检索结果-南通市图书馆

Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder

Neural Regeneration Research 2025年第6期20卷 1541-1554页

作者： Jinmei Ye Cong Duan Jiaxin Han Jinrong Chen Ning Sun Yuan Li Tifei Yuan Daihui Peng Division of Mood Disorder Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Shanghai Key Laboratory of Psychotic Disorders Brain Health InstituteNational Center for Mental DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Co-Innovation center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release from stress-induced dysfunctional central nervous system mitochondria into peripheral circulation. This evidence supports the potential use of peripheral mitochondrial DNA as a neuroinflammatory biomarker for the diagnosis and treatment of major depressive disorder. Herein, we critically review the neuroinflammation theory in major depressive disorder, providing compelling evidence that mitochondrial DNA release acts as a critical biological substrate, and that it constitutes the neuroinflammatory disease pathway. After its release, mitochondrial DNA can be carried in the exosomes and transported to extracellular spaces in the central nervous system and peripheral circulation. Detectable exosomes render encaged mitochondrial DNA relatively stable. This mitochondrial DNA in peripheral circulation can thus be directly detected in clinical practice. These characteristics illustrate the potential for mitochondrial DNA to serve as an innovative clinical biomarker and molecular treatment target for major depressive disorder. This review also highlights the future potential value of clinical applications combining mitochondrial DNA with a panel of other biomarkers, to improve diagnostic precision in major depressive disorder.

关键词： biomarker cytokine exosomes inflammasome major depressive disorder microglia mitochondrial DNA mitochondrial dysfunction neuroinflammation Toll-like receptor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

AAV2-PDE6B restores retinal structure and function in the retinal degeneration 10 mouse model of retinitis pigmentosa by promoting phototransduction and inhibiting apoptosis

引用

Neural Regeneration Research 2025年第8期20卷 2408-2419页

作者： Ruiqi Qiu Mingzhu Yang Xiuxiu Jin Jingyang Liu Weiping Wang Xiaoli Zhang Jinfeng Han Bo Lei Henan Eye Hospital Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Eye Institute Henan Academy of Innovations in Medical ScienceZhengzhouHenan ProvinceChina Branch of National Clinical Research center for Ocular Disease Henan Provincial People’s HospitalZhengzhouHenan ProvinceChina Academy of Medical science Zhengzhou UniversityZhengzhouHenan ProvinceChina

Retinitis pigmentosa is a group of inherited diseases that lead to retinal degeneration and photoreceptor cell ***,there is no effective treatment for retinitis pigmentosa caused by PDE6B ***-associated virus(AAV)-mediated gene therapy is a promising strategy for treating retinitis *** aim of this study was to explore the molecular mechanisms by which AAV2-PDE6B rescues retinal *** do this,we injected retinal degeneration 10(rd10)mice subretinally with AAV2-PDE6B and assessed the therapeutic effects on retinal function and structure using dark-and light-adapted electroretinogram,optical coherence tomography,and ***-independent acquisition-mass spectrometry-based proteomic analysis was conducted to investigate protein expression levels and pathway enrichment,and the results from this analysis were verified by real-time polymerase chain reaction and western ***2-PDE6B injection significantly upregulated PDE6βexpression,preserved electroretinogram responses,and preserved outer nuclear layer thickness in rd10 *** expressed proteins between wild-type and rd10 mice were closely related to visual perception,and treating rd10 mice with AAV2-PDE6B restored differentially expressed protein expression to levels similar to those seen in wild-type *** Encyclopedia of Genes and Genome analysis showed that the differentially expressed proteins whose expression was most significantly altered by AAV2-PDE6B injection were enriched in phototransduction ***,the phototransductionrelated proteins Pde6α,Rom1,Rho,Aldh1a1,and Rbp1 exhibited opposite expression patterns in rd10 mice with or without AAV2-PDE6B ***,Bax/Bcl-2,p-ERK/ERK,and p-c-Fos/c-Fos expression levels decreased in rd10 mice following AAV2-PDE6B *** data suggest that AAV2-PDE6B-mediated gene therapy promotes phototransduction and inhibits apoptosis by inhibiting the ERK signaling pathway and upr

