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Science Bulletin 2024年第10期 1380-1385页

作者：张思唐婷婷朱亦橙张绪哲刘金平蔡杰张凌雪夏霓聂少芳张敏朱争凤胡德胜王维民张丽廖玉华董念国程翔 Department of Cardiology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Hubei Key Laboratory of Biological Targeted Therapy Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Hubei Provincial Engineering Research center of Immunological Diagnosis and Therapy for Cardiovascular diseases Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Cardiovascular Surgery Zhongnan Hospital of Wuhan University Department of Cardiovascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Integrated Traditional Chinese and Western Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Immunology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and Technology Department of Ultrasound Union HospitalTongji Medical CollegeHuazhong University of Science and Technology

heart failure (HF) remains a rising global epidemic worldwide[1,2].It is widely recognized that immune cells play important roles in the pathogenesis of *** hearts of HF patients are characterized by persistent low-grade inflammation,which has been linked to adverse ventricular remodeling as it promotes interstitial fibrosis and cardiomyocyte dysfunction and ***,the results of phase 3 clinical trials of therapies targeting inflammation were disappointing[3].The lack of success may be explained by:(1) the lack of an in-depth understanding of the immune responses in the failing hearts of HF patients;(2) the lack of inflammatory biomarkers to identify potential patients who could benefit from treatment;(3) the off-target activity of immunotherapies on cardiac immune *** cells constitute the main immune cell population in the *** key phenotypic features of myeloid cells and identifying effective biomarkers are critical steps to develop immunotherapies for HF ***-cell analysis is a powerful tool for defining the heterogeneity of immune cells,discovering homogeneity in heterogeneous immune microenvironments and revealing lineage development.

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Demethylation and Up-Regulation of an Oncogene after Hypomethylating Therapy

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四川生理科学杂志 2022年第5期44卷 897-897页

作者： Yao-Chung Liu From the Department of Pathology Brigham and Women's Hospital (Y.-C.L. C. Gao Jun Liu J.Y. L. Chai) Harvard Stem Cell Institute Harvard Medical School (A.I.J. M.A.B. D.G.T.) and the Department of Medical Oncology Dana-Farber Cancer Institute (R.P.) - all in Boston the Division of Hematology Department of Medicine Taipei Veterans General Hospital (Y.-C.L.) and the Faculty of Medicine and the Program in Molecular Medicine Institute of Biopharmaceutical Sciences School of Life Science National Yang Ming Chiao Tung University (Y.-C.L. J.-H.L.) - both in Taipei Taiwan the Cancer Science Institute of Singapore Singapore (J.K. Y.V.L. H.Y. M.A.B. D.G.T.) the Department of Biomedicine and Prevention University of Rome Tor Vergata (E.F. G.F. L.V. C. Gurnari M.T.V.) and UniCamillus-Saint Camillus International University of Health Sciences (E.F.) Rome and Cellular Signaling Laboratory Department of Biomedical and Neuromotor Sciences University of Bologna (M.Y.F. L. Cocco) and IRCCS Azienda Ospedaliero-Universitaria di Bologna Istituto di Ematologia "Seràgnoli" (C.F.) Bologna - all in Italy the National Clinical Research center for Blood diseases and State Key Laboratory of Experimental Hematology Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin China (Z.X. Jinqin Liu H.H.) and the School of Medical Sciences and Lowy Cancer Research Centre (J.A.I.T. J.E.P.) and Prince of Wales Clinical School and Lowy Cancer Research Centre (A.U. J.E.P.) Faculty of Medicine University of New South Wales Sydney and the Department of Hematology Prince of Wales Hospital Randwick NSW (J.E.P.) - both in Australia.

Background:Although hypomethylating agents are currently used to treat patients with cancer,whether they can also reactivate and up-regulate oncogenes is not well ***:We examined the effect of hypomethylating agents on SALL4,a known oncogene that plays an important role in myelodysplastic syndrome and other *** bone marrow samples that were obtained from two cohorts of patients with myelodysplastic syndrome before and after treatment with a hypomethylating agent were used to explore the relationships among changes in SALL4 expression,treatment response,and clinical *** cell lines with low or undetectable SALL4 expression were used to study the relationship between SALL4 methylation and expression.A locus-specific demethylation technology,CRISPR-DNMT1-interacting RNA(CRISPR-DiR),was used to identify the CpG island that is critical for SALL4 expression.

关键词： SALL4 expression. patients

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