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Congenital Disseminated Pyogenic Granuloma:A Case With Numerous Mucocutaneous and Visceral Lesions

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Maternal-Fetal Medicine 2024年第3期6卷 190-195页

作者： Siavash Ghaderi-Sohi Behnaz Moradi Mahboobeh Shirazi Rahil Rahimi Romina Ravanbakhsh Ariana Kariminejad Elham Feizabad Kariminejad-Najmabadi Pathology&Genetics center Tehran ***Iran Department of Radiology Advanced Diagnostic and Interventional Radiology Research Center(ADIR)Tehran University of Medical SciencesTehran ***Iran Yas Complex Hospital Tehran University of Medical SciencesTehran ***Iran Nikan Hospital Tehran ***Iran

Congenital disseminated pyogenic granuloma(CDPG)is characterized by eruptive disseminated or localized lesions,which may arise spontaneously or secondary to predisposing *** rarer is the occurrence of CDPG with numerous lesions affecting variable organs,which develop during the fetal *** report describes the case of a 32-week-old fetus presenting with severe hydrocephalus and vascular intracranial and right lung masses on magnetic resonance *** labor occurred at the 32^(nd)week due to preterm premature rupture of membranes,and the newborn died due to cardiac dysfunction within 2 hours *** subsequent autopsy revealed multiple violaceous to dark red papules,nodules,pedunculated and un-pedunculated mucocutaneous masses,as well as two brain lesions,a lung lesion,a thoracic wall intramuscular mass,and a pyloric *** examination and immunohistochemical evaluation for glucose transporter 1(GLUT1)confirmed the diagnosis of *** represents a rare condition with an elusive etiology and limited reports in the *** diagnosis from multifocal infantile hemangioma,based on GLUT1 negativity of CDPG,is imperative due to differing clinical course and treatment *** report underscores a severe case of CDPG characterized by preterm labor and demise shortly after delivery,notable for its extensive involvement across multiple organs,including the brain,lung,intestine,musculoskeletal system,mucosal,and numerous cutaneous sites.

关键词： Pyogenic Granuloma Congenital Hemangioma

Instrumented assisted soft tissue mobilization vs extracorporeal shock wave therapy in treatment of myofascial pain syndrome

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World Journal of Orthopedics 2023年第7期14卷 572-581页

作者： Nourhan Elsayed Shamseldeen Mohammed Moustafa Aldosouki Hegazy Nadia Abdalazeem Fayaz Nesreen Fawzy Mahmoud Department of Physical Therapy for musculoskeletal Disorders&Its surgery Faculty of Physical TherapyCairo UniversityCairo 14531Egypt

BACKGROUND Active myofascial trigger points(TrPs)often occur in the upper region of the upper trapezius(UT)*** TrPs can be a significant source of neck,shoulder,and upper back pain and *** TrPs and their related pain and disability can adversely affect an individual’s everyday routine functioning,work-related productivity,and general quality of *** To investigate the effects of instrument assisted soft tissue mobilization(IASTM)vs extracorporeal shock wave therapy(ESWT)on the TrPs of the UT *** A randomized,single-blind,comparative clinical study was conducted at the Medical center of the Egyptian Railway Station in *** patients(28 females and 12 males),aged between 20-years-old and 40-years-old,with active myofascial TrPs in the UT muscle were randomly assigned to two equal groups(A and B).Group A received IASTM,while group B received *** group was treated twice weekly for 2 *** groups received muscle energy technique for the UT *** were evaluated twice(pre-and posttreatment)for pain intensity using the visual analogue scale and for pain pressure threshold(PPT)using a pressure *** Comparing the pre-and post-treatment mean values for all variables for group A,there were significant differences in pain intensity for TrP1 and TrP2(P=0.0001)and PPT for TrP1(P=0.0002)and TrP2(P=0.0001).Also,for group B,there were significant differences between the pre-and post-treatment pain intensity for TrP1 and TrP2 and PPT for TrP1 and TrP2(P=0.0001).There were no significant differences between the two groups in the post-treatment mean values of pain intensity for TrP1(P=0.9)and TrP2(P=0.76)and PPT for TrP1(P=0.09)and for TrP2(P=0.91).CONCLUSION IASTM and ESWT are effective methods for improving pain and PPT in patients with UT muscle *** is no significant difference between either treatment method.

