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China Stroke Statistics 2019:A Report From the National center for Healthcare Quality Management in Neurological diseases,China National Clinical Research center for Neurological diseases,the Chinese Stroke Association,National center for chronic and Non-communicable disease Control and Prevention,Chinese center for disease Control and Prevention and Institute for Global Neuroscience and Stroke Collaborations

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Stroke & Vascular Neurology 2020年第3期5卷 211-239页

作者： Yong-Jun Wang Zi-Xiao Li Hong-Qiu Gu Yi Zhai Yong Jiang Xing-Quan Zhao Yi-Long Wang Xin Yang Chun-Juan Wang Xia Meng Hao Li Li-Ping Liu Jing Jing Jing Wu An-Ding Xu Qiang Dong David Wang Ji-Zong Zhao On behalf of China Stroke Statistics 2019 Writing Committee China National Clinical Research center for Neurological diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National center for Healthcare Quality Management in Neurological diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National center for chronic and Non-communicable disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Department of Neurology and Stroke center The First Affiliated HospitalJinan UniversityGuangzhouGuangdongChina Department of Neurology Huashan HospitalFudan UniversityShanghaiChina Neurovascular Division Department of NeurologyBarrow Neurological InstituteSt.Joseph's Hospital and Medical CenterPhoenixArizonaUSA 不详

China faces the greatest challenge from stroke in the *** death rate for cerebrovascular diseases in China was 149.49 per 100000,accounting for 1.57 million deaths in *** ranked third among the leading causes of death behind malignant tumours and heart *** age-standardised prevalence and incidence of stroke in 2013 were 1114.8 per 100000 population and 246.8 per 100000 person-years,*** to the Global Burden of disease Study 2017,the years of life lost(YLLs)per 100000 population for stroke increased by 14.6%;YLLs due to stroke rose from third highest among all causes in 1990 to the highest in *** absolute numbers and rates per 100000 population for all-age disability-adjusted life years(DALYs)for stroke increased substantially between 1990 and 2017,and stroke was the leading cause of all-age DALYs in *** main contributors to cerebrovascular diseases include behavioural risk factors(smoking and alcohol use)and pre-existing conditions(hypertension,diabetes mellitus,dyslipidaemia and atrial fibrillation(AF)).The most prevalent risk factors among stroke survivors were hypertension(63.0%-84.2%)and smoking(31.7%-47.6%).The least prevalent was AF(2.7%-7.4%).The prevalences for major risk factors for stroke are high and most have increased over *** on the latest national epidemiological data,26.6%of adults aged≥15 years(307.6 million adults)smoked tobacco *** those aged≥18 years,age-adjusted prevalence of hypertension was 25.2%;adjusted prevalence of hypercholesterolaemia was 5.8%;and the standardised prevalence of diabetes was 10.9%.For those aged≥40 years,the standardised prevalence of AF was 2.31%.Data from the Hospital Quality Monitoring System showed that 3010204 inpatients with stroke were admitted to 1853 tertiary care hospitals during *** those,2466785(81.9%)were ischaemic strokes(ISs);447609(14.9%)were intracerebral haemorrhages(ICHs);and 95810(3.2%)were subarachnoid haemorrhages(SAHs).The average age

关键词： admitted smoke insurance

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Spatio-temporal analysis of female breast cancer incidence in Shenzhen,2007-2012

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Chinese Journal of Cancer 2015年第5期34卷 198-204页

作者： Hai-Bin Zhou Sheng-Yuan Liu Lin Lei Zhong-Wei Chen Ji Peng Ying-Zhou Yang Xiao-Li Liu Shenzhen center for chronic disease Control Shenzhen Nanshan center for chronic disease Control

