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Blockade of HCN2 Channels Provides Neuroprotection Against Ischemic Injury via Accelerating Autophagic Degradation in Hippocampal Neurons

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Neuroscience Bulletin 2020年第8期36卷 875-894页

作者： Cheng Chen Li Liu Ya-Qiao Shu Ping Jing Yun Lu Xiao-Xue Zhang Xian-Gang Zong Lian-Jun Guo Chang-Jun Li Department of Pharmacology School of Basic Medical SciencesTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Neurology The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Office of Academic Research The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pharmacy Zhongnan Hospital of Wuhan UniversityWuhan 430030China Department of Clinical Laboratory Wuhan PuAi HospitalWuhan 430033China Key Laboratory of Drug Target Research and Pharmacodynamic Evaluation Wuhan 430030China center for integrated protein science and zentrum fur pharmaforschung Department PharmazieLudwig-Maximilians-Universitat Miinchen80539 MunichGermany

In the central nervous system,hyperpolarizationactivated cyclic nucleotide-gated(HCN)channels are essential to maintain normal neuronal *** studies have shown that HCN channels may be involved in the pathological process of ischemic brain injury,but the mechanisms remain *** is activated in cerebral ischemia,but its role in cell death/survival remains *** this study,our results showed that the HCN channel blocker ZD7288 remarkably decreased the percentage of apoptotic neurons and corrected the excessive autophagy induced by oxygen-glucose deprivation followed by reperfusion(OGD/R)in hippocampal HT22 ***,in the OGD/R group,p-mTOR,p-ULK1(Ser757),and p62 were significantly decreased,while p-ULK1(Ser317),atg5,and beclin1 were remarkably ***7288 did not change the expression of p-ULK1(Ser757),ULK1(Ser317),p62,Beclin1,and atg5,which are involved in regulating autophagosome ***,we found that OGD/R induced a significant increase in Cathepsin D expression,but not *** with ZD7288 at 10μmol/L in the OGD/R group did not change the expression of cathepsin D and ***,chloroquine(CQ),which decreases autophagosome-lysosome fusion,eliminated the correction of excessive autophagy and neuroprotection by ***,shRNA knockdown of HCN2 channels significantly reduced the accumulation of LC3-Ⅱand increased neuron survival in the OGD/R and transient global cerebral ischemia(TGCI)models,and CQ also eliminated the effects of ***,we found that the percentage of LC3-positive puncta that co-localized with LAMP-1-positive lysosomes decreased in Con-shRNAtransfected HT22 neurons exposed to OGD/R or *** HCN2-shRNA-transfected HT22 neurons,the percentage of LC3-positive puncta that co-localized with LAMP-1-positive lysosomes increased under OGD/R;however,the percentage was significantly decreased by the addition of CQ to HCN2-shRNA-transfected HT22 *** present re

关键词： HCN2 channel Autophagy Neuroprotection Oxygen-glucose deprivation/reperfusion Transient global cerebral ischemia

Photon polarization effects in polarized electron–positron pair production in a strong laser field

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Matter and Radiation at Extremes 2022年第1期7卷 5-14页

作者： Ya-Nan Dai Bai-Fei Shen Jian-Xing Li Rashid Shaisultanov Karen Z.Hatsagortsyan Christoph H.Keitel Yue-Yue Chen Department of Physics Shanghai Normal UniversityShanghai 200234China State Key Laboratory of High Field Laser Physics and CAS center for Excellence in Ultra-intense Laser science Shanghai Institute of Optics and Fine Mechanics(SIOM)Chinese Academy of Sciences(CAS)Shanghai 201800China School of Physics Xi’an Jiaotong UniversityXi’an 710049China Max-Planck-Institut fur Kernphysik Saupfercheckweg 169117 HeidelbergGermany Helmholtz-zentrum Dresden-Rossendorf Bautzner Landstraße 40001328 DresdenGermany

Deep understanding of the impact of photon polarization on pair production is essential for the efficient generation of laser-driven polarized positron beams and demands a complete description of polarization effects in strong-field QED *** fully polarization-resolved Monte Carlo simulations,we investigate correlated photon and electron(positron)polarization effects in the multiphoton Breit–Wheeler pair production process during the interaction of an ultrarelativistic electron beam with a counterpropagating elliptically polarized laser *** show that the polarization of e−e+pairs is degraded by 35%when the polarization of the intermediate photon is resolved,accompanied by an∼13%decrease in the pair ***,in this case,the polarization direction of energetic positrons at small deflection angles can even be reversed when high-energy photons with polarization parallel to the laser electric field are involved.