关键词： apoptosis AAV2-PDE6B ERK1/2 gene therapy phototransduction proteomics rd10 retinitis pigmentosa

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Regulation of graphdiyne-based nanozymes with enhanced oxidaselike activity by cobalt and nitrogen codoping

引用

Nano Research 2025年第1期18卷 21-29页

作者： Jiali Liu Xiaoli Wang Yongfu Lian Xue Wang Xiuxiu Wang Xingfa Gao Baoyun Sun Xihong Guo CAS Key Laboratory for Biomedical Effects of Nanomaterial&Nanosafety Institute of High Energy PhysicsChinese Academy of ScienceBeijing 100049China Key Laboratory of Functional Inorganic Material Chemistry Ministry of EducationSchool of Chemistry and Materials ScienceHeilongjiang UniversityHarbin 150080China Laboratory of Theoretical and Computational Nanoscience National Center for Nanoscience and TechnologyBeijing 100190China university of Chinese Academy of sciences Beijing 100049China

The development of nanozymes with excellent intrinsic oxidase-like activity and specificity has received increasing ***(GDY)could be a promising choice for designing nanozymes with enhanced oxidase(OXD)-like activity due to its unique structure and ***,Co-N-GDY with high OXD activity but no peroxidase(POD)activity was synthesized by codoping of cobalt(Co)and nitrogen(N)into GDY and compared with other GDY-based nanozymes(including GDY,Co-GDY,and N-GDY).Upon analyzing the doping effect of Co and N on the OXD-like and POD-like activities,we found that the combination of Co and N in GDY played a significant role in enhancing the OXD-like activity,and even reversed the POD-like activity of N-GDY to OXD-like activity of *** electrochemical experiment and the theoretical calculations provided an explanation for the mechanism and showed that the activity was closely linked to the reduction ability of O_(2) or H_(2)O_(2) on the nanozyme substrates,which was determined by the ratedetermining step of the catalytic reaction.

关键词： nanozymes oxidase-like activity graphdiyne heteroatom doping regulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A novel solution treatment and aging for powder bed fusion-laser beam Ti-6Al-2Sn-4Zr-6Mo alloy:Microstructural and mechanical characterization

引用

International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 414-424页

作者： Gianluca Pirro Alessandra Martucci Alessandro Morri Mariangela Lombardi Lorella Ceschini Department of Industrial Engineering(DIN) Alma Mater Studiorum-University of BolognaBologna 40136Italy Department of Applied science and Technology(DISAT) Politecnico di TorinoTorino TO 10129Italy

Ti-6Al-4Zr-2Sn-6Mo alloy is one of the most recent titanium alloys processed using powder bed fusion-laser beam(PBF-LB)*** alloy has the potential to replace Ti-6Al-4V in automotive and aerospace applications,given its superior mechanical properties,which are approximately 10%higher in terms of ultimate tensile strength(UTS)and yield strength after appropriate heat *** as-built conditions,the alloy is characterized by the presence of soft orthorhombicα″martensite,necessitating a postprocessing heat treatment to decompose this phase and enhance the mechanical properties of the ***,PBFed Ti6246 components undergo an annealing process that transforms theα″martensite into anα-βlamellar *** primary objective of this research was to develop a solution treatment and aging(STA)heat treatment tailored to the unique microstructure produced by the additive manufacturing process to achieve an ultrafine bilamellar microstructure reinforced by precipitation *** study investigated the effects of various solution temperatures in theα-βfield(ranging from 800 to 875℃),cooling media(air and water),and aging time to determine the optimal heat treatment parameters for achieving the desired bilamellar *** each heat treatment condition,differentα-βmicrostructures were found,varying in terms of theα/βratio and the size of the primaryα-phase *** attention was given to how these factors were influenced by increases in solution temperature and how microhardness correlated with the percentage of the metastableβphase present after *** tests were performed on samples subjected to the most promising heat treatment parameters.A comparison with literature data revealed that the optimized STA treatment enhanced hardness and UTS by13%and 23%,respectively,compared with those of the annealed *** surface analyses were conducted to investigate fracture mechanisms.

