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Strong and tough chitin hydrogel constructed by dehydration and rehydration strategy

Nano Research 2024年第9期17卷 8192-8199页

作者： Rui-Rui Liu Li-Bo Mao Shu-Hong Yu Division of Nanomaterials and Chemistry Hefei National Research Center for Physical Sciences at the MicroscaleDepartment of ChemistryInstitute of Biomimetic Materials and ChemistryAnhui Engineering Laboratory of Biomimetic MaterialsUniversity of Science and Technology of ChinaHefei 230026China Institute of Innovative Materials Department of Materials Science and EngineeringDepartment of ChemistrySouthern University of Science and TechnologyShenzhen 518055China

As a renewable,biocompatible,biodegradable soft material,chitin hydrogels have better advantages in stability,antibacterial activity,antifouling,cost,immunogenicity,and so on than most polymer ***,compared with other widely used polymer hydrogels with high strength and toughness,the practical applications of chitin-based hydrogels have been limited by their weak mechanical properties,such as cartilage repair and meniscus ***,we present the design and fabrication of chitin hydrogels with excellent mechanical strength and toughness by a dehydration and rehydration *** sequential dehydration and rehydration processes,the crystalline domains in the chitin hydrogels can be properly *** optimized crystallinity,the elastic modulus of the chitin hydrogels exceeds all previously reported values,and the fracture toughness is even comparable to some synthetic polymer hydrogels,while maintaining a high-water-content of about 80 wt.%.At the same water content,the mechanical properties of the chitin hydrogels are positively correlated with the hydrogel crystallinity,which proves that the change of mechanical properties of hydrogels is not simply dependent on weight *** hydrogels can be further strengthened by incorporating other biopolymers that are intrinsically weak,which makes the hydrogels promising for applications in fields such as cartilage repair and meniscus ***,the hydrogels enable loading and release of water-soluble and poorly water-soluble *** highly extendable strengthening and toughening strategy of chitin and chitin-based biopolymer hydrogels paves the way for their widely applications.

关键词： chitin hydrogel crystallinity rehydration chemical transformation strong and tough

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Genome editing of PAR2 through targeted delivery of CRISPR-Cas9 system for alleviating acute lung inflammation via ERK/NLRP3/IL-1β and NO/iNOS signalling

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1441-1456页

作者： Xin Zhuo Yue Wu Xiujuan Fu Jianbin Li Yuxin Xiang Xiaoyu Liang Canquan Mao Yuhong Jiang Sichuan Engineering Research center for biomimetic Synthesis of Natural Drugs School of Life Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China

Excessive and uncontrollable inflammatory responses in alveoli can dramatically exacerbate pulmonary disease progressions through vigorous cytokine releases,immune cell infiltration and protease-driven tissue *** is an urgent need to explore potential drug strategies for mitigating lung ***-activated receptor 2(PAR2)as a vital molecular target principally participates in various inflammatory diseases via intracellular signal ***,it has been rarely reported about the role of PAR2 in lung *** study applied CRISPR-Cas9 system encoding Cas9 and sg RNA(p Cas9-PAR2)for PAR2 knockout and fabricated an anionic human serum albuminbased nanoparticles to deliver p Cas9-PAR2 with superior inflammation-targeting efficiency and stability(TAP/p Cas9-PAR2).TAP/p Cas9-PAR2 robustly facilitated p Cas9-PAR2 to enter and transfect inflammatory cells,eliciting precise gene editing of PAR2 in vitro and in ***,PAR2 deficiency by TAP/p Cas9-PAR2 effectively and safely promoted macrophage polarization,suppressed proinflammatory cytokine releases and alleviated acute lung inflammation,uncovering a novel value of *** also revealed that PAR2-mediated pulmonary inflammation prevented by TAP/p Cas9-PAR2was mainly dependent on ERK-mediated NLRP3/IL-1β and NO/i NOS ***,this work indicated PAR2 as a novel target for lung inflammation and provided a potential nanodrug strategy for PAR2 deficiency in treating inflammatory diseases.

