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Betaine combined with traditional Chinese medicine ointment to treat skin wounds in microbially infected diabetic mice

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World Journal of Diabetes 2025年第1期16卷 104-120页

作者： Wen-Yan Xu Yuan-Yuan Dai Shi-Xian Yang Hao Chen Yan-Qiang Huang Pei-Pei Luo Zhong-Heng Wei Guangxi technology Innovation Cooperation Base of Prevention and control Pathogenic Microbes with Drug Resistance Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Guangxi Clinical Medical Research center for Hepatobiliary Diseases Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Pathology Wannan Medical CollegeWuhu 241002Anhui ProvinceChina Guangxi Zhuang autonomous Region Engineering Research center of Clinical Prevention and control technology and Leading Drug for Microorganisms with Drug Resistance in Border Ethnic Areas Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Gastroenterology Wujin People’s Hospital Affiliated to Jiangsu UniversityChangzhou 213004Jiangsu ProvinceChina

BACKGROUND Skin wounds are highly common in diabetic patients,and with increasing types of pathogenic bacteria and antibiotic resistance,wounds and infections in diabetic patients are difficult to treat and *** To explore the effects of betaine ointment(BO)in promoting the healing of skin wounds and reducing the inflammation and apoptosis of skin cells in microbially infected diabetic *** By detecting the minimum inhibitory concentrations(MICs)of betaine and plant monomer components such as psoralen,we prepared BO with betaine as the main ingredient,blended it with traditional Chinese medicines such as gromwell root and psoralen,and evaluated its antibacterial effects and safety in vitro and in *** skin infection wound models of ordinary mice and diabetic mice were constructed,and the OTC drugs mupirocin ointment and Zicao ointment were used as controls to evaluate the antibacterial effects in vivo and the anti-inflammatory and anti-apoptotic effects of *** The MICs of betaine against microorganisms such as Staphylococcus aureus(***),Candida albicans and Cryptococcus neoformans ranged from 4 to 32μg/*** root and psoralea,both of which contain antimicrobial components,mixed to prepare BO with MICs ranging from 16 to 64μg/mL,which is 32-256 times lower than those of Zicao ointment,although the MIC is greater than that of *** 15 days of treatment with BO for USA300-infected ordinary mice,the wound scab removal rates were 83.3%,while those of mupirocin ointment and Zicao ointment were 66.7%and 0%,respectively,and the differences were statistically *** diabetic mice,the wound scab removal rate of BO and mupirolacin ointment was 80.0%,but BO reduced wound inflammation and the apoptosis of skin cells and facilitated wound *** The ointment prepared by mixing betaine and traditional Chinese medicine can effectively inhibit common skin microorganisms and has a strong effect on the skin wounds of sensit

关键词： Betaine ointment Staphylococcus aureus Drug resistance Skin infection Diabetes mellitus

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Velocity Calculation by Automatic Camera Calibration Based on Homogenous Fog Weather Condition

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International Journal of Automation and computing 2013年第2期10卷 143-156页

作者： Hong-Jun Song Yang-Zhou Chen Yuan-Yuan Gao center for autonomous technology and intelligent control Beijing University of Technology College of Information and Engineering Zhejiang Agriculture and Forestry University

A novel algorithm for vehicle average velocity detection through automatic and dynamic camera calibration based on dark channel in homogenous fog weather condition is presented in this paper. Camera fixed in the middle of the road should be calibrated in homogenous fog weather condition, and can be used in any weather condition. Unlike other researches in velocity calculation area, our traffic model only includes road plane and vehicles in motion. Painted lines in scene image are neglected because sometimes there are no traffic lanes, especially in un-structured traffic scene. Once calibrated, scene distance will be got and can be used to calculate vehicles average velocity. Three major steps are included in our algorithm. Firstly, current video frame is recognized to discriminate current weather condition based on area search method （ASM）. If it is homogenous fog, average pixel value from top to bottom in the selected area will change in the form of edge spread function （ESF）. Secondly, traffic road surface plane will be found by generating activity map created by calculating the expected value of the absolute intensity difference between two adjacent frames. Finally, scene transmission image is got by dark channel prior theory, camera s intrinsic and extrinsic parameters are calculated based on the parameter calibration formula deduced from monocular model and scene transmission image. In this step, several key points with particular transmission value for generating necessary calculation equations on road surface are selected to calibrate the camera. Vehicles pixel coordinates are transformed to camera coordinates. Distance between vehicles and the camera will be calculated, and then average velocity for each vehicle is got. At the end of this paper, calibration results and vehicles velocity data for nine vehicles in different weather conditions are given. Comparison with other algorithms verifies the effectiveness of our algorithm.