关键词： polarized positron resolved

Neutron Spectroscopy Evidence for a Possible Magnetic-Field-Induced Gapless Quantum-Spin-Liquid Phase in a Kitaev Materialα-RuCl3

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Chinese Physics Letters 2022年第5期39卷 87-93页

作者： Xiaoxue Zhao Kejing Ran Jinghui Wang Song Bao Yanyan Shangguan Zhentao Huang Junbo Liao Bo Zhang Shufan Cheng Hao Xu Wei Wang Zhao-Yang Dong Siqin Meng Zhilun Lu Shin-ichiro Yano Shun-Li Yu Jian-Xin Li Jinsheng Wen National Laboratory of Solid State Microstructures and Department of Physics Nanjing UniversityNanjing 210093China School of Physical science and Technology and ShanghaiTech Laboratory for Topological Physics ShanghaiTech UniversityShanghai 200031China School of science Nanjing University of Posts and TelecommunicationsNanjing 210023China Department of Applied Physics Nanjing University of Science and TechnologyNanjing 210094China Helmholtz-zentrum Berlin fur Materialien und Energie GmbH Hahn-Meitner-Platz 1D-14109 BerlinGermany China Institute of Atomic Energy Beijing 102413China School of Engineering and the Built Environment Edinburgh Napier UniversityEdinburgh EH105DTUnited Kingdom National Synchrotron Radiation Research center Hsinchu 30077China Collaborative Innovation center of Advanced Microstructures Nanjing UniversityNanjing 210093China

As one of the most promising Kitaev quantum-spin-liquid(QSL)candidates,α-RuCl_(3)has received a great deal of ***,its ground state exhibits a long-range zigzag magnetic order,which defies the QSL ***,the magnetic order is fragile and can be completely suppressed by applying an external magnetic ***,we explore the evolution of magnetic excitations ofα-RuCl;under an in-plane magnetic field,by carrying out inelastic neutron scattering measurements on high-quality single *** zero field,there exist spin-wave excitations near the M point and a continuum near theΓpoint,which are believed to be associated with the zigzag magnetic order and fractional excitations of the Kitaev QSL state,*** increasing the magnetic field,the spin-wave excitations gradually give way to the continuous *** the verge of the critical fieldμ_(0)H_(c)=7.5 T,the former ones vanish and only the latter ones are left,indicating the emergence of a pure QSL *** further increasing the field strength,the excitations near theΓpoint become more *** following the gap evolution of the excitations near theΓpoint,we are able to establish a phase diagram composed of three interesting phases,including a gapped zigzag order phase at low fields,possibly gapless QSL phase nearμ;H;,and gapped partially polarized phase at high *** results demonstrate that an in-plane magnetic field can driveα-RuCl;into a long-sought QSL state near the critical field.

关键词： field excitation zigzag

A brief review on/μSR studies of unconventional Fe-and Cr-based superconductors

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science China(Physics,Mechanics & Astronomy) 2018年第12期61卷 3-24页

作者： A.Bhattacharyya D.T.Adroja M.Smidman V.K.Anand ISIS Facility Rutherford Appleton LaboratoryChiltonDidcot OxonOX11OQXUK Department of Physics Ramakrishna Mission Vivekananda Educational and Research InstituteHowrah 711202India Highly Correlated Matter Research Group Physics DepartmentUniversity of JohannesburgAuckland Park 2006South Africa center for Correlated Matter and Department of Physics Zhejiang UniversityHangzhou 310058China Helmholtz-zentrum Berlin fur Materialien und Energie GmbH Berlin D-14109Germany

Muon spin relaxation/rotation(μSR) is a vital technique for probing the superconducting gap structure, pairing symmetry and time reversal symmetry breaking, enabling an understanding of the mechanisms behind the unconventional superconductivity of cuprates and Fe-based high-temperature superconductors, which remain a puzzle. Very recently double layered Fe-based superconductors having quasi-2 D crystal structures and Cr-based superconductors with a quasi-1D structure have drawn considerable attention. Here we present a brief review of the characteristics of a few selected Fe-and Cr-based superconducting materials and highlight some of the major outstanding problems, with an emphasis on the superconducting pairing symmetries of these materials. We focus on μSR studies of the newly discovered superconductors ACa_2Fe_4As_4F_2(A = K, Rb, and Cs), ThFeAsN, and A_2Cr_3As_3(A = K, Cs), which were used to determine the superconducting gap structures, the presence of spin fluctuations, and to search for time reversal symmetry breaking in the superconducting states. We also briefly discuss the results of μSR investigations of the superconductivity in hole and electron doped BaFe_2As_2.

