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Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan Choi Soo-Ho Choi Keun-Young Kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National center for microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

High strength and ductility of titanium matrix composites by nanoscale design in selective laser melting

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Journal of Materials Science & Technology 2022年第23期118卷 114-127页

作者： Joseph A.Otte Jin Zou Matthew S.Dargusch School of Mechanical and Mining Engineering The University of QueenslandBrisbaneQLD 4072Australia center for microscopy and microanalysis The University of QueenslandBrisbaneQLD 4072Australia

The use of selective laser melting(SLM)to produce titanium matrix composites(TMCs)with high strength while retaining sufficient tensile ductility suitable for structural applications is emerging as an attractive opportunity in the field of advanced ***,the presence of coarse ceramic reinforcements as well as difficulties in optimizing the SLM process is a barrier to the application of *** this study,we demonstrated the production of TMCs reinforced with in situ high aspect ratio Ti B nanowhiskers by selective laser melting using nanosized BN powder *** Ti with 2.5 vol.%nanosized BN powder showed promise for producing high performance TMCs with retained *** acted to produce Ti B nanowhiskers with diameter<50 ***,by controlling post process furnace annealing Ti B retained a low diameter but exhibited a high aspect ratio,up to *** addition to Ti B refinement,nanosized BN addition promoted grain refinement during SLM,both acting as a solute to induce nucleation events and,as Ti B is formed,providing nucleation sites leading to an ultrafine grain structure in as printed samples and after *** produced TMCs exhibit high tensile yield strength,up to1392 MPa,while retaining tensile ductility up to 10%.This study has shown how nanoscale design in powder bed fusion additive manufacturing techniques can be used to produce high performance TMCs through a combination of refined grain structure and high aspect ratio Ti B leading to TMCs with significant improvement in strength,isotropic properties and retained tensile ductility.

关键词： Additive manufacturing Selective laser melting Metal matrix composite Mechanical properties Nanostructure Nanowires

Unlocking the ultrastructure of colorectal cancer cells in vitro using selective staining

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World Journal of Gastroenterology 2010年第22期16卷 2743-2753页

作者： Joanna M Biazik Kristina A Jahn Filip Braet Australian Key Centre for microscopy and microanalysis Madsen Building F09 The University of Sydney

AIM: To characterise differences between three widely used colorectal cancer cell lines using ultrastructural selective staining for glycogen to determine variation in metastatic properties. METHODS: Transmission electron microscopy was used in this investigation to help identify intracellular structures and morphological features which are precursors of tumor invasion. In addition to morphological markers, we used selective staining of glycogen as a marker for neoplastic cellular proliferation and determined whether levels of glycogen change between the three different cell lines. RESULTS: Ultrastructural analysis revealed morphological differences between the cell lines, as well as differentiation into two sub-populations within each cell line. Caco-2 cells contained large glycogen deposits as well as showing the most obvious morphological changes between the two sub-populations. SW480 cells also contained large glycogen stores as well as deep cellular protrusions when grown on porous filter membranes. HT-29 cells had trace amounts of glycogen stores with few cellular projections into the filter pores and no tight junction ***: Morphology indicative of metastatic properties coincided with larger glycogen deposits, providing strong evidence for the use of selective staining to determine the neoplastic properties of cells.

关键词： Cancer Colorectal Electron microscopy Glycogen Potassium ferrocyanide

Activating AIN thin film by introducing Co nanoparticles as a new anode material for thin-film lithium batteries

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Rare Metals 2018年第8期37卷 625-632页

作者： Zhong Yan Xiao-Ye Niu Xiao-Qin Du Qin-Chao Wang Xiao-Jing Wu Yong-Ning Zhou Department of Materials Science National Microanalysis CenterFudan University

A1N/Co nanocomposite thin films were fabricated by pulsed laser deposition and investigated as new anode materials for lithium-ion batteries for the first time. The combination of electrochemically inactive A1N and Co in nanometer scale boosted the electrochemical performance of the thin films surprisingly. A high reversible capacity of 555 mAh.g^-1 after 100 discharge-charge cycles at a current density of 500 mA.g^-1 is obtained for the A1N/Co nanocomposite thin films, and 372 mAh.g^-1 can be retained at a high rate up to 16C, exhibiting promising cycle stability and rate capability. The electrochemical reaction mechanism study reveals that Co nanoparticles could not only provide high electronic conductivity for the thin films, which facilitate the thorough decomposition of A1N in the initial discharge process, but also react with Li3N to form a new species CozN during charge process, thus ensuring large capacity and high reversibility of A1N/Co nanocomposite thin films in sub- sequent cycles. This study provides a new perspective to design advanced electrode materials for lithium-ion batteries.

