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Low-power STED nanoscopy based on temporal and spatial modulation

Nano Research 2022年第4期15卷 3479-3486页

作者： Luwei Wang Yue Chen Yong Guo Weixin Xie Zhigang Yang Xiaoyu Weng Wei Yan JunleQu center for biomedical photonics&college of physics and optoelectronic engineering Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong ProvinceShenzhen 518060China college of Electronics and Information engineering Shenzhen UniversityShenzhen 518060China

Stimulated emission depletion(STED)nanoscopy enables the visualization of subcellular organelles in unprecedented ***,reducing the power dependency remains one of the greatest challenges for STED imaging in living ***,we propose a new method,called modulated STED,to reduce the demand for depletion power in STED imaging by modulating the information from the temporal and spatial *** this approach,an excitation pulse is followed by a depletion pulse with a longer delay;therefore,the fluorescence decay curve contains both confocal and STED photons in a laser pulse *** time-resolved detection,we can remove residual diffraction-limited signals pixel by pixel from STED photons by taking the weighted difference of the depleted ***,fluorescence emission in the periphery of an excitation spot is further inhibited through spatial modulation of fluorescent signals,which replaced the increase of the depletion power in conventional *** demonstrate that the modulated STED method can achieve a resolution of<100 nm in both fixed and living cells with a depletion power that is dozens of times lower than that of conventional STED,therefore,it is very suitable for long-term superresolution imaging of living ***,the idea of the method could open up a new avenue to the implementation of other experiments,such as light-sheet imaging,multicolor and three-demensional(3D)super-resolution imaging.

关键词： fluorescence microscopy super-resolution imaging stimulated emission depletion fluorescence lifetime signal modulation

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Intermolecular hydrogen-bonding as a robust tool toward significantly improving the photothermal conversion efficiency of a NIR-II squaraine dye

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Chinese Chemical Letters 2024年第4期35卷 310-315页

作者： Songtao Cai Liuying Wu Yuan Li Soham Samanta Jinying Wang Bing Liu Feihu Wu Kaitao Lai Yingchao Liu Junle Qu Zhigang Yang center for biomedical photonics&Key Laboratory of optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China

The photothermal therapy(PTT) has come across as a promising noninvasive therapeutic strategy for tumor treatment. However, low photothermal conversion efficiency(PCE) and hydrophobicity may impede the therapeutic efficacy of organic photothermal agents and an efficient PTT-agent must overcome these two major challenges. In this work, we developed a new strategy to promote higher PCE wherein the intermolecular hydrogen-bonding interaction between the single dye molecule and water facilitated the transformation of the absorbed energy into the heat. A hydrophilic squaraine dye(SCy1) with the second near-infrared region(NIR-II) absorption and extremely low emission were designed to exhibit much higher PCE than that of the analogues of pentamethine-dyes(PCy1, PCy2). The presence of the ‘–O-' at middle of squaric cycle enabled the intermolecular H-bonding formation between the SCy1 and water to promote the energy dissipation channel. Moreover, the introduction of long-chain phenylsulfonate groups helped in to improve the water solubility apart from serving as an additional means of further enhancing PCE through fluorescence quenching. Therefore, SCy1 with a squaraine backbone and long-chain sulfonate moieties revealed outstanding photothermal stability and anti-aggregation activity apart from showing exceptionally high PCE(74%) in water. SCy1 demonstrated excellent therapeutic efficacy when applied in the PTT treatment of tumor-bearing mice under a laser irradiation of 915 nm.