关键词： Vehicle velocity calculation homogenous fog weather condition dark channel prior monocular camera calibration

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Tailoring Light–Matter Interactions in Overcoupled Resonator for Biomolecule Recognition and Detection

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Nano-Micro Letters 2025年第1期17卷 262-280页

作者： Dongxiao Li Hong Zhou Zhihao Ren Cheng Xu Chengkuo Lee Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore center for intelligent Sensors and MEMS(CISM) National University of SingaporeSingapore 117608Singapore

Plasmonic nanoantennas provide unique opportunities for precise control of light–matter coupling in surface-enhanced infrared absorption(SEIRA)spectroscopy,but most of the resonant systems realized so far suffer from the obstacles of low sensitivity,narrow bandwidth,and asymmetric Fano resonance ***,we demonstrated an overcoupled resonator with a high plasmon-molecule coupling coefficient(μ)(OC-Hμresonator)by precisely controlling the radiation loss channel,the resonator-oscillator coupling channel,and the frequency detuning *** observed a strong dependence of the sensing performance on the coupling state,and demonstrated that OC-Hμresonator has excellent sensing properties of ultra-sensitive(7.25%nm^(−1)),ultra-broadband(3–10μm),and immune asymmetric Fano *** characteristics represent a breakthrough in SEIRA technology and lay the foundation for specific recognition of biomolecules,trace detection,and protein secondary structure analysis using a single array(array size is 100×100μm^(2)).In addition,with the assistance of machine learning,mixture classification,concentration prediction and spectral reconstruction were achieved with the highest accuracy of 100%.Finally,we demonstrated the potential of OC-Hμresonator for SARS-CoV-2 *** findings will promote the wider application of SEIRA technology,while providing new ideas for other enhanced spectroscopy technologies,quantum photonics and studying light–matter interactions.

关键词： Plasmonic nanoantennas Light-matter interaction Surface-enhanced infrared absorption Overcoupled Biosensing

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Robust interface and excellent as-built mechanical properties of Ti–6Al–4V fabricated through laser-aided additive manufacturing with powder and wire

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 154-168页

作者： Fei Weng Guijun Bi Youxiang Chew Shang Sui Chaolin Tan Zhenglin Du Jinlong Su Fern Lan Ng Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationShandong Engineering&Technology Research Center for Superhard MaterialSchool of Materials Science and EngineeringShandong UniversityJinan 250061China Institute of intelligent Manufacturing Guangdong Academy of SciencesGuangzhou 510095China Singapore Institute of Manufacturing technology 5 Cleantech Loop636732Singapore

The feasibility of manufacturing Ti-6Al-4V samples through a combination of laser-aided additive manufacturing with powder(LAAM_(p))and wire(LAAM_(w))was explored.A process study was first conducted to successfully circumvent defects in Ti-6Al-4V deposits for LAAM_(p) and LAAM_(w),*** the optimized process parameters,robust interfaces were achieved between powder/wire deposits and the forged substrate,as well as between powder and wire *** characterization results revealed the epitaxial prior β grains in the deposited Ti-6Al-4V,wherein the powder deposit was dominated by a finerα′microstructure and the wire deposit was characterized by lamellar α *** mechanisms of microstructure formation and correlation with mechanical behavior were analyzed and *** mechanical properties of the interfacial samples can meet the requirements of the relevant Aerospace Material Specifications(AMS 6932)even without post heat *** fracture occurred within the interfacial area,further suggesting the robust *** findings of this study highlighted the feasibility of combining LAAM_(p) and LAAM_(w) in the direct manufacturing of Ti-6Al-4V parts in accordance with the required dimensional resolution and deposition rate,together with sound strength and ductility balance in the as-built condition.