Introduction:Breast cancer is a leading tumor with a high mortality in *** study examined the spatio-temporal distribution of the incidence of female breast cancer in Shenzhen between 2007 and ***:The data on breast cancer incidence were obtained from the Shenzhen Cancer Registry *** describe the temporal trend,the average annual percentage change(AAPC) was analyzed using a pinpoint regression *** autocorrelation and a retrospective spatio-temporal scan approach were used to detect the spatio-temporal cluster distribution of breast cancer ***:Breast cancer ranked first among different types of cancer in women in Shenzhen between 2007 and 2012 with a crude incidence of 20.0/100,000 *** age-standardized rate according to the world standard population was 21.1/100,000 in 2012,with an AAPC of 11.3%.The spatial autocorrelation analysis showed a spatial correlation characterized by the presence of a hotspot in south-central Shenzhen,which included the eastern part of Luohu District(Donghu and Liantang Streets) and Yantian District(Shatoujiao,Haishan,and Yantian Streets).Five spatio-temporal cluster areas were detected between 2010 and 2012,one of which was a Class 1 cluster located in southwestern Shenzhen in 2010,which included Yuehai,Nantou,Shahe,Shekou,and Nanshan Streets in Nanshan District with an incidence of 54.1/100,000 and a relative risk of 2.41;the other four were Class 2 clusters located in Yantian,Luohu,Futian,and Longhua Districts with a relative risk ranging from 1.70 to ***:This study revealed the spatio-temporal cluster pattern for the incidence of female breast cancer in Shenzhen,which will be useful for a better allocation of health resources in Shenzhen.

关键词：深圳地区时空分析乳腺癌发病率女性空间自相关分析时空分布空间相关性

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Serum 25(OH)D and Lipid Levels in Chinese Obese and Normal Weight Males before and after Oral Vitamin D Supplementation

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Biomedical and Environmental Sciences 2013年第10期26卷 801-807页

作者： ZHOU Ji Chang ZHU Yu Mei GUO Ping CHEN Zheng XIE Feng Zhu LIU Xiao Li HE Shan Molecular Biology Laboratory Shenzhen Center for Chronic Disease Control Health Service center of Shuiku Community Shenzhen Center for Chronic Disease Control

Objective To study the effect of oral vitamin D （VD） supplementation on VD status and serum lipid in Chinese obese and healthy normal-weight men. Methods Twenty-one obese men with their body mass index （BMI）〉28 kg/m2 served as an obese group and 22 healthy normal-weight men with their BMI〈24 kg/m2 served as a control group in this study. After they were given 50 000 IU of oral VD, once a week for 8 weeks, the serum 25-hydroxyvitamin D [25（OH）D] concentration was measured with an enzyme-immunoassay kit. Results After oral VD supplementation, the serum 25（OH）D concentration significantly increased from 46.1＋9.1 nmol/L to 116.7_＋20.3 nmol/L in the obese subjects （P〈O.01） and from 52.8_＋17.8 nmol/L to 181.3_＋30.2 nmol/L in the control ones （P=0.13）. The serum high-density lipoprotein cholesterol （HDL-C） level was reduced within the normal reference range in the obese group. However, no significant change was observed in the level of other serum lipids （triglycerides, total cholesterol, and low-density lipoprotein cholesterol） in either of the two groups. Conclusion The effect of high-dose oral VD supplementation is weaker on VD status in the obese group than in the control group. High-dose oral VD supplementation has no side effect on serum lipid level in obese and control groups.

关键词： Vitamin D Obesity Serum 25(OH)D Serum lipid

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Development and Validation of a Model for Predicting Diabetic Nephropathy in Chinese People

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Biomedical and Environmental Sciences 2017年第2期30卷 106-112页

作者： MIAO Dan Dan PAN En Chun ZHANG Qin SUN Zhong Ming QIN Yu WU Ming Department of chronic disease Prevention and Control Huai’an City Center for Disease Control and Prevention Department of chronic disease Prevention and Control Jiangsu Provincial Center for Disease Control and Prevention