关键词： unconventional superconductors iron-based superconductors Cr-based superconductors superconducting pairing symmetry time reversal symmetry muon spin rotation/relaxation

Evidence for Magnetic Fractional Excitations in a Kitaev Quantum-Spin-Liquid Candidate α-RuCl_(3)

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Chinese Physics Letters 2022年第2期39卷 72-77页

作者： Kejing Ran Jinghui Wang Song Bao Zhengwei Cai Yanyan Shangguan Zhen Ma Wei Wang Zhao-Yang Dong P.Cermak A.Schneidewind Siqin Meng Zhilun Lu Shun-Li Yu Jian-Xin Li Jinsheng Wen School of Physical science and Technology and ShanghaiTech Laboratory for Topological PhysicsShanghaiTech UniversityShanghai 200031China National Laboratory of Solid State Microstructures and Department of Physics Nanjing UniversityNanjing 210093China Institute for Advanced Materials Hubei Normal UniversityHuangshi 435002China School of science Nanjing University of Posts and TelecommunicationsNanjing 210023China Department of Applied Physics Nanjing University of Science and TechnologyNanjing 210094China Julich Centre for Neutron science(JCNS)at Heinz Maier-Leibnitz zentrum(MLZ) Forschungszentrum Jülich GmbHLichtenbergstr.185748 GarchingGermany Charles University Faculty of Mathematics and PhysicsDepartment of Condensed Matter PhysicsKe Karlovu 512116PrahaCzech Republic Helmholtz-zentrum Berlin fur Materialien und Energie GmbH Hahn-Meitner-Platz 1D-14109BerlinGermany China Institute of Atomic Energy(CIAE) Beijing 102413China The Henry Royce Institute and Department of Materials science and Engineering The University of SheffieldSir Robert Hadfield BuildingSheffieldS13JDUnited Kingdom Collaborative Innovation center of Advanced Microstructures Nanjing UniversityNanjing 210093China

It is known that α-RuCl_(3) has been studied extensively because of its proximity to the Kitaev quantum-spin-liquid(QSL)phase and the possibility of approaching it by tuning the competing *** we present the first polarized inelastic neutron scattering study on α-RuCl_(3) single crystals to explore the scattering continuum around the Γ point at the Brillouin zone center,which was hypothesized to be resulting from the Kitaev QSL state but without concrete *** polarization analyses,we find that,while the spin-wave excitations around the Γ point vanish above the transition temperature T_(N),the pure magnetic continuous excitations around the Γ point are robust against ***,by calculating the dynamical spin-spin correlation function using the cluster perturbation theory,we derive magnetic dispersion spectra based on the K-Γ model,which involves with a ferromagnetic Kitaev interaction of −7.2 meV and an off-diagonal interaction of 5.6 *** find this model can reproduce not only the spin-wave excitation spectra around the Γ point,but also the non-spin-wave continuous magnetic excitations around the Γ *** results provide evidence for the existence of fractional excitations around the Γ point originating from the Kitaev QSL state,and further support the validity of the K-Γ model as the effective minimal spin model to describe α-RuCl_(3).

