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神经损伤与功能重建 2008年第5期3卷 342-351,356页

作者： WEI-LIN LIU YI-HSUAN LEE SHIH-YING TSAI CHUNG YI HSU YU-YO SUN LIANG-YO YANG SHING-HAN TSAI AND WEI-CHUNG VIVIAN YANG Graduate Institute of biomedical Materials and engineering Taipei Medical University Taipei Taiwan Graduate Institute of neuroscience College of Medicine Taipei Medical Uni- versity Taipei Taiwan Division of Physiology and neuroscience Graduate Institute of Medi- cal Sciences College of Medicine Taipei Medical University Taipei Taiwan Department of Physiology School of Medicine College of Medicine Taipei Medical University Taipei Tai- wan Graduate Institute of Injury Prevention and Control Taipei Medical University Taipei Taiwan Department of Neurosurgery Taipei Municipal WanFang Hospital Taipei Taiwan

创伤后的神经胶质增生导致硫酸软骨素蛋白聚糖(CSPG)的显著表达,从而抑制轴突生长和再生。甲基强地松龙(MP),一种合成的糖皮质激素,在急性脊髓损伤(SCI)的治疗中有神经保护作用和抗炎效应。但是,MP对于CSPG在活性胶质细胞中的表达的作... 详细信息

创伤后的神经胶质增生导致硫酸软骨素蛋白聚糖(CSPG)的显著表达,从而抑制轴突生长和再生。甲基强地松龙(MP),一种合成的糖皮质激素,在急性脊髓损伤(SCI)的治疗中有神经保护作用和抗炎效应。但是,MP对于CSPG在活性胶质细胞中的表达的作用尚不清楚。本文用a-氨基-3-羟基-5-甲基-4-异恶唑丙酸酯(AM-PA)诱导星形胶质细胞再活化,用环噻嗪模拟SCI的兴奋性中毒刺激。AMPA治疗后,星形胶质细胞再活化的标志物-胶质纤维酸性蛋白(GFAP)、CSPG神经聚糖和磷酸盐的表达都显著上调。AMPA治疗星形胶质细胞的条件培养液强烈抑制大鼠背根神经节中神经元的轴突生长,但这种作用能被MP的预处理所逆转。此外,MP下调成年SCI大鼠中GFAP和CSPG的表达,对抗RU486的糖皮质激素受体(GR)和GR si RNA能逆转MP对GFAP和神经聚糖表达的抑制作用。这些结果提示,MP能在兴奋性中毒损伤后通过GR介导的星形胶质细胞再活化下调和GSPG表达抑制来改善神经修复,促进轴突生长。

关键词：中枢神经系统硫酸软骨素蛋白聚糖神经胶质增生糖皮质激素脊髓损伤

Bioorthogonal microglia-inspired mesenchymal stem cell bioengineering system creates livable niches for enhancing ischemic stroke recovery via the hormesis

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1412-1427页

作者： Jianpei Xu Yinzhe Sun Yang You Yuwen Zhang Dan Huang Songlei Zhou Yipu Liu Shiqiang Tong Fenfen Ma Qingxiang Song Chengxiang Dai Suke Li Jigang Lei Zhihua Wang Xiaoling Gao Jun Chen Shanghai Pudong Hospital&Department of Pharmaceutics School of PharmacyFudan UniversityShanghai 201203China Key Laboratory of Smart Drug Delivery Ministry of EducationSchool of PharmacyFudan UniversityShanghai 201203China Department of Pharmacology and Chemical Biology State Key Laboratory of Oncogenes and Related GenesShanghai Universities Collaborative Innovation Center for Translational MedicineShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Emergency Shanghai Pudong HospitalFudan University Pudong Medical CenterShanghai 201399China Institute of Science and Technology for Brain-Inspired Intelligence&Department of Neurology Fudan UniversityShanghai 201203China Department of Rehabilitation Medicine Huashan HospitalFudan UniversityShanghai 201203China Daxing Research Institute University of Science and Technology BeijingBiomedical Industry BaseZhongguancun Science and Technology ParkBeijing 102600China Cellular Biomedicine Group Inc. Shanghai 201210China

Mesenchymal stem cells(MSCs)experience substantial viability issues in the stroke infarct region,limiting their therapeutic efficacy and clinical *** levels of deadly reactive oxygen radicals(ROS)and proinflammatory cytokines(PC)in the infarct milieu kill transplanted MSCs,whereas low levels of beneficial ROS and PC stimulate and improve engrafted MSCs’*** on the intrinsic hormesis effects in cellular biology,we built a microglia-inspired MSC bioengineering system to transform detrimental high-level ROS and PC into vitality enhancers for strengthening MSC *** system is achieved by bioorthogonally arming metabolic glycoengineered MSCs with microglial membrane-coated nanoparticles and an antioxidative extracellular protective *** this system,extracellular ROSscavenging and PC-absorbing layers effectively buffer the deleterious effects and establish a microlivable niche at the level of a single MSC for ***,the infarct’s inanimate milieu is transformed at the tissue level into a new living niche to facilitate *** engineered MSCs achieved viability five times higher than natural MSCs at seven days after transplantation and exhibited a superior therapeutic effect for stroke recovery up to 28 *** vitality-augmented system demonstrates the potential to accelerate the clinical translation of MSC treatment and boost stroke recovery.

