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Forthrightly monitoring ferroptosis induced by endoplasmic reticulum stresses through fluorescence lifetime imaging of microviscosity increases with a specific rotor

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Chinese Chemical Letters 2022年第5期33卷 2537-2540页

作者： Chuanhao Liu Lin Zhou Lijuan Xie Ying Zheng Huizi Man Yi Xiao Engineering research center of Molecular Medicine of Ministry of Education Key Laboratory of Fujian Molecular MedicineSchool of MedicineHuaqiao UniversityQuanzhou 362021China State Key Laboratory of fine chemicals Dalian University of TechnologyDalian 116024China

To test the hypothesis that the microviscosity changes of Endoplasmic Reticulum(ER)can be a useful indicator of ferroptosis promoted by ER Stresses(ERS),a new ER targeting viscosity rotor,L-Vis-1 was developed and applied in the quantitation of viscosity by FLIM imaging in live *** FLIM imag-ing exhibited an excellent resolution almost as good as the corresponding confocal imaging,more sig-nificantly,during ferroptosis processes promoted by different types of ERS,the viscosity increases were clearly monitored by FLIM of L-Vis-1 within ER,which has not been demonstrated before.

关键词： Ferroptosis Viscosity FLIM ERS Rotor

Different-shaped ligand mediating efficient structurally similar cage-to-cage transformation

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Chinese Chemical Letters 2023年第4期34卷 251-253页

作者： Jinkang Zhu Chunhui Li Xiuqin Li Qiaochun Wang Lei Zou Key Laboratory for Advanced Materials Joint International Research Laboratory of Precision Chemistry and Molecular EngineeringFeringa Nobel Prize Scientist Joint Research CenterFrontiers Science Center for Materiobiology and Dynamic ChemistryInstitute of Fine ChemicalsSchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China

The transformation of a Palladium-based metal-organic cage to a structurally similar one by direct ligand replacement usually leads to unwanted ligand scrambling. In this work, an intermediate ligand with different shape and basicity from the initial/final ones was introduced to avoid ligand scrambling to achieve the efficient indirect cage-to-similar-cage transformation. Compared with the direct transformation, the stepwise conversion has the advantages of high efficiency(93%) and simple workup.

关键词： Cage to cage transformation Ligand scrambling Ligand exchange Metal-organic cage M2L4

Light-driven interconversion of Pd_(2)L_(4)cage and mononuclear PdL_(2)mediated by the isomerization of azobenzene ligand

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Chinese Chemical Letters 2023年第6期34卷 358-361页

作者： Jinkang Zhu Xujin Chen Xin Jin Qiaochun Wang Key Laboratory for Advanced Materials Joint International Research Laboratory of Precision Chemistry and Molecular EngineeringFeringa Nobel Prize Scientist Joint Research CenterFrontiers Science Center for Materiobiology and Dynamic ChemistryInstitute of Fine ChemicalsSchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China

The lantern-shaped cage Pd_(2)L_(4)and tweezer-like PdL_(2)can be synthesized from the trans-and cis-isomer of an azobenzene-containing ligand,respectively,which were characterized by^(1)H,^(13)C,^(1)H-^(1)H COSY,DOSY NMR spectroscopies,high-resolution ESI-MS and density function theory(DFT)*** interconversion of Pd_(2)L_(4)and PdL_(2)can be achieved via the cis-trans isomerization of the azobenzene unit on the ligand upon alternative irradiation of light 365 nm or 420 nm.

关键词： Molecular cage Azobenzene Isomerization Pd_(2)L_(4) PdL_(2)

Clickable rhodamine spirolactam based spontaneously blinking probe for super-resolution imaging

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Chinese Chemical Letters 2021年第12期32卷 3862-3864页

作者： Zengjin Liu Ying Zheng Ting Xie Zihan Chen Zhenlong Huang Zhiwei Ye Yi Xiao Drug research center of Integrated Traditional Chinese and Western Medicine Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000China State Key Laboratory of fine chemicals Dalian University of TechnologyDalian 116024China

Spontaneously blinking probe, which switches between dark and bright state without UV or external additives, is extremely attractive in super resolution imaging of live cells. Herein, a clickable rhodamine spirolactam probe, Atto565-Tet, is rationally constructed for spontaneously blinking after biorthogonal labelling and successfully applied to super resolution imaging of mitochondria and lysosomes.

