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DMF-scMT-seq linking methylome and transcriptome within single cells with digital microfluidics

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Science China Chemistry 2024年第6期67卷 2070-2078页

作者： Xing Xu Xi Zeng Xin Lin Shiyan Lin Shanshan Liang Tian Tian Rui Su Jia Song Chaoyong Yang Collaborative Innovation center of Chemistry for Energy materials The MOE Key Laboratory of Spectrochemical Analysis and InstrumentationState Key Laboratory of Physical Chemistry of Solid SurfacesDepartment of Chemical BiologyCollege of Chemistry and Chemical EngineeringThe First Affiliated Hospital of Xiamen UniversityXiamen UniversityXiamen361005China Institute of Molecular Medicine Renji HospitalShanghai Jiao Tong University School of MedicineShanghai200127China Chemistry and materials Science College Shanghai Normal UniversityShanghai200234China Chemistry and Biomedicine Innovation center(ChemBIC) School of Chemistry and Chemical EngineeringNanjing UniversityNanjing210023China

Single-cell joint analysis of methylome and transcriptome reveals how the methylation regulates the transcriptional ***,traditional bench-top protocols for single-cell DNA methylation and RNA transcription co-detection are laborintensive,cost-ineffective and ***,we establish the DMF-sc MT-seq,a highly-efficient and cost-effective method to simultaneously analyze single-cell DNA methylation and transcriptional activity based on digital *** MT-seq automates the workflow of single-cell isolation,cellular hypotonic lysis,nucleic acid separation and methylome/transcriptome library construction in a contactless and addressable *** system ensures high accuracy(R>0.85),high gene detection ability(14,697 genes per cell at 4 million sequencing depth),and high CpG coverage(677,198 CpG sites per cell at 1million sequencing depth).By using DMF-sc MT-seq,the relationship of DNA methylation and RNA transcription under different genomic contexts is *** further apply DMF-sc MT-seq to study the dynamics of transcription regulation with methylation-inhibiting anti-tumor Decitabine,and identify the methylated promoter/gene body driven genes in response to Decitabine ***-sc MT-seq facilitates the construction of the correlation of DNA methylation and transcriptional activity at the single-cell level in a flexible,sensitive and accurate way,which is anticipated to be a powerful tool in studying single-cell biological systems.

关键词： single-cell analysis digital microfluidics methylome sequencing transcriptome sequencing

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Experimental observation of multiple topological nodal structure in LaSb_(2)

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 138-145页

作者： Yuxi Qiao Fuyi Wang Huaiqiang Wang Zicheng Tao Zhicheng Jiang Zhengtai Liu Soohyun Cho Fayuan Zhang Qingkai Meng Wei Xia Yichen Yang Zhe Huang Jishan Liu Zhonghao Liu Zengwei Zhu Shan Qiao Yanfeng Guo Haijun Zhang Dawei Shen state Key laboratory of Functional materials for Informatics Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China National Synchrotron Radiation laboratory and School of Nuclear Science and TechnologyUniversity of Science and Technology of ChinaHefei 230026China National laboratory of solid state Microstructures School of PhysicsNanjing UniversityNanjing 210093China School of Physics and Technology Nanjing Normal UniversityNanjing 210023China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China Shenzhen Institute for Quantum Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Wuhan National High Magnetic Field center and School of Physics Huazhong University of Science and TechnologyWuhan 430074China ShanghaiTech laboratory for Topological Physics ShanghaiTech UniversityShanghai 201210China Institute of High-Pressure Physics School of Physical Science and Technology Ningbo UniversityNingbo 315211China Collaborative Innovation center of Advanced Microstructures Nanjing UniversityNanjing 210093China center of materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

Unconventional fermions in the immensely studied topological semimetals are the source for rich exotic topological ***,using symmetry analysis and first-principles calculations,we propose the coexistence of multiple topological nodal structure in LaSb_(2),including topological nodal surfaces,nodal lines and in particular eightfold degenerate nodal points,which have been scarcely observed in a single ***,utilizing angle-resolved photoemission spectroscopy,we confirm the existence of nodal surfaces and eightfold degenerate nodal points in LaSb_(2).The intriguing multiple topological nodal structure might play a crucial role in giving rise to the large linear *** work renews the insights into the exotic topological phenomena in LaSb_(2).

