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Telemedicine platform for health assessment remotely by an integrated nanoarchitectonics FePS_(3)/rGO and Ti_(3)C_(2)-based wearable device

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npj Flexible Electronics 2022年第1期6卷 735-744页

作者： Jayraj V.Vaghasiya Carmen C.Mayorga-Martinez Martin Pumera center for advanced functional nanorobots Department of Inorganic ChemistryFaculty of Chemical TechnologyUniversity of Chemistry and Technology PragueTechnická516628 PragueCzech Republic Energy Research Institute@NTU(ERI@N) Research Techno PlazaX-Frontier BlockLevel 550 Nanyang Drive637553 SingaporeSingapore Faculty of Electrical Engineering and Computer Science VSB-Technical University of Ostrava17.listopadu 2172/1570800 OstravaCzech Republic Department of Medical Research China MedicalUniversity HospitalChina Medical UniversityNo.91 Hsueh-Shih RoadTaichung 40402Taiwan

Due to the emergence of various new infectious(viral/bacteria)diseases,the remote surveillance of infected persons has become most important,especially if hospitals need to isolate infected patients to prevent the spreading of pathogens to health care ***,we develop a remote health monitoring system by integrating a stretchable asymmetric supercapacitor(SASC)as a portable power source with sensors that can monitor the human physical health condition in real-time and *** abnormal body temperature and breathing rate could indicate a person’s sickness/infection *** we integrated FePS3@graphene-based strain sensor and SASC into an all-in-one textile system and wrapped it around the abdomen to continuously monitor the breathing cycle of the *** real body temperature was recorded by integrating the temperature sensor with the *** proposed system recorded physiological parameters in real-time and when monitored remotely could be employed as a screening tool for monitoring pathogen infection status.

关键词： integrating wear portable

Biodegradable germanium electronics for integrated biosensing of physiological signals

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npj Flexible Electronics 2022年第1期6卷 632-641页

作者： Haonan Zhao Zhongying Xue Xiaozhong Wu Zhihuan Wei Qiuyu Guo Miao Xu Chunyan Qu Chunyu You Yongfeng Mei Miao Zhang Zengfeng Di Qinglei Guo School of Microelectronics Center of NanoelectronicsShandong University250100 JinanP.R.China State Key Laboratory of functional Materials for Informatics Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences200050 ShanghaiP.R.China Department of Hematology Qilu HospitalCheeloo College of MedicineShandong University250100 JinanP.R.China Department of Materials Science International Institute for Intelligent Nanorobots and NanosystemsFudan University200433 ShanghaiP.R.China State Key Laboratory of ASIC and Systems Fudan University200433 ShanghaiP.R.China Institute of Optoelectronics Yiwu Research InstituteFudan University200433 ShanghaiP.R.China

Transient electronics that can disappear or degrade via physical disintegration or chemical reaction over a pre-defined operational period provide essential for their applications in implantable bioelectronics due to the complete elimination of the second surgical ***,the dissolution of commonly utilized bioresorbable materials often accompanies hydrogen production,which may cause potential or irreparable harm to the human *** paper introduces germanium nanomembrane-based bioresorbable electronic sensors,where the chemical dissolution of all utilized materials in biofluidic theoretically have no gaseous *** particular,the superior electronic transport of germanium enables the demonstrated bioresorbable electronic sensors to successfully distinguish the crosstalk of different physiological signals,such as temperature and strain,suggesting the significant prospect for the construction of dual or multi-parameter *** studies reveal the gauge factor and temperature coefficient of resistance comparable to otherwise similar devices with gaseous products during their dissolution.

