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Mechanism by which Rab5 promotes regeneration and functional recovery of zebrafish Mauthner axons

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Neural Regeneration research 2025年第6期20卷 1816-1824页

作者： Jiantao Cui Yueru Shen Zheng Song Dinggang Fan Bing Hu center for advanced Interdisciplinary science and Biomedicine of IHM Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina

Rab5 is a GTPase protein that is involved in intracellular membrane trafficking. It functions by binding to various effector proteins and regulating cellular responses, including the formation of transport vesicles and their fusion with the cellular membrane. Rab5 has been reported to play an important role in the development of the zebrafish embryo;however, its role in axonal regeneration in the central nervous system remains unclear. In this study, we established a zebrafish Mauthner cell model of axonal injury using single-cell electroporation and two-photon axotomy techniques. We found that overexpression of Rab5 in single Mauthner cells promoted marked axonal regeneration and increased the number of intra-axonal transport vesicles. In contrast, treatment of zebrafish larvae with the Rab kinase inhibitor CID-1067700markedly inhibited axonal regeneration in Mauthner cells. We also found that Rab5 activated phosphatidylinositol 3-kinase(PI3K) during axonal repair of Mauthner cells and promoted the recovery of zebrafish locomotor function. Additionally, rapamycin, an inhibitor of the mechanistic target of rapamycin downstream of PI3K, markedly hindered axonal regeneration. These findings suggest that Rab5 promotes the axonal regeneration of injured zebrafish Mauthner cells by activating the PI3K signaling pathway.

关键词： axonal regeneration Mauthner cell nerve regeneration Rab5 zebrafish

Microstructural landscape of amorphous carbon

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National science Review 2024年第5期11卷 94-95页

作者： Huiyang Gou center for high pressure science and technology advanced research (HPSTAR)

Due to its diverse bonding hybridization forms (sp, sp2and sp3), amorphous carbon exhibits multifaceted properties and important application prospects, which have aroused extensive research interest[1–5]. In amorphous solids, some degree of atomic short-to medium-range order is thought to be ubiquitous, and the recent synthesis of new amorphous carbon has further increased our understanding of the atomic disorder in materials [4].

关键词： landscape amorphous carbon microstructural

Potential dependence in electrocatalysis: a theoretical perspective

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science China Chemistry 2025年第01期 21-25页

作者： Leyu Liu Zhaoming Xia Zeyu Wang Yinjuan Chen Hai Xiao Department of Chemistry Tsinghua University Fundamental science center of Rare Earths Ganjiang Innovation Academy Chinese Academy of Sciences Key Laboratory of advanced Catalytic Materials and technology Advanced Catalysis and Green Manufacturing Collaborative Innovation Center Changzhou University

Electrocatalysis is a key technology for the new energy era and sustainable development, serving as the interface for interconversion of electrical and chemical energies, which spans a wide spectrum of applications in sustainable energy and environmental engineering. Electrocatalytic reactions including electrochemical CO2reduction reaction （eCO2RR）, hydrogen evolution reaction （HER）, and oxygen evolution/reduction reactions （OER/ORR）, hold essential promise for renewable energy technologies as well as complement the biogeochemical carbon and oxygen cycles.

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Asthenosphere dynamics based on the H2O dependence of element diffusivity in olivine

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National science Review 2021年第4期8卷 9-11页

作者： Tomoo Katsura Hongzhan Fei Bayerisches Geoinstitut University of Bayreuth center for high pressure science and technology advanced research

The oceanic asthenosphere is one of the most enigmatic regions in the Earth’s interior. The presence of seismic lowvelocity zones implies high softness at the top of the asthenosphere, which may cause smooth plate mo... 详细信息

关键词： scanning tunneling microscopy phenyl-based molecular film electronic correlation electron-vibration coupling Kondo effect

research status and prospects of the fractal analysis of metal material surfaces and interfaces

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 20-38页

作者： Qinjin Dai Xuefeng Liu Xin Ma Shaojie Tian Qinghe Cui Beijing advanced Innovation center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation University of Science and Technology BeijingBeijing 100083China Laboratory for advanced Materials Processing of Ministry of Education University of Science and Technology BeijingBeijing 100083China School of Mechanical and Electrical Engineering Xinjiang Institute of EngineeringUrumqi 830023China

As a mathematical analysis method,fractal analysis can be used to quantitatively describe irregular shapes with self-similar or self-affine *** analysis has been used to characterize the shapes of metal materials at various scales and *** methods make it difficult to quantitatively describe the relationship between the regular characteristics and properties of metal material surfaces and ***,fractal analysis can be used to quantitatively describe the shape characteristics of metal materials and to establish the quantitative relationships between the shape characteristics and various properties of metal *** the perspective of two-dimensional planes and three-dimensional curved surfaces,this paper reviews the current research status of the fractal analysis of metal precipitate interfaces,metal grain boundary interfaces,metal-deposited film surfaces,metal fracture surfaces,metal machined surfaces,and metal wear *** relationship between the fractal dimensions and properties of metal material surfaces and interfaces is *** from three perspectives of fractal analysis,namely,research scope,image acquisition methods,and calculation methods,this paper identifies the direction of research on fractal analysis of metal material surfaces and interfaces that need to be *** is believed that revealing the deep influence mechanism between the fractal dimensions and properties of metal material surfaces and interfaces will be the key research direction of the fractal analysis of metal materials in the future.

