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Cinnamaldehyde targets SarA to enhance β-lactam antibiotic activity against methicillin-resistant Staphylococcus aureus

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mLife 2024年第2期3卷 291-306页

作者： Jianguo Li Tingyin Lu Yuefei Chu Yuejun Zhang Jing Zhang Wenzhen Fu Jian Sun Yahong Liu Xiao-Ping Liao Yu-Feng Zhou State Key Laboratory for Animal disease control and Prevention South China Agricultural UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation South China Agricultural UniversityGuangzhouChina Yantai Fushan center for Animal disease control and Prevention YantaiChina

Methicillin-resistant Staphylococcus aureus(MRSA)is a current global public health problem due to its increasing resistance to the most recent antibiotic *** critical approach is to develop ways to revitalize existing ***,we show that the phytogenic compound cinnamaldehyde(CIN)and β-lactam antibiotic combinations can functionally synergize and resensitize clinical MRSA isolates to β-lactam therapy and inhibit MRSA biofilm *** studies indicated that the CIN potentiation effect on β-lactams was primarily the result of inhibition of the mecA expression by targeting the staphylococcal accessory regulator *** alone or in combination with β-lactams decreased sarA gene expression and increased SarA protein phosphorylation that impaired SarA binding to the mecA promoter element and downregulated virulence genes such as those encoding biofilm,α-hemolysin,and *** of SarA-mecA binding thus interfered with PBP2a biosynthesis and this decreased MRSA resistance to β-***,CIN fully restored the anti-MRSA activities of β-lactam antibiotics in vivo in murine models of bacteremia and biofilm ***,our results indicated that CIN acts as a β-lactam adjuvant and can be applied as an alternative therapy to combat multidrug-resistant MRSA infections.

关键词： cinnamaldehyde MRSA SarA β-lactamresistance

Risk Factors for Norovirus Outbreaks in Schools and Kindergartens — Beijing Municipality, China, July 2017–June 2022

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China CDC weekly 2024年第33期6卷 841-845页

作者： Baiwei Liu Yu Wang Mengdi Tan Boran E Dongxue Zhang Hanqiu Yan Quanyi Wang Daitao Zhang Lei Jia Zhiyong Gao Institute for Infectious disease and Endemic disease control Beijing Center for Disease Prevention and ControlBeijingChina School of Public Health China Medical UniversityShenyang CityLiaoning ProvinceChina School of Public Health Capital Medical UniversityBeijingChina Department of Endocrinology Beijing Shijitan HospitalCapital Medical UniversityBeijingChina

Summary What is already known on this topic?Norovirus is the leading cause of global acute gastroenteritis *** outbreaks mainly occur in schools and kindergartens in China,always causing public health *** is added by this report?Conditional logistic regression method was used to analyze the risk factors for norovirus outbreaks in schools and kindergartens,and found that students vomiting at school or kindergarten,case activity in public areas,and the first case’s classroom less than 5 meters from toilets were risk *** are the implications for public health practice?Effective measures to address these factors can help reduce the risk of norovirus outbreaks in schools and kindergartens.

关键词： let garten schools

Urgent call for attention to diabetes-associated hospital infections

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World Journal of Diabetes 2024年第8期15卷 1683-1691页

作者： Xue-Lu Yu Li-Yun Zhou Xiao Huang Xin-Yue Li Qing-Qing Pan Ming-Ke Wang Ji-Shun Yang Department of disease control and Prevention Naval Medical Center of PLANaval Medical UniversityShanghai 200052China Medical Care center Naval Medical Center of PLANaval Medical UniversityShanghai 200052China