关键词： companies utilized otherwise

Recent Progress of Magnetically Actuated DNA Micro/nanorobots

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Cyborg and Bionic Systems 2022年第1期2022卷 43-54页

作者： Fengyu Liu Xiaoming Liu Qiang Huang Tatsuo Arai Key Labraoryof Bmetic Robts and Sym Minsry of EduationState KeyLaboratoryofInteligent Controlandcisnof Complex SystemBejing Advanced Innovation Center for Intlligent Robots and Systems and School of Mechatron ical Engineering Bejing Institute of TechnologyBeijing 100081China center for Neuroscience and Biomedical Enginring The University of Eletro-CommunicationsTokyo 182-8585 Japan

In the past few decades,the field of DNA origami based micro/nanotechnology has developed dramatically and spawned attention increasingly,as its high integrality,rigid structure,and excellent resistance ability to enzyme *** two-dimensional and three-dimensional DNA nanostructures coordinated with optical,chemical,or magnetic triggers have been designed and assembled,extensively used as versatile templates for molecular robots,nanosensors,and intracellular drug *** magnetic field has been widely regarded as an ideal driving and operating system for micro/nanomaterials,as it does not require high intensity lasers like light control,nor does it need to change the chemical composition similar to chemical ***,we review the recent achievements in the induction and actuation of DNA origami-based nanodevices that respond to magnetic *** magnetic actuation-based DNA nanodevices were regularly combined with magnetic beads or gold nanopartides and applied to generate single stranded scaffolds,assemble various DNA nanostructures,and purify specific DNA ***,they also produced artificial magnetism or moved regularly driven by *** fields to explain deeper scientific issues.

关键词： resistance magnetic versatile

Recent advances in microsystem approaches for mechanical characterization of soft biological tissues

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Microsystems & Nanoengineering 2022年第4期8卷 1-16页

作者： Enming Song Ya Huang Ningge Huang Yongfeng Mei Xinge Yu John A.Rogers Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception Institute of OptoelectronicsFudan UniversityShanghai 200433China International Institute of Intelligent nanorobots and Nanosystems Fudan UniversityShanghai 200433China Department of Biomedical Engineering City University of Hong KongHong Kong 999077China Department of Materials Science Fudan UniversityShanghai 200433China Querrey Simpson Institute for Bioelectronics Department of Materials Science and EngineeringDepartments of Biomedical EngineeringNeurological SurgeryChemistryMechanical EngineeringElectrical Engineering and Computer ScienceNorthwestern UniversityEvanstonIL 60208USA

Microsystem technologies for evaluating the mechanical properties of soft biological tissues offer various capabilities relevant to medical research and clinical diagnosis of pathophysiologic *** progress includes(1)the development of tissue-compliant designs that provide minimally invasive interfaces to soft,dynamic biological surfaces and(2)improvements in options for assessments of elastic moduli at spatial scales from cellular resolution to macroscopic areas and across depths from superficial levels to deep *** review summarizes a collection of these technologies,with an emphasis on operational principles,fabrication methods,device designs,integration schemes,and measurement *** core content begins with a discussion of platforms ranging from penetrating filamentary probes and shape-conformal sheets to stretchable arrays of ultrasonic *** sections examine different techniques based on planar microelectromechanical system(MEMS)approaches for biocompatible interfaces to targets that span scales from individual cells to *** highlighted example includes miniature electromechanical devices that allow depth profiling of soft tissue biomechanics across a wide range of *** clinical utility of these technologies is in monitoring changes in tissue properties and in targeting/identifying diseased tissues with distinct variations in *** results suggest future opportunities in engineered systems for biomechanical sensing,spanning a broad scope of applications with relevance to many aspects of health care and biology research.

关键词： advances identifying utility

Foldable-circuit-enabled miniaturized multifunctional sensor for smart digital dust

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Chip 2022年第4期1卷 82-89页

作者： Chun-Yu You Bo-Fan Hu Bo-Rui Xu Zi-Yu Zhang Bin-Min Wu Gao-Shan Huang En-Ming Song Yong-Feng Mei Department of Materials Science&State Key Laboratory of Molecular Engi-neering of Polymers Fudan UniversityShanghai 200438People’s Republic of China Shanghai Frontiers Science Research Base of Intelligent Optoelec-tronics and Perception Institute of OptoelectronicsFudan UniversityShang-hai 200438People’s Republic of China International Institute of Intelligent nanorobots and Nanosystems Fudan UniversityShanghai 200438People’s Republic of China Yiwu Research Institute of Fudan University Yiwu 322000ZhejiangPeople’s Republic of China