关键词： Ischemic stroke Mesenchymal stem cell Cell engineering Hormesis effect Bioorthogonal chemistry Microglia Reactive oxygen spices Proinflammatory cytokines

A Modular Synthetic Approach to Monocyclic 1,4-Azaborines

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A Modular Synthetic Approach to Monocyclic 1,4-Azaborines

Sci Rep:科学家阐明线粒体的程序性细胞死亡过程

中国化学会第九届全国有机化学学术会议

作者： Xuguang Liu Fredrik Haeffner Bo Li Lev N.Zakharov Shih-Yuan Liu Department of Chemistry Boston College center for Advanced Materials Characterization in Oregon University of Oregon College of Chemistry and Chemical engineering Tianjin University of Technology

The BN/CC isosterism has emerged as a powerful strategy to increase the chemical space of compounds relevant to materials science and biomedical research1].In the last decade,BN-bond-containing analogues of benzene ha...

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现代生物医学进展 2016年第35期16卷 I0004-I0004页

作者： Ted D. Pham Phi Q. Pham Jinfeng Li Anthony G. Letai Douglas C. Wallace Peter J. Burke Department of biomedical engineering University of California Irvine CA USA Department of Chemical engineering and Materials Science University of California Irvine CA USA Department of Chemical engineering and Materials Science University of California Irvine CA USA Dana-Farber Cancer Institute Harvard University Boston MA USA center for Mitochondrial and Epigenomic Medicine Children’s Hospital of Philadelphia and Department of Pathology and Laboratory Medicine University of Pennsylvania Philadelphia PA USA Department of biomedical engineering University of California Irvine CA USA Department of Chemical engineering and Materials Science University of California Irvine CA USA Department of Electrical engineering and Computer Science University of California Irvine CA USA

日前。发表在Scientific Reports杂志上的一篇研究报告中，来自加利福尼亚大学等机构的研究人员通过利用一种由石墨烯组成的新型传感器深入解析了线粒体的程序性细胞死亡过程，该研究或为驱动癌细胞自我毁灭提供了新的线索。研究者通过... 详细信息

日前。发表在Scientific Reports杂志上的一篇研究报告中，来自加利福尼亚大学等机构的研究人员通过利用一种由石墨烯组成的新型传感器深入解析了线粒体的程序性细胞死亡过程，该研究或为驱动癌细胞自我毁灭提供了新的线索。研究者通过研究开发了一种监测线粒体改变的电子学方法，该方法能够指示出细胞进行自我毁灭的开始阶段，我们机体每个细胞中都有数百个、甚至数千个线粒体。每个线粒体都有着内膜和外膜结构；作为细胞的能量工厂，线粒体会对细胞中的碳水化合物和脂肪进行代谢产能以便细胞利用并且储存。但同时线粒体还有第二个角色，那就是调节细胞的生死通路。

关键词：死亡过程癌细胞线粒体程序性 Sci 科学家 Rep 加利福尼亚大学

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neuroscience Bulletin 2019年第4期35卷 688-696页

作者： Yin Lin Mingli Li Yi Zhou Wei Deng Xiaohong Ma Qiang Wang Wanjun Guo Yinfei Li Lijun Jiang Xun Hu Nanyin Zhang Tao Li Mental Health Centre and Psychiatric Laboratory State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu 610041 China West China Brain Research Centre West China Hospital Sichuan University Chengdu 610041 China Department of Psychology Shenzhen Children's Hospital Shenzhen 518038 China Department of Radiology Hospital for Chengdu Office of Tibetan Autonomous Region Branch Hospital of West China Hospital Sichuan University Chengdu 610041 China Huaxi Biobank West China Hospital Sichuan University Chengdu 610041 China Department of biomedical engineering Huck Institutes of the Life Sciences The Pennsylvania State University University Park PA 16802 USA

Substantial evidence supports the neurodevelopmental hypothesis of ***,progressive neurodegenerative processes have also been reported,leading to the hypothesis that neurodegeneration is a characteristic component in the neuropathology of ***,a major challenge for the neurodegenerative hypothesis is that antipsychotic drugs used by patients have profound impact on brain *** clarify this potential confounding factor,we measured the cortical thickness across the whole brain using highresolution T1-weighted magnetic resonance imaging in 145 first-episode and treatment-naive patients with schizophrenia and 147 healthy *** results showed that,in the patient group,the frontal,temporal,parietal,and cingulate gyri displayed a significant age-related reduction of cortical *** the control group,age-related cortical thickness reduction was mostly located in the frontal,temporal,and cingulate gyri,albeit to a lesser ***,relative to healthy controls,patients exhibited a significantly smaller age-related cortical thickness in the anterior cingulate,inferior temporal,and insular gyri in the right *** results provide evidence supporting the existence of neurodegenerative processes in schizophrenia and suggest that these processes already occur in the early stage of the illness.