关键词： Super resolution imaging Spontaneously blinking pKa Rhodamine spirolactam

To gel or not to gel：A prior prediction of gelation in solvent mixtures

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Chinese Chemical Letters 2017年第4期28卷 771-776页

作者： Peng Lin Nan-Xiang Zhang Jing-Jing Li Jing Zhang Jia-Hui Liu Bao Zhang Jian Song School of Chemical Engineering and Technology Tianjin University Tianjin 300350 China The Co-innovation center of Chemistry and Ch-emicai Engineering of Tianjin Tianjin 300072 China Renai College of Tianjin University Tianjin 301636 China Tianjin Engineering research center of-Functional fine chemicals Tianjin 300072 China

The gelation behaviours of low molecular weight gelators 1,3：2,5：4.6-tris（3,4-dichlorobenzylidene）-Dmannitol（G1） and 2,4-（3.4-dichlorobenzylidene）-N-（3-aminopropyl）-D-gluconamide（G2） in 34 solvents have been *** found that sample dissolved at low concentrations may become a gel or precipitate at higher *** Hansen solubility parameters（HSPs） and a Teas plot were employed to correlate the gelation behaviours with solvent properties,but with no success if the concentration of the tests was not maintained ***,on the basis of the gelation results obtained for the G1 and G2 in single solvents,we studied the gelation behaviours of G1 and G2 in23 solvent mixtures and found that the tendency of a gelator to form a gel in mixed solvents is strongly correlated with its gelation behaviours in good *** the gelation occurs in a good solvent at higher concentrations,it will take place as well in a mixed solvent（the good solvent plus a poor solvent） at a certain volume *** contrast,if the gelator forms a precipitate in a good solvent at higher concentrations,no gelation is to be observed in the mixed solvents.A gelation rule for mixed solvents is thus proposed,which may facilitate decision making with regard to solvent selection for gel formation in the solvent mixtures in practical applications.

关键词： Gelation rule Prediction Solvent mixtures Concentration Good solvent Teas plot Aggregation mode

Molecularly near-infrared fluorescent theranostics for in vivo tracking tumor-specific chemotherapy

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Chinese Chemical Letters 2019年第10期30卷 1849-1855页

作者： Chenxu Yan Limin Shi Zhiqian Guo Weihong Zhu Key Laboratory for Advanced Materials and Joint International research Laboratory of Precision Chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research CenterShanghai Key Laboratory of Functional Materials ChemistryInstitute of Fine ChemicalsSchool of Chemistry and Molecular EngineeringEast China University of Science and Technology

Molecularly near-infrared(NIR) theranostics, combining in vivo sensing and tumor-specific therapeutic capability within one molecular system, have received considerable attention in recent years. Compared with the visible fluorescence imaging, NIR imaging(emission wavelength at 650–900 nm) possesses unique advantages including the minimum photodamage to biological samples, deep penetration, and low interference from auto-fluorescence. In over past decades, there has been an explosive development in the design of molecular imaging contrasts and imaging-guided therapeutics. In this review, we have sumarried the strategies of the NIR theranostics for imaging and tumor-specific chemotherapy applications in living systems. It is noted that the molecularly NIR theranostic design strategy could address current challenges of real-time in vivo sense-and-release for the intelligent biosensing and personalized treatment.

关键词： Near-infrared fluorescence Fluorescent probe Theranostic Prodrug Chemotherapy

Two 3-D Neutral Zn(Ⅱ)-MOFs Generated from the Asymmetric Schiff-base Ligand

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Chinese Journal of Structural Chemistry 2014年第9期33卷 1326-1332页

作者：吴祥雯张东吴振华马建平 College of Chemistry Chemical Engineering and Materials Science Key Laboratory of Molecular and Nano Probes Engineering Research Center of Pesticide and Medicine Intermediate Clean Production Ministry of Education Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals Shandong Normal University

