检索结果-南通市图书馆

Analysis and Optimization of Transient Mode Switching Behavior for Power Split Hybrid Electric Vehicle with Clutch Collaboration

引用

Automotive Innovation 2024年第1期7卷 150-165页

作者： Dehua Shi Sheng Liu Yujie Shen Shaohua Wang Chaochun Yuan Long Chen Automotive Engineering Research Institute Jiangsu UniversityZhenjiang 212013China Jiangsu Province Engineering Research center of Electric Drive system and Intelligent Control for Alternative Vehicles Zhenjiang 212013China

The power split hybrid electric vehicle(HEV)adopts a power coupling configuration featuring dual planetary gearsets and multiple clutches,enabling diverse operational modes through clutch engagement and *** multi-clutch configuration usually involves the collaboration of two clutches during the transient mode switching process,thereby substantially elevating control *** study focuses on power split HEVs that integrate multi-clutch mechanisms and investigates how different clutch collaboration manners impact the characteristics of transient mode *** powertrain model for the power-split HEV is established utilizing matrix-based *** the formulation of clutch torque curves and clutch collaboration models,this research systematically explores the effects of clutch engagement timing and the duration of clutch slipping state on transient mode switching *** upon this analysis,an optimization problem for control parameters pertaining to the two collaborative clutches is *** simulated annealing algorithm is employed to optimize these control *** results demonstrate that the clutch collaboration manners have a great influence on the transient mode switching *** with the pre-calibrated benchmark and the optimal solution derived by the genetic algorithm,the maximal longitudinal jerk and clutch slipping work during the transient mode switching process is reduced obviously with the optimal control parameters derived by the simulated annealing *** study provides valuable insights for the dynamic coordinated control of the power-split HEVs featuring complex clutch collaboration mechanisms.

关键词： Power split hybrid electric vehicle Transient mode switching Clutch collaboration Simulated annealing Powertrain model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Meridional deflection of global eddy propagation derived from tandem altimetry: Mechanism and implication

引用

Science China Earth Sciences 2024年第3期67卷 811-825页

作者： Ge CHEN Xiaoyan CHEN Frontiers Science center for Deep Ocean Multispheres and Earth system School of Marine TechnologyOcean University of ChinaQindao 266100China Laboratory for Regional Oceanography and Numerical Modeling Laoshan LaboratoryQindao 266237China

A common view on meridional deflection of eddy propagation is poleward for cyclones and equatorward for anticyclones. This widely accepted polarity-sensitive pattern has been increasingly undermined given that it is systematically violated on both zonal and regional scales as recently reported. Here, we approach the problem by exploring these violations in terms of eddy effects of spatiotemporal geostrophy, thermal fading, and flow dragging, yielding the following main conclusions.(1) The polarity-dependent deflection discrepancy is a pseudo feature resulting from a biased fit to the normalized eddy tracks which are spatially asymmetric(though azimuthally symmetric) between the two signs;Instead, the primary pattern of eddy deflection appears to be geographically correlated and polarity independent.(2) Geostrophic adjustment plays a critical role in defining the meridional movement of an eddy. Specifically, a consistent poleward(equatorward) trajectory bending of spatially(temporally) ageostrophic eddies is observed irrespective of their polarity.(3) The mechanism of eddy deflection is also determined by its zonal propagation direction. Westward propagating eddies are substantially affected by thermal fading, while opposite ones by flow dragging. A realistic and comprehensive understanding of eddy deflection mechanisms serves as a significant contribution to the prediction of eddy trajectory, and the protection of ocean environment.

关键词： Mesoscale eddies Eddy propagation Eddy meridional deflection Satellite observation Geostrophic adjustment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Classification analysis of prediction skill among ensemble members in MJO subseasonal predictions——based on the results of the CAMS-CSM subseasonal prediction system

引用

Atmospheric and Oceanic Science Letters 2024年第4期17卷 8-14页

作者： Yihao Peng Xiaolei Liu Jingzhi Su Xinli Liu State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijingChina center for Earth system Modeling and Prediction of CMA(CEMC) BeijingChina Key Laboratory of Earth system Modeling and Prediction China Meteorological Administration BeijingChina