关键词： temperature excitation diagonal

Cell type specificity of signaling:view from membrane receptors distribution and their downstream transduction networks

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protein & Cell 2012年第9期3卷 701-713页

作者： Ying He Zhonghao Yu Dongya Ge Rui Wang-Sattler Hans-Jurgen Thiesen Lu Xie Yixue Li Key Laboratory of Systems Biology Chinese Academy of SciencesShanghai 200031China Shanghai center for Bioinformation Technology Shanghai 200235China Graduate University of the Chinese Academy of sciences Shanghai 200031China Research unit of Molecular Epidemiology Helmholtz Zentrum MunchenNeuherberg 85764Germany Office of Technology Transfer Shanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China Institut fur Immunologie Universitat RostockRostock 18057Germany

Studies on cell signaling pay more attention to spatial dynamics and how such diverse organization can relate to high order of cellular *** overview the specificity of cell signaling,we integrated human receptome data with proteome spatial expression profiles to systematically investigate the specificity of receptors and receptor-triggered transduction networks across 62 normal cell types and 14 cancer *** percent receptors showed cell-type-specific expression,and 4% signaling networks presented enriched cell-specific proteins induced by the *** introduced a concept of“response context”to annotate the cell-type dependent signaling *** found that most cells respond similarly to the same stimulus,as the“response contexts”presented high functional *** this,the subtle spatial diversity can be observed from the difference in network *** architecture of the signaling networks in nerve cells displayed less completeness than that in glandular cells,which indicated cellular-context dependent signaling patterns are elaborately spatially ***,in cancer cells most signaling networks were generally dysfunctional and less complete than that in normal ***,glioma emerged hyper-activated transduction mechanism in malignant *** ATP6AP2 and TNFRSF21 induced rennin-angiotensin and apoptosis signaling were found likely to explain the glioma-specific *** work represents an effort to decipher context-specific signaling network from spatial *** results indicated that although a majority of cells engage general signaling response with subtle differences,the spatial dynamics of cell signaling can not only deepen our insights into different signaling mechanisms,but also help understand cell signaling in disease.

关键词： plasma membrane receptor cellular signaling transduction network diversity cell type specific spatial expression profile

Comparison of Cox Model Methods in A Low-dimensional Setting with Few Events

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Genomics, Proteomics & Bioinformatics 2016年第4期14卷 235-243页

作者： Francisco M. Ojeda Christian Miiller Daniela Bornigen David-Alexandre Tregouet Arne Schillert Matthias Heinig Tanja Zeller Renate B. Schnabel Department of General and Interventional Cardiology University Heart Center Hamburg-Eppendorf 20246 Hamburg Germany German center for Cardiovascular Research (DZHK) Hamburg |Kiel| Luebeck Germany Sorbonne Universites University Pierre et Marie Curie Paris 06 Institut National pour la Sante et la Recherche Medicale (INSERM) Unite Mixte de Recherche en Sante (UMR_S) 1166 F-75013 Paris France Institute for Cardiometaholism and Nutrition (ICAN) F-75013 Paris France Institut fur Medizinische Biometrie und Statistik Universitat zu Lubeck Universitatsklinikum Schleswig-Holstein Campus Lubeck 23562 Lubeck Germany Institute of Computational Biology German Research Center for Environmental Health Helmholtz Zentrum Munchen 85764 Neuherberg Germany

Prognostic models based on survival data frequently make use of the Cox proportional hazards model. Developing reliable Cox models with few events relative to the number of predictors can be challenging, even in low-dimensional datasets, with a much larger number of observations than variables. In such a setting we examined the performance of methods used to estimate a Cox model, including （i） full model using all available predictors and estimated by standard techniques, （ii） backward elimination （BE）, （iii） ridge regression, （iv） least absolute shrinkage and selection operator （lasso）, and （v） elastic net. Based on a prospective cohort of patients with manifest coronary artery disease （CAD）, we performed a simulation study to compare the predictive accuracy, calibration, and discrimination of these approaches, Candidate predictors for incident cardiovascular events we used included clinical variables, biomarkers, and a selection of genetic variants associated with CAD. The penalized methods, i.e., ridge, lasso, and elastic net, showed a comparable performance, in terms of predictive accuracy, calibration, and discrimination, and outperformed BE and the full model. Excessive shrinkage was observed in some cases for the penalized methods, mostly on the simulation scenarios having the lowest ratio of a number of events to the number of variables. We conclude that in similar settings, these three penalized methods can be used interchangeably. The full model and backward elimination are not recommended in rare event scenarios.

