggestive evidence indicating a role of Piezo1 and/or Piezo2 in *** we addressed the question if and how chondrocyte expression of the mechanosensitive proteins Piezo1 or Piezo2 controls physiological endochondral ossification and pathological osteoarthritis(OA)*** with chondrocyte-specific inactivation of Piezo1(Piezo1^(Col2a1Cre)),but not of Piezo2,developed a near absence of trabecular bone below the chondrogenic growth plate ***,all Piezo1^(Col2a1Cre) animals displayed multiple fractures of rib bones at 7 days of age,which were located close to the growth *** skeletal growth was only mildly affected in these mice,OA pathologies were markedly less pronounced compared to littermate controls at 60 weeks of ***,when OA was induced by anterior cruciate ligament transection,only the chondrocyte inactivation of Piezo1,not of Piezo2,resulted in attenuated articular cartilage ***,osteophyte formation and maturation were also reduced in Piezo1^(Col2a1Cre) *** further observed increased Piezo1 protein abundance in cartilaginous zones of human ***,we identified Ptgs2 and Ccn2 as potentially relevant Piezo1 downstream genes in ***,our data do not only demonstrate that Piezo1 is a critical regulator of physiological and pathological endochondral ossification processes,but also suggest that Piezo1 antagonists may be established as a novel approach to limit osteophyte formation in OA.

关键词： Piezo1 markedly ossification

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Tppp3~+synovial/tendon sheath progenitor cells contribute to heterotopic bone after trauma

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Bone Research 2023年第3期11卷 548-559页

作者： Ji-Hye Yea Mario Gomez-Salazar Sharon Onggo Zhao Li Neelima Thottappillil Masnsen Cherief Stefano Negri Xin Xing Qizhi Qin Robert Joel Tower Chen-Ming Fan Benjamin Levi Aaron W.James Department of Pathology Johns Hopkins UniversityBaltimoreMD 21205USA Orthopaedic and trauma surgery Unit Department of SurgeryDentistryPaediatrics and Gynaecology of the University of VeronaVeronaItaly center for Organogenesis and trauma Department of SurgeryUniversity of Texas SouthwesternDallasTXUSA Carnegie Institution for Science BaltimoreMDUSA

Heterotopic ossification(HO)is a pathological process resulting in aberrant bone formation and often involves synovial lined *** this process,mesenchymal progenitor cells undergo endochondral ***,the specific cell phenotypes and mechanisms driving this process are not well understood,in part due to the high degree of heterogeneity of the progenitor cells ***,using a combination of lineage tracing and single-cell RNA sequencing(sc RNA-seq),we investigated the extent to which synovial/tendon sheath progenitor cells contribute to heterotopic bone *** this purpose,Tppp3(tubulin polymerization-promoting protein family member 3)-inducible reporter mice were used in combination with either Scx(Scleraxis)or Pdgfra(platelet derived growth factor receptor alpha)reporter *** tendon injury-and arthroplasty-induced mouse experimental HO models were *** RNA-seq of tendon-associated traumatic HO suggested that Tppp3 is an early progenitor cell marker for either tendon or osteochondral *** HO induction,Tppp3 reporter^(+)cells expanded in number and partially contributed to cartilage and bone formation in either tendon-or joint-associated *** double reporter animals,both Pdgfra^(+)Tppp3^(+)and Pdgfra^(+)Tppp3^(-) progenitor cells gave rise to HO-associated ***,analysis of human samples showed a substantial population of TPPP3^(-) expressing cells overlapping with osteogenic markers in areas of heterotopic ***,these data demonstrate that synovial/tendon sheath progenitor cells undergo aberrant osteochondral differentiation and contribute to HO after trauma.

关键词： progenitor tendon reporter

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