关键词： Myofascial trigger points Upper trapezius muscle Instrument-assisted soft tissue mobilization Extracorporeal shock wave therapy Myofascial pain syndrome

Long-term outcomes of the four-corner fusion of the wrist:A systematic review

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World Journal of Orthopedics 2022年第1期13卷 112-121页

作者： Octavian Andronic Ladislav Nagy Marco D Burkhard Fabio A Casari Daniel Karczewski Philipp Kriechling Andreas Schweizer Lukas Jud Department of Orthopaedics Balgrist University HospitalUniversity of ZürichSwitzerlandZürich 8008Switzerland Department of Trauma and Orthopaedics CharitèUniversity Medicine BerlinCenter for Musculoskeletal SurgeryBerlin 10117Germany

BACKGROUND Four-corner fusion(4CF)is a motion sparing salvage procedure that is used to treat osteoarthritis secondary to advanced scapholunate collapse or longstanding scaphoid nonunion advanced *** is known about the long-term survivorship and outcomes of *** To report on clinical and functional long-term outcomes as well as conversion rates to total wrist fusion or *** The systematic review protocol was registered in the international prospective register of systematic reviews(PROSPERO)and followed the PRISMA *** articles were screened using four different *** with a minimum Level IV of evidence that reported on long-term outcome after 4CF with a minimum follow-up of 5 years were *** assessment was performed using the Methodological Index for Non-Randomized Studies *** A total of 11 studies including 436 wrists with a mean follow-up of 11±4 years(range:6-18 years)was *** assessment according to Methodological Index for Non-Randomized Studies criteria tool averaged 69%±11%(range:50%-87%).Fusion rate could be extracted from 9/11 studies and averaged 91%.Patient-reported outcomes were extracted at last follow-up from 8 studies with an average visual analog scale of 1±1(range:0-2)and across 9 studies with an average Disabilities of the Arm,Shoulder and Hand score of 21±8(range:8-37).At last follow-up,the cumulative conversion rate to total wrist fusion averaged 6%.There were no conversions to total wrist *** The 4CF of the wrist is a reliable surgical technique,capable of achieving a good long-term patient satisfaction and survivorship with low rates of conversion to total wrist fusion.

关键词： Four-corner fusion Partial wrist arthrodesis Midcarpal arthrodesis Scapholunate collapse wrist Scaphoid nonunion advanced collapse Scaphoid nonunion

Systemic IL-27 administration prevents abscess formation and osteolysis via local neutrophil recruitment and activation

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Bone Research 2022年第4期10卷 826-837页

作者： Yugo Morita Motoo Saito Javier Rangel-Moreno Anthony M.Franchini John R.Owen John C.Martinez John L.Daiss Karen L.de Mesy Bentley Stephen L.Kates Edward M.Schwarz Gowrishankar Muthukrishnan center for musculoskeletal Research University of Rochester Medical CenterRochesterNYUSA Division of Allergy Immunology and RheumatologyDepartment of MedicineUniversity of Rochester Medical CenterRochesterNYUSA Department of Environmental Medicine University of Rochester School of Medicine and DentistryRochesterNYUSA Department of Orthopedic surgery Virginia Commonwealth UniversityRichmondVAUSA Department of Orthopedics University of Rochester Medical CenterRochesterNYUSA Department of Pathology and Laboratory Medicine University of Rochester Medical CenterRochesterNYUSA

Interleukin-27 is a pleiotropic cytokine whose functions during bacterial infections remain controversial,and its role in patients with *** osteomyelitis is *** address this knowledge gap,we completed a clinical study and observed elevated serum IL-27 levels(20-fold higher,P<0.05)in patients compared with healthy ***,IL-27 serum levels were 60-fold higher in patients immediately following septic death than in uninfected patients(P<0.05),suggesting a pathogenic role of *** test this hypothesis,we evaluated *** osteomyelitis in WT and IL-27Rα^(−/−)mice with and without exogenous IL27 induction by intramuscular injection of rAAV-IL-27p28 or rAAV-GFP,*** found that IL-27 was induced at the surgical site within 1 day of *** infection of bone and was expressed by M0,M1 and M2 macrophages and osteoblasts but not by ***,exogenous IL-27p28(~2 ng·mL^(−1) in serum)delivery ameliorated soft tissue abscesses and periimplant bone loss during infection,accompanied by enhanced local IL-27 expression,significant accumulation of RORγt^(+)neutrophils at the infection site,a decrease in RANK^(+) cells,and compromised osteoclast *** effects were not observed in IL-27Rα^(−/−)mice compared with WT mice,suggesting that IL-27 is dispensable for immunity but mediates redundant immune and bone cell functions during *** vitro studies and bulk RNA-seq of infected tibiae showed that IL-27 increased nos1,nos2,il17α,il17f,and rorc expression but did not directly stimulate ***,these results identify a novel phenomenon of IL-27 expression by osteoblasts immediately following *** infection of bone and suggest a protective role of systemic IL-27 in osteomyelitis.

