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Neural Regeneration Research 2025年第5期20卷 1403-1404页

作者： Oliver Kann Lennart Soder Babak Khodaie Institute of Physiology and Pathophysiology Heidelberg UniversityHeidelbergGermany interdisciplinary center for Neurosciences(IZN) Heidelberg UniversityHeidelbergGermany

The metabolite lactate (L-lactate) can be generated and released by diverse brain cells,including neurons,astrocytes,and oligodendrocytes (Kann,2023;Rae et al.,2024).Lactate production usually requires the degradation of glucose (D-glucose)-and glycogen in astrocytes-to pyruvate by glycolysis and subsequent conversion of pyruvate to lactate by the enzyme lactate dehydrogenase(Figure 1A;Dienel,2019;Rae et al.,2024).

关键词： consequences Figure restoration

Decision making module based on stochastic magnetic tunnel junctions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 202-209页

作者： Yifan Miao Li Zhao Yajun Zhang Zhe Yuan center for Advanced Quantum Studies and Department of Physics Beijing Normal University Institute for Nanoelectric Devices and Quantum Computing Fudan University interdisciplinary center for Theoretical Physics and Information Sciences Fudan University

In biological neural systems, noise is ubiquitous but does not affect the correct decisions made in the complex cognitive ***-making in biological neural system is typically achieved by accumulating input information over a period of *** by recent developments in neurosciences, we design a decision-making module based on spintronic devices, utilizing superparamagnetic tunnel junctions as artificial neurons. The feasibility of this decision-making module is verified through circuit simulations. Taking a multi-layer perceptron as an example, the module significantly improves the accuracy of the perceptron in the handwritten digit recognition task. Furthermore, the spintronic decision-making module offers advantages over the conventional pooling methods, such as adaptive decision time, high performance and the absence of analog-to-digital conversion. The decision-making module is flexible to be integrated into artificial neural networks and provides a general yet effective solution to enhance performance against device noise.

关键词： neuromorphic computing spintronics magnetic tunnel junction neural networks

Mechanism by which Rab5 promotes regeneration and functional recovery of zebrafish Mauthner axons

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Neural Regeneration Research 2025年第6期20卷 1816-1824页

作者： Jiantao Cui Yueru Shen Zheng Song Dinggang Fan Bing Hu center for Advanced interdisciplinary Science and Biomedicine of IHM Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina

Rab5 is a GTPase protein that is involved in intracellular membrane trafficking. It functions by binding to various effector proteins and regulating cellular responses, including the formation of transport vesicles and their fusion with the cellular membrane. Rab5 has been reported to play an important role in the development of the zebrafish embryo;however, its role in axonal regeneration in the central nervous system remains unclear. In this study, we established a zebrafish Mauthner cell model of axonal injury using single-cell electroporation and two-photon axotomy techniques. We found that overexpression of Rab5 in single Mauthner cells promoted marked axonal regeneration and increased the number of intra-axonal transport vesicles. In contrast, treatment of zebrafish larvae with the Rab kinase inhibitor CID-1067700markedly inhibited axonal regeneration in Mauthner cells. We also found that Rab5 activated phosphatidylinositol 3-kinase(PI3K) during axonal repair of Mauthner cells and promoted the recovery of zebrafish locomotor function. Additionally, rapamycin, an inhibitor of the mechanistic target of rapamycin downstream of PI3K, markedly hindered axonal regeneration. These findings suggest that Rab5 promotes the axonal regeneration of injured zebrafish Mauthner cells by activating the PI3K signaling pathway.

关键词： axonal regeneration Mauthner cell nerve regeneration Rab5 zebrafish

Rapid and scalable preparation of highly quaternized polymer networks to achieve efficient simultaneous adsorption of iodide and pertechnetate

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Science China Chemistry 2025年第01期 337-349页

作者： Meiyun Xu Song Gu Fulong Chen Zhe Zhao Peng Liu Daoben Hua State Key Laboratory of Radiation Medicine and Protection School of Radiological and Interdisciplinary Sciences (RAD-X) Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions Soochow University

The efficient separation of fission products,such as TcO4-and I-,holds strategic significance for the management of radioactive wastes and environmental *** this study,we propose an ultrafast strategy for scalable preparation of a highly quaternized organic network to facilitate efficient and synchronous separation of iodide and *** network can be prepared within a few minutes at room temperature,using polyethylenimine and 1,2,4,5-tetrakis（bromomethyl）benzene as building *** chlorine replacement,the network,abundantly decorated with quaternary ammonium groups （Cl@QPN）,exhibits an ultrahigh positive charge density of 7.6 mmol/*** enables the rapid and efficient enrichment of target anions through strong electrostatic Coulomb *** a result,Cl@QPN exhibits significantly higher adsorption rate constants of 0.830 g/（mg min） for ReO4-（a nonradioactive surrogate of TcO4-） and 0.677 g/（mg min） for I-compared to other ***,it possesses high adsorption capacities,reaching 1,681 mg/g for ReO4-and 917.4 mg/g for I-.Cl@QPN also demonstrates good selectivity towards target ions and shows efficient adsorption for99TcO4-.Additionally,Cl@QPN exhibits high dynamic processing capacities,handling up to 3,100 and 7,400 kg of simulated streams per kilogram of material for I-and ReO4-,respectively.

