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A hybrid memory architecture supporting fine-grained data migration

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Frontiers of computer science 2024年第2期18卷 31-41页

作者： Ye CHI Jianhui YUE Xiaofei LIAO Haikun LIU Hai JIN National Engineering Research center for Big Data technology and System Services Computing Technology and System LabCluster and Grid Computing LabSchool of Computer Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China Department of computer science Michigan Technological UniversityMichigan 49931USA

Hybrid memory systems composed of dynamic random access memory(DRAM)and Non-volatile memory(NVM)often exploit page migration technologies to fully take the advantages of different memory *** previous proposals usually migrate data at a granularity of 4 KB pages,and thus waste memory bandwidth and DRAM *** this paper,we propose Mocha,a non-hierarchical architecture that organizes DRAM and NVM in a flat address space physically,but manages them in a cache/memory *** the commercial NVM device-Intel Optane DC Persistent Memory Modules(DCPMM)actually access the physical media at a granularity of 256 bytes(an Optane block),we manage the DRAM cache at the 256-byte size to adapt to this feature of *** design not only enables fine-grained data migration and management for the DRAM cache,but also avoids write amplification for Intel Optane *** also create an Indirect Address Cache(IAC)in Hybrid Memory Controller(HMC)and propose a reverse address mapping table in the DRAM to speed up address translation and cache ***,we exploit a utility-based caching mechanism to filter cold blocks in the NVM,and further improve the efficiency of the DRAM *** implement Mocha in an architectural *** results show that Mocha can improve application performance by 8.2%on average(up to 24.6%),reduce 6.9%energy consumption and 25.9%data migration traffic on average,compared with a typical hybrid memory architecture-HSCC.

关键词： non-volatile memory hybrid memory system data migration fine-grained caching

A disk I/O optimized system for concurrent graph processing jobs

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Frontiers of computer science 2024年第3期18卷 13-29页

作者： Xianghao XU Fang WANG Hong JIANG Yongli CHENG Dan FENG Peng FANG School of computer science and Engineering Nanjing University of Science and TechnologyNanjing 210094China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China Department of computer science&Engineering University of Texas at ArlingtonArlingtonTX 76019USA College of computer and Data science Fuzhou UniversityFuzhou 350108China Zhejiang Lab Hangzhou 311121China

In order to analyze and process the large graphs with high cost efficiency,researchers have developed a number of out-of-core graph processing systems in recent years based on just one commodity *** the other hand,with the rapidly growing need of analyzing graphs in the real-world,graph processing systems have to efficiently handle massive concurrent graph processing(CGP)***,due to the inherent design for single graph processing job,existing out-of-core graph processing systems usually incur unnecessary data accesses and severe competition of I/O bandwidth when handling the CGP *** this paper,we propose GraphCP,a disk I/O optimized out-of-core graph processing system that efficiently supports the processing of CGP *** proposes a benefit-aware sharing execution model to share the I/O access and processing of graph data among the CGP jobs and adaptively schedule the graph data loading based on the states of vertices,which efficiently overcomes above challenges faced by existing out-of-core graph processing ***,GraphCP adopts a dependency-based future-vertex updating model so as to reduce disk I/Os in the future *** addition,GraphCP organizes the graph data with a Source-Sorted Sub-Block graph representation for better processing capacity and I/O access *** evaluation results show that GraphCP is 20.5×and 8.9×faster than two out-of-core graph processing systems GridGraph and GraphZ,and 3.5×and 1.7×faster than two state-of-art concurrent graph processing systems Seraph and GraphSO.