关键词： eightfold degenerate points multiple topological nodal structure angle-resolved photoemission spectroscopy linear unsaturated magnetoresistance

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Ultrafast photoexcitation dynamics behavior of hydrogen-bonded polyfluorenol

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Chinese Chemical Letters 2024年第1期35卷 486-491页

作者： Man Xu Chuanxin Wei Yunlong Zhang Hao Li Jingyao Ma Jinyi Lin Shengjie Wang Wei Xue Qi Wei Linghai Xie Wei Huang state Key laboratory of Organic Electronics and Information Displays&School of Chemistry and Life Sciences&Institute of Advanced materials(IAM) Nanjing University of Posts&TelecommunicationsNanjing 210023China Key laboratory of Flexible Electronics(KLOFE)&Institute of Advanced materials(IAM) Nanjing Tech University(NanjingTech)Nanjing 211816China Frontiers Science center for Flexible Electronics(FSCFE) Shaanxi Institute of Flexible Electronics(SIFE)&Shaanxi Institute of Biomedical Materials and Engineering(SIBME)Northwestern Polytechnical UniversityXi’an 710072China

Exciton behavior is crucial to the exploitation of light-emitting conjugated polymer(LCPs)for optoelectronic *** excitons are easily trapped by the intrinsically defect ***,we set a polyfluorenol(PPFOH)as an example to systematically investigate its photophysical behavior to check the role of defect structures in *** to time-resolved photoluminescence analysis,the feature emission peaks from individual chain of PPFOH in diluted DMF solution is effectively avoided the influence of fluorenone formation,but the residual green-band emission at 550nm is easily observed in the PL spectra of PPFOH dilute toluene solution obtained delay 1.5 ns,confirmed the formation of“guest”physical aggregation-induced defect ***,efficient and ultrafast energy transfer from individual chain to defect structure is observed in PPFOH ***,the efficient energy transfer happened for the film obtained from DMF solution(200 ps)than those of toluene ones(600 ps).Meanwhile,compared to relatively stable green-band emission in PPFOH film from toluene solution,red-shifted emission peak(11 nm)of PPFOH film from DMF solutions exposed to saturated DNT vapor also confirmed their different aggregation-induced green-band ***,this aggregation defect structures are influenced on the photophysical property of LCPs in solid states.

关键词： Photoexcitation dynamics Polyfluorenol Aggregation behavior Energy transfer Exciton migration

Semi-empirical estimation for enhancing negative thermal expansion in PbTiO_(3)-based perovskites

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International Journal of Minerals,Metallurgy and materials 2022年第4期29卷 783-786页

作者： Tao Yang Longlong Fan Yilin Wang Kun Lin Jun Chen Xianran Xing Beijing Advanced Innovation center for materials Genome Engineering Institute of Solid State ChemistryDepartment of Physical ChemistryUniversity of Science and Technology BeijingBeijing 100083China College of Physics and materials Science Tianjin Normal UniversityTianjin 300387China Institute of Advanced materials Jiangsu National Synergetic Innovation Center for Advanced MaterialsNanjing Tech UniversityNanjing 211816China

Generally,most materials expand when heated and contract when cooled,whereas negative thermal expansion(NTE)materials are very *** a typical NTE material,PbTiO_(3) and related compounds have drawn particular interest in recent *** discovery of an enhanced NTE system in PbTiO_(3) is beneficial to deepen our understanding of its mechanism and regulate its *** present,the method of discriminating an enhanced NTE material based on PbTiO_(3) is not ***,we propose a semi-empirical method through evaluating the average lattice distortion in related systems to estimate the relative coefficient of thermal expansion *** rationality of the method was verified by the analysis of the 0.6PbTiO_(3)-0.4Bi(Ga_(x)Fe_(1-x))O_(3) *** far,all PbTiO_(3)-based compounds with enhanced NTE conform well to this *** method provides the possibility to find more enhanced NTE PbTiO_(3)-based materials.