关键词： Squaraine-based cyanine Hydrogen bonds High PCE Anti-aggregation Photothermal therapy

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Observations of intracellular second-harmonic generation imaging in black phosphorus nanosheets

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Journal of Innovative Optical Health Sciences 2021年第2期4卷 11-18页

作者： Xiao Peng Yiwan Song Zheng Peng Kaixuan Nie Hao Liu Yingxin Zhou Feifan Zhou Yufeng Yuan Jun Song Junle Qu center for biomedical Optics and photonics(CBOP)&college of physics and optoelectronic engineering Key Laboratory of optoelectronic Devices and Systems of Ministry of Education and Guangdong Province Shenzhen University Shenzhen 518060P.R.China

Functionalized black phosphorus(BP)nanosheets have been considered as promising nanoagents in cancer therapy due to their excellent photothermal conversion ***,it is still difficult to visually monitor the dynamic localization of BP nanoagents in cancer *** this paper,we systematically studied the second-harmonic generation(SHG)signals originating from exfoliated BP ***,under the excitation of a high frequency pulsed laser at 950 nm,the SHG signals of BP nanosheets in vitro are almost undetectable because of their poor ***,the intracellular SHG signals from BP nanosheets could be measured by in vivo optical imaging due to the efficient enrichment of living HeLa ***,the SHG signal intensity from BP nanosheets increases with the prolonged incubation *** can be expected that the BP nanosheets could be a promising intracellular SHG nanoprobe employed for visually in vivo biomedical imaging in practical cancer photothermal therapy(PIT).

关键词： Second harmonic generation nanoprobe black phosphorus nanosheets in vivo im-aging HeLa cells visual monitoring

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Shedding light on biology and healthcare--preface to the special issue on biomedical Optics

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Light(Science & Applications) 2022年第7期11卷 1315-1317页

作者： Peng Xi Xunbin Wei Junle Qu Valery V.Tuchin Department of biomedical engineering College of Future TechnologyPeking University100871BeijingChina Department of biomedical engineering Peking University100081BeijingChina center for biomedical Optics and photonics(CBOP)&college of physics and optoelectronic engineering Key Laboratory of Optoelectronic Devices and Systems of Guangdong Province and Ministry of EducationShenzhen University518060ShenzhenChina Saratov State University 83 Astrakhanskaya str.Saratov410012Russia

During the past decade,there has been an explosion in the development of novel optical techniques in biomedical research and clinical *** progress has been made in optical imaging and detection to provide necessary biological information for disease diagnosis and in-depth understanding of biological ***,recent advances integrating laser technology with biomarkers have enabled novel diagnostic and treatment approaches for different types of diseases.

关键词： optical integrating diagnosis

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Halogen-doped phosphorescent carbon dots for grayscale patterning

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Light(Science & Applications) 2022年第7期11卷 1464-1474页

作者： Yanfeng Liu Mahmoud Al-salihi Yong Guo Roman Ziniuk Songtao Cai Luwei Wang Yuan Li Zhigang Yang Dengfeng Peng Kai Xi Zhongfu An Xudong Jia Liwei Liu Wei Yan Junle Qu center for biomedical photonics and college of physics and optoelectronic engineering Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong ProvinceShenzhen UniversityShenzhen 518060China School of Chemistry and Chemical engineering Nanjing University163 Xianlin RoadNanjing 210023China Key Laboratory of Flexible Electronics(KLOFE)and Institute of Advanced Materials(IAM) Nanjing Tech University(NanjingTech)30 South Puzhu RoadNanjing 211816China

Flexible organic materials that exhibit dynamic ultralong room temperature phosphorescence(DURTP)via photoactivation have attracted increasing research interest for their fascinating functions of reversibly writing-reading-erasing graphic information in the form of a long ***,due to the existence of a nonnegligible activation threshold for the initial exposure dose,the display mode of these materials has thus far been limited to binary *** resorting to halogen element doping of carbon dots(CDs)to enhance intersystem crossing and reduce the activation threshold,we were able to produce,for the first time,a transparent,flexible,and fully programmable DURTP composite film with a reliable grayscale display *** of promising applications in UV photography and highly confidential steganography were constructed,partially demonstrating the broad future applications of this material as a programmable platform with a high optical information density.