由于模式误差和初始误差所致,次季节-季节预报技巧整体偏低.国际上多数模式都采用集合预报的方式来提高次季节预报的准确率.热带大气季节内振荡(MJO)作为次季节尺度可预报性的重要来源,其预测水平取决于模式性能和MJO事件本身的物理特性... 详细信息

由于模式误差和初始误差所致,次季节-季节预报技巧整体偏低.国际上多数模式都采用集合预报的方式来提高次季节预报的准确率.热带大气季节内振荡(MJO)作为次季节尺度可预报性的重要来源,其预测水平取决于模式性能和MJO事件本身的物理特性.根据中国气象科学研究院气候系统模式次季节预测系统的回报结果,结合不同类型MJO事件的特征,对模式集合成员间的预报技巧进行了分类和比较.在集合成员预报技巧普遍较高的一类MJO事件中,对流异常信号持续时间较长,强度较大,强对流异常中心主要位于印度洋区域,并逐渐东传至西太平洋.在集合成员预报技巧多数较差的MJO事件中,对流异常信号的强度最弱,维持时间最短.在集合成员预报技巧优劣参半的类别中,MJO往往持续时间较短,强度较低,在后续传播过程中,对流异常中心多停驻在海洋性大陆区域.

关键词：次季节-季节预测预报技巧热带大气季节内振荡

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A novel marine-derived anti-acute kidney injury agent targeting peroxiredoxin 1 and its nanodelivery strategy based on ADME optimization

引用

Acta Pharmaceutica Sinica B 2024年第7期14卷 3232-3250页

作者： Ping Yu Tanwei Gu Yueyang Rao Weimin Liang Xi Zhang Huanguo Jiang Jindi Lu Jianglian She Jianmin Guo Wei Yang Yonghong Liu Yingfeng Tu Lan Tang Xuefeng Zhou Guangdong Provincial Key Laboratory of New drug Screening Guangdong-Hong Kong-Macao Joint Laboratory for New Drug ScreeningSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology Guangdong Key Laboratory of Marine Materia MedicaSouth China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China NMPA Key Laboratory for Research and Evaluation of drug Metabolism School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Guangdong Lewwin Pharmaceutical Research Institute Co. Ltd.Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and ResearchGuangdong Engineering Research Center for Innovative Drug Evaluation and ResearchGuangzhou 510990China

Insufficient therapeutic strategies for acute kidney injury(AKI)necessitate precision therapy targeting its *** study reveals the new mechanism of the marine-derived anti-AKI agent,piericidin glycoside S14,targeting peroxiredoxin 1(PRDX1).By binding to Cys83 of PRDX1 and augmenting its peroxidase activity,S14 alleviates kidney injury efficiently in Prdx1-overexpression(Prdx1-OE)***,S14 also increases PRDX1 nuclear translocation and directly activates the Nrf2/HO-1/NQO1 pathway to inhibit ROS *** to the limited druggability of S14 with low bioavailability(2.6%)and poor renal distribution,a pH-sensitive kidney-targeting dodecanaminechitosan nanoparticle system is constructed to load S14 for precise treatment of AKI.L-Serine conjugation to chitosan imparts specificity to kidney injury molecule-1(Kim-1)-overexpressed *** developed S14-nanodrug exhibits higher therapeutic efficiency by improving the in vivo behavior of S14 *** encapsulation with micelles,the AUC_(0-t),half-life time,and renal distribution of S14 increase 2.5-,1.8-,and 3.1-fold,*** main factors contributing to the improved druggability of S14 nanodrugs include the lower metabolic elimination rate and UDPglycosyltransferase(UGT)-mediated *** summary,this study identifies a new therapeutic target for the marine-derived anti-AKI agent while enhancing its ADME properties and druggability through nanotechnology,thereby driving advancements in marine drug development for AKI.