Two new Zn（Ⅱ）-MOFs were synthesized based on an asymmetric Schiff-base ligand LH, which is obtained by the condensation of 5-formyl-8-hydroxyquinoline and 3-pyridinecar- boxylic acid hydrazide. In different mixed solvents, we get two new isomorphism compounds, [Zn（L）2]＇CaHsO2-2MeOH （1） and [Zn（L）2]＇CH2CIz＇2MeOH （2）. Compounds 1 and 2 have been characterized by single-crystal X-ray diffraction, elemental analysis and IR. Compound 1 crystallizes in monoclinic, space group P2/c, with a - 13.856（4）, b = 14.156（4）, c = 9.620（3）А, β = 110.167（5）°, V = 1771.3（9） /k3, Dc = 1.500 g/cm3, C3sH3sNsOsZn, Mr = 800.13, F（000） = 832, p（MoKa） = 0.761 mm-1, Z = 2, the final R = 0.0596 and wR = 0.1221 for 2112 observed reflections （I 〉 2σ（0）. Compound 2 belongs to monoclinic, space group P21/c, with a = 13.575（3）, b = 14.130（3）, c = 9.485（2） A, β = 107.908（3）°, V= 1731.2（6） A3, Dc = 1.529 g/cm3, CasH32C12NsO6Zn, Mr = 796.96, F（000） = 820, g（MoKa） = 0.926 mm-1, Z = 2, the final R -- 0.0527 and wR = 0.1395 for 2501 observed reflections （I 〉 2σ-（/））. The Zn（II） centers in both 1 and 2 display a distorted octahedral coordination geometry. The octahedral Zn（lI） nodes and L linkages build up 2-D nets consisting of parallelogram-like grids in the ab plane. The neighboring nets stack through hydrogen bonds to generate 3-D rhombic channels. In 1, the 1,4-dioxane and MeOH guests alternatively arrange in the channels and effectively take up the free space; while in 2, the CH2CI/guests are arranged in the channels. In addition, the encapsulated MeOH molecules are bonded to the framework by hydrogen bonds.

关键词： Zn(Ⅱ) isomorphism asymmetric Schiff-base ligand channels guests

Supramolecular self-assembling strategy for constructing cucurbit[6]uril derivative-based amorphous pure organic room-temperature phosphorescence complex featuring extra-high efficiency

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Chinese Chemical Letters 2022年第2期33卷 877-880页

作者： Chunhui Li Xiuqin Li Qiaochun Wang Key Laboratory for Advanced Materials Joint International Research Laboratory of Precision Chemistry and Molecular EngineeringFeringa Nobel Prize Scientist Joint Research CenterFrontiers Science Center for Materiobiology and Dynamic ChemistryInstitute of Fine ChemicalsSchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China

The preparation of amorphous pure organic room-temperature phosphorescence materials with high efficiency is still a challenging task. Herein, we introduce a CB[6] derivative-based supramolecular selfassembling strategy. A water soluble and ellipsoidal deformed CB[6] derivative is used to self-assemble with 4-(4-bromophenyl)-1-methylpyridin-1-ium chloride, bromide and hexafluorophosphate in water. After freeze-drying, the obtained amorphous complexes exhibit brilliant green phosphorescence emission under ambient conditions, with phosphorescence efficiency up to 59%, 60% and 72%, respectively. This is the first report of amorphous non-polymeric pure organic room-temperature phosphorescence with such a high efficiency. In view of the dynamic self-assembling property, the complexes are responsive to water,which could enable information encryption.

关键词： Room temperature phosphorescence Amorphous Cucurbituril Supramolecular self-assembling Heavy-atom effect

A two-photon mitotracker based on a naphthalimide fluorophore:Synthesis, photophysical properties and cell imaging

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Chinese Chemical Letters 2014年第7期25卷 1001-1005页

作者： Yong Dai Bao-Kuo Lv Xin-Fu Zhang Yi Xiao Department of Criminal Science and Technology Sichuan Police College State Key Laboratory of fine chemicals Dalian University of Technology Liaoning Water Environment Monitoring center Shenyang Branch

PAHPN. a naphthalimide-based mitotracker with reasonable two-photon excitation emission activity and polarity-sensitive fluorescence properties has been efficiently synthesized and studied in twophoton, co-localizatio... 详细信息

关键词： Mitotracker Mitochondria Namphthalimide Two-photon Fluorescence imaging