关键词： powder bed fusion-laser beam titanium alloys heat treatments mechanical properties fractographic analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Edge detection based multi-material interface extraction on industrial CT volumes

引用

science China(Information sciences) 2013年第9期56卷 74-82页

作者： OHTAKE Yutaka SUZUKI Hiromasa Research center for Advanced science and Technology The University of Tokyo

X-ray CT scanning is recently becoming a popular technology for industrial applications as well as medical ones. Since the geometrical accuracy is often important for industrial applications, more precise methods for processing CT volumes are required. This paper proposes a method for extracting the multimaterial interfaces on CT volumes obtained by industrial CT scanners. Instead of extracting isosurfaces we detect edge-points, at which the norm of the volume gradient takes a local maximum in the gradient direction, and then interpolate the points as the material interfaces represented by the zero-level of compounded implicit functions. In order to achieve a robust material-identification, multilabel graph-cut is utilized in our method. Using edge-points, we can reduce the inaccuracy caused by CT scanning artifacts.

关键词： CT volume multi-material interface segmentation edge extraction

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Observation of Central Toroidal Rotation Induced by ICRF on EAST

引用

Plasma science and Technology 2016年第2期18卷 114-119页

作者：潘夏云王福地张新军吕波陈俊李颖颖符佳石跃江余羿叶民友万宝年 School of nuclear science and Technology University of Science and Technology of China Institute of Plasma Physics Chinese Academy of Sciences Hefei science center Chinese Academy of Sciences Department of nuclear Engineering Seoul National University

Core plasma rotation of both L-mode and H-mode discharges with ion cyclotron range of frequency（ICRF） minority heating（MH） scheme was measured with a tangential X-ray imaging crystal spectrometer on EAST（Experimental Advanced Superconducting Tokamak）.Cocurrent central impurity toroidal rotation change was observed in ICRF-heated L-and H-mode *** increment as high as 30 km/s was generated at ~1.7 MW ICRF *** results showed similar trend as the Rice scaling but with significant scattering,especially in L-mode *** varied the plasma current,toroidal field and magnetic configuration individually to study their effect on L-mode plasma rotation,while keeping the other major plasma parameters and heating unchanged during the *** was found that larger plasma current could induce plasma rotation more efficiently.A scan of the toroidal magnetic field indicated that the largest rotation was obtained for on-axis ICRF heating.A comparison between lower-single-null（LSN）and double-null（DN） configurations showed that LSN discharges rendered a larger rotation change for the same power input and plasma parameters.

关键词： central toroidal rotation ICRF flow drive minority heating X-ray imaging crystal spectrometer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

“Slope-adsorption & plateau-pore filling” mechanism unlocking the potential of hard carbon anodes for “fast-charging & large-sized”batteries

引用

science China Materials 2025年第1期 309-311页

作者： Tian Liang Xiaoming Zhu Hubei Key Laboratory of Radiation Chemistry and Functional Materials School of Nuclear Technology and Chemistry & Biology Hubei University of Science and Technology

To date, there has been no report on fast-charging and Ahlevel sodium-ion batteries (SIBs) by utilizing thick hard carbon anodes that demonstrate prolonged cycling life and high areal capacity at high rates. Further, the relationship among the complex structure of hard carbon, storage mechanism, and fastcharging performance in alkali-metal ion batteries has been a subject of ongoing debate [1,2].