关键词： graph processing disk I/O concurrent jobs

Wearable and interactive multicolored photochromic fiber display

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Light(science & Applications) 2024年第3期13卷 454-465页

作者： Pan Li Yuwei Wang Xiaoxian He Yuyang Cui Jingyu Ouyang Ju Ouyang Zicheng He Jiayu Hu Xiaojuan Liu Hang Wei Yu Wang Xiaoling Lu Qian Ji Xinyuan Cai Li Liu Chong Hou Ning Zhou Shaowu Pan Xiangru Wang Huamin Zhou Cheng-Wei Qiu Yan-Qing Lu Guangming Tao State Key Laboratory of Material Processing and Die&Mould technology School of Materials Science and Engineering and Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430074China Key Laboratory of Vascular Aging(HUST) Ministry of EducationWuhan 430030China School of Optoelectronic science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China Department of Electrical and computer Engineering National University of SingaporeSingapore 117583Singapore National Laboratory of Solid State Microstructures Key Laboratory of Intelligent Optical Sensing and ManipulationCollege of Engineering and Applied Sciencesand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210023China School of Performing Arts Wuhan Conservatory of MusicWuhan 430060China School of Mechanical science and Engineering Huazhong University of Science and TechnologyWuhan 430074China School of Architecture and Urban Planning Huazhong University of Science and TechnologyWuhan 430074China School of Fashion Beijing Institute of Fashion TechnologyBeijing 100029China School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China Tongji Medical College Huazhong University of Science and TechnologyWuhan 430074China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China

Endowing flexible and adaptable fiber devices with light-emitting capabilities has the potential to revolutionize the current design philosophy of intelligent,wearable interactive ***,significant challenges remain in developing fiber devices when it comes to achieving uniform and customizable light effects while utilizing lightweight ***,we introduce a mass-produced,wearable,and interactive photochromic fiber that provides uniform multicolored light *** designed independent waveguides inside the fiber to maintain total internal reflection of light as it traverses the *** impact of excessive light leakage on the overall illuminance can be reduced by utilizing the saturable absorption effect of fluorescent materials to ensure light emission uniformity along the transmission *** addition,we coupled various fluorescent composite materials inside the fiber to achieve artificially controllable spectral radiation of multiple color systems in a single *** prepared fibers on mass-produced kilometer-long using the thermal drawing *** fibers can be directly integrated into daily wearable devices or clothing in various patterns and combined with other signal input components to control and display patterns as *** work provides a new perspective and inspiration to the existing field of fiber display interaction,paving the way for future human–machine integration.

关键词： fiber interactive colored

Microsnoop: A generalist tool for microscopy image representation

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The Innovation 2024年第1期5卷 109-117页

作者： Dejin Xun Rui Wang Xingcai Zhang Yi Wang Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China State Key Lab of computer-aided design&computer Graphics Zhejiang UniversityHangzhou 310058China John A.Paulson School of Engineering and Applied sciences Harvard UniversityCambridgeMA 02138USA Innovation Institute for Artificial Intelligence in Medicine of Zhejiang university Hangzhou 310018China National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314100China

Accurate profiling of microscopy images from small scale to high throughput is an essential procedure in basic and applied biological ***,we present Microsnoop,a novel deep learning–based representation tool trained on large-scale microscopy images using masked self-supervised *** can process various complex and heterogeneous images,and we classified images into three categories:single-cell,full-field,and batch-experiment *** benchmark study on 10 high-quality evaluation datasets,containing over 2,230,000 images,demonstrated Microsnoop’s robust and state-ofthe-art microscopy image representation ability,surpassing existing generalist and even several custom *** can be integrated with other pipelines to perform tasks such as superresolution histopathology image and multimodal ***,Microsnoop can be adapted to various hardware and can be easily deployed on local or cloud computing *** will regularly retrain and reevaluate the model using communitycontributed data to consistently improve Microsnoop.

