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Balloon cells in malformations of cortical development:friends or foes?

癫痫学报（英文） 2024年第2期7卷 87-99页

作者： Zili Liu Xuefeng Shen Kaomin Lin Fengpeng Wang Jin Gao Yi Yao Jianyuan Sun CAS Key Laboratory of Brain Connectome and Manipulation Shenzhen-Hong Kong Institute of Brain ScienceShenzhen Institute of Advanced Technology(SIAT)Chinese Academy of SciencesShenzhen 518055China The Brain Cognition and Brain Disease Institute SIATCASShenzhen 518055China HH-SIAT Joint center for Epilepsy Research Fujian Medical University Affiliated Xiamen Humanity HospitalXiamen 361003China Epilepsy center Fujian Medical University Affiliated Xiamen Humanity HospitalXiamen 361003China HH-SIAT Joint center for Epilepsy Research Fujian Medical University Affiliated Xiamen Humanity HospitalXiamen 361003China Department of Pathology Fujian Medical University Affiliated Xiamen Humanity HospitalXiamen 361003China HH-SIAT Joint center for Epilepsy Research Fujian Medical University Affiliated Xiamen Humanity HospitalXiamen 361003China CAS Key Laboratory of Brain Connectome and Manipulation Shenzhen-Hong Kong Institute of Brain ScienceShenzhen Institute of Advanced Technology(SIAT)Chinese Academy of SciencesShenzhen 518055China Epilepsy center Fujian Medical University Affiliated Xiamen Humanity HospitalXiamen 361003China HH-SIAT Joint center for Epilepsy Research Fujian Medical University Affiliated Xiamen Humanity HospitalXiamen 361003China

Balloon cells(BCs)are specific pathological marker of cortical malformations during brain development,often associ-ated with epilepsy and development *** a large number of studies have investigated the role of BCs in these diseases,the specific function of BCs as either epileptogenic or antiepileptic remains ***,we reviewed literatures on BCs,delved into the molecular mechanisms and signaling pathways,and updated their profile in several ***,BCs are heterogeneous and some of them show progenitor/stem cell ***,BCs are relatively silent in electrophysiology but not completely isolated from their ***,abnormal mTOR signaling and aberrant immunogenic process have been observed within BCs-containing malformations of cortical development(MCDs).The question whether BCs function as the evildoer or the defender in BCs-containing MCDs is further ***,this review provides perspectives on future investigations of the potential role of BCs in epilepsy.

关键词： Balloon cells MCD Epilepsy mTOR pathway

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Influencing Factors of Healthy Aging Risk Assessed Using Biomarkers:A Life Course Perspective

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China CDC weekly 2024年第11期6卷 219-224,I0014-I0017页

作者： Cedric Zhang Bo Lua Yajie Gao Jinming Li Xingqi Cao Xinwei Lyu Yinuo Tu Shuyi Jin Zuyun Liu center for Clinical Big Data and Analytics of the Second Affiliated Hospital and Department of Big Data in Health Science School of Public Healththe Key Laboratory of Intelligent Preventive Medicine of Zhejiang ProvinceZhejiang University School of MedicineHangzhou CityZhejiang ProvinceChina Institute of Epidemiology and Health Care University College LondonLondonUK College of Chemical and Biological Engineering Zhejiang UniversityHangzhou CityZhejiang ProvinceChina

Assessing individual risks of healthy aging using biomarkers and identifying associated factors have become important areas of *** this study,we conducted a literature review of relevant publications between 2018 and 2023 in both Chinese and English *** studies have predominantly used single biomarkers,such as C-reactive protein,or focused on specific life course stages and factors such as socioeconomic status,mental health,educational levels,and unhealthy *** summarizing the progress in this field,our study provides valuable insights and future directions for promoting healthy aging from a life course perspective.

关键词： such insight directions

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The switch triggering the invasion process:Lipid metabolism in the metastasis of hepatocellular carcinoma

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Chinese Medical Journal 2024年第11期137卷 1271-1284页

作者： Jiaqian Zhang Zhicheng Zhang Zhangfan Wu Yufei Wang Zerui Zhang Limin Xia Department of Gastroenterology Institute of Liver and Gastrointestinal DiseasesHubei Key Laboratory of Hepato-Pancreato-Biliary DiseasesTongji Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research center for Digestive Diseases Xijing Hospital of Digestive DiseasesFourth Military Medical UniversityXi’anShaanxi 710032China

