检索结果-南通市图书馆

Peptide-based strategies for overcoming multidrug-resistance in cancer therapy

chinese Chemical Letters 2025年第1期36卷 110-118页

作者： Xiaofang Luo Ye Wu Xiaokun Zhang Min Tang Feiye Ju Zuodong Qin Gregory J Duns Wei-Dong Zhang Jiang-Jiang Qin Xin Luan Hunan Engineering Technology Research center for Comprehensive Development and Utilization of Biomass Resources College of Chemistry and BioengineeringHunan University of Science and EngineeringYongzhou 425199China Shanghai Frontiers Science center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine Research and Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China Zhejiang Cancer Hospital Hangzhou Institute of Medicine(HIM)Chinese Academy of SciencesHangzhou 310022China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Institute of Medicinal Plant DevelopmentChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100700China

Despite ongoing advancements in cancer treatment,the emergence of primary and acquired resistance poses a significant challenge for both traditional chemotherapy and immune checkpoint blockade *** demand for targeted therapeutics for multidrug-resistant cancer is more important than ***,as emerging alternatives to current anticancer drugs,offer exquisite versatility in facilitating the design of novel oncology drugs,with the core superiorities of good biocompatibility and a low tendency to induce drug *** review comprehensively introduces the pharmacological mechanisms of peptide-based drugs and strategies for overcoming multidrug resistance(MDR)in cancers,including inducing cell membrane lysis,targeting organelles,activating anticancer immune responses,enhancing drug uptake,targeting ATP-binding cassette(ABC)transporters,and targeting B-cell lymphoma-2(BCL-2)family ***,the current clinical applications of representative peptides in combating MDR cancers and their potential directions for medicinal chemistry research have been thoroughly *** review offers essential insights into the novel treatment approaches for MDR cancers and highlights the trends and perspectives in this field.

关键词： Drug resistance Antitumor peptides Mechanism of action Targeted therapeutics Immunotherapy Medicinal chemistry

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

W_(18)O_(49)Crystal and ICG Labeled Macrophage:An Efficient Targeting Vector for Fluorescence Imagingguided Photothermal Therapy

引用

Biomedical and Environmental Sciences 2025年第1期38卷 100-105页

作者： Yang Bai Guoqing Feng Muskan Saif khan Qingbin Yang Tingting Hua Haolin Guo Yuan Liu Bowen Li Yiwen Wu Bin Zheng Niansong Qian Qing Yuan Department of Stomatology Tianjin Medical University General HospitalHeping DistrictTianjin 300052China Academy of Medical Engineering and Translational medicine Tianjin UniversityTianjin 300072China School of traditional chinese medicine Beijing University of Chinese MedicineBeijing 102401China Tianjin Anding Hospital Tianjin 300222China Beijing National Day School Beijing 100000China Department of Respiratory the Eighth Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Urology The Third Medical CenterChinese People’s Liberation Army(PLA)General HospitalBeijing 100853China

Photothermal therapy(PTT)uses heat generated by photothermal agents to efficiently kill cancer cells in the least invasive *** nanoparticles,such as precious metals and carbon nanoparticles,have been extensively studied for their ability to convert near-infrared(NIR)light(700-900 nm)into heat[1].However,these nanoparticles are easily captured by the reticuloendothelial system,which severely limits their clinical applications[2].Despite targeted and stealth modifications,these issues remain unresolved;therefore,researchers are seeking more effective methods.

关键词： seeking thermal spite

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A new horizon for neuroscience:terahertz biotechnology in brain research

引用

Neural Regeneration Research 2025年第2期20卷 309-325页

作者： Zhengping Pu Yu Wu Zhongjie Zhu Hongwei Zhao Donghong Cui Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry Kangci Hospital of JiaxingTongxiangZhejiang ProvinceChina Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied PhysicsChinese Academy of ScienceShanghaiChina National Facility for Protein Science in Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina

Terahertz biotechnology has been increasingly applied in various biomedical fields and has especially shown great potential for application in brain *** this article,we review the development of terahertz biotechnology and its applications in the field of *** evidence indicates promising prospects for the use of terahertz spectroscopy and terahertz imaging techniques in the diagnosis of amyloid disease,cerebrovascular disease,glioma,psychiatric disease,traumatic brain injury,and myelin *** vitro and animal experiments have also demonstrated the potential therapeutic value of terahertz technology in some neuropsychiatric *** the precise underlying mechanism of the interactions between terahertz electromagnetic waves and the biosystem is not yet fully understood,the research progress in this field shows great potential for biomedical noninvasive diagnostic and therapeutic ***,the biosafety of terahertz radiation requires further exploration regarding its two-sided efficacy in practical *** review demonstrates that terahertz biotechnology has the potential to be a promising method in the field of neuropsychiatry based on its unique advantages.

