检索结果-南通市图书馆

Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 93-106页

作者： Yujie Yang Xinyi Li Jiaying Lu Jingjie Ge Mingjia Chen Ruixin Yao Mei Tian Jian Wang Fengtao Liu Chuantao Zuo Key Laboratory of Arrhythmias Ministry of EducationDepartment of Medical GeneticsShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Neurology National Research Center for Aging and MedicineNational Center for Neurological Disordersand State Key Laboratory of Medical NeurobiologyHuashan HospitalFudan UniversityShanghaiChina Department of nuclear Medicine&PET center National Center for Neurological Disordersand National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghaiChina International Human Phenome Institutes(Shanghai) ShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of *** review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest *** conducted a thorough literature search using reputable databases such as PubMed and Web of *** criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical *** findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting ***,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo *** validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic *** summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders.

关键词： aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease parkinsonism positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2

Single-cell omics: experimental workflow, data analyses and applications

在线全文

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

The relativistic consistent angular-momentum projected shell model study of the N=Z nucleus ^(52)Fe

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2009年第10期52卷 1471-1476页

作者： LI YanSong1,2 & LONG GuiLu1,2 1 Department of Physics,Tsinghua University,Beijing 100084,China 2 center of nuclear theory,National Laboratory of Heavy Ion Accelerator of Lanzhou,Lanzhou 730000,China Department of Physics Tsinghua University Beijing China center of nuclear theory National Laboratory of Heavy Ion Accelerator of Lanzhou Lanzhou China

The relativistic consistent angular-momentum projected shell model(ReCAPS) is used in the study of the structure and electromagnetic transitions of the low-lying states in the N=Z nucleus *** model calculations show a reasonably good agreement with the *** backbending at 12+ is reproduced and the energy level structure suggests that neutron-proton interactions play important roles.

关键词： ReCAPS relativistic mean field angular-momentum projection method 52Fe neutron-proton interaction

Low-lying states and isospin excitation in the Ge isotopes

在线全文

学校读者我要写书评

暂无评论

Chinese Physics C 2009年第7期33卷 538-546页

作者： Falih H. Al-Khudair Department of Physics Tsinghua University center of nuclear theory Lanzhou Heavy Ion National Laboratory Department of Physics College of EducationBasrah University

The level structure of ^64-70Ge isotopes has been studied within the framework of the interacting boson model-3（IBM-3） . The symmetry character in the proton and neutron degrees of freedom of the energy levels has been investigated. The isospin excitation states（T 〉 Tz） have been assigned for the ^64Ge（N = Z） nucleus. Some intruder states in these nuclei have been suggested. The calculated energy levels and transition probabilities are in good agreement with recent experimental data. The study indicates that the Ge isotopes are in transition from γ-unstable to vibrational.

关键词： IBM-3 Isospin Z ≈ N nuclei, ^64-70Ge isotopes

Neutron and Ion Beams Emitted from Plasma Focus (112.5 J) Device

在线全文

学校读者我要写书评

暂无评论

Plasma Science and Technology 2010年第1期12卷 1-5页

作者： G.M.EL-ARAGI Plasma Physics and nuclear Fusion Department Nuclear Research Center

Preliminary results of recent experiments performed within the Mather-type 112.5 J plasma focus device are presented. The ion beams from the focus device operated with deuterium filling at 1 mbar were registered using CR-39 solid state nuclear track detectors （SSNTD） and a Faraday cup detector for time-resolved measurements. The time-resolved neutron emission from the focus region measurements was detected with a photomultiplier tube （IP-28） optically coupled with a plastic scintillator NE 102.

关键词： plasmas neutron scintillator detectors photomultiplier Faraday

The detection, extraction and parameter estimation of extreme-mass-ratio inspirals with deep learning

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 86-96页

作者： Qianyun Yun Wen-Biao Han Yi-Yang Guo He Wang Minghui Du Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences Shanghai Astronomical Observatory Chinese Academy of Sciences School of Physics and Astronomy Shanghai Jiao Tong University School of Astronomy and Space Science University of Chinese Academy of Sciences Taiji Laboratory for Gravitational Wave Universe (Beijing/Hangzhou) University of Chinese Academy of Sciences Lanzhou center for Theoretical Physics Key Laboratory of Theoretical Physics of Gansu Province Key Laboratory of Quantum Theory and Applications of MoE Lanzhou University Institute of Theoretical Physics & Research center of Gravitation Lanzhou University International Centre for Theoretical Physics Asia-Pacific (ICTP-AP) University of Chinese Academy of Sciences (UCAS) center for Gravitational Wave Experiment National Microgravity Laboratory Institute of Mechanics Chinese Academy of Sciences