In humans,the liver is a central metabolic organ with a complex and unique histological *** carcinoma(HCC),which is a highly aggressive disease with a poor prognosis,accounts for most cases of primary liver *** an emerging hallmark of cancers,metabolic reprogramming acts as a runaway mechanism that disrupts homeostasis of the affected organs,including the ***,rewiring of the liver metabolic microenvironment,including lipid metabolism,is driven by HCC cells,propelling the phenotypes of HCC cells,including dissemination,invasion,and even metastasis in *** resulting formation of this vicious loop facilitates various malignant behaviors of HCC ***,few articles have comprehensively summarized lipid reprogramming in HCC ***,we have reviewed the general situation of the liver microenvironment and the physiological lipid metabolism in the liver,and highlighted the effects of different aspects of lipid metabolism on HCC metastasis to explore the underlying *** addition,we have recapitulated promising therapeutic strategies targeting lipid metabolism and the effects of lipid metabolic reprogramming on the efficacy of HCC systematical therapy,aiming to offer new perspectives for targeted therapy.

关键词： Hepatocellular carcinoma Invasion Metastasis Lipid metabolism Tumor microenvironment

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Latest Scientific Results of China's Lunar and Deep Space Exploration(2022–2024)

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空间科学学报 2024年第4期44卷 622-632页

作者： XU Lin LI Lei LIU Jianzhong LIN Honglei LI Yang LIU Yang XIE Lianghai ZHANG Jinhai QIAO Fuhao HAN Juanjuan ZOU Yongliao General Office of the Lunar and Deep Space Exploration Chinese Academy of SciencesBeijng 100190 State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190 Institute of Geochemistry Chinese Academy of SciencesGuiyang 550081 Institute of Geology and Geophysics Chinese Academy of SciencesBeijing 100029

China has successfully launched six lunar probes so *** Chang'E-1 to Chang'E-4,they completed the circling,landing and roving exploration,of which Chang'E-4 was the first landing on the far side of the Moon in human ***'E-5 was launched in December 2020,bringing back 1731 g of lunar soil *** the detailed analysis of the samples,the scientists understand the history of late lunar volcanism,specifically extending lunar volcanism by about 800 million to 1 billion years,and proposed possible *** addition,there are many new understandings of space weathering such as meteorite impacts and solar wind radiation on the ***'s first Mars exploration mission Tianwen-1 was successfully launched in July *** the study of scientific data,a number of important scientific achievements have been made in the topography,water environment and shallow surface structure of *** paper introduces the main scientific achievements of Chang'E-4,Chang'E-5 and Tianwen-1 in the past two years,excluding technical and engineering *** to the large number of articles involved,this paper only introduces part of the results.

关键词： Lunar and deep space exploration of China Chang’E-4 mission Chang’E-5 mission Tianwen-1 mission

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Numerical study on characteristics of radio-frequency discharge at atmospheric pressure in argon with small admixtures of oxygen

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Plasma science and Technology 2017年第7期19卷 50-56页

作者： Yinan WANG Yue LIU College of science Liaoning Shihua Univerisity Fushun 113001 People＇s Republic of China Key Laboratory of Materials Modification by laser Ion and Electron Beams （Dalian University of Technology） Ministry of Education People＇s Republic of China

In this paper, a 1D fluid model is developed to study the characteristics of a discharge in argon with small admixtures of oxygen at atmospheric pressure. This model consists of a series of equations, including continuity equations for electrons, positive ions, negative ions and neutral particles, the energy equation, and the Poisson equation for electric potential. Special attention has been paid to the electron energy dissipation and the mechanisms of electron heating, while the admixture of oxygen is in the range of 0.1%-0.6%. It is found that when the oxygen-to-argon ratio grows, the discharge is obviously divided into three stages： electron growth, electron reduction and the electron remaining unchanged. Furthermore, the cycle-averaged electric field, electron temperature, electron Ohmic heating, electron collisionless heating, electron energy dissipation and the net electron production are also studied in detail, and when the oxygen-to- argon ratio is relatively larger （R = 0.6%）, double value peaks of electron Ohmic heating appear in the sheath. According to the results of the numerical simulation, various oxygen-to-argon ratios result in different amounts of electron energy dissipation and electron heating.