关键词： biological effect brain neuron neuropsychiatry neuroscience non-thermal effect terahertz imaging terahertz radiation terahertz spectroscopy terahertz technology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Xiangbinfang granules enhance gastric antrum motility via intramuscular interstitial cells of Cajal in mice

引用

World Journal of Gastroenterology 2021年第7期27卷 576-591页

作者： Qi-Cheng Chen Zhi Jiang Jun-Hong Zhang Li-Xing Cao Zhi-Qiang Chen The Research Team of TCM applications of perioperative The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangdong Provincial Hospital of Traditional Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Department of Research Public Service center The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangdong Provincial Hospital of Traditional Chinese MedicineGuangzhou 510120Guangdong ProvinceChina

BACKGROUND Interdigestive migrating motor complexes(MMC)produce periodic contractions in the gastrointestinal tract,but the exact mechanism of action still remains *** interstitial cells of Cajal(ICC-IM)participate in gastrointestinal hormone and neuromodulation,but the correlation between ICCIM and MMC is also *** found that xiangbinfang granules(XBF)mediated the phase III contraction of ***,the effects of XBF on gastric antrum motility in W/Wv mice and the effects of ICC-IM on gastric antrum MMC are *** To observe the effects of ICC-IM on gastric antrum motility and to establish the mechanism of XBF in promoting gastric antrum *** The density of c-kit-positive ICC myenteric plexus(ICC-MP)and ICC-IM in the antral muscularis of W/Wv and wild-type(WT)mice was examined by confocal *** effects of XBF on gastric antrum slow waves in W/Wv and WT mice were recorded by intracellular amplification ***-strain-gauge force transducers were implanted into the gastric antrum to monitor the MMC and the effect of XBF on gastric antrum motility in conscious W/Wv and WT *** In the gastric antrum of W/Wv mice,c-kit immunoreactivity was significantly reduced,and no ICC-IM network was *** rhythmic slow waves also appeared in the antrum of W/Wv mice,but the amplitude of the antrum slow wave decreased significantly in W/Wv mice(22.62±2.23 mV vs 2.92±0.52 mV,P<0.0001).MMCs were found in 7 of the 8 WT mice but no complete MMC cycle was found in W/Wv *** contractile frequency and amplitude index of the gastric antrum were significantly increased in conscious WT compared to W/Wv mice(frequency,3.53±0.18 cpm vs 1.28±0.12 cpm;amplitude index,23014.26±1798.65 mV·20 min vs 3782.16±407.13 mV·20 min;P<0.0001).XBF depolarized smooth muscle cells of the gastric antrum in WT and W/Wv mice in a dose-dependent ***,the gastric antrum motility in WT mice was significantly increased after

关键词： Interstitial cells of Cajal Migrating motor complex W/Wv Gastric antrum motility Xiangbinfang granules chinese medicine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular characterization and structure basis of a malonyltransferase with both substrate promiscuity and catalytic regiospecificity from Cistanche tubulosa

引用

Acta Pharmaceutica Sinica B 2024年第5期14卷 2333-2348页

作者： Xiao Liu Yuyu Liu Xiping Xu Wenqian Huang Yaru Yan Yingxia Wang Weisheng Tian Ting Mo Xiaoxue Cui Jun Li She-Po Shi Pengfei Tu Modern Research center for traditional chinese medicine Beijing Research Institute of Chinese MedicineBeijing University of Chinese MedicineBeijing 100029China Modern Research center for traditional chinese medicine School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijing 100029China