In this editorial,we discuss the recent article by Zhao et al published in the World Journal of Diabetes,which highlights the importance of recognizing the risk indicators associated with diabetes mellitus(DM).Given the severe implications of healthcare-associated infections(HAIs)in hospitalized individuals-such as heightened mortality rates,prolonged hospitalizations,and increased costs-we focus on elucidating the connection between DM and nosocomial *** patients are susceptible to pathogenic bacterial invasion and subsequent infection,with some already harboring co-infections upon ***,DM is an important risk factor for nosocomial urinary tract infections and surgical site infections,which may indirectly affect the occurrence of nosocomial bloodstream infections,especially in patients with DM with poor glycemic *** evidence regarding the impact of DM on healthcare-associated pneumonias remains inconclusive,attention to this potential association is *** patients with DM should prioritize meticulous blood glucose management,adherence to standard operating procedures,hand hygiene practices,environmental disinfection,and rational use of drugs during *** studies are imperative to explore the main risk factors of HAIs in patients with DM,enabling the development of preventative measures and mitigating the occurrence of HAIs in these patients.

关键词： Diabetes mellitus Healthcare-associated infections Nosocomial urinary tract infections Surgical site infections Nosocomial bloodstream infections

Comparative Effectiveness of Mobile Health-Based Comprehensive Smoking Cessation Modalities and Traditional Clinic-Delivered Treatments—Beijing Municipality,China,May 2022 to April 2024

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China CDC weekly 2024年第22期6卷 516-521页

作者： Shuilian Chu Hang Jing Di Zhang Yuan Cao Yunliang Qian Xiurong Liu Lin Xiao Zhaohui Tong Lirong Liang Department of Research on Tobacco Dependence Therapies Beijing Institute of Respiratory Medicine and Beijing Chao-Yang HospitalCapital Medical UniversityBeijingChina Beijing center for disease Prevention and control BeijingChina Tobacco control Office Chinese Center for Disease Control and PreventionBeijingChina Department of Respiratory and Critical Care Medicine Beijing Institute of Respiratory Medicine and Beijing Chao-Yang HospitalCapital Medical UniversityBeijingChina

What is already known about this topic?Most Chinese smokers have not accessed professional help due to a lack of sufficient smoking cessation *** health(mHealth)can mitigate obstacles related to time and transportation,thereby providing effective support for smokers seeking to *** is added by this report?This study offers real-world evidence supporting the effectiveness of mHealth-based comprehensive smoking cessation *** findings indicate that these modalities can significantly enhance abstinence rates,albeit to a lesser extent compared to traditional clinicbased *** to the intervention was identified as a critical factor influencing the effectiveness of smoking cessation *** are the implications for public health practice?The mHealth-based comprehensive smoking cessation modalities,with or without mailing cessation medications,present a promising approach to enhancing access to and utilization of smoking cessation *** strategy addresses the significant challenge of limited smoking cessation resources in China.

关键词： smoke Health thereby

Preparation and immunoprotective effects of a virus-like particle candidate vaccine of the dominant epidemic D3 genotype coxsackievirus A6 in China

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Biosafety and Health 2024年第1期6卷 28-34页

作者： Xiaoliang Li Xizhu Xu Jichen Li Huanhuan Lu Congcong Wang Rui Wang Jinbo Xiao Ying Liu Yang Song Jingdong Song Qiang Sun Yong Zhang Department of Public Health and Health Administration Shandong First Medical UniversityJinan 250117China National Key Laboratory of Intelligent Tracking and Forecasting for Infectious diseases(NITFID) National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China National Polio Laboratory WHO WPRO Regional Polio Reference LaboratoryNational Health Commission Key Laboratory for BiosafetyNational Health Commission Key Laboratory for Medical VirologyNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBejing 102206China Department of Medical Microbiology Weifang Medical UniversityWeifang 261053China