Objective To develop a risk model for predicting later development of diabetic nephropathy （DN） in Chinese people with type 2 diabetes mellitus （T2DM） and evaluate its performance with independent validation. Methods We used data collected from the project ＇Comprehensive Research on the Prevention and Control of Diabetes＇, which was a community-based study conducted by the Jiangsu center for disease Control and Prevention in 2013. A total of 11,771 eligible participants were included in our study. The endpoint was a clear diagnosis of DN. Data was divided into two components： a training set for model development and a test set for validation. The Cox proportional hazard regression was used for survival analysis in men and women. The model＇s performance was evaluated by discrimination and calibration. Results The incidence （cases per 10,000 person-years） of DN was 9.95 （95% CI; 8.66-11.43） in women and 11.28 （95% CI; 9.77-13.03） in men. Factors including diagnosis age, location, body mass index, high-density-lipoprotein cholesterol, creatinine, hypertension, dyslipidemia, retinopathy, diet control, and physical activity were significant in the final model. The model showed high discrimination and good calibration. Conclusion The risk model for predicting DN in people with T2DM can be used in clinical practice for improving the quality of risk management and intervention.

关键词： Type 2 diabetes mellitus Diabetic nephropathy Risk factors Model development andvalidation

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Pulmonary Heart disease Associated Mortality—China,2014–2021

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China CDC weekly 2023年第35期5卷 779-784页

作者： Yangyang Xu Zhe Liu Jinlei Qi Lijun Wang Maigeng Zhou Peng Yin National center for chronic and Noncommunicable disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

Introduction:Over the latter half of the previous century,pulmonary heart disease(PHD)emerged as a significant public health issue in ***,the current mortality rate is *** the Multiple Cause of Death database,the present study aims to investigate the current state and progression of PHD-associated death in ***:Data from the China National Mortality Surveillance System were used to analyze progression in mortality rates attributable to PHD from 2014 to *** standardize population structure for each year during the investigation period,demographic information from the 2020 census was employed as the reference *** mortality rates(ASMR)were determined based on sex,urban-rural area,and *** identify trends in ASMR,a joinpoint regression analysis was ***:The ASMR of PHD exhibited a marked decrease,falling from 61.68 per 100,000 in 2014 to 28.53 per 100,000 in *** downward trend was observable in both genders,all regions,and both urban and rural *** greatest ASMR values were documented in the western *** observations revealed a higher ASMR in rural areas versus urban ones and in males versus *** deaths predominantly occurred among older individuals,particularly those aged 80 and *** obstructive pulmonary disease(COPD)emerged as the principal underlying cause of death PHD-associated mortalities,accounting for between 87.41%and 93.42%of cases throughout the period 2014–***:There was a declining trend in PHD mortality in China from 2014 to 2021,with COPD accounting for a significant proportion of these *** the high prevalence of COPD and the escalating population aging in China,PHD remains a significant health concern that warrants further attention.

关键词： latter downward urban

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chronic Obstructive Pulmonary disease-Associated Mortality — China, 2014–2021

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China CDC weekly 2024年第43期6卷 1105-1110页

作者： Zifang Zhou Lijun Wang Maigeng Zhou Peng Yin National center for chronic and Non-communicable disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

Introduction:China faces a growing burden of chronic obstructive pulmonary disease(COPD).Previous mortality estimations were primarily based on the underlying cause of *** study analyzed COPD-associated death and its comorbidities using all COPD cases listed on the chain of events on death ***:A retrospective analysis of the National Mortality Surveillance System(NMSS)was conducted to estimate COPD-associated mortality from 2014 to ***-standardized mortality rates(ASMRs)were calculated stratified by sex,region,and *** regression was used to estimate the average annual percentage change(AAPC)during the study ***:From 2014 to 2021,the ASMR of COPD decreased from 91.85 to 45.90 per 100,000 *** but uneven decreases in COPD mortality were observed across gender[females:AAPC:−11.2%,95%confidence interval(CI):−11.9 to−10.4%;males:AAPC:−8.0%,95%CI:−9.2 to−6.8%],regions(eastern:AAPC:−10.7%,95%CI:−11.5 to−9.9%;central:AAPC:−9.9%,95%CI:−10.9 to−8.9%;western:AAPC:−7.7%,95%CI:−10.6 to−4.7%),and residential areas(urban:AAPC:−10.9%,95%CI:−12.3 to−9.5%;rural:AAPC:−8.3%,95%CI:−9.1 to−7.4%).Other than COPD,cardiovascular diseases and respiratory conditions were the major underlying causes of death in COPDassociated ***:COPD is a significant comorbidity of other disorders in *** COPDassociated mortality substantially decreased from 2014 to 2021,the burden remained high in underdeveloped regions.