关键词： Schizophrenia Cortical thickness Age-related

Thermoacoustic tomography of in vivo rat brain

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Journal of Innovative Optical Health Sciences 2017年第4期10卷 84-90页

作者： Yuan Zhao Zihui Chi Lin Huang Zhu Zheng Jinge Yang Huabei Jiang School of Physical Electronics University of Electronic Science and Technology of China No.2006 Xiyuan AveWest Hi-Tech Zone ChengduSichuan 611731P.R.China Department of Medical engineering University of South Florida Tampa FL 33620USA center for Information in Medicine University of Electronic Science and Technology of China No.2006 Xiyuan AveWest Hi-Tech Zone ChengduSichuan 611731P.R.China

We present for the¯rst time in vivo imaging of rat brain using microwave-induced thermoacoustic tomography(TAT).The in vivo imaging of rat brain was realized through an unconventional delivery of microwave energy from the front of rat brain(while the transducer was scanned along coronal plane of the animal brain),which maximized the microwave penetration into the *** addition,we found that the imaging contrast was highly dependent on the direction of the electric¯eld polarization(EFP)and that more tissue structures/compositions could be revealed when both X-and Y-EFPs were used for *** in vivo TAT images of rat brain obtained were compared with the 3.0 T MRI images and histological photographs,and numerous important brain anatomical structures were identi¯*** example of our TAT approach for imaging a foreign object embedded in a rat brain was also *** study suggests that TAT has a great potential to be used in neuroscience studies and in noninvasive imaging of brain disorders.

关键词： Thermoacoustic imaging tomography rat brain

Giant ultrafast dichroism and birefringence with active nonlocal metasurfaces

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Light(Science & Applications) 2024年第10期13卷 2240-2250页

作者： Giulia Crotti Mert Akturk Andrea Schirato Vincent Vinel Anton A.Trifonov Ivan C.Buchvarov Dragomir N.Neshev Remo Proietti Zaccaria Paolo Laporta Aristide Lemaître Giuseppe Leo Giulio Cerullo Margherita Maiuri Giuseppe Della Valle Department of Physics Politecnico di Milano20133 MilanoItaly Istituto Italiano di Tecnologia 16163 GenovaItaly Laboratoire Matériaux et Phénomènes Quantiques(MPQ) UniversitéParis Cité&CNRS75013 ParisFrance John Atanasoff center for Bio and Nano Photonics(JAC BNP) 1164 SofiaBulgaria Department of Physics St.Kliment Ohridski University of Sofia5 James Bourchier Boulevard1164 SofiaBulgaria ARC Centre of Excellence for Transformative Meta-Optical Systems(TMOS) Research School of PhysicsAustralian National UniversityActonACT 2601Australia. Cixi Institute of biomedical engineering Ningbo Institute of Industrial TechnologyChinese Academy of SciencesNingbo 315201China. Istituto di Fotonica e Nanotecnologie(IFN) Consiglio Nazionale delle Ricerche20133 MilanoItaly. UniversitéParis-Saclay CNRSCentre de Nanosciences et de Nanotechnologies10 Boulevard Thomas Gobert91120 PalaiseauFrance Institut Universitaire de France(IUF) ParisFrance

Switching of light polarization on the sub-picosecond timescale is a crucial functionality for applications in a variety of contexts,including telecommunications,biology and *** ability to control polarization at ultrafast speed would pave the way for the development of unprecedented free-space optical links and of novel techniques for probing dynamical processes in complex systems,as chiral *** high switching speeds can only be reached with an all-optical paradigm,i.e.,engineering active platforms capable of controlling light polarization via ultrashort laser *** we demonstrate giant modulation of dichroism and birefringence in an all-dielectric metasurface,achieved at low fluences of the optical control *** performance,which leverages the many degrees of freedom offered by all-dielectric active metasurfaces,is obtained by combining a high-quality factor nonlocal resonance with the giant third-order optical nonlinearity dictated by photogenerated hot carriers at the semiconductor band edge.