关键词： Protease-activated receptor 2(PAR2) CRISPR-Cas9 Gene editing Inflammation Acute lung inflammation NLRP3 Nanoparticles Drug delivery

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Multidimensional hollow SiO_(2)/C nanofibers modified by magnetic nanocrystals for electromagnetic energy conversion and lithium battery storage

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Nano Research 2024年第8期17卷 7301-7314页

作者： Chen Han Qi Zheng Juncheng Jin Jiajia Zhang Wen-Qiang Cao Kun Xiang Min Zhang Mao-Sheng Cao Anhui Provincial Laboratory of biomimetic sensor and Detecting Technology College of Materials and Chemical EngineeringWest Anhui UniversityLu’an 237012China School of Materials science and Engineering Beijing Institute of TechnologyBeijing 100081China Department of Physics Beijing Technology and Business UniversityBeijing 100048China

Multifunctional materials are powerful tools to support the advancement of energy conversion *** with prominent electromagnetic and electrochemical properties can realize the conversion of electromagnetic energy and solve the subsequent storage ***,an electrospinning-thermal reduction method is employed to construct ultrafine nickel nanoparticle modified porous SiO_(2)/C(Ni-SiO_(2)/C)hollow nanofibers as promising materials for applications in both electromagnetic wave absorption(EMA)and lithium-ion ***,when used as an EMA material,the reflection loss(RL)of Ni-SiO_(2)/C can reach−47.8 dB at 15.8 GHz with a matching thickness of 2.2 *** excellent microwave absorption performance can be attributed to the enhanced conduction loss,polarization relaxation,synergistic magnetic loss,and preferred impedance matching,which result from multi-component magnetic/dielectric synergy and the unique interconnected multidimensional hollow ***,the electronic conductivity and electrochemical activity of the samples are significantly enhanced due to the uniform distribution of ultrafine Ni nanoparticles in the amorphous SiO_(2)/C ***,the hierarchical hollow porous structure provides sufficient free space for volume change during lithiation/delithiation ***,the Ni-SiO_(2)/C nanocomposite exhibits a high reversible capacity of 917.6 mAh·g^(−1)at 0.1 A·g^(−1).At a high current density of 2 A·g^(−1),a capacity of 563.9 mAh·g^(−1)can be maintained after 300 *** energy conversion-storage device is designed to store waste electromagnetic energy in the form of useful electrical *** work inspires the development of high-performance bifunctional materials.

关键词： Ni-SiO_(2)/C nanofiber electromagnetic absorption lithium-ion storage electrospinning multidimensional structure

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Iron oxide/CNT-based artificial nacre for electromagnetic interference shielding

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Nano Research 2024年第7期17卷 6560-6566页

作者： Cheng-Xin Yu Yu-Feng Meng Bo Yang Jun Pang Xiang-Sen Meng Zi-Ye Zhao Qing-Yue Wang Li-Bo Mao Zhi-Kun Wu Shu-Hong Yu Institute of Physical science and Information Technology Anhui UniversityHefei 230601China Key Laboratory of Materials Physics Anhui Key Laboratory of Nanomaterials and NanotechnologyCAS Center for Excellence in NanoscienceInstitute of Solid State PhysicsHFIPSChinese Academy of SciencesHefei 230031China Department of Chemistry New Cornerstone Science LaboratoryInstitute of Biomimetic Materials&ChemistryAnhui Engineering Laboratory of Biomimetic MaterialsDivision of Nanomaterials&ChemistryHefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China