关键词： activation resort negligible

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Near-resonance enhanced label-free stimulated Raman scattering microscopy with spatial resolution near 130 nm

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Light(Science & Applications) 2018年第1期7卷 279-288页

作者： Yali Bi Chi Yang Yage Chen Shuai Yan Guang Yang Yaozu Wu Guoping Zhang Ping Wang Britton Chance center for biomedical photonics Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and TechnologyWuhanHubei 430074China MoE Key Laboratory for biomedical photonics Collaborative Innovation Center for Biomedical EngineeringSchool of Engineering SciencesHuazhong University of Science and TechnologyWuhanHubei 430074China MoE Key Laboratory of Quark and Lepton physics and college of physics Science and Technology Central China Normal UniversityWuhan 430079China

High-resolution optical microscopes that can break 180 nm in spatial resolution set to conventional microscopies are much-needed ***,current optical microscopes have to rely on exogenous fluorescent labels to achieve high resolution in biological ***,we report near-resonance enhanced label-free stimulated Raman scattering(SRS)microscopy with a lateral resolution near 130 nm,in which the high-resolution image contrast originates directly from a low concentration of endogenous biomolecules,with sensitivity gains of approximately 23 ***,by using a 0.3-m-long optical fiber,we developed hyperspectral SRS microscopy based on spectral focusing *** to enhancements in spatial resolution and sensitivity,we demonstrated highresolution imaging of three-dimensional structures in single cells and high-resolution mapping of large-scale intact mouse brain tissues in *** using enhanced high-resolution hyperspectral SRS,we chemically observed sphingomyelin distributed in the myelin sheath that insulates single *** concept opens the door to biomedical imaging with~130 nm resolution.

关键词： resolution resonance approximate

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Plasmon-resonant gold nanoparticles for cancer optical imaging

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Science China(physics,Mechanics & Astronomy) 2013年第3期56卷 506-513页

作者： WANG Zhen Britton Chance center for biomedical photonics Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology MoE Key Laboratory for biomedical photonics Department of Biomedical EngineeringHuazhong University of Science and Technology

Gold nanoparticles(AuNPs) interact with light and have strong and tunable surface plasmon resonance,which can be detected using multiple imaging *** provide an unique opportunity for their potential applications in optical imaging for early detection of *** this review,we summarized nanoparticles targeting properties for cancer,plasmon optical properties of AuNPs,application of AuNPs for cancer optical *** discussed is the safety of AuNPs.

关键词： gold nanoparticles surface plasmon resonance optical imaging cancer

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Laser-Induced Recoverable Fluorescence Quenching of Perovskite Films at a Microscopic Grain Scale

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Energy & Environmental Materials 2022年第4期5卷 1189-1199页

作者： Yuren Xiang Yameng Cao Wenqiang Yang Rui Hu Sebastian Wood Bowei Li Qin Hu Fan Zhang Jujie He Mozhgan Yavari Jinlai Zhao Yunlong Zhao Jun Song Junle Qu Rui Zhu Thomas P.Russell S.Ravi P.Silva Wei Zhang center for biomedical Optics and photonics(CBOP)&college of physics and optoelectronic engineering Key Laboratory of Optoelectronic Devices and SystemsShenzhen UniversityShenzhen 518060China Advanced Technology Institute University of SurreyGuildford GU27XHUK National Physical Laboratory Hampton RoadTeddington TW110LWUK Department of Polymer Science and engineering University of MassachusettsAmherst MA 01003USA State Key Laboratory for Artificial Microstructure and Mesoscopic physics School of PhysicsPeking UniversityBeijing 100871China college ofmaterials science and engineering Shenzhen Key laboratory of Polymer Science and TechnologyGuangdong Research Center for interfacial Engineering of FunctionalMaterialsShenzhen UniversityShenzhen 518060China

Understanding the fundamental properties of metal-halide perovskite materials is driving the development of novel optoelectronic ***,we report the observation of a recoverable laser-induced fluorescence quenching phenomenon in perovskite films with a microscopic grain-scale restriction,accompanied by spectral *** fluorescence quenching depends on the laser intensity and the dwell time under Auger recombination dominated *** features indicate that the perovskite lattice deformation may take the main responsibility for the transient and show a new aspect to understand halide perovskite *** further modulate this phenomenon by adjusting the charge carrier recombination and extraction,revealing that efficient carrier transfer can improve the bleaching resistance of perovskite *** results provide future opportunities to attain high-performance devices by tuning the perovskite lattice disorder and harvesting the energetic carriers.