Coxsackievirus A6 of the D3a genotype(CVA6 D3a)is a primary pathogen causingmainland of China's hand,foot,and mouth disease(HFMD).Viral‐like particle(VLP)vaccines represent a potential candidate vaccine to prevent *** study collected Anti‐CVA6 D3a VLPs serum from BALB/c female mice immunized using CVA6 D3a *** neutralizing antibody levels were compared against the representative 14‐JX2018(D3a)and N4‐YN2015(D3b)strains between the antisera of different immune *** immunoprotective effect of anti‐CVA6 D3a VLPs against these strains was monitored using pathological sections and immuno-histochemical results of lung and skeletal muscle tissues in seven‐day‐old Institute of Cancer Research(ICR)*** protection against different branches of viruses was evaluated in 7‐day‐old(serum passive immune protection)and 14‐day‐old(VLPs active immune protection)neonatal ICR mice ***‐neutralizing antibody levels were positively correlated with the number of immunizations and higher against 14‐JX2018 than against N4‐***,these levels were significantly higher with abdominal injection than intramuscular *** immunized serum of 7‐day‐old ICR mice inoculated three times was 100%protected against CVA6 D3a 14‐JX2018(lethal titer:106.25 TCID 50)and CVA6 D3b N4‐YN2015(lethal titer:105.25TCID 50)fatal attacks,*** ICR mice that have completed two active immunizations for 14 days,both CVA6 D3a 14‐JX2015(challenge titer:108.25 TCID 50)and CVA6 D3b N4‐YN2015(challenge titer:107.25 TCID 50)were used for the challenge,and the mice were able to ***,the CVA6 D3a VLPs prepared in this study are a potential vaccine candidate for CVA6,as it has the optimal protective effect against both CVA6 D3a and D3b evolutionary branches viruses.

关键词： Coxsackievirus A6 D3 genotype Virus‐like particle Immunoprotective effect

Effective Nucleic Acid Contamination Disinfection in Laboratory Settings using Ozone Gas

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Biomedical and Environmental Sciences 2024年第9期37卷 1095-1100页

作者： Yingyi Long Linlin Liang Xingyan Zhou Fei Ren Lu Wang Peng Zhang Jing Wang Department of Laboratory The Second People’s Hospital of Jiulongpo DistrictChongqing 400030China Jiulongpo District center for disease control and Prevention Chongqing 400030China

The Nucleic Acid Laboratory,a division of the Clinical Laboratory Department,is responsible for performing real-time PCR(qPCR)assays to rapidly detect infectious diseases,genetic disorders,and more[1].As the gold standard,qPCR has played an indispensable role in diagnosing pandemic infections,such as the coronavirus disease 2019(COVID-19)[2].

关键词： qPCR indispensable performing

Rapid identification of full-length genome and tracing variations of monkeypox virus in clinical specimens based on mNGS and amplicon sequencing

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Virologica Sinica 2024年第1期39卷 134-143页

作者： Changcheng Wu Ruhan A Sheng Ye Fei Ye Weibang Huo Roujian Lu Yue Tang Jianwei Yang Xuehong Meng Yun Tang Shuang Chen Li Zhao Baoying Huang Zhongxian Zhang Yuda Chen Dongfang Li Wenling Wang Ke-jia Shan Jian Lu Wenjie Tan NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing100052China Chongqing Municipal Key Laboratory for High Pathogenic Microbes Chongqing Center for Disease Control and PreventionChongqing400042China MGI BGI-ShenzhenShenzhen518083China Thermo Fisher Scientific Beijing100013China School of Public Health Baotou Medical CollegeBaotou014030China BGI PathoGenesis Pharmaceutical Technology Shenzhen518000China State Key Laboratory of Protein and Plant Gene Research Center for BioinformaticsSchool of Life SciencesPeking UniversityBeijing100871China College of Life Sciences University of Chinese Academy of SciencesBeijing100049China