Enzymatic malonylation of natural glycosides provides a promising alternative method for drug-like malonylated glycosides ***,the catalytic potential and structural basis of plant malonyltransferase are far from being fully *** work identified a new malonyltransferase CtMaT1 from Cistanche *** displayed unprecedented mono-and/or di-malonylation activity toward diverse glucosides with different aglycons.A“one-pot”system by CtMaT1 and a malonyl-CoA synthetase was established to biosynthesize nine new malonylated *** investigations revealed that CtMaT1 possesses an adequately spacious acyl-acceptor pocket capable of accommodating diverse ***,it recognizes malonyl-CoA through strong electrotactic and hydrogen ***/MM calculation revealed the H167-mediated SN2 reaction mechanism of CtMaT1,while dynamic simulations detected the formation of stable hydrogen bonds between the glucose-6-OH group and H167,resulting in its high malonylation *** energy profiles of two isomeric glycosides highlighted lower reaction energy barriers towards glucoside substrates,emphasizing CtMaT1's preference for ***,a mutant CtMaT1H36A with notably increased di-malonylation activity was *** underlying molecular mechanism was illuminated through MM/GBSA binding free energy *** study significantly advances the understanding of plant acyltransferases from both functional and protein structural perspectives,while also providing a versatile tool for enzymatic malonylation applications in pharmacology.

关键词： Plant acyltransferase Malonyltransferase Malonylated glycosides Enzymatic catalysis Enzyme promiscuity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Global landscape of hepatic organoid research:A bibliometric and visual study

引用

World Journal of Hepatology 2025年第2期17卷 225-237页

作者： Tao Li Rong-Qiang Bo Jun Yan Nadia L Johnson Meng-Ting Liao Yuan Li Yan Chen Jie Lin Jian Li Fu-Hao Chu Xia Ding School of traditional chinese medicine Beijing University of Chinese MedicineBeijing 100700China Dongzhimen Hospital Beijing University of Chinese MedicineBeijing 100700China Department of Histology and Embryology School of Traditional Chinese MedicineBeijing University of Chinese MedicineBeijing 102488China Institute of Regulatory Science for traditional chinese medicine Beijing University of Chinese MedicineBeijing 100029China

BACKGROUND Hepatic organoid-based modelling,through the elucidation of a range of in vivo biological processes and the recreation of the intricate liver microenvironment,is yielding groundbreaking insights into the pathophysiology and personalized medicine approaches for liver *** This study was designed to analyse the global scientific output of hepatic organoid research and assess current achievements and future trends through bibliometric *** Articles were retrieved from the Web of Science Core Collection,and CiteSpace 6.3.R1 was employed to analyse the literature,including outputs,journals,and countries,among *** Between 2010 and 2024,a total of 991 articles pertaining to hepatic organoid research were *** journal Hepatology published the greatest number of papers,and journals with an impact factor greater than 10 constituted 60%of the top 10 *** United States and Utrecht University were identified as the most prolific country and institution,*** H emerged as the most prolific author,whereas Huch M had the highest number of cocitations,suggesting that both are ideal candidates for academic *** on hepatic organoids has exhibited a progressive shift in focus,evolving from initial investigations into model building,differentiation research in stem cells,bile ducts,and progenitor cells,to a broader spectrum encompassing lipid metabolism,single-cell RNA sequencing,and therapeutic *** phrases exhibiting citation bursts from 2022 to 2024 include“drug resistance”,“disease model”,and“patient-derived tumor organoids”.CONCLUSION Research on hepatic organoids has increased over the past decade and is expected to continue to *** research areas include applications for liver diseases and drug *** trends likely to gain focus include patient-derived tumour organoids,disease modelling,and personalized medicine.

关键词： Hepatic organoid Bibliometric analysis CiteSpace Web of Science Core Collection Three-dimensional culture

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in CRISPR-based gene editing technology and its application in nucleic acid detection

引用

BIOCELL 2025年第1期49卷 21-43页

作者： LIUJIE CHEN LILI DUAN JIA LI JUN CHEN DUANFANG LIAO NONGYUE HE KAI LI ZHENG HU Translational medicine Institute the First People’s Hospital of ChenzhouHengyang Medical SchoolUniversity of South ChinaChenzhou423000China The First Clinical College of Xiangnan University The First Affiliated Hospital of Xiangnan UniversityChenzhou423000China National Engineering Research center of Personalized Diagnostic and Therapeutic Technology Hunan University of Chinese MedicineChangsha410208China State Key Laboratory of Digital Medical Engineering School of Biological Science and Medical EngineeringSoutheast UniversityNanjing210096China