关键词：

来源：

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Feature-aware regularization for sparse online learning

引用

science China(Information sciences) 2014年第5期57卷 65-85页

作者： OIWA Hidekazu MATSUSHIMA Shin NAKAGAWA Hiroshi Graduate School of Information science and Technology The University of Tokyo Information Technology center The University of Tokyo

Learning a compact predictive model in an online setting has recently gained a great deal of *** combination of online learning with sparsity-inducing regularization enables faster learning with a smaller memory space than the previous learning *** optimization methods and learning algorithms have been developed on the basis of online learning with L1-regularization.L1-regularization tends to truncate some types of parameters,such as those that rarely occur or have a small range of values,unless they are emphasized in ***,the inclusion of a pre-processing step would make it very difficult to preserve the advantages of online *** propose a new regularization framework for sparse online *** focus on regularization terms,and we enhance the state-of-the-art regularization approach by integrating information on all previous subgradients of the loss function into a regularization *** resulting algorithms enable online learning to adjust the intensity of each feature’s truncations without pre-processing and eventually eliminate the bias of *** show theoretical properties of our framework,the computational complexity and upper bound of *** demonstrated that our algorithms outperformed previous methods in many classification tasks.

关键词： online learning supervised learning sparsity-inducing regularization feature selection sentiment analysis

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Deuterium depth distribution study in Yb

引用

Chinese Physics C 2017年第5期41卷 104-108页

作者：关兴彩路咏凯何厚军赵江涛王强方开洪蒙萱王铁山 Jirohta Kasagi School of nuclear science and Technology Lanzhou University Research center for Electron Photon science Tohoku University

The deuterium depth distribution for a 20 keV/D D_3~＋beam implanted into ytterbium（Yb） at a temperature between 300 and 340 K was studied using the D（d,p）T *** analyzing the proton yields,the deuterium depth distribution from the front surface to 500 nm depth was *** results indicate that an equilibrium deuterium distribution region from the front surface to a depth approximately equal to the mean range of implanted deuterons was formed in Yb during the *** deduced deuterium concentration in the equilibrium deuterium distribution region was D/Yb = 22%.

关键词： proton implanted implantation isotopes deduced saturated saturation details nuclei transformed

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Structure and electrochemical performance of delafossite AgFeO_(2)nanoparticles for supercapacitor electrodes

引用

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 201-213页

作者： Choulong Veann Thongsuk Sichumsaeng Ornuma Kalawa Narong Chanlek Pinit Kidkhunthod Santi Maensiri School of Physics Institute of ScienceSuranaree University of TechnologyNakhon Ratchasima 30000Thailand SUT center of Excellence on Advanced Functional Materials Suranaree University of TechnologyNakhon Ratchasima 30000Thailand Synchrotron Light Research Institute Nakhon Ratchasima 30000Thailand Department of Physics Universitas Negeri MalangMalang 65145Indonesia

Delafossite AgFeO_(2)nanoparticles with a mixture of 2H and 3R phases were successfully fabricated by using a simple co-precipitation *** resulting precursor was calcined at temperatures of 100,200,300,400,and 500℃to obtain the delafossite AgFe0_(2)*** morphology and microstructure of the prepared AgFeO_(2)samples were characterized by using field emission scanning electron microscopy(FESEM),transmission electron microscopy(TEM),N_(2) adsorption/desorption,X-ray absorption spectroscopy(XAS),and Xray photoelectron spectroscopy(XPS)techniques.A three-electrode system was employed to investigate the electrochemical properties of the delafossite AgFeO_(2)nanoparticles in a 3 M KOH *** delafossite AgFeO_(2)nanoparticles calcined at 100℃(AFO100)exhibited the highest surface area of 28.02 m^(2)·g^(-1)and outstanding electrochemical performance with specific capacitances of 229.71 F·g^(-1)at a current density of 1 A·g^(-1)and 358.32 F·g^(-1)at a scan rate of 2 mV·s^(-1).This sample also demonstrated the capacitance retention of 82.99% after 1000 charge/discharge cycles,along with superior specific power and specific energy values of 797.46 W·kg^(-1)and 72.74Wh·kg^(-1),*** findings indicate that delafossite AgFeO_(2)has great potential as an electrode material for supercapacitor applications.

关键词： nanoparticles delafossite electrochemical properties X-ray absorption spectroscopy co-precipitation supercapacitor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：