Biological structural materials,despite consisting of limited kinds of compounds,display multifunctionalities due to their complex hierarchical *** some biomimetic strategies have been applied in artificial materials to enhance their mechanical stability,the simultaneous optimization of other functions along with the mechanical properties via biomimetic designs has not been thoroughly ***,iron oxide/carbon nanotube(CNT)-based artificial nacre with both improved mechanical and electromagnetic interference(EMI)shielding performance is fabricated via the mineralization of Fe_(3)O_(4)onto a CNTincorporated *** micro-and nano-structures of the artificial nacre are similar to those of natural nacre,which in turn improves its mechanical *** alternating electromagnetic wave-reflective CNT layers and the wave-absorptive iron oxide layers can improve the multiple reflections of the waves on the surfaces of the reflection layers,which then allows sufficient interactions between the waves and the absorption ***,compared with the reflection-dependent EMI-shielding of the non-structured material,the artificial nacre exhibits strong absorption-dependent shielding behavior even with a very low content of wave-absorptive *** to the high mechanical stability,the shielding effectiveness of the artificial nacre that deeply cut by a blade is still maintained at approximately 70%−96%depending on the incident wave *** present work provides a new way for designing structural materials with concurrently enhanced mechanical and functional properties,and a path to combine structural design and intrinsic properties of specific materials via a biomimetic strategy.

关键词： artificial nacre electromagnetic interference shielding biomineralization biomimetic material hierarchical structure

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Ultra-Robust and High-Performance Rotational Triboelectric Nanogenerator by Bearing Charge Pumping

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Energy & Environmental Materials 2024年第2期7卷 347-353页

作者： Xianpeng Fu Yuhan Qin Zhi Zhang Guoxu Liu Jie Cao Beibei Fan Zhaozheng Wang Zheng Wang Chi Zhang CAS center for Excellence in Nanoscience Beijing Key Laboratory of Micronano Energy and Sensor Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences School of Nanoscience and Technology University of Chinese Academy of Sciences center on Nanoenergy Research School of Physical Science and Technology Guangxi University

As an emerging technology to convert environmental high-entropy energy into electrical energy, triboelectric nanogenerator(TENG) has great demands for further enhancing the service lifetime and output performance in practical applications. Here, an ultra-robust and high-performance rotational triboelectric nanogenerator(R-TENG) by bearing charge pumping is proposed. The R-TENG composes of a pumping TENG(P-TENG), an output TENG(O-TENG), a voltage-multiplying circuit(VMC), and a buffer *** P-TENG is designed with freestanding mode based on a rolling ball bearing, which can also act as the rotating mechanical energy harvester. The output low charge from the P-TENG is accumulated and pumped to the noncontact O-TENG, which can simultaneously realize ultralow mechanical wear and high output performance. The matched instantaneous power of R-TENG is increased by 32 times under 300 r/min. Furthermore, the transferring charge of R-TENG can remain 95% during 15 days(6.4 × 10～6cycles)continuous operation. This work presents a realizable method to further enhance the durability of TENG, which would facilitate the practical applications of high-performance TENG in harvesting distributed ambient micro mechanical energy.

关键词： bearing charge pumping triboelectric nanogenerators ultralow mechanical wear ultra-robust voltage-multiplying circuit

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Thylakoid engineered M2 macrophage for sonodynamic effect promoted cell therapy of early atherosclerosis

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Nano Research 2024年第4期17卷 2919-2928页

作者： Guanghao Wu Changwen Mu Qianru Zhao Yao Lei Ran Cheng Weidong Nie Jiamin Qu Yuping Dong Ruili Yang Haiyan Xie State Key Laboratory of Natural and biomimetic Drugs School of Pharmaceutical SciencesChemical Biology CenterPeking UniversityBeijing 100191China School of Materials science and Engineering Beijing Institute of TechnologyBeijing 100081China School of Life science Beijing Institute of TechnologyBeijing 100081China School of Stomatology Peking UniversityBeijing 100081China

Atherosclerosis is the most common cause of cardiovascular diseases that contribute to the major morbidity worldwide,but still lacking of effective treatment ***,a hybrid cell is constructed for the sonodynamic effect promoted cell therapy of early atherosclerosis by fusing M2 macrophages with thylakoid(TK)*** systemic administration,the obtained TK-M2 actively accumulates in the early atherosclerotic plaques,wherein M2 macrophages relieve the cholesterol accumulation and the inflammation in the foam ***,the TK membranes decorated on the M2 macrophages exhibit both type I and type II sonodynamic effects under ultrasound(US)activation,inducing the direct apoptosis of foam *** cooperation of M2 and TK leads to significant outcome in eliminating atherosclerotic plaques without obvious side-effects,providing a new avenue for atherosclerosis treatment.

