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SERPINE2 promotes liver cancer metastasis by inhibiting c-Cbl-mediated EGFR ubiquitination and degradation

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Cancer Communications 2024年第3期44卷 384-407页

作者： Shiyu Zhang Xing Jia Haojiang Dai Xingxin Zhu Wenfeng Song Suchen Bian Hao Wu Shinuo Chen Yangbo Tang Junran Chen Cheng Jin Mengqiao Zhou Haiyang Xie Shusen Zheng Penghong Song Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangP.R.China National Health Commission Key Laboratory of Combined Multi-organ Transplantation HangzhouZhejiangP.R.China Key Laboratory of the Diagnosis and Treatment of Organ Transplantation Research Unit of Collaborative Diagnosis and Treatment for Hepatobiliary and Pancreatic CancerChinese Academy of Medical SciencesHangzhouZhejiangP.R.China Key Laboratory of Organ Transplantation Research Center for Diagnosis and Treatment of Hepatobiliary DiseasesHangzhouZhejiangP.R.China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangP.R.China

Background:Liver cancer is a malignancy with high morbidity and mortality *** family E member 2(SERPINE2)has been reported to play a key role in the metastasis of many *** this study,we aimed to investigate the potential mechanism of SERPINE2 in liver cancer ***:The Cancer Genome Atlas database(TCGA),including DNA methy-lation and transcriptome sequencing data,was utilized to identify the crucial oncogene associated with DNA methylation and cancer progression in liver *** from the TCGA and RNA sequencing for 94 pairs of liver cancer tissues were used to explore the correlation between SERPINE2 expression and clin-ical parameters of *** methylation sequencing was used to detect the DNA methylation levels in liver cancer tissues and *** sequencing,cytokine assays,immunoprecipitation(IP)and mass spectrometry(MS)assays,protein stability assays,and ubiquitination assays were performed to explore the regulatory mechanism of SERPINE2 in liver cancer ***-derived xenografts and tumor organoid models were established to determine the role of SERPINE2 in the treatment of liver cancer using ***:Based on the public database screening,SERPINE2 was identified as a tumor promoter regulated by DNA ***2 expression was significantly higher in liver cancer tissues and was associated with the dismal prognosis in patients with liver ***2 promoted liver cancer metas-tasis by enhancing cell pseudopodia formation,cell adhesion,cancer-associated fibroblast activation,extracellular matrix remodeling,and ***/MS assays confirmed that SERPINE2 activated epidermal growth factor receptor(EGFR)and its downstream signaling pathways by interacting with ***,SERPINE2 inhibited EGFR ubiquitination and maintained its protein stability by competing with the E3 ubiquitin ligase,***,EGFR was activated in liver cancer cells after sorafenib treatment,and SER

关键词： liver cancer metastasis DNA methylation SERPINE2 EGFR c-Cbl ubiquitination

Targeting CD47-SIRPα axis for Hodgkin and non-Hodgkin lymphoma immunotherapy

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Genes & Diseases 2024年第1期11卷 205-217页

作者： Pengcheng Zhao Longyan Xie Lei Yu Ping Wang School of Life Sciences and Medicine Shandong University of TechnologyZiboShandong 255000China Tongji University Cancer center Shanghai Tenth People's HospitalSchool of MedicineTongji UniversityShanghai 200092China

The interaction between cluster of differentiation 47(CD47)and signal regulatory proteinα(SiRPa)protects healthy cells from macrophage attack,which is crucial for maintain-ing immune *** of CD47 occurs widely across various tumor cell types and transmits the"don't eat me"signal to macrophages to avoid phagocytosis through binding to *** of the CD47-SIRPa axis is therefore a promising approach for cancer *** is the most common hematological malignancy and is an area of unmet clin-ical *** review mainly described the current strategies targeting the CD47-SIRPa axis,including antibodies,SiRPaFc fusion proteins,small molecule inhibitors,and peptides both in preclinical studies and clinical trials with Hodgkin lymphoma and non-Hodgkin lymphoma.