Nucleic acid analysis is a key technique that enables accurate detection of various *** nucleic acid testing typically requires access to specialized laboratories,equipment,and trained personnel,which hinders the widespread use of on-site testing for DNA and RNA ***,integrating gene editing technology with traditional nucleic acid detection methods,especially isothermal amplification technology,can help overcome the limitations associated with on-site *** combination can accomplish precise and swift detection of nucleic acid sequences,offering a robust tool for on-site *** Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated proteins(CRISPR/Cas)technology,which comprises the CRISPR system and Cas effector proteins,is a powerful tool that is advancing the field of nucleic acid ***,Cas12,Cas13,and Cas14 proteins have emerged as straightforward,effective,precise,sensitive,and cost-effective methods for in vitro nucleic acid detection because of their“collateral cleavage”*** combined with the“collateral cleavage”ability of Cas protein and isothermal amplification,CRISPR/Cas systems have great potential to advance nucleic acid *** article summarizes the research progress of different CRISPR/Cas systems and their applications in nucleic acid detection and future perspectives.

关键词： CRISPR/Cas Pathogen Clinical application

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Efficacy of Wuda Granule on Recovery of Gastrointestinal Function after Laparoscopic Bowel Resection:A Randomized Double-Blind Controlled Trial

引用

chinese Journal of Integrative medicine 2024年第12期30卷 1059-1067页

作者： ZENG Hai-ping CAO Li-xing DIAO De-chang WEN Ze-huai OUYANG Wen-wei OU Ai-hua WAN Jin PENG Zhi-jun WANG Wei CHEN Zhi-qiang Department of Surgery Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120China center of traditional chinese medicine applications perioperative Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120China Department of Colorectal Surgery Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120China Key Unit of Methodology in Clinical Research the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120China Guangdong Provincial Key Laboratory of Clinical Research on traditional chinese medicine Syndrome Guangzhou 510120China Department of Global Public Health Karolinska InstituteStockholm 17176Sweden Department of Big Data Research of traditional chinese medicine Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120China Gastrointestinal Cancer center Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120China The Second School of Clinical medicine Guangzhou University of Chinese MedicineGuangzhou 510405China

Objective:To evaluate the efficacy and safety of Wuda Granule(WDG)on recovery of gastrointestinal function after laparoscopic bowel resection in the setting of enhanced recovery after surgery(ERAS)-based perioperative ***:A total of 108 patients aged 18 years or older undergoing laparoscopic bowel resection with a surgical duration of 2 to 4.5 h were randomly assigned(1:1)to receive either WDG or placebo(10 g/bag)twice a day from postoperative days 1-3,combining with ERAS-based perioperative *** primary outcome was time to first *** outcomes were time to first flatus,time to first tolerance of liquid or semi-liquid food,gastrointestinal-related symptoms and length of *** analysis of the primary outcome according to sex,age,tumor site,surgical time,histories of underlying disease or history of abdominal surgery was *** eventse were observed and ***:A total of 107patients[53 in the WDG group and 54 in the placebo group;61.7±12.1 years;50 males(46.7%)]were included in the intention-to-treat *** patients in the WDG group had a significantly shorter time to first defecation and flatus[between-group difference-11.01 h(95%CI-20.75 to-1.28 h),P=0.012 for defecation;-5.41 h(-11.10 to 0.27 h),P=0.040 for flatus]than the placebo ***,the extent of improvement in postoperative gastrointestinal-related symptoms in the WDG group was significantly better than that in the placebo group(P<0.05).Subgroup analyses revealed that the benefits of WDG were significantly superior in patients who were male,or under 60 years old,or surgical time less than 3 h,or having no history of basic disease or no history of abdominal *** were no serious adverse ***:The addition of WDG to an ERAS postoperative care may be a viable strategy to enhance gastrointestinal function recovery after laparoscopic bowel resection surgery.(Registry ***2100046242)

