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Perspectives on new biomarkers in gastric cancer: Diagnostic and prognostic applications

World Journal of Gastroenterology 2014年第33期20卷 11574-11585页

作者： Danilo do Rosário Pinheiro Wallax Augusto Silva Ferreira Mariceli Baia Leo Barros Mariana Diniz Araújo Symara Rodrigues-Antunes Bárbara do Nascimento Borges Master Program of Animal Health and Production Federal Rural University of Amazonia Belém PA 66077-530 Brazil Molecular Biology Laboratory Biological Science Institute Federal University of Pará Belém PA 66075-110 Brazil center of agropecuary technology Socio-environmental and Hydric Resources Institute Federal Rural University of Amazonia Belém PA 66077-530 Brazil

Gastric cancer is considered one of the most deadly tumors worldwide. Even with the decline in its incidence, the mortality rate of this disease has remained high, mainly due to its late diagnosis and to the lack of precise prognostic markers. The main purpose of this review is to present genetic, epigenetic and proteomic molecular markers that may be used in a diagnostic and prognostic manner and to discuss the pros and cons of each type of marker for improving clinical practice. In this sense, we observed that the use of genetic markers, especially mutations and polymorphisms, should be carefully considered, as they are strongly affected by ethnicity. Proteomic-based markers show promise, but the higher costs of the associated techniques con-tinue to make this approach expensive for routine use. Alternatively, epigenetic markers appear to be very promising, as they can be detected in bodily fluids as well as tissues. However, such markers must be used carefully because epigenetic changes may occur due to environmental factors and aging. Despite the advances in technology and its access, to date, there are few defined biomarkers of prognostic and diagnostic use for gastric tumors. Therefore, the use of a panel of several approaches(genetic, epigenetic and proteomic) should be considered the best alternative for clinical practice.

关键词： Molecular markers Epigenetic Genetic Proteomic Dia

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Seed Vigor Variation of <i>Agave durangensis</i>Gentry (Agavaceae)

引用

American Journal of Plant Sciences 2013年第11期4卷 2227-2239页

作者： Gerardo Barriada-Bernal Norma Almaraz-Abarca Tzahyri Gallardo-Velázquez Isabel Torres-Morán Yolanda Herrera-Arrieta Socorro González-Elizondo Eli Amanda Delgado-Alvarado 1Interdisciplinary Research center for the Integral Regional Development Durango National Polytechnical Institute (CIIDIR IPN Durango) Durango México Interdisciplinary Research center for the Integral Regional Development Durango National Polytechnical Institute (CIIDIR IPN Durango) Durango México National School of Biological Sciences National Polytechnical Institute (ENCB IPN) México DF México University center of Biological and agropecuary Sciences University of Guadalajara (CUCBA) Zapopan México

Agave durangensis propagates basically by seeds. This species is economically important because it supports a mescal industry in Durango, Mexico. At present, its exploitation is overall by collecting plants from the wild populations. In order to reduce the negative impact of the collection in the natural populations of A. durangensis and to improve the mescal industry, it is necessary to establish plantations with selected seeds for a high vigor. In this paper, the variation in morphological features, physiological behavior of germination, and biochemical indicators of seed vigor among three natural populations of A. durangensis was assessed. Variation was found in the seed weight (0.68 to 1.15 mg/seed), seed dimensions (3.51 × 5.29 to 4.62 × 5.92 mm), germinability reduction at 15°°C related to 25°C (4% to 51%), germination rate at 25°C (44.0 to 48.5 seeds/day) and at 15°C (5.17 to 6.77 seeds/day), development reduction at 15°C related to 25°C (86.66% to 91.99%), levels of seed accumulated phenols (71 to 85 μg/seed), antioxidant potential (42% to 50% reduction of DPPH*), seed alcohol dehydrogenase activity (ADH) (180 to 1100 μmol NAD+/mg protein/min), highest ADH activity after imbibitions at 25°C (310.24 to 520.2 μmol NAD+/mg protein/min), and highest ADH activity after imbibitions at 15°C (170.74 to 440.71 μmol NAD+/mg protein/min). The variation in the seed vigor was revealed by a principal component analysis (PCA) based on all the parameters evaluated. PCA clearly discriminated among the three populations.

关键词： Agave Durangensis Seed Vigor Germinability Natural Variation

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