One of the primary goals of space-borne gravitational wave detectors is to detect and analyze extreme-mass-ratio inspirals(EMRIs). This task is particularly challenging because EMRI signals are complex, lengthy, and faint. In this work, we introduce a2-layer convolutional neural network(CNN) approach to detect EMRI signals for space-borne detectors, achieving a true positive rate(TPR) of 96.9% at a 1% false positive rate(FPR) for signal-to-noise ratio(SNR) from 50 to 100. Especially, the key intrinsic parameters of EMRIs such as the mass, spin of the supermassive black hole(SMBH) and the initial eccentricity of the orbit can also be inferred directly by employing a neural network. The mass and spin of the SMBH can be determined at 99% and 92% respectively. This will greatly reduce the parameter spaces and computing cost for the following Bayesian parameter *** model also has a low dependency on the accuracy of the waveform model. This study underscores the potential of deep learning methods in EMRI data analysis, enabling the rapid detection of EMRI signals and efficient parameter estimation.

关键词： gravitational wave EMRIs deep-learing

Autonomous attitude coordinated control for spacecraft formation with input constraint,model uncertainties, and external disturbances

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2014年第3期27卷 602-612页

作者： Zheng Zhong Song Shenmin center for Control theory and Guidance Technology Harbin Institute of Technology

To synchronize the attitude of a spacecraft formation flying system, three novel autonomous control schemes are proposed to deal with the issue in this paper. The first one is an ideal autonomous attitude coordinated controller, which is applied to address the case with certain models and no disturbance. The second one is a robust adaptive attitude coordinated controller, which aims to tackle the case with external disturbances and model uncertainties. The last one is a filtered robust adaptive attitude coordinated controller, which is used to overcome the case with input con- straint, model uncertainties, and external disturbances. The above three controllers do not need any external tracking signal and only require angular velocity and relative orientation between a spacecraft and its neighbors. Besides, the relative information is represented in the body frame of each spacecraft. The controllers are proved to be able to result in asymptotical stability almost everywhere. Numerical simulation results show that the proposed three approaches are effective for attitude coordination in a spacecraft formation flying system.

关键词： Attitude coordinatedcontrol Backstepping Command filter Robust adaptive control Spacecraft formation flying

Robust Chattering-Free Finite Time Attitude Tracking Control with Input Saturation

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Science & Complexity 2019年第6期32卷 1597-1629页

作者： CHEN Haitao SONG Shenmin center for Control theory and Guidance Technology Harbin Institute of Technology

This paper addresses the attitude tracking control problem of a rigid spacecraft in the presence of the modeling uncertainty,external disturbance,and saturated control input by designing two robust att计ude tracking *** basic controller is formulated using an integral sliding mode surface which is continuous and provides an asymptotic convergence rate for the closed-loop *** this case,only the external disturbance with the prior information is ***,to provide a finite time convergence rate and further improve the robustness of the control system under the unknown system uncertainty containing both the modeling uncertainty and external disturbance,a novel integral terminal sliding mode surface(ITSMS)is designed and associated w计h the continuous adaptive control ***,a command filter is utilized to deal with the immeasurability problem within the proposed ITSMS and an auxiliary system to counteract the input saturation *** simulations are presented to verify the effectiveness of the proposed controllers.

关键词： Chattering-free continuous adaptive control finite time convergence input saturation integral terminal sliding mode surface

Stabilization of linear time-varying systems with state and input constraints using convex optimization

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Engineering and Electronics 2016年第3期27卷 649-655页

作者： Feng Tan Mingzhe Hou Guangren Duan center for Control theory and Guidance Technology Harbin Institute of Technology

The stabilization problem of linear time-varying systems with both state and input constraints is considered. Sufficient conditions for the existence of the solution to this problem are derived and a gain-switched（gain-scheduled） state feedback control scheme is built to stabilize the constrained timevarying system. The design problem is transformed to a series of convex feasibility problems which can be solved efficiently. A design example is given to illustrate the effect of the proposed algorithm.

关键词： linear time-varying stabilization state constraints convex optimization