关键词： radio-frequency discharge numerical simulation small admixtures of oxygen

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Microseismic observations reveal that internal waves intensify seabed methane release

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science China Earth sciences 2024年第10期67卷 3186-3203页

作者： Zhaoyang TIAN Yonggang JIA Junjiang ZHU Tian CHEN Hui WANG Chunsheng JI Chengyu LIU Longyu LU Manchao HE Shandong Provincial Key Laboratory of Marine Environment and Geological Engineering Ocean University of China Frontiers science center for Deep Ocean Multispheres and Earth System Key Lab of Submarine Geosciences and Prospecting TechniquesMOE and College of Marine Geosciences Ocean University of China Guangzhou Marine Geological Survey China Geological Survey Shandong Earthquake Agency State Key Laboratory for Tunnel Engineering China University of Mining and Technology (Beijing)

Internal waves transport material and energy from the upper water column to the deep ocean, disturbing seabed sediments and resulting in phenomena such as seabed erosion and changes in topography. On the northern slope of the South China Sea and in many coastal margins worldwide, the zones with internal wave action closely overlap with areas where natural gas hydrates are present. However, due to significant differences in the spatial and temporal scales, understanding the influence of internal waves on methane releases from deep seabeds is challenging. In this study, in situ observations of seabed microseismicity and internal waves are conducted at water depths of 655 meters and 1450 meters in the Pearl River Canyon of the South China Sea. The microseismicity caused by internal waves and seabed methane releases is identified, and a method to establish the correlation between internal waves and seabed methane releases through the use of microseismic recordings is proposed, aiming to obtain direct observational evidence of internal waves intensifying seabed methane releases. The results show that internal waves and seabed methane releases generate significant microseismic signals, indicating the continuous influence of internal waves on the deep seabed of the northern slope of the South China Sea and revealing active methane release phenomena on the seabed. At both long and short time scales, internal waves increase the frequency of seabed methane releases by 4.2 times and 2.4 times, respectively, while also enhancing the intensity of these releases. These changes are influenced by the alterations in seabed flow velocity, pressure, and temperature that are induced by internal wave activities. This study emphasizes that microseismic signals are effective carriers of information for multiscale geological processes on seabeds and suggests that internal waves exacerbate marine geological hazards and contribute to global climate change by intensifying seabed methane relea

关键词： Internal waves Seabed methane release Microseismic observation Ocean bottom seismometer Northern slope of the South China Sea

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A modified back analysis method for deep excavation with multi-objective optimization procedure

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第4期16卷 1373-1387页

作者： Chenyang Zhao Le Chen Pengpeng Ni Wenjun Xia Bin Wang State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China Guangdong Research center for Underground Space Exploitation Technology School of Civil EngineeringSun Yat-sen UniversityGuangzhou510275China Southern Marine science and Engineering Guangdong Laboratory (Zhuhai) Zhuhai519000China Jiangsu Provincial Transportation Engineering Construction Bureau Nanjing210004China

Real-time prediction of excavation-induced displacement of retaining pile during the deep excavation process is crucial for construction *** paper proposes a modified back analysis method with multi-objective optimization procedure,which enables a real-time prediction of horizontal displacement of retaining pile during *** opposed to the traditional stage-by-stage back analysis,time series monitoring data till the current excavation stage are utilized to form a multi-objective ***,the multi-objective particle swarm optimization (MOPSO) algorithm is applied for parameter *** optimized model parameters are immediately adopted to predict the excavation-induced pile deformation in the continuous construction *** achieve efficient parameter optimization and real-time prediction of system behavior,the back propagation neural network (BPNN) is established to substitute the finite element model,which is further implemented together with MOPSO for automatic *** proposed approach is applied in the Taihu tunnel excavation project,where the effectiveness of the method is demonstrated via the comparisons with the site monitoring *** method is reliable with a prediction accuracy of more than 90%.Moreover,different optimization algorithms,including non-dominated sorting genetic algorithm (NSGA-II),Pareto Envelope-based Selection Algorithm II (PESA-II) and MOPSO,are compared,and their influences on the prediction accuracy at different excavation stages are *** results show that MOPSO has the best performance for high dimensional optimization task.

关键词： Multi-objective optimization Back analysis Surrogate model Multi-objective particle swarm optimization(MOPSO) Deep excavation

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Warhead fragments motion trajectories tracking and spatio-temporal distribution reconstruction method based on high-speed stereo photography

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Defence Technology（防务技术） 2024年第7期37卷 162-172页

作者： Pengyu Hu Jiangpeng Wu Zhengang Yan Meng He Chao Liang Hao Bai Xi'an Modern Control Technology Research Institute Xi'an710065China Xi'an OET science and Technology Co. LtdXi'an710076China