关键词： Lithium-ion battery Anode material Thinfilm Aluminum nitride Pulsed laser deposition

Crystallization behavior of Ni_(54)Mn_(25.1)Ga_(20.9) ferromagnetic shape memory thin film

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Rare Metals 2007年第S1期26卷 139-142页

作者： MARTIN Saunders Centre for microscopy and microanalysis University of Western AustraliaNedlandsW.A.6009Australia

NiMnGaferromagnetic shape memory thin film was deposited onto Al foil using *** sputtering *** crystallization behavior of the film was investigated by XRD and *** activation energy of crystallization of the film was calculated by Kissinger’s *** results show that the crystallization temperature of NiMnGafree-standing thin film in martensite state is 372 ℃,and the activation energy of crystallization is about 191.9 kJ·mol-1.

关键词： Ni-Mn-Ga ferromagnetic shape memory alloys thin films crystallization

Compositional design and microstructure analysis of Zr-based bulk metallic glasses

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中国有色金属学会会刊：英文版 2007年第6期17卷 1433-1440页

作者：严明邹进沈军孙剑飞 School of Materials Science and Engineering Harbin Institute of Technology School of Engineering and Centre for microscopy and microanalysis University of Queensland QLD 4072 Australia

The systematical studies of Zr-based BMGs were summarized in terms of their compositional design and their structural characterization. In particular, several key issues of BMG materials were focused, including initial alloy design and subsequent composition optimization, solidification microstructure characterization and crystallization process specification. The results show that a compositional designing approach is successfully developed and, through extensive microstructure characterization using transmission electron microscopy, several new crystalline phases are discovered in these newly developed Zr-based BMG alloys. Crystallization behavior of Zr-based BMG is also determined based on the microstructure analysis.

关键词：金属玻璃微观结构凝固结晶

The role of aluminium in the preservation of microbial biosignatures

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Geoscience Frontiers 2019年第3期10卷 1125-1138页

作者： Alan Levett Emma J.Gagen Hui Diao Paul Guagliardo Llew Rintoul Anat Paz Paulo M.Vasconcelos Gordon Southam School of Earth and Environmental Sciences University of Queensland Centre for microscopy and microanalysis University of Queensland Centre for microscopy Characterisation and Analysis University of Western Australia School of Chemistry Physics & Mechanical EngineeringQueensland University of Technology

Demonstrating the biogenicity of presumptive microfossils in the geological record often requires supporting chemical signatures, including isotopic signatures. Understanding the mechanisms that promote the preservation of microbial biosignatures associated with microfossils is fundamental to unravelling the palaeomicrobiological history of the material. Organomineralization of microorganisms is likely to represent the first stages of microbial fossilisation and has been hypothesised to prevent the autolytic degradation of microbial cell envelope structures. In the present study, two distinct fossilisation textures(permineralised microfossils and iron oxide encrusted cell envelopes)identified throughout iron-rich rock samples were analysed using nanoscale secondary ion mass spectrometry(NanoSIMS). In this system, aluminium is enriched around the permineralised microfossils, while iron is enriched within the intracellularly, within distinct cell envelopes. Remarkably,while cell wall structures are indicated, carbon and nitrogen biosignatures are not preserved with permineralised microfossils. Therefore, the enrichment of aluminium, delineating these microfossils appears to have been critical to their structural preservation in this iron-rich environment. In contrast,NanoSIMS analysis of mineral encrusted cell envelopes reveals that preserved carbon and nitrogen biosignatures are associated with the cell envelope structures of these microfossils. Interestingly, iron is depleted in regions where carbon and nitrogen are preserved. In contrast aluminium appears to be slightly enriched in regions associated with remnant cell envelope structures. The correlation of aluminium with carbon and nitrogen biosignatures suggests the complexation of aluminium with preserved cell envelope structures before or immediately after cell death may have inactivated autolytic activity preventing the rapid breakdown of these organic, macromolecular ***, these results highlig