Smart dust,which refers to miniaturized,multifunctional sensor motes,would open up data acquisition opportunities for Internet of Things(IoT)and Environmental protection ***,critical obstacles remain challenging in the integration of high-density sensors,further miniaturization of device platforms,and reduction of ***,we demonstrate the concept of smart digital dust to address these problems,the results of which combine the benefit of(i)maturity of complementary metal-oxide semiconductor(CMOS)processing approaches and(ii)unique form factors of emerging flex-ible *** a prototype for smart digital dust,we present a millimeter-scale multifunctional optoelectronic sensor platform con-sisting of high-performance optoelectronic sensor cores and commer-cially available integrated-circuit *** smart material-assisted optoelectronic sensing mechanism enables real-time,high-sensitivity hydrogen,temperature,and relative humidity(RH)sens-ing based on a single chip with ultralow power *** a microsystem presented here introduces a viable solution to the multi-functional sensing need of IoT and could serve as a building block for the rapidly evolving future framework of smart dust.

关键词： Smart dust Flexible electronics Nanomembrane devices Multifunctional sensors

Pt/CNT Micro-nanorobots Driven by Glucose Catalytic Decomposition

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Cyborg and Bionic Systems 2021年第1期2021卷 246-253页

作者： Hao Wang Jiacheng Kan Xin Zhang Chenyi Gu Zhan Yang Robotics and Microsystems center College of Mechanical and Electric EngineeringSoochow UniversityChina

Swimming micro-nanorobots have attracted researchers’interest in potential medical applications on target therapy,biosensor,drug carrier,and *** present,the experimental setting of the swimming micro-nanorobots was mainly studied in pure water or H_(2)O_(2) *** paper presents a micro-nanorobot that applied glucose in human body fluid as driving *** on the catalytic properties of the anode and cathode materials of the glucose fuel cell,platinum(Pt)and carbon nanotube(CNT)were selected as the anode and cathode materials,respectively,for the *** innovative design adopted the method of template electrochemical and chemical vapor deposition to manufacture the Pt/CNT micro-nanorobot *** the scanning electron microscope(SEM)and transmission electron microscope(TEM)were employed to observe the morphology of the sample,and its elements were analyzed by energy-dispersive X-ray spectroscopy(EDX).Through a large number of experiments in a glucose solution and according to Stoker’s law of viscous force and Newton’s second law,we calculated the driving force of the fabricated *** was concluded that the structure of the Pt/CNT micronanorobot satisfied the required characteristics of both biocompatibility and motion.

关键词： Pt/C driving robot

Design and analysis of an untethered micro flapping robot which can glide on the water

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Science China(Technological Sciences) 2022年第8期65卷 1749-1759页

作者： CHEN YanHong LIU YiDe LIU TaiShan LI Hua QU ShaoXing YANG Wei State Key Laboratory of Fluid Power&Mechatronic System Key Laboratory of Soft Machines and Smart Devices of Zhejiang ProvincesCenter for X-MechanicsDepartment of Engineering MechanicsZhejiang UniversityHangzhou 310027China

Flapping-wing flying insects possess various advantages,such as high agility and *** design and manufacture of insect-scale flapping-wing micro aerial vehicle(FWMAV)have attracted increasing attention in recent *** to the limitations of size and weight,the FWMAV with an onboard battery which can fully mimic insect flight has not been *** this work,we design and fabricate a highly integrated flapping-wing microrobot named *** Robomoth consists of a carbon chassis,customized power and control devices,and two piezoelectric ceramic actuators symmetrically distributed in the thorax and controlled *** weighs 2.487 g,spans 5.9 cm in length,possesses 9 cm of wingspan,and carries a 0.355 g rechargeable lithium *** demonstrate the mobility of the Robomoth through untethered gliding and making turns on the water surface.A simplified dynamic model of the flapping system is proposed to explain the relationship between the driving frequency and the flapping *** Robomoth is one new untethered bioinspired flapping-wing robot that can perform stable water surface motion,which holds potential applications such as search and rescue on the *** robot can also provide insight for designing insect-scale flying vehicles.