关键词： abscess protective immunity

Estimating the Effects of the COVID-19 Outbreak on the Decreasing Number of Acquired Immune Deficiency Syndrome Cases and Epidemiological Trends in China

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Biomedical and Environmental Sciences 2022年第2期35卷 141-145页

作者： LI Yan Yan DING Wen Hao BAI Yi Chun WANG Lei WANG Yong Bin Department of Epidemiology and Health Statistics School of Public HealthXinxiang Medical UniversityXinxiangHenanChina center for musculoskeletal surgery Charité-Universitätsmedizin BerlinCorporate Member of Freie Universität BerlinHumboldt-Universität Zu Berlin and Berlin Institute of HealthBerlinGermany

Since the first case of acquired immune deficiency syndrome(AIDS)was detected in the United States in 1981,this disease has spread to every corner of the *** the annual incidence of AIDS showing a slight decline since 1997,it remains a major cause of infectious disease-related death *** global epidemiological trends,the number of notified AIDS cases has increased in recent years in China[1].Moreover,among the class B notifiable infectious diseases,AIDS was responsible for the highest mortality rate from 2008 to 2019,still failing to be identified as a vaccine-preventable disease[1].Thus,to provide more unambiguous and quantitative direction for the effective formulation of preventive planning strategies and for the reasonable allocation of limited resources,a forecasting model with high precision and accuracy to understand the future epidemic behaviors of AIDS is *** the model-building process,accurate statistics are vital to ensure the forecasting accuracy of the model.

关键词： forecasting spite formulation

Outcomes after arthroscopic repair of rotator cuff tears in the setting of mild to moderate glenohumeral osteoarthritis

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World Journal of Orthopedics 2022年第7期13卷 631-643页

作者： Ian S Hong Allison J Rao Tyler L CarlLee Joshua D Meade Daniel J Hurwit Gregory Scarola David P Trofa Shadley C Schiffern Nady Hamid Patrick M Connor James E Fleischli Bryan Michael Saltzman Department of Orthopedic surgery Atrium Health Musculoskeletal InstituteCharlotteNC 28207United States Department of Sports Medicine Orthocarolina Research InstituteCharlotteNC 28207United States Department of Orthopedic surgery Columbia University Irving Medical CenterNew York CityNY 10032United States Department of Orthopaedic surgery Carolinas Medical CenterCharlotteNC 28207United States Department of Orthopedic surgery OrthoCarolina Sports Medicine CenterCharlotteNC 28207United States

BACKGROUND Rotator cuff pathology is a very common source of shoulder ***,osteoarthritis of the glenohumeral joint can cause shoulder pain and produce similar *** management can be indicated for both pathologies,however,outcomes data is limited when examining rotator cuff repair(RCR) in the setting of glenohumeral arthritis(GHOA).Thus,this study sought to determine outcomes for patients who undergo RCR in the setting of *** To evaluate if a relationship exists between outcomes of RCR in the setting of *** This was a retrospective analysis of patients who underwent arthroscopic rotator cuff repair with concurrent glenohumeral osteoarthritis between *** were stratified based on rotator cuff tear size and glenohumeral osteoarthritis *** were paired 1:1 with patients without glenohumeral *** included had a minimum two year *** of conversion to total shoulder arthroplasty,complication rates following initial surgery,and patient-reported outcome measures were *** A total of 142 patients were *** number of patients that required total shoulder arthroplasty within two years after index surgery was low.2/71(2.8%) patients with GHOA,and 1/71(1.4%) without *** rotator cuff repair,both groups showed favorable patientreported *** Patients with glenohumeral osteoarthritis who underwent arthroscopic rotator cuff repair showed comparable outcomes to patients without glenohumeral osteoarthritis.