关键词： Aluminium Microfossils Biosignatures NanoSIMS Organomineralisation

Tribological behaviour of fused deposition modelling printed short carbon fibre reinforced nylon composites with surface textures under dry and water lubricated conditions

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Friction 2022年第12期10卷 2045-2058页

作者： Ming LUO Siyu HUANG Ziyan MAN Julie M.CAIRNEY Li CHANG School of Aerospace Mechanical and Mechatronic EngineeringThe University of SydneySydney NSW 2006Australia Australian Centre for microscopy and microanalysis The University of SydneySydney NSW 2006Australia

Fused deposition modelling(FDM)printed short carbon fibre reinforced nylon(SCFRN)composites were *** friction and wear behaviour of printed materials were systematically investigated under both dry sliding and water lubricated *** results showed that with short fibre enhancements,the printed SCFRN achieved a lower friction coefficient and higher wear resistance than nylon under all tested ***,under water lubricated conditions,the printed SCFRN exhibited a low,stable friction coefficient due to the cooling and lubricating effects of ***,the specific wear rate of the printed specimens could be higher than that obtained under dry sliding conditions,especially when the load was relatively *** square textured surface was designed and created in the printing process to improve materials’tribological *** was found that with the textured surface,the wear resistance of the printed SCFRN was improved under dry sliding conditions,which could be explained by the debris collection or cleaning effect of surface ***,such a cleaning effect was less noticeable under lubricated conditions,as the liquid could clean the surface *** the other hand,surface textures could increase the surface area exposed to water,causing surface softening due to the higher water absorption *** a result,the samples having surface textures showed higher wear rates under lubricated *** work has provided new insights into designing wear resistant polymer materials using three-dimensional(3D)printing technologies,subjected to different sliding conditions.

关键词： fused deposition modelling(FDM) short carbon fibre reinforced nylon(SCFRN)composites transfer film friction and wear

Upconversion hollow nanospheres CeF_(3) co-doped with Yb^(3+) and Tm^(3+) for photocatalytic nitrogen fixation

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Journal of Rare Earths 2022年第4期40卷 586-594,I0003页

作者： Minghui Zhong Zhendong Wang Da Dai Baozhu Yang Shixiang Zuo Chao Yao Fengqin Wu Xiazhang Li Advanced Catalysis and Green Manufacturing Collaborative Innovation center Jiangsu Key Laboratory of Advanced Catalytic Materials and TechnologyChangzhou UniversityChangzhou 213164China W.M.Keck center for Advanced microscopy and microanalysis University of DelawareNewarkDE19716USA

Solar driven nitrogen(N_(2))fixation to synthesize ammonia is a potential alternative for the traditional Haber-Bosch approach to meeting industrial demand,but is largely hampered by the difficulties in the harvesting of solar energy and activating inert N_(2).In this work,hollow CeF_(3) nanospheres co-doped with activator Tm^(3+)and sensitizer Yb^(3+)(Yb^(3+):Tm^(3+):CeF_(3))were prepared by microwave hydrothermal *** product was employed as a catalyst for photo-driven N_(2) fixation by adjusting the molar ratio of Ce^(3+):Yb^(3+):Tm^(3+).Results show that the porous hollow structure enhances the light-harvesting by physical scattering and *** addition,heteroatom doping generates abundant fluorine vacancies(F_(V))which provide abundant active sites for adsorption and activation of N_(2).The sample with molar ratio of CeF_(3):Yb^(3+):Tm^(3+)at 178:20:2 demonstrates the highest utilization of solar energy attributed to the strongest upconversion capability of near-infrared(NIR)light to visible and ultraviolet(UV)light,and the NH_(4)+concentration achieves the highest value of 15.06μmol/(gcat∙h)under simulated sunlight while nearly 6.22μmol/(gcat∙h)under NIR *** study offers a promising and sustainable strategy for the fixation of atmospheric N_(2) using full-spectrum solar energy.

关键词： Rare earth CeF_(3) Hollow structure Upconversion Fluorine vacancy Photocatalytic nitrogen fixation