关键词： Acute kidney injury Piericidin glycoside Peroxiredoxin 1 Nanodrug Kim-1 targeted ADME Marine drug druggability

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Massively parallel algorithms for fully dynamic all-pairs shortest paths

引用

Frontiers of Computer Science 2024年第4期18卷 201-203页

作者： Chilei WANG Qiang-Sheng HUA Hai JIN Chaodong ZHENG National Engineering Research center for Big Data Technology and system Services Computing Technology and System LabCluster and Grid Computing LabSchool of Computer Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China State Key Laboratory for Novel Software Technology Nanjing UniversityNanjing 210023China

1 Introduction In recent years,the Massively Parallel Computation(MPC)model has gained significant ***,most of distributed and parallel graph algorithms in the MPC model are designed for static graphs[1].In fact,the graphs in the real world are constantly *** size of the real-time changes in these graphs is smaller and more *** graph algorithms[2,3]can deal with graph changes more efficiently[4]than the corresponding static graph ***,most studies on dynamic graph algorithms are limited to the single machine ***,a few parallel dynamic graph algorithms(such as the graph connectivity)in the MPC model[5]have been proposed and shown superiority over their parallel static counterparts.

关键词： dynamic shortest gained

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integrated Active Suspension and Anti-Lock Braking Control for Four-Wheel-Independent-Drive Electric Vehicles

引用

Chinese Journal of Mechanical Engineering 2024年第1期37卷 87-98页

作者： Ze Zhao Lei Zhang Xiaoling Ding Zhiqiang Zhang Shaohua Li Liang Gu National Engineering Research center for Electric Vehicles Beijing Institute of TechnologyBeijing 100081China State Key Laboratory of Mechanical Behavior and system Safety of Traffic Engineering Structures Shijiazhuang Tiedao UniversityShijiazhuang 050043China

This paper presents an integrated control scheme for enhancing the ride comfort and handling performance of a four-wheel-independent-drive electric vehicle through the coordination of active suspension system(ASS)and anti-lock braking system(ABS).First,a longitudinal-vertical coupled vehicle dynamics model is established by integrating a road input *** the coupling mechanisms between longitudinal and vertical vehicle dynamics are *** ASS-ABS integrated control system is proposed,utilizing an H∞controller for ASS to optimize load transfer effect and a neural network sliding mode control for ABS ***,the effectiveness of the proposed control scheme is evaluated through comprehensive tests conducted on a hardware-in-loop(HIL)test *** HIL test results demonstrate that the proposed control scheme can significantly improve the braking performance and ride comfort compared to conventional ABS control methods.

关键词： Four-wheel-independent-drive electric vehicles Active suspension system(ASS) Anti-lock braking system(ABS) Vertical-longitudinal vehicle dynamics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Media Power Measuring via Emotional Contagion

引用

Journal of Social Computing 2024年第1期5卷 15-35页

作者： Xue Lin Hong Huang Zongya Li Hai Jin National Engineering Research center for Big Data Technology and system Services Computing Technology and System LabCluster and Grid Computing LabSchool of Computer Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China School of Journalism Huazhong University of Science and TechnologyWuhan 430074China

Media power,the impact that media have on public opinion and perspectives,plays a significant role in maintaining internal stability,exerting external influence,and shaping international dynamics for nations/***,prior research has primarily concentrated on news content and reporting time,resulting in limitations in evaluating media *** more accurately assess media power,we use news content,news reporting time,and news emotion simultaneously to explore the emotional contagion between *** use emotional contagion to measure the mutual influence between media and regard the media with greater impact as having stronger media *** propose a framework called Measuring Media Power via Emotional Contagion(MMPEC)to capture emotional contagion among media,enabling a more accurate assessment of media power at the media and national/regional *** also interprets experimental results through correlation and causality analyses,ensuring *** analyses confirm the higher accuracy of MMPEC compared to other baseline models,as demonstrated in the context of COVID-19-related news,yielding compelling and interesting insights.

关键词： explainability media power emotional contagion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Efficient Penetration Testing Path Planning Based on Reinforcement Learning with Episodic Memory

引用

Computer Modeling in Engineering & Sciences 2024年第9期140卷 2613-2634页

作者： Ziqiao Zhou Tianyang Zhou Jinghao Xu Junhu Zhu Henan Key Laboratory of Information Security National Engineering Technology Research Center of the Digital Switching SystemZhengzhou450000China School of Cryptographic Engineering Information Engineering UniversityZhengzhou450000China

Intelligent penetration testing is of great significance for the improvement of the security of information systems,and the critical issue is the planning of penetration test *** view of the difficulty for attackers to obtain complete network information in realistic network scenarios,Reinforcement Learning(RL)is a promising solution to discover the optimal penetration path under incomplete information about the target *** RL-based methods are challenged by the sizeable discrete action space,which leads to difficulties in the ***,most methods still rely on experts’*** address these issues,this paper proposes a penetration path planning method based on reinforcement learning with episodic ***,the penetration testing problem is formally described in terms of reinforcement *** speed up the training process without specific prior knowledge,the proposed algorithm introduces episodic memory to store experienced advantageous strategies for the first ***,the method offers an exploration strategy based on episodic memory to guide the agents in *** design makes full use of historical experience to achieve the purpose of reducing blind exploration and improving planning ***,comparison experiments are carried out with the existing RL-based *** results reveal that the proposed method has better convergence *** running time is reduced by more than 20%.