关键词： hardware image representation

Screening-current-induced magnetic fields and strains in a compact REBCO coil in self field and background field

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Superconductivity 2024年第1期9卷 35-49页

作者： Yufan Yan Donghui Jiang Peng Song Jeonghwan Park Seungyong Hahn Yunfei Tan Timing Qu Department of Electrical and computer Engineering Seoul National UniversitySeoul 08826Republic of Korea State Key Laboratory of Clean and Efficient Turbomachinery Power Equipment Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China High Magnetic Field Laboratory Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China Wuhan National High Magnetic Field center Huazhong University of Science and TechnologyWuhan 430074China

REBa_(2)Cu_(3)O_(7−x)(REBCO)coated conductors,owing to its high tensile strength and current‐carrying ability in a background field,are widely regarded a promising candidate in high‐field *** the great potentials,recent studies have highlighted the challenges posed by screening currents,which are featured by a highly nonuniform current distribution in the superconducting *** this paper,we report a comprehensive study on the behaviors of screening currents in a compact REBCO coil,specifically the screeningcurrent‐induced magnetic fields and *** were carried out in the self‐generated magnetic field and a background field,*** the self‐field condition,the full hysteresis of the magnetic field was obtained by applying current sweeps with repeatedly reversed polarity,as the nominal center field reached 9.17 T with a maximum peak current of 350 *** a background field of 23.15 T,the insert coil generated a center field of 4.17 T with an applied current of 170 ***,a total center field of 32.58 T was achieved before *** the sequential model and the coupled model considering the perpendicular field modification due to conductor deformation are *** comparative study shows that,for this coil,the electromagnetic–mechanical coupling plays a trivial role in self‐field conditions up to 9 *** contrast,with a high axial field dominated by the background field,the coupling effect has a stronger influence on the predicted current and strain *** discussions regarding the role of background field on the strains in the insert suggest potential design strategies to maximize the total center field.

关键词： Electromagnetic-mechanical analysis High‐field insert coil REBCO coated conductor Screening‐current‐induced magnetic field Screening‐current‐induced stress

Multi-omics Approach Reveals Influenza-A Virus Target Genes Associated Genomic,Clinical and Immunological Characteristics in Cancers

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Biomedical and Environmental sciences 2024年第7期37卷 698-715页

作者： Jiaojiao Wang Yong Liao Pinglian Yang Weile Ye Yong Liu Chunxia Xiao Weixiong Liao Chunbo Chen Zhiping Liu Zunnan Huang center of Scientific Research Department of CardiologyMaoming People’s HospitalMaoming 525000GuangdongChina Department of Pharmacy Maoming People’s HospitalMaoming 525000GuangdongChina State Key Laboratory of Bioactive Molecules and Druggability Assessment Jinan UniversityGuangzhou 510632GuangdongChina Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research College of PharmacyJinan UniversityGuangzhou 510632GuangdongChina Key Laboratory of Big Data Mining and Precision Drug design of Guangdong Medical university Key Laboratory of Computer-Aided Drug Design of Dongguan CityKey Laboratory for Research and Development of Natural Drugs of Guangdong ProvinceSchool of PharmacyGuangdong Medical UniversityDongguan 523808GuangdongChina Department of Critical Care Medicine Maoming People’s HospitalMaoming 525000GuangdongChina

Objective To examine the precise function of influenza A virus target genes(IATGs)in *** Using multi-omics data from the TCGA and TCPA datasets,33 tumor types were evaluated for *** expression in cancer cells was analyzed using transcriptome *** number variation(CNV)was assessed using GISTICS ***’s analysis was used to correlate mRNA expression with methylation *** was used for the enrichment ***’s correlation analysis was used to examine the association between IATG mRNA expression and *** ImmuCellAI algorithm was used to calculate the infiltration scores of 24 immune cell *** In 13 solid tumors,IATG mRNA levels were atypically *** for UCS,UVM,KICH,PCPG,THCA,CHOL,LAMI,and MESO,most cancers contained somatic IATG *** main types of CNVs in IATGs are heterozygous amplifications and *** most tumors,IATG mRNA expression is adversely associated with ***-PCR demonstrated that EGFR,ANXA5,CACNA1C,CD209,UVRAG were upregulated and CLEC4M was downregulated in KIRC cell lines,consistent with the TCGA and GTEx *** Genomic changes and clinical characteristics of IATGs were identified,which may offer fresh perspectives linking the influenza A virus to cancer.