关键词： enhanced negative thermal expansion crystal structure lead titanate spontaneous polarization

Dielectric Characteristics and Layer Periodic Effects of Ferroelectric Superlattice BaTiO_(3)/SrTiO_(3)

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Chinese Physics Letters 2001年第9期18卷 1271-1274页

作者：张建尹真张明生陈万春 National laboratory of solid state Microstructures and center for materials analysis Nanjing UniversityNanjing 210093 Institute of Physics Chinese Academy of SciencesBeijing 100080

A pseudospin-phonon coupled model in double-time Green's function theory has been developed to investi- gate the dielectric susceptibility of the ferroelectric-dielectric superlattice BaTiO_(3)/SrTiO_(3) (BTO/STO). As the pseudospin-pseudospin and pseudospin-phonon interactions increase, the dielectric susceptibility changes from a narrow shape into the strong and broad shape with the peak shifting to a higher temperature region. With increasing pseudospin-phonon interaction in the BTO layer and at smallpseudospin-pseudospin interaction in BTO layer, the dielectric susceptibility was sensitively adjusted around the transition temperature of strontium titanate, and at large pseudospin-pseudospin interaction in the BTO layer, the dielectric susceptibility was increased in the high-temperature region covering the tetragonal-cubic transition temperature of barium titanate. A critical period of 10/I0 in the BTO/STO superlattice has been obtained, which is in good agreement with the experimental data of 40A, for ten unit cells.

关键词： dielectric susceptibility interaction

Low Frequency Raman Spectra in Ester Liquid Crystals Near Phase Transitions

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Chinese Physics Letters 1991年第2期8卷 90-93页

作者： ZHANG Mingsheng HU Gongjian CHEN Qiang SUN Zhengmin YIN Zhen center for materials analysis Nanjing UniversityNanjing 210008 Department of Physics Nanjing UniversityNanjing 210008 also laboratory of solid state Microstructures Nanjing UniversityNanjing 210008

Phase transitions of the ferroelectric liquid crystal were studied by recording low-frequency Raman spectra and three Raman lines at 15,49 and 93cm^(-1) were *** intensities of the 15 and 49 cm^(-1) modes reduce to zero at smectic C*transition temperature,and in the isotropic phase the 93cm^(-1) Raman line with partial frequency shift totally disappears.

关键词： Phase Transition totally

A RKKY Model Fitting of Nuclear Magnetic Resonance Spectra of ^(63)Cu in Fe/Cu Multilayers

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Chinese Physics Letters 1995年第4期12卷 237-240页

作者： ZHAI Ya ZHU Xiaobing HU Chen ZHU Jiangang LU Mu ZHAI Hongru Department of Physics Southeastern UniversityNanjing 210096 state Key laboratory of solid state Microstructures Center of Materials AnalysisNanjing UniversityXanjing 210093 center for Advanced Studies in Science and Technology of Microstructures Nanjing 210093

In this letter,a theoretical fit of nuclear magnetic resonance spectra of ^(63)Cu in Cu layers of Fe/Cu multilayers is given based on RKKY *** values of exchange field and additional Knight shift are fitted,which agre... 详细信息

关键词： theory. Fe/Cu RKKY

Tuning dual-atom mediator toward high-rate bidirectional polysulfide conversion in Li-S batteries

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Journal of Energy Chemistry 2023年第12期87卷 462-472,I0012页

作者： Yifan Ding Zhongti Sun Jianghua Wu Tianran Yan Lin Shen Zixiong Shi Yuhan Wu Xiaoqing Pan Liang Zhang Qiang Zhang Jingyu Sun College of Energy Soochow Institute for Energy and Materials InnovationsKey Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu ProvinceSoochow UniversitySuzhou 215006JiangsuChina School of materials Science and Engineering Jiangsu UniversityZhenjiang 212013JiangsuChina National laboratory of solid-state Microstructures Jiangsu Key Laboratory of Artificial Functional MaterialsCollege of Engineering and Applied Sciences and Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093JiangsuChina Institute of Functional Nano&Soft materials Jiangsu Provincial Key Laboratory for Carbon-Based Functional Materials and DevicesSoochow UniversitySuzhou 215006JiangsuChina Department of Chemical Engineering Tsinghua UniversityBeijing 100084China