关键词： Rotator cuff repair Rotator cuff tear Glenohumeral osteoarthritis Shoulder Arthroscopic Outcomes

Now-and Fore-casting the Secular Epidemiological Trends and Seasonality of the Comeback of Scarlet Fever in China:A 16-year Time Series Analysis

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Biomedical and Environmental Sciences 2022年第6期35卷 563-567页

作者： WANG Yong Bin LI Yan Yan LU Hao TAO Ying Jun LI Yu Hong WANG Lei LIANG Wen Juan Department of Epidemiology and Health Statistics School of Public HealthXinxiang Medical UniversityXinxiang 453003HenanChina National center for Tuberculosis Control and Prevention China Center for Disease Control and PreventionBeijing 102206China center for musculoskeletal surgery Charité-Universitätsmedizin BerlinCorporate Member of Freie Universität BerlinHumboldt-Universität Zu Berlin and Berlin Institute of HealthBerlinGermany

Scarlet fever(SF)is a common communicable disease that results from group A Streptococcus(GAS)infections[1].SF accounted for the global loss of life among children 5–15 years of age in the 18th and 19th centuries[2].A rapid reduction in SF morbidity and mortality occurred due to the scale-up of effective antibiotics and improvements in sanitation and nutrition[3].The unexpected increase in the incidence of SF has attracted a renewed interest in infectious diseases[3].Because the triggers that cause SF outbreaks are not fully understood and there is a scarcity of available vaccines protecting susceptible populations from GAS infections,effective prevention and control plans are required to stop the continued spread of SF.

关键词： prevention mortality continued

Advancing drug delivery to articular cartilage:From single to multiple strategies

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药学学报:英文版 2023年第10期13卷 4127-4148页

作者： Tianyuan Zhao Xu Li Hao Li Haoyuan Deng Jianwei Li Zhen Yang Songlin He Shuangpeng Jiang Xiang Sui Quanyi Guo Shuyun Liu Institute of Orthopedics The First Medical CenterChinese PLA General HospitalBeijing Key Lab of Regenerative Medicine in OrthopedicsKey Laboratory of Musculoskeletal Trauma&War Injuries PLABeijing 100853China School of Medicine Nankai UniversityTianjin 300071China musculoskeletal Research Laboratory Department of Orthopedics&TraumatologyThe Chinese University of Hong Kong999077Hong KongChina Arthritis Clinic&Research center Peking University People’s HospitalPeking UniversityBeijing 100044China Department of Joint surgery Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

Articular cartilage(AC) injuries often lead to cartilage degeneration and may ultimately result in osteoarthritis(OA) due to the limited self-repair ability. To date, numerous intra-articular delivery systems carrying various therapeutic agents have been developed to improve therapeutic localization and retention, optimize controlled drug release profiles and target different pathological processes. Due to the complex and multifactorial characteristics of cartilage injury pathology and heterogeneity of the cartilage structure deposited within a dense matrix, delivery systems loaded with a single therapeutic agent are hindered from reaching multiple targets in a spatiotemporal matched manner and thus fail to mimic the natural processes of biosynthesis, compromising the goal of full cartilage regeneration. Emerging evidence highlights the importance of sequential delivery strategies targeting multiple pathological processes. In this review, we first summarize the current status and progress achieved in single-drug delivery strategies for the treatment of AC diseases. Subsequently, we focus mainly on advances in multiple drug delivery applications, including sequential release formulations targeting various pathological processes, synergistic targeting of the same pathological process, the spatial distribution in multiple tissues, and heterogeneous regeneration. We hope that this review will inspire the rational design of intraarticular drug delivery systems(DDSs) in the future.

关键词： Drug delivery systems Articular cartilage Cartilage injury Osteoarthritis Cartilage regeneration Multiple drug delivery strategy Biomaterials Therapeutic factors

Analysis of Intelligent Equipment Usage for Work-Related musculoskeletal Disorders Prevention in Miners—Shanxi Province,China,2023

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China CDC weekly 2024年第34期6卷 862-866页

作者： Haimiao Yu Zepeng Xu Ying Xia Shuo Zhang Xiaoting Jia School of Economics and Management China University of Mining and TechnologyXuzhouJiangsu ProvinceChina Administrators Training center National Health Commission of the People’s Republic of ChinaBeijingChina

Summary What is already known about this topic?Work-related musculoskeletal disorders(WMSDs)are prevalent in the workforce and occur across various *** show that the prevalence of WMSDs among miners is generally over 50%.What is added by this report?High levels of intelligent equipment usage(IEU)can decrease the prevalence of WMSDs among miners by 7.49%and reduce pain by 13.69%on average.

关键词： WMS Work skeletal