关键词： laser-aided additive manufacturing powder deposition wire deposition interfacial characteristic mechanical behavior

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Assessing the corrosion protection property of coatings loaded with corrosion inhibitors using the real-time atmospheric corrosion monitoring technique

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 119-126页

作者： Xiaoxue Wang Lulu Jin Jinke Wang Rongqiao Wang Xiuchun Liu Kai Gao Jingli Sun Yong Yuan Lingwei Ma Hongchang Qian Dawei Zhang School of Energy and Power Engineering Beihang UniversityBeijing 100191China Beijing Institute of Space Long March Vehicle Beijing 100076China National Materials Corrosion and Protection Data center University of Science and Technology BeijingBeijing 100083China Institute of Materials intelligent technology Liaoning Academy of MaterialsShenyang 110004China Shanghai Spaceflight Precision Machinery Institute Shanghai 201600China

The atmospheric corrosion monitoring(ACM)technique has been widely employed to track the real-time corrosion behavior of metal ***,limited studies have applied ACM to the corrosion protection properties of organic *** study compared a bare epoxy coating with one containing zinc phosphate corrosion inhibitors,both applied on ACM sensors,to observe their corrosion protection properties over *** with artificial damage via scratches were exposed to immersion and alternating dry and wet environments,which allowed for monitoring galvanic corrosion currents in *** the corrosion tests,the ACM currents of the zinc phosphate/epoxy coating were considerably lower than those of the blank epoxy *** trend in ACM current variations closely matched the results obtained from regular electrochemical tests and surface *** alignment highlights the potential of the ACM technique in evaluating the corrosion protection capabilities of organic *** with the blank epoxy coating,the zinc phosphate/epoxy coating showed much-decreased ACM current values that confirmed the effective inhibition of zinc phosphate against steel corrosion beneath the damaged coating.

关键词： atmospheric corrosion monitoring technology corrosion inhibitor coating carbon steel corrosion protection

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Event-triggered consensus control of heterogeneous multi-agent systems: model-and data-based approaches

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Science China(Information Sciences) 2023年第9期66卷 151-167页

作者： Xin WANG Jian SUN Fang DENG Gang WANG Jie CHEN School of Automation Beijing Institute of Technology National Key Lab of autonomous intelligent Unmanned Systems Beijing Institute of technology Chongqing Innovation center Department of control Science and Engineering Tongji University

This article addresses the model-and data-based event-triggered consensus of heterogeneous leader/follower multi-agent systems(MASs). A dynamic periodic transmission protocol is developed to alleviate the communication and computational burden, where the followers can interact locally with neighbors to approach the dynamics of the leader. Capitalizing on a discrete-time looped-functional, a model-based consensus condition for the closed-loop MASs is derived as linear matrix inequalities(LMIs), along with a design method for obtaining distributed event-triggered controllers and the associated triggering *** collecting noise-corrupted state-input measurements in offline open-loop experiments, a data-based leader/follower MAS representation is derived and employed to address the data-driven consensus control problem without explicit MAS models. This result is subsequently generalized to guarantee an H∞-consensus control performance. Finally, a simulation example is given to corroborate the efficiency of the proposed distributed triggering scheme and the data-driven consensus controller.

关键词： data-driven control multi-agent system consensus looped-functional LMI

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Adaptive fuzzy backstepping control for attitude stabilization of flexible spacecraft with signal quantization and actuator faults

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Science China(Information Sciences) 2021年第5期64卷 135-150页

作者： Qiuhong LIU Ming LIU Guangren DUAN Research Institute of intelligent control Systems Harbin Institute of Technology Research center of Satellite technology Harbin Institute of Technology center for control Theory and Guidance technology Harbin Institute of Technology

In this study, the fault-tolerant attitude control of flexible spacecraft is investigated over digital communication channels, where a uniform quantizer is considered with respect to the sensor signals and controller indexes. Further, an adaptive fuzzy backstepping control strategy has been developed for the considered attitude stabilization issue, where the adaptive fuzzy logic method is used to approximate the rigid-flexible coupled nonlinearity of the spacecraft. In this design, the online adjusting quantizer parameters are injected into the controller gains to simultaneously compensate for the quantization errors and timevarying actuator faults. In the proposed control method, the attitude stabilization task is achieved in the presence of external disturbances, time-varying actuator faults, and signal quantization. Finally, the practical examples are compared to demonstrate the effectiveness of the proposed control strategy.