关键词： laparoscopic bowelresection gastrointestinal function postoperative ileus Wuda Granule enhanced recovery after surgery randomized double-blind controlled trial chinese medicine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Emerging biotechnology applications in natural product and synthetic pharmaceutical analyses

引用

Acta Pharmaceutica Sinica B 2022年第11期12卷 4075-4097页

作者： Shilin Chen Zheng Li Sanyin Zhang Yuxin Zhou Xiaohe Xiao Pengdi Cui Binjie Xu Qinghe Zhao Shasha Kong Yuntao Dai Institute of Herbgenomics Chengdu University of Traditional Chinese MedicineChengdu 611137China Institute of chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China State Key Laboratory of Component traditional chinese medicine College of Pharmaceutical Engineering of Traditional Chinese MedicineHaihe Laboratory of Modern Chinese MedicineTianjin University of Traditional Chinese MedicineTianjin 301617China Innovative Institute of chinese medicine and Pharmacy Chengdu University of Traditional Chinese MedicineChengdu 611137China China Military Institute of chinese medicine Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China

Pharmaceutical analysis is a discipline based on chemical, physical, biological, and information technologies. At present, biotechnological analysis is a short branch in pharmaceutical analysis;however, bioanalysis is the basis and an important part of medicine. Biotechnological approaches can provide information on biological activity and even clinical efficacy and safety, which are important characteristics of drug quality. Because of their advantages in reflecting the overall biological effects or functions of drugs and providing visual and intuitive results, some biotechnological analysis methods have been gradually applied to pharmaceutical analysis from raw material to manufacturing and final product analysis,including DNA super-barcoding, DNA-based rapid detection, multiplex ligation-dependent probe amplification, hyperspectral imaging combined with artificial intelligence, 3D biologically printed organoids,omics-based artificial intelligence, microfluidic chips, organ-on-a-chip, signal transduction pathwayrelated reporter gene assays, and the zebrafish thrombosis model. The applications of these emerging biotechniques in pharmaceutical analysis have been discussed in this review.

关键词： Biotechnology Pharmaceutical analysis Rawmaterials Manufacturing control Quality analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A nano-cocrystal strategy to improve the dissolution rate and oral bioavailability of baicalein

引用

Asian Journal of Pharmaceutical Sciences 2019年第2期14卷 154-164页

作者： Jiaxin Pi Shuya Wang Wen Li Dereje Kebebe Ying Zhang Bing Zhang Dongli Qi Pan Guo Nan Li Zhidong Liu Tianjin State Key Laboratory of Modern chinese medicine Tianjin University of Traditional Chinese Medicine Engineering Research center of Modern chinese medicine Discovery and Preparation Technique Ministry of Education Tianjin University of Traditional Chinese Medicine Institute of health sciences Jimma University

Baicalein(BE) is one of the main active flavonoids representing the variety of pharmacological effects including anticancer, anti-inflammatory and cardiovascular protective activities, but it's very low solubility, dissolution rate and poor oral absorption limit the therapeutic applications. In this work, a nano-cocrystal strategy was successfully applied to improve the dissolution rate and bioavailability of BE. Baicalein-nicotinamide(BE-NCT) nanococrystals were prepared by high pressure homogenization and evaluated both in vitro and in vivo. Physical characterization results including scanning electron microscopy, dynamic light scattering, powder X-ray diffraction and differential scanning calorimetry demonstrated that BE-NCT nano-cocrystals were changed into amorphous state with mean particle size of 251.53 nm. In the dissolution test, the BE-NCT nano-cocrystals performed 2.17-fold and 2.54-fold enhancement than BE coarse powder in FaSSIF-V2 and FaSSGF. Upon oral administration, the integrated AUC0-t of BE-NCT nano-cocrystals(6.02-fold) was significantly higher than BE coarse powder(1-fold), BE-NCT cocrystals(2.87-fold) and BE nanocrystals(3.32-fold). Compared with BE coarse powder, BE-NCT cocrystals and BE nanocrystals, BENCT nano-cocrystals possessed excellent performance both in vitro and in vivo ***, it can be seen that nano-cocrystal is an appropriate novel strategy for improving dissolution rate and bioavailability of poor soluble natural products such as BE.

关键词： Baicalein Nano-cocrystals Cocrystals Bioavailability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：