关键词： Proportional hazards regression Penalized regression Events per variable Coronary artery disease

Symmetry Reduction upon Size Mismatch:The Non-lcosahedral Intermetalloid Cluster [Co@Ge12]^3-

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Chinese Journal of Chemistry 2018年第12期36卷 1165-1168页

作者： Chao Liu Lei-Jiao Li Ivan A.Popov Robert J.Wilson Cong-qiao Xu Jun Li Alexander I.Boldyrev Zhong-Ming Sun State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of Sciences5625 Renmin StreetChangchunJilin 130022China University of Chinese Academy of sciences Beijing 100049China School of Materials science and Engineering Research Center of Rare Earth and Inorganic Functional MaterialsNankai UniversityTianjin 300350China School of Chemistry & Environmental Engineering Chang chun University of Science & TechnologyChangchunJilin 130022China Department of Chemistry and Biochemistry Utah State University0300 Old Main HillLosanUtah84322-0300USA Fachbereich Chemie und Wissenschaftliches zentrum fur Materialwissenschaften (WZMW) Philipps-Universtat MarburgHans-Meerwein-Straβe35043 MarburgGermany Department of Chemistry and Key Laboratory of Organic Optoelectronics & Molecular Engineering of Ministry of Education Tsinghua UniversityBeijing 200084China

A new complex comprising [Co@Ge 12 ] 3– cluster core was synthesized through the reaction of CoMe(PMe 3 ) 4 and K 4 Ge 9 in ethylenediamine solution. The pseudo‐ D 5d geometry of this cluster can be viewed as structurally derived from an icosahedral cage via Jahn‐Teller effect, leading to notable bonding differences from I h ‐[M@E 12 ] q − clusters (E = Sn, Pb with q = 2, 3). The [Co@Ge 12 ] 3– cluster represents a structural conundrum. On the basis of the geometric considerations it could be viewed as a sandwich complex. However, chemical bonding analysis revealed that there is a direct covalent multicenter bonding between the two pentagons, thus indicating that the structure should be viewed as an elongated icosahedron. further theoretical calculations on [M@Ge 12 ] 3− (M = Rh, Ir, Mt) indicate that similar compounds of larger‐size metal atoms can drive the complete transformation of [M@Ge 12 ] 3− clusters from icosahedron structure to a sandwich one.

关键词： Zintl ions intermetalloid cluster icosahedron Sandwich complex

Immobilization of Oxyanions on the Reconstructed Heterostructure Evolved from a Bimetallic Oxysulfide for the Promotion of Oxygen Evolution Reaction

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Nano-Micro Letters 2023年第10期15卷 547-564页

作者： Kai Yu Hongyuan Yang Hao Zhang Hui Huang Zhaowu Wang Zhenhui Kang Yang Liu Prashanth W.Menezes Ziliang Chen Institute of Functional Nano and Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon‑Based Functional Materials and DevicesJoint International Research Laboratory of Carbon‑Based Functional Materials and DevicesSoochow UniversitySuzhou 215123People’s Republic of China Department of Chemistry:Metalorganics and Inorganic Materials Technical University of BerlinStrase Des 17 Juni 135.Sekr.C210623 BerlinGermany Materials Chemistry Group for Thin Film Catalysis–CatLab Helmholtz-Zentrum Berlin fur Materialien und EnergieAlbert‑Einstein‑Str.1512489 BerlinGermany School of Physics and Engineering Longmen LaboratoryHenan University of Science and TechnologyLuoyang 471023People’s Republic of China

Efficient and durable oxygen evolution reaction(OER)requires the electrocatalyst to bear abundant active sites,optimized electronic structure as well as robust component and mechanical ***,a bimetallic lanthanum-nickel oxysulfide with rich oxygen vacancies based on the La_(2)O_(2)S prototype is fabricated as a binder-free precatalyst for alkaline *** combination of advanced in situ and ex situ characterizations with theoretical calculation uncovers the synergistic effect among La,Ni,O,and S species during OER,which assures the adsorption and stabilization of the oxyanion SO_(4)^(2-)onto the surface of the deeply reconstructed porous heterostructure composed of confining Ni OOH nanodomains by La(OH)_3 *** coupling,confinement,porosity and immobilization enable notable improvement in active site accessibility,phase stability,mass diffusion capability and the intrinsic Gibbs free energy of oxygen-containing *** optimized electrocatalyst delivers exceptional alkaline OER activity and durability,outperforming most of the Ni-based benchmark OER electrocatalysts.

关键词： Lanthanum-nickel oxysulfide Rare earth metal Immobilization of oxyanions Structural reconstruction Oxygen evolution catalysis