关键词： Cancer treatment CD47-SIRPαaxis Hodgkin lymphoma Immunotherapy Non-Hodgkin lymphoma

Comparative effects of artemisia vulgaris and charcoal moxa stimulating Zhongwan(CV 12) on body temperature in healthy participants:a cross-over single-blind randomized study

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Journal of Traditional Chinese Medicine 2015年第5期35卷 551-557页

作者： Ho-Yeon Go Ju Ah Lee Sunyoung Park Sunju Park Jeong-Su Park Chunhoo Cheon Seong-Gyu Ko Kyung-Hwan Kong Chan-yong Jun Jong-hyeong Park Mi-Ran Shin Se-Hoon Lee Department of Internal Medicine College of Korean MedicineSemyung University Department of Public Health The Catholic University of Korea Medical research Division Korea Institute of Oriental Medicine Department of Physiology College of Korean MedicineSemyung University Department of Preventive Medicine College of Korean MedicineDaejeon University center for clin ical research and genomics College of Oriental Medicine and Institu te of Oriental MedicineKyung Hee University Department of Internal Medicine College of Korean MedicineGachon University Department of Sasang Constitutional Medicine College of Korean MedicineSemyung University

OBJECTIVE:To evaluate the efficacy,safety,satisfaction,discomfort and patient preference of moxa cones of artemisia vulgaris and charcoal ***:This comparative study of moxibustion treatment with Artemisia vulgaris and charcoal moxa cone stimulating Zhongwan(CV 12) is a cross-over single-blinded,randomized clinical trial.A total of 40 healthy subjects(24 males and 16females) participated in this *** subjects dropped out of the ***-eight subjects were treated with Artemisia vulgaris and charcoal moxa cones for 30 min in a cross-over *** treatment,the patients underwent a 30 minute waiting period,and then the temperatures at Tanzhong(CV 17),Zhongwan(CV 12) and Guanyuan(CV 4) were measured using digital infrared thermal ***:After the use of Artemisia vulgaris moxa,the patients' body temperatures were slightly lowered at Tanzhong(CV 17),Zhongwan(CV 12)and Guanyuan(CV 4),but the changes were not statistically *** the use of charcoal moxa,the patients' body temperatures were somewhat increased at Zhongwan(CV 12) and Guanyuan(CV 4),but the changes were not statistically *** Artemisia vulgaris moxa use,the body temperature difference between Zhongwan(CV 12) and Guanyuan(CV 4)was significantly *** charcoal moxa use,the body temperature difference between Tanzhong(CV 17) and Zhongwan(CV 12) was significantly decreased in males and in the whole *** change was caused by the difference in the moxibustion type and by gender ***:This pilot study found that moxibustion did not raise the body temperature,but temperature differences between acupoints were *** large-scale randomized controlled trials are needed for the effect of moxibustion on body temperature.

关键词：随机对照试验温度差木炭艾草健康体内临床试验交叉设计

Cistrome Data Browser and Toolkit:analyzing human and mouse genomic data using compendia of ChlP-seq and chromatin accessibility data

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Quantitative Biology 2020年第3期8卷 267-276页

作者： Rongbin Zheng Xin Dong Changxin Wan Xiaoying Shi Xiaoyan Zhang Clifford A.Meyer clin ical Tran slati onal research center Shan ghai Pulmonary HospitalSchool of Life Science and Tech no logyTbngji UniversityShanghai 200433China Department of Bioinformatics School of Life Science and TechnologyTongji UniversityShanghai 200092China Department of Data Science Dana-Farber Cancer Institute and Harvard T.H.Chan School of Public HealthBostonMA 02215USA center for Functional Cancer Epigenetics Dana-Farber Cancer InstituteBostonMA 02215USA

The Cistrome Data Browser(DB)at the website(***/db)provides about 56,000 published human and mouse ChlP-seq,DNase-seq,and ATAC-seq chromatin profiles,which we have processed using uniform analysis and quality control *** Cistrome DB Toolkit at the website(***)was developed to allow users to investigate fundamental questions using this data *** this tutorial,we describe how to use the Cistrome DB to search for publicly available chromatin profiles,to assess sample quality,to access peak results,to visualize signal intensities,to explore DNA sequence motifs,and to identify putative target genes・We also describe the use of the Toolkit module to seek the factors most likely to regulate a gene of interest,the factors that bind to a given genomic interval(enhancer,SNP,etc.),and samples that have significant peak overlaps with user-defined peak *** tutorial guides biomedical researchers in the use of Cistrome DB resources to rapidly obtain valuable insights into gene regulatory questions.