关键词： fault-tolerant control attitude stabilization signal quantization adaptive fuzzy control back-stepping control

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Data-driven consensus control of fully distributed event-triggered multi-agent systems

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Science China(Information Sciences) 2023年第5期66卷 147-161页

作者： Yifei LI Xin WANG Jian SUN Gang WANG Jie CHEN School of Automation Beijing Institute of Technology The State Key Lab of autonomous intelligent Unmanned Systems Beijing Institute of Technology Beijing Institute of technology Chongqing Innovation center Department of control Science and Engineering Tongji University

This study investigates the consensus control issue in discrete-time linear multi-agent systems(MASs) using data-driven control under undirected communication networks. To alleviate the communication burden, an adaptive event-triggered control strategy involving only local information is proposed and a model-based stability condition is derived that guarantees the asymptotic consensus of MASs. Furthermore,a data-based consensus condition for unknown MASs is established by combining a data-based system representation with the model-based stability condition, using only pre-collected noisy input-state data instead of the accurate system information a priori. Specifically, both model-based and data-driven event-triggered controllers can be utilized without requiring any global information. The validity and correctness of the controllers and associated theoretical results are demonstrated via numerical simulations.

关键词： distributed control event-triggered control data-driven control discrete-time MASs

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A bi-level optimization approach for joint rack sequencing and storage assignment in robotic mobile fulfillment systems

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Science China(Information Sciences) 2023年第11期66卷 127-149页

作者： Xiang SHI Fang DENG Sai LU Yunfeng FAN Lin MA Jie CHEN Key Laboratory of intelligent control and Decision of Complex Systems Beijing Institute of Technology Beijing Institute of technology Chongqing Innovation center Zhejiang Cainiao Supply Chain Management Co. Ltd. Shanghai Research Institute for intelligent autonomous Systems

This paper studies a novel rack scheduling problem with multiple types of multiple storage locations(RS-MTMS), which can decide the retrieval sequence of racks and assign each rack a storage location after visiting a picking station. A major challenge in RS-MTMS is that the storage assignment problem and the retrieval sequence decision are closely coupled. If the RS-MTMS is solved directly, the storage assignment scheme and the retrieval sequence of racks are generally generated separately, thus resulting in poor performance. To overcome this difficulty, we propose a bi-level optimization approach for jointly optimizing the storage assignment and retrieval sequence(Bi JSR). In Bi JSR, the storage assignment problem is solved by variable neighborhood search(VNS) in the upper-level optimization. Effective candidate modes are incorporated into VNS to improve solution quality and computational efficiency. The sequencing optimization is obtained in the lower-level according to the given storage location set. A transformation strategy with sufficient problem-specific knowledge is developed to identify the lower-level optimization as the traveling salesman problem and its variants. Then these identified problems are solved using the loop-based *** results show that the proposed Bi JSR is more effective and efficient than the representative algorithms in solving the RS-MTMS problem.

关键词： rack scheduling sequence decision storage assignment bi-level optimization robotic mobile fulfillment system

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A FAS approach for stabilization of generalized chained forms: part 2. Continuous control laws

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Science China(Information Sciences) 2024年第3期67卷 114-135页

作者： Guang-Ren DUAN center for control Theory and Guidance technology Harbin Institute of Technology Shenzhen Key Laboratory of control Theory and intelligent Systems Southern University of Science and Technology

In this paper, continuous time-varying stabilizing controllers for the type of general nonholonomic systems proposed and treated in part 1 are designed using the fully actuated system(FAS) approach. The key step is to differentiate the first scalar equation, and by control of the obtained second-order scalar system, a proportional plus integral feedback form for the first control variable is obtained. With the solution to this designed second-order scalar system, the rest equations in the nonholonomic system form an independent time-varying subsystem which is then handled by the FAS approach. The overall designed controller contains an almost arbitrarily chosen design parameter, and is proven to guarantee the uniformly and globally exponential stability of the closed-loop system. The proposed approach is simple and effective,and is demonstrated with a practical example of ship control.

关键词： nonholonomic systems feedback stabilization fully actuated systems Lyapunov stability continuous controllers

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