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Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

Comparison of Advanced Technology Microwave Sounder Biases Estimated Using Radio Occultation and Hurricane Florence(2018) Captured by NOAA-20 and S-NPP

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Advances in Atmospheric Sciences 2020年第3期37卷 269-277页

作者： Xiaoxu TIAN Xiaolei ZOU Earth Science System interdisciplinary center University of Maryland

The second Advanced Technology Microwave Sounder(ATMS)was onboard the National Oceanic and Atmospheric Administration(NOAA)-20 satellite when launched on 18 November *** nearly six months of the earliest NOAA-20 observations,the biases of the ATMS instrument were compared between NOAA-20 and the Suomi National Polar-Orbiting Partnership(S-NPP)*** biases of ATMS channels 8 to 13 were estimated from the differences between antenna temperature observations and model simulations generated from Meteorological Operational(MetOp)-A and MetOp-B satellites’Global Positioning System(GPS)radio occultation(RO)temperature and water vapor *** was found that the ATMS onboard the NOAA-20 satellite has generally larger cold biases in the brightness temperature measurements at channels 8 to 13 and small standard *** observations from ATMS on both S-NPP and NOAA-20 are shown to demonstrate an ability to capture a less than 1-h temporal evolution of Hurricane Florence(2018)due to the fact that the S-NPP orbits closely follow those of NOAA-20.

关键词： ATMS NOAA-20 S-NPP biases calibration Hurricane Florence

Variation of the fine-structure constant from the de Sitter invariant special relativity

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Chinese Physics C 2008年第8期32卷 612-616页

作者：陈绍霞肖能超闫沐霖 interdisciplinary center for Theoretical Study University of Science and Technology of China

We discuss the variation of the fine-structure constant, α. There are obvious discrepancies among the results of α-variation from recent Quasi-stellar observation experiments and from the Oklo uranium mine analysis. We use dS Sitter invariant Special Relativity （SRc,R） and Dirac large number hypothesis to discuss this puzzle, and present a possible solution to the disagreement. By means of the observational data and the discussions presented in this paper, we estimate the radius of the Universe in SRc,R which is about -2√5× 10^11.y.

关键词： quasi-stellar objects Oklo nature nuclear reactor Dirac large number hypothesis de Sitterinvariant special relativity

MDSSD:multi-scale deconvolutional single shot detector for small objects

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Science China(Information Sciences) 2020年第2期63卷 98-100页

作者： Lisha CUI Rui MA Pei LV Xiaoheng JIANG Zhimin GAO Bing ZHOU Mingliang XU center for interdisciplinary Information Science Research Zhengzhou University

Dear editor,Object detection has always been the focus and challenge in the field of computer vision, especially the small object detection. With the arrival of deep convolutional networks (Conv Nets [1]), the perform... 详细信息

关键词： MDSSD:multi-scale deconvolutional single shot detector for small objects SSD

A Classification of Long-Range Interactions between Two Stacks of p＆ p＇-Branes

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Communications in Theoretical Physics 2015年第2期63卷 195-208页

作者：欧阳君吴超 interdisciplinary center for Theoretical Study University of Science and Technology of China

We generalize the computations of the long-range interactions between two parallel stacks of branes to various cases when two stacks of branes are not placed parallel to each other. We classify the nature of interaction(repulsive or attractive) for each special case and this classification can be used to justify the nature of long-range interaction between two complicated brane systems such as brane bound states. We will provide explicit examples in this paper to demonstrate this.

关键词： long-range interaction effective field theory computation non-parallel branes flux

Quintessence Field as a Perfect Cosmic Fluid of Constant Pressure

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Communications in Theoretical Physics 2015年第3期63卷 391-400页

作者：刘文中欧阳君杨焕雄 interdisciplinary center for Theoretical Study University of Science and Technology of China

We study the cosmology of a quintessence scalar held which is equivalent to a non-barotropic perfect fluid of constant *** coincidence problem is alleviated by such a quintessence equation-of-state that interpolates between plateau of zero at large redshifts and plateau of minus one as the redshift approaches to *** quintessence Geld is neither a unified dark matter nor a mixture of cosmological constant and cold dark matter,relying on the facts that the quintessence density contrasts of sub-horizon modes would undergo a period of late-time dechne and the squared sound speeds of quintessence perturbations do not *** a role does the quintessence play is dynamic dark energy,its clustering could remarkably reduce the growth rate of the density perturbations of non-relativistic matters.

关键词： dark energy quintessence