关键词： atherosclerosis thylakoid ultrasound M2 macrophage

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Bioinspired polysaccharide-based nanocomposite membranes with robust wet mechanical properties for guided bone regeneration

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National science Review 2024年第3期11卷 215-226页

作者： Jian-Hong Xiao Zhen-Bang Zhang JiaHao Li Si-Ming Chen Huai-Ling Gao YinXiu Liao Lu Chen ZiShuo Wang YiFan Lu YuanZhen Hou HengAn Wu DuoHong Zou Shu-Hong Yu Department of Chemistry New Cornerstone Science Laboratory Institute of Biomimetic Materials&Chemistry Anhui Engineering Laboratory of Biomimetic MaterialsDivision of Nanomaterials&Chemistry Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of China Department of Dental Implant center Stomatologic Hospital and College Key Laboratory of Oral Diseases Research of Anhui Province Anhui Medical University CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Modern Mechanics CAS Center for Excellence in Complex System Mechanics University of Science and Technology of China Department of Oral Surgery College of Stomatology National Clinical Research Center for Oral DiseasesShanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Institute of Innovative Materials(I2M) Department of Chemistry Department of Materials Science and Engineering Southern University of Science and Technology

Polysaccharide-based membranes with excellent mechanical properties are highly desired. However, severe mechanical deterioration under wet conditions limits their biomedical applications. Here, inspired by the structural heterogeneity of strong yet hydrated biological materials, we propose a strategy based on heterogeneous crosslink-and-hydration（HCH） of a molecule/nano dual-scale network to fabricate polysaccharide-based nanocomposites with robust wet mechanical properties. The heterogeneity lies in that the crosslink-and-hydration occurs in the molecule-network while the stress-bearing nanofiber-network remains unaffected. As one demonstration, a membrane assembled by bacterial cellulose nanofiber-network and Ca2+-crosslinked and hydrated sodium alginate molecule-network is designed. Studies show that the crosslinked-and-hydrated molecule-network restricts water invasion and boosts stress transfer of the nanofiber-network by serving as interfibrous bridge. Overall, the molecule-network makes the membrane hydrated and flexible; the nanofiber-network as stress-bearing component provides strength and *** HCH dual-scale network featuring a cooperative effect stimulates the design of advanced biomaterials applied under wet conditions such as guided bone regeneration membranes.

关键词： bioinspiration heterogeneous crosslink-and-hydration dual-scale network nanocomposite membrane wet mechanical properties guided bone regeneration

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biomimetic chitin hydrogel via chemical transformation

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Nano Research 2024年第2期17卷 771-777页

作者： Rui-Rui Liu Qian-Qian Shi Yu-Feng Meng Yong Zhou Li-Bo Mao Shu-Hong Yu Division of Nanomaterials&Chemistry Hefei National Research Center for Physical Sciences at the MicroscaleDepartment of ChemistryInstitute of Biomimetic Materials&ChemistryAnhui Engineering Laboratory of Biomimetic MaterialsUniversity of Science and Technology of ChinaHefei 230026China College&Hospital of Stomatology Key Laboratory of Oral Diseases Research of Anhui ProvinceAnhui Medical UniversityHefei 230032China Department of Dental Implantology College&Hospital of StomatologyAnhui Medical UniversityHefei 230032China

Chitin hydrogel has been recognized as a promising material for various biomedical applications because of its biocompatibility and ***,the fabrication of strong chitin hydrogel remains a big challenge because of the insolubility of chitin in many solvents and the reduced chain length of chitin regenerated from *** herein introduce the fabrication of chitin hydrogel with biomimetic structure through the chemical transformation of chitosan,which is a water-soluble deacetylated derivative of *** reacetylation of the amino group in chitosan endows the obtained chitin hydrogel with outstanding resistance to swelling,degradation,extreme temperature and pH conditions,and organic *** chitin hydrogel has excellent mechanical properties while retaining a high water content(more than 95 wt.%).It also shows excellent antifouling performance that it resists the adhesion of proteins,bacteria,blood,and ***,as the initial chitosan solution can be feasibly frozen and templated by ice crystals,the chitin hydrogel structure can be either nacre-like or wood-like depending on the freezing method of the precursory chitosan *** to these anisotropic structures,such chitin hydrogel can exhibit anisotropic mechanics and mass transfer *** current work provides a rational strategy to fabricate chitin hydrogels and paves the way for its practical applications as a superior biomedical material.