关键词： metal material surfaces and interfaces fractal analysis fractal dimension homogeneity

Yi-Gang Xu: the Earth's deep interior holds the key to habitability

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National science Review 2021年第4期8卷 35-38页

作者： Jin Liu Ho-Kwang Mao the center for high pressure science and technology advanced research (HPSTAR) HPSTAR

The deep Earth is the engine of whole Earth systems and plays a key role in surface evolution and geological hazards. Scientists have been deciphering the internal processes that shape our habitable planet, especially since the formulation of plate tectonics theory. To date, how the deep Earth works remains mysterious. At the end of 2020,

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Phase Stability and Hydroxyl Vibration of Brucite Mg(OH)_(2) at high pressure and high Temperature

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Chinese Physics Letters 2021年第3期38卷 111-115页

作者： Wei-Bin Gui Chao-Shuai Zhao Jin Liu center for high pressure science and technology advanced research(HPSTAR) Beijing 100094China

Brucite Mg(OH)_(2) is an archetypal hydrous mineral and it has attracted a great deal of ***,little is known about the evolution of hydroxyl groups in brucite with respect to subduction *** carried out Raman measurements up to 15.4 GPa and 874 K via an externally heated diamond anvil cell,investigating the stability of brucite under the conditions relevant to subducting *** hydroxyl vibration mode A_(1g)(I) of brucite is weakened under simultaneous high pressure-temperature ***,the presence of carbonated solution can destabilize the hydroxyl groups of brucite at low *** results suggest that brucite releases water when reacting with hydrogen carbonate ion to form magnesite MgCO_(3) in subduction *** implies that the global water cycle is largely coupled with the deep carbon cycle in Earth’s interior.

关键词： hydroxyl cycle implies

Electronic and optical properties of lithium niobate under high pressure: A first-principles study

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Chinese Physics B 2015年第7期24卷 420-425页

作者：桑丹丹王庆林韩崇陈凯潘跃武 Mathematics and Physical sciences technology Xuzhou Institute of Technology center for high pressure science and technology advanced research

We theoretically study the structural, electronic, and optical properties of lithium niobate under pressure using the plane-wave pseudopotential density functional theory by CASTEP code. It was found that there is a phase transition from the R3 c structure to the Pnma structure at a pressure of 18.7 GPa. The Pnma structure was dynamically stable according to the calculation of phonon dispersion. From the charge density distributions, there exist covalent interactions along the Nb–O bond. The hybridization between O 2p and Nb 4d orbital in the Pnma phase increases with increasing pressure, while it is not changed in the R3c phase. With increasing pressure, the average Nb–O bond length decreases and the Nb–O bond population increases, indicating the increased covalent character between Nb and O atoms under high pressure at Pnma phase, which leads to the increased hybridization between O 2p and Nb 4d orbitals. Furthermore, the optical dielectric function, refractive index, extinction coefficient, electron energy, loss and reflectivity are calculated.

关键词： pressure electronic structure optical properties hybridization

Chemical transformations of n-hexane and cyclohexane under the upper mantle conditions

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Geoscience Frontiers 2021年第2期12卷 1010-1017页

作者： Xin Yang Yapei Li Yajie Wang Haiyan Zheng Kuo Li Ho-kwang Mao center for high pressure science and technology advanced research Beijing100094China

Alkanes are an important part of petroleum,the stability of alkanes under extreme conditions is of great significance to explore the origin of petroleum and the carbon cycle in the deep ***,we performed Raman and infrared(IR)spectroscopy studies of n-hexane and cyclohexane under high pressure up to~42 GPa at room temperature(RT)and high temperature(HT).n-Hexane and cyclohexane undergo several phase transitions at RT around 1.8,8.5,18 GPa and 1.1,2.1,4.6,13,30 GPa,respectively,without any chemical *** using resistive heating combined with diamond anvil cell at pressure up to 20 GPa and temperature up to 1000 K,both n-hexane and cyclohexane decompose to hydrogenated graphitic carbon and n-hexane exhibits higher stability than *** results indicate that hydrocarbons tend to dehydrogenate in the upper mantle,and the extension of carbon chains may lead to the formation of some unsaturated compounds and eventually transfer into graphitic products.

关键词： Alkanes high pressure and high temperature Dehydrogenation Hydrocarbon Upper mantle conditions