关键词： Intelligent penetration testing penetration testing path planning reinforcement learning episodic memory exploration strategy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Click chemistry and natural products

引用

Chinese Journal of Natural Medicines 2024年第2期22卷 97-99页

作者： ZHANG Chen WU Jianbing ZHANG Yihua HUANG Zhangjian State Key Laboratory of Natural Medicines Jiangsu Key Laboratory of Drug Discovery for Metabolic DiseasesCenter of Drug DiscoveryChina Pharmaceutical UniversityNanjing 210009China State Key Laboratory of Pathogenesis Prevention and Treatment of High Incidence Diseases in Central AsiaXinjiang Key Laboratory of Natural Medicines Active Components and Drug Release TechnologySchool of PharmacyXinjiang Medical UniversityUrumqi 830054China

The 2022 Nobel Prize in Chemistry was awarded to American scientists Carolyn Bertozzi,*** Sharpless,and Danish scientist Morten *** for their contributions to the development of click chemistry and bioorthogonal chemi... 详细信息

关键词： Click chemistry Natural product Target identification drug discovery

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Narciclasine induces colon carcinoma cell apoptosis by inhibiting the IL-17A/Act1/TRAF6/NF-kB signaling pathway

引用

Genes & Diseases 2024年第5期11卷 428-441页

作者： Huiming Deng Qiang Liu Siman Yu Lifan Zhong Lianfang Gan Huiquan Gu Qianru Wang Ruxin Cheng Yong Liu Li Liu Ling Huang Ronghua Xu Department of Gastrointestinal Surgery Huazhong University of Science and Technology Union Shenzhen HospitalShenzhenGuangdong 518000China Research center for drug Safety Evaluation of Hainan Province HaikouHainan 571199China Department of Pharmacology Hainan Medical UniversityHaikouHainan 571199China Department of Pathology Guangzhou Panyu Central HospitalGuangzhouGuangdong 511400China Hainan Province Key Laboratory for drug Preclinical Study of Pharmacology and Toxicology Research Hainan Medical UniversityHaikouHainan 571199China Hainan center for drug and Medical Device Evaluation and Service Hainan Medical Products AdministrationHaikouHainan 570216China

IL-17 A is a promoter of colorectal cancer initiation and *** is a polyhydroxy alkaloid compound isolated from Narcissus plants,which has potent anti-inflammatory and antitumor *** effects of narciclasine on colorectal tumors were evaluated,with a focus on IL-17 *** reduced the growth of HCT-116 and SW-480 colon cancer cells in vitro and in vivo in murine *** results of flow cytometry on JC-1 and Annexin V/PI revealed that narciclasine significantly reduced the mitochondrial membrane potential and induced apoptosis,findings confirmed by western blotting results of reduced Bcl2 and enhanced Bax expression,as well as accumulation of cleaved Caspase-3,Caspase-8,Caspase-9,and cytoplasmic *** narciclasine incubation,IL-17 A,Act1,and TRAF6 were down-regulated,while p-P65(Ser536)accumulated in the cytoplasm,a finding confirmed by laser scanning confocal ***17A substitution could partly reverse these narciclasine effects while they were elevated by IL17A ***,IL-17 A,Act1,and TRAF6 were significantly expressed to greater extents in human colorectal cancer compared to normal adjacent tissue specimens and were closely linked with a poor *** study provided evidence that narciclasine may be a useful therapeutic drug for colorectal cancer treatment through its actions in down-regulating the L-17A/Act1/TRAF6/NF-kB anti-apoptotic signaling pathway.

关键词： Act1 Apoptosis Colonrectal cancer IL-17A Narciclasine NF-kB

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：