关键词： mortality listed stratified

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Prevalence of Major Cardiovascular Risk Factors and Cardiovascular disease in Women in China: Surveillance Efforts

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Biomedical and Environmental Sciences 2016年第3期29卷 205-211页

作者： LI Jian Hong WANG Li Min LI Yi Chong ZHANG Mei WANG Lin Hong National center for chronic and Noncommunicable disease Control and Prevention Chinese Center for Disease Control and Prevention

In this study, we aimed to assess the relationship of socioeconomic status and acculturation with cardiovascular disease （CVD） risk profiles and CVD and examine the CVD risk factors associated with CVD. We used data from the 2010 China chronic disease and Risk Factor Surveillance surveys, which consisted of a nationally representative sample of women. The following prevalence was found： myocardial infarction （MI）：

关键词： CVD Surveillance Efforts Prevalence of Major Cardiovascular Risk Factors and Cardiovascular disease in Women in China

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Unintentional Drowning Mortality Among Individuals Under Age 20—China,2013–2021

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China CDC weekly 2023年第47期5卷 1058-1062页

作者： Zi Li Xiao Deng Ye Jin Leilei Duan Pengpeng Ye National center for chronic and Noncommunicable disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

ABSTRACT Introduction:This study seeks to elucidate the evolving trend and identify disparities among subgroups in the mortality rate due to unintentional drowning in individuals under the age of 20 from the timeframe... 详细信息

关键词： subgroups China. identif

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Trends in Fruit and Vegetable Intake Among the Labor Force Population—China,2010-2018

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China CDC weekly 2024年第18期6卷 401-407,I0008页

作者： Lan Wang Mei Zhang Xiao Zhang Zhenping Zhao Chun Li Mengting Yu Taotao Xue Feng Tan Limin Wang Division of chronic disease and Risk Factor Surveillance National Center for Chronic and Non-communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Chinese center for disease Control and Prevention BeijingChina

Introduction:This research investigates trends pertaining to the prevalence of low fruit and vegetable consumption among the labor force population in *** study considered data derived from four nationally representative cross-sectional ***:The data under review for this study was derived from the China chronic disease and Risk Factor Surveillance(CCDRFS)carried out in 2010,2013,2015,and 2018,*** utilized a food frequency questionnaire to evaluate the quantity and frequency of fruit and vegetable *** estimated prevalence of low fruit and vegetable consumption was calculated for each survey,while considering factors such as sex,age,location,and socioeconomic status(SES).Participants’SES was ascertained via latent class analysis,serving to identify distinct classes based on criteria such as education,occupation,and household income per *** regression was deployed to determine the statistical significance of ***:From 2010 to 2018,there was a notable increase in the average daily consumption of vegetables and fruits among the working population,rising from 418.6 g/day to 491.8 g/day(P0.05 for trend).Conclusion:Over the past nine years,there has been a notable decline in the prevalence of low fruit and vegetable consumption among the labor force population in ***,the comparatively deficient intake of fruits and vegetables evident among individuals of lower SES warrants further attention.

关键词： intake occupation utilized

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Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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Neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-Núñez María Fernanda González Ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced center for chronic diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3K/AKT/connexin 43,and Notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

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