关键词： ChlP-seq chromatin accessibility gene regulatory analysis transcription factor

Identification of Regulatory DNA Elements Using Genome-wide Mapping of DNase I Hypersensitive Sites during Tomato Fruit Development

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Molecular Plant 2016年第8期9卷 1168-1182页

作者： Zhengkun Qiu Ren Li Shuaibin Zhang Ketao Wang Meng Xu Jiayang Li Yongchen Du Hong YU Xia Cui Key Laboratory of Biology and Genetic Improvement of Horticultural Crops of the Ministry of Agriculture Sino-Dutch Joint Laboratory of Horticultural Genomics Institute of Vegetables and Flowers Chinese Academy of Agricultural Sciences Beijing 100081 China State Key Laboratory of Plant genomics and National center for Plant Gene research (Beijing) Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China These authors contributed equally to this article.

Development and ripening of tomato fruit are precisely controlled by transcriptional regulation, which de- pends on the orchestrated accessibility of regulatory proteins to promoters and other c/s-regulatory DNA elements. This accessibility and its effect on gene expression play a major role in defining the develop- mental process. To understand the regulatory mechanism and functional elements modulating morpholog- ical and anatomical changes during fruit development, we generated genome-wide high-resolution maps of DNase I hypersensitive sites （DHSs） from the fruit tissues of the tomato cultivar ＂Moneymaker＂ at 20 days post anthesis as well as break stage. By exploring variation of DHSs across fruit development stages, we pinpointed the most likely hypersensitive sites related to development-specific genes. By detecting binding motifs on DHSs of these development-specific genes or genes in the ascorbic acid biosynthetic pathway, we revealed the common regulatory elements contributing to coordinating gene transcription of plant ripening and specialized metabolic pathways. Our results contribute to a better understanding of the regulatory dynamics of genes involved in tomato fruit development and ripening.

关键词： DNase I hypersensitive sites cis-regulatory element gene expression fruit development tomato

Long-term outcomes of intraoperative radiotherapy for early-stage breast cancer in China: amulticenter real-world study

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Cancer Communications 2022年第3期42卷 277-280页

作者： Xin Wang Kexin Feng Wenyan Wang Xiangzhi Meng Jiaqi Liu Yang Yang Yuting Zhong Jingruo Li Shikai Wu Minghui Li Pan Ma Qinfu Feng Hongmei Zeng Yuanting Gu Xiru Li Zhaoqing Fan Xiang Wang Department of Breast Surgical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021P.R.China Department of Breast Surgery Beijing Tiantan Hospital affiliated to Capital Medical UniversityBeijing 100021P.R.China Key Laboratory of Carcinogenesis and Translational research(Ministry of Education) Breast Cancer CenterPeking University Cancer Hospital and InstituteBeijing 100142P.R.China Department of General Surgery the First Medical CenterChinese PLA General HospitalBeijing 100853P.R.China Department of Breast Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052P.R.China Oncology Department Peking University First HospitalBeijing 100034P.R.China Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021P.R.China National Office for Cancer Prevention and Control National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021P.R.China

Dear Editor,Intraoperative radiotherapy(IORT)is an accelerated par-tial breast irradiation(APBI)treatment that is accom-plished *** clinical trials indicate that IORT is safe and effective,non-inferior to standard whole-breast external beam radiotherapy(EBRT)for low-risk patients who receive breast-conserving surgery[1-3].Nevertheless,these studies mainly included non-Asians and thus lack adequate evidence to support the value of IORT in Asian patients with breast cancer.

关键词： breast radiotherapy intraoperative

The RppC-AvrRppC NLR-effector interaction mediates the resistance to southern corn rust in maize

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Molecular Plant 2022年第5期15卷 904-912页