The monkeypox virus(MPXV)has triggered a current outbreak *** sequencing of MPXV and rapid tracing of genetic variants will benefit disease diagnosis and *** is a significant challenge but necessary to optimize the strategy and application of rapid full-length genome identification and to track variations of MPXV in clinical specimens with low viral loads,as it is one of the DNA viruses with the largest genome and the most AT-biased,and has a significant number of tandem *** we evaluated the performance of metagenomic and amplicon sequencing techniques,and three sequencing platforms in MPXV genome sequencing based on multiple clinical specimens of five mpox cases in Chinese *** rapidly identified the full-length genome of MPXV with the assembly of accurate tandem repeats in multiple clinical *** sequencing enables cost-effective and rapid sequencing of clinical specimens to obtain high-quality MPXV ***-generation sequencing facilitates the assembly of the terminal tandem repeat regions in the monkeypox virus genome and corrects a common misassembly in published ***,several intra-host single nucleotide variations were identified in the first imported mpox *** study offers an evaluation of various strategies aimed at identifying the complete genome of MPXV in clinical *** findings of this study will significantly enhance the surveillance of MPXV.

关键词： Monkeypox virus(MPXV) Metagenomic Next generation sequencing Amplicon Third-generation sequencing

Post-Marketing Surveillance of Adverse Events Following Immunization with Haemophilus Influenzae Type b Conjugate Vaccine — China, 2010–2021

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China CDC weekly 2024年第33期6卷 834-840页

作者： Minrui Ren Keli Li Yan Li Chunxiang Fan Yuyang Xu Lina Zhang Yuan Li Lei Cao Wenzhou Yu Zundong Yin National Key Laboratory of Intelligent Tracking and Forecasting for Infectious diseases(NITFID) National Immunization ProgrammeChinese Center for Disease Control and PreventionBeijingChina Department of Expanded Programme on Immunization Hangzhou Center for Disease Control and PreventionHangzhou CityZhejiang ProvinceChina

Introduction The Haemophilus influenzae type b(Hib)conjugate vaccine is widely administered in *** We extracted data on Hib vaccine doses administered and adverse events following immunization(AEFI)reported between 2010 and 2021 from the Chinese National Immunization Information System(CNIIS).A descriptive analysis was conducted to examine the characteristics and incidence rates of AEFI with the Hib *** In China,between 2010 and 2021,a total of 52,910 AEFIs with the Hib vaccine were reported,resulting in an overall AEFI reporting rate of 38.10 per 100,000 ***(typically minor)and rare(potentially serious)vaccine reactions occurred at rates of 34.71 and 2.78 per 100,000 doses,*** the common vaccine reactions,the incidences of fever(axillary temperature≥38.6℃),injection site redness and swelling(>2.5 cm in diameter),and injection site induration(>2.5 cm in diameter)were 11.93,9.69,and 3.38 per 100,000 doses,*** vaccine reactions included anaphylactic rash,angioedema,and febrile convulsion with reported incidences of 2.42,0.10,and 0.05 per 100,000 doses,*** incidence of serious rare vaccine reactions was 0.16 per 100,000 *** The reported incidence of AEFI with the Hib vaccine was low,with the occurrence of serious rare adverse reactions also being markedly low throughout the period 2010–2021 in China.

关键词： doses markedly injection

Analysis of Trends of Cancer Epidemiology in Two Provinces of the Western and Eastern China

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Journal of Clinical and Nursing Research 2024年第4期8卷 213-218页

作者： Shimin Deng Xianbin Ding Xiaoyan Lu Zhifu Dong Hongdan Cao Wanzhen Tang Department of Nursing Medicine Chongqing Medical and Pharmaceutical CollegeChongqing 401331China Department of chronic and Non-communicable disease Prevention and control Chongqing Municipal Centre for Disease Prevention and ControlChongqing 400042China

In this paper, the literature on the incidence and death of malignant tumors in the Chongqing and Jiangsu provinces from 2014-2016 was collected through a literature review. The overall incidence, mortality, tumor spectrum, and possible risk factors of malignant tumor incidence and death in the Chongqing and Jiangsu provinces were compared and analyzed. This aims to provide references and suggestions for the prevention and control of malignant tumors in China.

关键词： Cancer Incidence Mortality