关键词： fluorescence quenching perovskite photophysics stability

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Metal–Oleate Complex?Derived Bimetallic Oxides Nanoparticles Encapsulated in 3D Graphene Networks as Anodes for Efficient Lithium Storage with Pseudocapacitance

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Nano-Micro Letters 2019年第1期11卷 250-263页

作者： Yingying Cao Kaiming Geng Hongbo Geng Huixiang Ang Jie Pei Yayuan Liu Xueqin Cao Junwei Zheng Hongwei Gu Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry Chemical Engineering and Materials Science and Collaborative Innovation Center of Suzhou Nano Science and TechnologySoochow University School of Chemical engineering and Light Industry Guangdong University of Technology School of Chemical and biomedical engineering Nanyang Technological University college of physics Optoelectronic and Energy Soochow University

In this manuscript, we have demonstrated the delicate design and synthesis of bimetallic oxides nanoparticles derived from metal–oleate complex embedded in 3D graphene networks(MnO/CoMn_2O_4  GN), as an anode material for lithium ion batteries. The novel synthesis of the MnO/CoMn_2O_4  GN consists of thermal decomposition of metal–oleate complex containing cobalt and manganese metals and oleate ligand, forming bimetallic oxides nanoparticles, followed by a selfassembly route with reduced graphene oxides. The MnO/CoMn_2O_4  GN composite, with a unique architecture of bimetallic oxides nanoparticles encapsulated in 3D graphene networks, rationally integrates several benefits including shortening the di usion path of Li^+ ions, improving electrical conductivity and mitigating volume variation during cycling. Studies show that the electrochemical reaction processes of MnO/Co Mn_2O_4  GN electrodes are dominated by the pseudocapacitive behavior, leading to fast Li^+ charge/discharge reactions. As a result, the MnO/CoMn_2O_4  GN manifests high initial specific capacity, stable cycling performance, and excellent rate capability.

关键词： Metal–oleate complex Bimetallic oxides nanoparticles Porous architecture 3D graphene networks Lithium ion batteries

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Hyperspectral imaging and remote trace detection of cis-1,3,4,6-tetranitrooctahydroimidazo-[4,5 d]imidazole(BCHMX)compared with traditional explosives using laser induced fluorescence

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Defence Technology（防务技术） 2021年第5期17卷 1609-1616页

作者： Hany S.Ayoub Ashraf F.El-Sherif Ahmed Elbeih Department of physics Faculty of ScienceCairo UniversityEgypt Laser photonics Research center Engineering Physics DepartmentMilitary Technical CollegeCairoEgypt Explosives Department Military Technical CollegeKobry ElkobbahCairoEgypt

cis-1,3,4,6-Tetranitrooctahydroimidazo-[4,5 d]imidazole(BCHMX)is an advanced energetic compound that expected to spread worldwide in the near ***,no approved remote detection methods were reported in current literature for this material,we performed hyper-spectral imaging and laser induced fluorescence(LIF)to a BCHMX sample under low laser fluence for determining the optimum laser wavelength used in any future BCHMX-LIF based remote detection *** this purpose,an experimental setup consisted of a sun spectrum lamp and hyper-spectral camera was built to illuminate and image white powder samples of BCHMX in comparison with the traditional explosives,HMX(1,3,5,7-tetranitro-1,3,5,7-tetraazacyclooctane),RDX(1,3,5-trinitro-1,3,5-triazacyclohexane),PETN(2,2-Bis[(nitroxy)methyl]propane-1,3-diyldinitrate).The imaging reveals strong BCHMX sample absorption contrast among other samples at wavelength ranging from 400 to 410 *** light source was replaced by a 405 nm laser diode illuminator,a strong BCHMX sample LIF at the spectral range from 425 to 700 nm was observed under low laser fluence condition of 0.1 mJ/cm^(2).Finally,we demonstrated successfully the ability of the 405 nm LIF and the hyperspectral imaging technique to detect finger print traces of BCHMX on white cellulose fabric from a distance of 15 m and a detection limit of 1 mg/cm^(2).

关键词： Hyperspectral imaging Remote trace detection BCHMX Laser induced fluorescence

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