An emerging practice in the realm of Li-S batteries lies in the employment of single-atom catalysts(SACs)as effective mediators to promote polysulfide conversion,but monometallic SACs affording isolated geometric dispersion and sole electronic configuration limit the catalytic benefits and curtail the cell ***,we propose a class of dual-atom catalytic moieties comprising hetero-or homo-atomic pairs anchored on N-doped graphene(NG)to unlock the liquid–solid redox puzzle of sulfur,readily realizing Li-S full cell under high-rate-charging *** for Fe-Ni-NG,in-depth experimental and theoretical analysis reveal that the hetero-atomic orbital coupling leads to altered energy levels,unique electronic structures,and varied Fe oxidation states in comparison with homo-atomic structures(FeFe-NG or Ni-Ni-NG).This would weaken the bonding energy of polysulfide intermediates and thus enable facile electrochemical kinetics to gain rapid liquid-solid Li_(2)S_(4)?Li_(2)S ***,a Li-S battery based on the S@Fe-Ni-NG cathode demonstrates unprecedented fast-charging capability,documenting impressive rate performance(542.7 mA h g^(-1)at 10.0 C)and favorable cyclic stability(a capacity decay of 0.016%per cycle over 3000 cycles at 10.0 C).This finding offers insights to the rational design and application of dual-atom mediators for Li-S batteries.

关键词： Li-S batteries Reaction kinetics Dual-atom Rate-determining step High-rate performance

Electron-phonon coupling-assisted universal red luminescence of o-phenylenediamine-based carbon dots

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Light(Science & Applications) 2022年第7期11卷 1501-1514页

作者： Boyang Wang Zhihong Wei Laizhi Sui Jingkun Yu Baowei Zhang Xiaoyong Wang Shengnan Feng Haoqiang Song Xue Yong Yuxi Tian Bai Yang Siyu Lu Green Catalysis center and College of ChemistryZhengzhou University450000 ZhengzhouChina Key laboratory of Mesoscopic Chemistry of MOE School of Chemistry and Chemical EngineeringJiangsu Key Laboratory of Vehicle Emissions ControlNanjing University210023 NanjingChina state Key Lab of Molecular Reaction Dynamics Dalian Institute of Chemical PhysicsChinese Academy of Sciences116023 DalianChina Nanochemistry Department Istituto Italiano di Tecnologia(IIT)via Morego 3016163 GenovaItaly School of Physics National Laboratory of Solid State MicrostructuresCollaborative Innovation Center of Advanced MicrostructuresNanjing University210093 NanjingChina Department of Chemistry University of SheffieldSheffield S37HFUK state Key Lab of Supramolecular Structure and materials College of ChemistryJilin University130012 ChangchunChina

Due to the complex core-shell structure and variety of surface functional groups,the photoluminescence(PL)mechanism of carbon dots(CDs)remain unclear.o-Phenylenediamine(oPD),as one of the most common precursors for preparing red emissive CDs,has been extensively ***,most of the red emission CDs based on oPD have similar PL emission ***,we prepared six different oPD-based CDs and found that they had almost the same PL emission and absorption spectra after *** and spectral characterization indicated that they had similar carbon core structures but diffferent surface polymer ***,single-molecule PL spectroscopy confirmed that the multi-modal emission of those CDs originated from the transitions of different vibrational energy levels of the same PL center in the carbon *** addition,the phenomenon of"spectral splitting"of single-particle CDs was observed at low temperature,which confirmed these oPD-based CDs were unique materials with properties of both organic molecules and quantum ***,theoretical calculations revealed their potential polymerization mode and carbon core ***,we proposed the PL mechanism of red-emitting CDs based on oPD precursors;that is,the carbon core regulates the PL emission,and the polymer shell regulates the PL *** work resolves the controversy on the PL mechanism of oPD-based red *** findings provide a general guide for the mechanism exploration and structural analysis of other types of CDs.

关键词： structure. carbon luminescence