关键词： Genomic changes Immune microenvironment Prognosis Drug resistance Experimental validation

Reach Envelope of Human Extremities

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Tsinghua science and technology 2004年第6期9卷 653-666页

作者：杨景周张云清陈立平 ABDEL-MALEK Karim center for computer-aided design university of Iowa Iowa City IA 52242-1000 USA center for computer aided design huazhong university of science and technology Wuhan 430074 China

Significant attention in recent years has been given to obtain a better understanding of human joint ranges, measurement, and functionality, especially in conjunction with commands issued by the central nervous system. While researchers have studied motor commands needed to drive a limb to follow a path trajectory, various computer algorithms have been reported that provide adequate analysis of limb modeling and motion. This paper uses a rigorous mathematical formulation to model human limbs, understand their reach envelope, delineate barriers therein where a trajectory becomes difficult to control, and help visualize these barriers. Workspaces of a typical forearm with 9 degrees of freedom, a typical finger modeled as a 4-degree-of-freedom system, and a lower extremity with 4 degrees of freedom are discussed. The results show that using the proposed formulation, joint limits play an important role in distinguishing the barriers.

关键词： human extremities degree of freedom biomechanics barriers

A General Simulation Method for Complex Deformation of Irregular-Shaped Origami Configurations

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Acta Mechanica Solida Sinica 2024年第1期37卷 90-98页

作者： Zhaochen Dong Yichao Zhu Xu Guo State Key Laboratory of Structural Analysis for Industrial Equipment Department of Engineering MechanicsInternational Research Center for Computational MechanicsDalian University of TechnologyDalian 116023China

Most existing treatments for origami-folding simulations have focused on regular-shaped *** article aims to introduce a general strategy for simulating and analyzing the deformation process of irregular shapes by means of computational capabilities *** better simulate origami deformation with folding orders,the concept of plane follow-up is introduced to achieve automated computer simulation of complex folding patterns,thereby avoiding intersection and penetration between *** on the evaluation criteria such as the lowest storage energy with tightening and the fastest pace from tightening to unfolding,the optimal crease distribution patterns for four irregular(‘N’-,‘T’-,‘O’-,and‘P’-shaped)origami configurations are then presented under five *** the dimensions of the origami are fixed,it is discovered that simpler folding patterns lead to faster deformation of the origami *** the folding complexity is fixed,higher strain energy results in more rapid origami expansion.

关键词： Irregular-shaped origami Complex deformation computer-aided origami design General simulation

CONTINUUM TOPOLOGY OPTIMIZATION FOR MONOLITHIC COMPLIANT MECHANISMS OF MICRO-ACTUATORS

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Acta Mechanica Solida Sinica 2006年第1期19卷 58-68页

作者： Luo Zhen Du Yixian Chen Liping Yang Jingzhou Karim Abdel-Malek School of Mechanical science ＆ Engineering Huazhong University of Science and Technology Wuhan 430074 China center for computer-aided design Mechanical Engineering Research Facility The University of Iowa Iowa City IA 52246 USA

A multi-objective scheme for structural topology optimization of distributed compliant mechanisms of micro-actuators in MEMS condition is presented in this work, in which mechanical flexibility and structural stiffness are both considered as objective functions. The compliant micro-mechanism developed in this way can not only provide sufficient output work but also have sufficient rigidity to resist reaction forces and maintain its shape when holding the work-piece. A density filtering approach is also proposed to eliminate numerical instabilities such as checkerboards, mesh-dependency and one-node connected hinges occurring in resulting mechanisms. SIMP is used as the interpolation scheme to indicate the dependence of material modulus on element-regularized densities. The sequential convex programming method, such as the method of moving asymptotes （MMA）, is used to solve the optimization problem. The validation of the presented methodologies is demonstrated by a typical numerical example.

关键词： structural optimization topology optimization compliant mechanisms microactuators filtering approach convex programming