关键词： micro/nanorobots biologically inspired robots flapping-wing flying piezoelectric ceramic actuator

Biomembrane-inspired design of medical micro/nanorobots:From cytomembrane stealth cloaks to cellularized Trojan horses

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Aggregate 2023年第5期4卷 63-95页

作者： Jinhua Li Huaijuan Zhou Chun Liu Shuailong Zhang Ran Du Yulin Deng Xuenong Zou School of Medical Technology Beijing Institute of TechnologyBeijingChina advanced Research Institute of Multidisciplinary Sciences Beijing Institute of TechnologyBeijingChina center for Translational Medicine Precision Medicine InstituteThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Orthopedics and Traumatology Department of Spinal SurgeryThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina School of Mechatronical Engineering Beijing Institute of TechnologyBeijingChina School of Materials Science&Engineering Key Laboratory of High Energy Density Materials of the Ministry of EducationBeijing Institute of TechnologyBeijingChina School of Life Science Beijing Institute of TechnologyBeijingChina

Micro/nanorobots are promising for a wide range of biomedical applications(such as targeted tumor,thrombus,and infection therapies in hard-to-reach body sites)because of their tiny size and high maneuverability through the actuation of external fields(e.g.,magnetic field,light,ultrasound,electric field,and/or heat).However,fully synthetic micro/nanorobots as foreign objects are susceptible to phagocytosis and clearance by diverse *** address this issue,researchers have attempted to develop various cytomembrane-camouflaged micro/nanorobots by two means:(1)direct coating of micro/nanorobots with cytomembranes derived from living cells and(2)the swallowing of micro/nanorobots by living immunocytes via *** camouflaging with cytomembranes or living immunocytes not only protects micro/nanorobots from phagocytosis,but also endows them with new characteristics or functionalities,such as prolonging propulsion in biofluids,targeting diseased areas,or neutralizing bacterial *** this review,we comprehensively summarize the recent advances and developments of cytomembrane-camouflaged medical micro/*** first discuss how cytomembrane coating nanotechnology has been employed to engineer synthetic nanomaterials,and then we review in detail how cytomembrane camouflage tactic can be exploited to functionalize micro/*** aim to bridge the gap between cytomembrane-cloaked micro/nanorobots and nanomaterials and to provide design guidance for developing cytomembrane-camouflaged micro/nanorobots.

关键词： camouflage cell membranes immune cells medical micromotors targeted drug delivery

Liquid Metal Swimming nanorobots

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Accounts of Materials Research 2022年第1期3卷 122-132页

作者： Zesheng Li Jie Xu Zhiguang Wu Bin Guo Qiang He Key Laboratory of Microsystems and Microstructures Manufacturing(Ministry of Education) Micro/Nanotechnology Research CenterHarbin Institute of TechnologyHarbin 150001China

CONSPECTUS:Room temperature liquid metal gallium-based materials have received tremendous attention owing to their potential promises in various aspects including bioengineering and smart medicine,flexible circuits and electronic skins,transformable activators and triboelectric nanogenerators,***,the usage of gallium-based liquid metals to construct humanoid robots to accomplish diverse dangerous missions leads to the considerable focus on the development of gallium-based flexible *** conventional metal materials with rigid properties and responsible mainly for the backbone,room temperature gallium-based liquid metals could serve as a new generation of smart flexible materials for robotic devices with its advantages,such as low toxicity,high fluidity,and plasticity at the micro/nanometer *** the expectation in biomedicine,such as targeted drug delivery,the past decade has led to the scaling down of the swimming robot to the micro-and *** nanorobots,which are defined as devices that can convert chemical energy in the surrounding environment and externally physical field into their own kinetic energy at the micro/nanoscale and achieve self-propulsion,have shown widespread potential in the field of in vivo *** the great promises,gallium-based liquid metal robots are primarily limited to the millimeter and subcentimeter *** toward clinical medical practices,however,these gallium-based liquid metal swimming robots are facing the biocompatible problem caused by their large sizes and propulsion ***,the manufacture,selfpropulsion,and navigation of nanoscale liquid metal swimming robots,ensuring the penetration though various tissues toward the disease area,is still *** of gallium-based swimming nanorobots is of vital importance both for fundamental research,such as the dynamics of individual nanorobots and emergence of nanorobotic swarms,as well as for engineeri

关键词： sizes smart collective