High speed photography technique is potentially the most effective way to measure the motion parameter of warhead fragment benefiting from its advantages of high accuracy,high resolution and high ***,it faces challenge in dense objects tracking and 3D trajectories reconstruction due to the characteristics of small size and dense distribution of fragment *** address these challenges,this work presents a warhead fragments motion trajectories tracking and spatio-temporal distribution reconstruction method based on high-speed stereo ***,background difference algorithm is utilized to extract the center and area of each fragment in the image ***,a multi-object tracking(MOT)algorithm using Kalman filtering and Hungarian optimal assignment is developed to realize real-time and robust trajectories tracking of fragment *** reconstruct 3D motion trajectories,a global stereo trajectories matching strategy is presented,which takes advantages of epipolar constraint and continuity constraint to correctly retrieve stereo correspondence followed by 3D trajectories refinement using polynomial ***,the simulation and experimental results demonstrate that the proposed method can accurately track the motion trajectories and reconstruct the spatio-temporal distribution of 1.0×10^(3)fragments in a field of view(FOV)of 3.2 m×2.5 m,and the accuracy of the velocity estimation can achieve 98.6%.

关键词： Warhead fragment measurement High speed photography Stereo vision Multi-object tracking Spatio-temporal reconstruction

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TMB相关免疫浸润调控评分(MOTIF)预测免疫治疗响应并指导联合增效

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science Bulletin 2024年第6期69卷 803-822页

作者：钱政宇潘艺芊李薛鑫陈衍行吴灏祥刘泽先 Martin Kosar Jiri Bartek 王梓贤徐瑞华 Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangdong Provincial Clinical Research Center for CancerResearch Unit of Precision Diagnosis and Treatment for Gastrointestinal CancerChinese Academy of Medical SciencesGuangzhou 510060China science for Life Laboratory Division of Genome BiologyDepartment of Medical Biochemistry and BiophysicsKarolinska InstituteStockholm S-17121Sweden Department of General Surgery The Fourth Affiliated HospitalChina Medical UniversityShenyang 110032China Bioinformatics Platform Sun Yat-sen University Cancer CenterGuangzhou 510060China Zhejiang University-University of Edinburgh Institute Zhejiang University School of MedicineHaining 314400China Edinburgh Medical School Biomedical SciencesCollege of Medicine and Veterinary MedicineThe University of EdinburghEdinburgh EH11LTUK Danish Cancer Society Research center Copenhagen DK-2100Denmark Laboratory of Artificial Intelligence and Data science Sun Yat-sen University Cancer CenterGuangzhou 510060China

Patients with high tumor mutational burden(TMB)levels do not consistently respond to immune checkpoint inhibitors(ICIs),possibly because a high TMB level does not necessarily result in adequate infiltration of CD8^(+)T *** bulk ribonucleic acid sequencing(RNA-seq)data from 9311 tumor samples across 30 cancer types,we developed a novel tool called the modulator of TMB-associated immune infiltration(MOTIF),which comprises genes that can determine the extent of CD8^(+)T cell infiltration prompted by a certain TMB *** confirmed that MOTIF can accurately reflect the integrity and defects of the cancer-immunity *** analyzing 84 human single-cell RNA-seq datasets from 32 types of solid tumors,we revealed that MOTIF can provide insights into the diverse roles of various cell types in the modulation of CD8^(+)T cell *** pretreatment RNA-seq data from 13 ICI-treated cohorts,we validated the use of MOTIF in predicting CD8^(+)T cell infiltration and ICI *** the components of MOTIF,we identified EMC3 as a negative regulator of CD8^(+)T cell infiltration,which was validated via in vivo ***,MOTIF provided guidance for the potential combinations of programmed death 1 blockade with certain immunostimulatory drugs to facilitate CD8^(+)T cell infiltration and improve ICI efficacy.

关键词： Tumor mutational burden Immunotherapy Cancer-immunity cycle Treatment efficacy prediction CD8^(+)T cell infiltration Combination therapy

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Characteristics of photonic bands generated by quadrangular multiconnected networks

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Chinese Physics B 2013年第10期22卷 328-336页

作者：罗瑞芳杨湘波卢剑刘承宜 Key Laboratory of laser Life science and Institute of laser Life science of Ministry of Education College of BiophotonicsSouth China Normal University School of Physical Education and Sports science South China Normal University

In this paper, by means of the network equation and generalized dimensionless Floquet-Bloch theorem, we study the influences of the number of connected waveguide segments （NCWS） between adjacent nodes and the matching ratio of waveguide length （MRWL） on the photonic bands generated by quadrangular multiconnected networks （QMNs）, and obtain a series of formulae. It is found that multicombining networks （MCNs） and repetitive combining networks （RCNs） are equivalent to each other and they can all be simplified into the simplest fundamental combining systems. It would be useful for adjusting the number, widths, and positions of photonic bands, and would possess potential applications for the designing of all-optical devices and photonic network devices.

关键词： photonic band gap waveguide network multiconnected network

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