作者： Ce Deng April Leonard James Cahill Meng Lv Yurong Li Shawn Thatcher Xueying Li Xiaodi Zhao Wenjie Du Zheng Li Huimin Li Victor Llaca Kevin Fengler Lisa Marshall Charlotte Harris Girma Tabor Zhimin Li Zhiqiang Tian Qinghua Yang Yanhui Chen Jihua Tang Xintao Wang Junjie Hao Jianbing Yan Zhibing Lai Xiaohong Fei Weibin Song Jinsheng Lai Xuecai Zhang Guoping Shu Yibo Wang Yuxiao Chang Weiling Zhu Wei Xiong Juan Sun Bailin Li Junqiang Ding College of Agronomy Henan Agricultural UniversityZhengzhou 450046China The State Key Laboratory of Wheat and Maize Crop Science and center for Crop Genome Engineering Henan Agricultural UniversityZhengzhou 450046China Corteva Agriscience JohnstonIA 50131USA Institute of Plant Protection Henan Academy of Agricultural SciencesZhengzhou 450002China National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070China State Key Laboratory of Plant Physiology and Biochemistry National Maize Improvement CenterCollege of Agronomy and BiotechnologyChina Agricultural UniversityBeijing 100193China International Maize and Wheat Improvement center(CIMMYT) El Batan56237 TexcocoMexico center of Biotechnology Beijing Lantron SeedZhengzhou 450001China Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China Henan Dingyou Agricultural Science and Technology Co. LtdZhengzhou 450001China

Southern corn rust(SCR),caused by the fungal pathogen Puccinia polysora,is a major threat to maize pro-duction *** breeding and deployment of resistant hybrids are key to achieving durable control of ***,we report the molecular cloning and characterization of RppC,which encodes an NLR-type immune receptor and is responsible for a major SCR resistance quantitative trait ***-more,we identified the corresponding avirulence effector,AvrRppC,which is secreted by *** and triggers RppC-mediated *** variation of AvrRppC directly determines the effectiveness of RppC-mediated resistance,indicating that monitoring of AvrRppC variants in the field can guide the rational deployment of RppC-containing hybrids in maize ***,RppC is the most frequently deployed SCR resistance gene in China,and a better understanding of its mode of action is crit-ical for extending its durability.

关键词： maize Zea mays RppC AvrRpp Csouthern corn rust SCR

iBIG:An Integrative Network Tool for Supporting Human Disease Mechanism Studies

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genomics, Proteomics & Bioinformatics 2013年第3期11卷 166-171页

作者： Jiya Sun Yuyun Pan Xuemei Feng Huijuan Zhang Yong Duan Hongxing Lei CAS Key Laboratory of Genome Sciences and Information Beijing Institute of GenomicsChinese Academy of Sciences Graduate University of Chinese Academy of Sciences UC Davis Genome center and Department of Biomedical Engineering

Understanding the mechanism of complex human diseases is a major scientitic challenge. Towards this end, we developed a web-based network tool named iBIG （stands for integrative BioloGy）, which incorporates a variety of information on gene interaction and regulation. The generated network can be annotated with various types of information and visualized directly online. In addition to the gene networks based on physical and pathway interactions, networks at a functional level can also be constructed. Furthermore, a supplementary R package is provided to process microarray data and generate a list of important genes to be used as input for iBIG. To demonstrate its usefulness, we collected 54 microarrays on common human diseases including cancer, neurolog- ical disorders, infectious diseases and other common diseases. We processed the microarray data with our R package and constructed a network of functional modules perturbed in common human diseases. Networks at the functional level in combination with gene networks may provide new insight into the mechanism of human diseases, iBIG is freely available at http：//***/ibig.

关键词： Network Functional module Disease mechanism Microarray Web server

Advancing Human Health through Exploration of Plant Metabolism and Reaping the Benefits of Edible Medicinal Plants

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Molecular Plant 2017年第3期10卷 533-536页

作者： Li Tian Yonghong Hu Xiao- Ya Chen Shanghai Chenshan Plant Science research center Chinese Academy of Sciences Shanghai 201602 China Shanghai Key Laboratory of Plant Functional genomics and Resources Shanghai Chenshan Botanical Garden Shanghai 201602 China Department of Plant Sciences University of California Davis Davis CA 95616 USA Shanghai Institute of Plant Physiology and Ecology Chinese Academy of Sciences Shanghai 200032 China

The metabolism of （edible） medicinal plants has increasingly become a central topic for research at the nexus of plant food and human health. Following the successful inaugural event in December of 2015, the 2rid International Symposium on Func- tional Food and Plant Metabolism （ISFFPM） was held on December 14-15,2016, at the scenic Shanghai Chenshan Botan- ical Garden （***）.

关键词： Advancing Human Health through Exploration Plant Metabolism