关键词： dielectric surfaces nonlinearity

Therapeutic gene editing strategies using CRISPR-Cas9 for theβ-hemoglobinopathies

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The Journal of biomedical Research 2021年第2期35卷 115-134页

作者： James B.Papizan Shaina N.Porter Akshay Sharma Shondra M.Pruett-Miller Department of Cellular and Molecular Biology St.Jude Children's Research HospitalMemphisTN 38105USA center for Advanced Genome engineering St.Jude Children's Research HospitalMemphisTN 38105USA Department of Bone Marrow Transplantation and Cellular Therapy St.Jude Children's Research HospitalMemphisTN 38105USA

With advancements in gene editing technologies,our ability to make precise and efficient modifications to the genome is increasing at a remarkable rate,paving the way for scientists and clinicians to uniquely treat a multitude of previously irremediable ***-Cas9,short for clustered regularly interspaced short palindromic repeats and CRISPR-associated protein 9,is a gene editing platform with the ability to alter the nucleotide sequence of the genome in living *** technology is increasing the number and pace at which new gene editing treatments for genetic disorders are moving toward the ***β-hemoglobinopathies are a group of monogenic diseases,which despite their high prevalence and chronic debilitating nature,continue to have few therapeutic options *** this review,we will discuss our existing comprehension of the genetics and current state of treatment forβ-hemoglobinopathies,consider potential genome editing therapeutic strategies,and provide an overview of the current state of clinical trials using CRISPR-Cas9 gene editing.

关键词： sickle cell disease sickle cell anemia fetal hemoglobin hemoglobinopathy CRISPR gene editing genome engineering

A smart DNA hydrogel for isolation of bacterial outer membrane vesicles and localized cancer immunotherapy

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Science China Materials 2024年第12期67卷 3872-3884页

作者： Rui Zhang Lele Chang Jing Wang Mengxue Huang Zhen Cui Siqi Li Jingwen Zhao Chi Yao Dayong Yang Department of Chemistry State Key Laboratory of Molecular Engineering of PolymersShanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsCollege of Chemistry and MaterialsFudan UniversityShanghai 200438China Frontiers Science center for Synthetic Biology Key Laboratory of Systems Bioengineering(MOE)School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300350China Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalTianjin 300350China

Bacterial outer membrane vesicles(OMVs)have shown great potential in cancer *** isolation of OMVs from complex media with high purity and high bioactivity is the prerequisite of therapeutic applications,which remains highly ***,we report a smart DNA hydrogel for the efficient isolation of OMVs from bacterial culture medium,which is further applied for localized cancer *** DNA hydrogel is constructed through the cross-linking of two ultralong DNA chains generated via rolling circle amplification(RCA).One chain contains polyvalent GN6 aptamer for the specific capture of OMVs,and the other contains polyvalent programmed death-1(PD-1)aptamer for the blocking of PD-1 immune checkpoint on the surface of T *** OMVs capsulated by DNA hydrogel maintain high immunostimulatory *** the mouse model of melanoma,this OMVs-containing DNA hydrogel shows a remarkable tumor inhibition rate of∼95%.This smart DNA hydrogel represents a promising biomedical platform for the efficient isolation of bacterial-derived OMVs,and provides a powerful strategy for cancer immunotherapy.

关键词： DNA nanotechnology DNA hydrogel bacterial outer membrane vesicles cancer immunotherapy

Corrigendum to“An Integrated Systems Biology Approach Identifies the Proteasome as A Critical Host Machinery for ZIKV and DENV Replication"[Genomics Proteomics Bioinformatics 19(1)(2021)108-122]

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Genomics, Proteomics & Bioinformatics 2022年第4期20卷 808-809页

作者： Guang Song Emily M. Lee Jianbo Pan Miao Xu Hee-Sool Rho Yichen Cheng Nadia Whitt Shu Yang Jennifer Kouznetsova Carleen Klumpp-Thomas Samuel G. Michael Cedric Moore Ki-Jun Yoon Kimberly M. Christian Anton Simeonov Wenwei Huang Menghang Xia Ruili Huang Madhu Lal-Nag Hengli Tang Wei Zheng Jiang Qian Hongjun Song Guo-li Ming Heng Zhu Department of Pharmacology & Molecular Sciences Johns Hopkins School of Medicine Baltimore MD 21205 USA Department of Biological Science Florida State University Tallahassee FL 32306 USA Department of Ophthalmology Johns Hopkins School of Medicine Baltimore MD 21205 USA National center for Advancing Translational Sciences National Institutes of Health Bethesda MD 20892 USA Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou 310016 China Institute for Cell engineering Johns Hopkins University School of Medicine Baltimore MD 21205 USA Department of neuroscience and Mahoney Institute for neurosciences Perelman School for Medicine University of Pennsylvania Philadelphia PA 19104 USA Department of Cell and Developmental Biology Perelman School for Medicine University of Pennsylvania Philadelphia PA 19104 USA Institute for Regenerative Medicine Perelman School for Medicine University of Pennsylvania Philadelphia PA 19104 USA The Epigenetics Institute Perelman School for Medicine University of Pennsylvania Philadelphia PA 19104 USA