关键词： chitin hydrogel biomimetic structure chemical stability mechanical strength antifouling

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Therapeutic strategies of targeting nonapoptotic regulated cell death (RCD) with smallmolecule compounds in cancer

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2815-2853页

作者： Xin Jin Wenke Jin Linlin Tong Jia Zhao Lan Zhang Na Lin Department of Ultrasound Department of Medical Oncology and Department of Hematologythe First Hospital of China Medical UniversityChina Medical UniversityShenyang 110001China Sichuan Engineering Research center for biomimetic Synthesis of Natural Drugs School of Life Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China

Regulated cell death(RCD)is a controlled form of cell death orchestrated by one or more cascading signaling pathways,making it amenable to pharmacological *** subroutines can be categorized as apoptotic or non-apoptotic and play essential roles in maintaining homeostasis,facilitating development,and modulating *** evidence has recently revealed that RCD evasion is frequently the primary cause of tumor *** non-apoptotic RCD subroutines have garnered attention as promising cancer therapies due to their ability to induce tumor regression and prevent relapse,comparable to ***,they offer potential solutions for overcoming the acquired resistance of tumors toward apoptotic *** an increasing understanding of the underlying mechanisms governing these non-apoptotic RCD subroutines,a growing number of small-molecule compounds targeting single or multiple pathways have been discovered,providing novel strategies for current cancer *** this review,we comprehensively summarized the current regulatory mechanisms of the emerging non-apoptotic RCD subroutines,mainly including autophagy-dependent cell death,ferroptosis,cuproptosis,disulfidptosis,necroptosis,pyroptosis,alkaliptosis,oxeiptosis,parthanatos,mitochondrial permeability transition(MPT)-driven necrosis,entotic cell death,NETotic cell death,lysosome-dependent cell death,and immunogenic cell death(ICD).Furthermore,we focused on discussing the pharmacological regulatory mechanisms of related small-molecule *** brief,these insightful findings may provide valuable guidance for investigating individual or collaborative targeting approaches towards different RCD subroutines,ultimately driving the discovery of novel small-molecule compounds that target RCD and significantly enhance future cancer therapeutics.

关键词： Regulated cell death(RCD) Non-apoptotic RCD subroutine Autophagy Ferroptosis Necroptosis Regulatory mechanism Small-molecule compound Cancer therapy

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Regulated polarization degree of upconversion luminescence and multiple anti-counterfeit applications

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Rare Metals 2024年第5期43卷 2172-2183页

作者： Dong-Ping Wen Ping Chen Yi Liang Xiao-Ming Mo Cao-Feng Pan center On Nanoenergy Research Guangxi Key Laboratory for Relativistic AstrophysicsSchool of Physical Science and TechnologyGuangxi UniversityNanning 530004China Key Laboratory of Micronano Energy and sensor CAS Center for Excellence in NanoscienceBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 100140China

Polarization upconversion luminescence(PUCL)of lanthanide ions(Ln^(3+))has been widely used in single particle tracking,microfluidics detection,three-dimensional displays,and so ***,no effective strategy has been developed for modulating *** we report a strategy to regulate PUCL in Ho^(3+)-doped NaYF4single nanorods based on the number of upconversion *** constructing a multiphoton upconversion system for Ho^(3+),we regulate the degree of polarization(DOP)of PUCL from 0.590 for two-photon luminescence to 0.929 for three-photon upconversion luminescence(UCL).Furthermore,our strategy is verified from cross-relaxation between Ho^(3+)and Yb^(3+),excitation wavelength,excitation power density,and local site *** this regulation strategy of PUCL has also been achieved in Tm^(3+),with the DOP ranging from 0.233 for two-photon luminescence to 0.925 for four-photon UCL Besides,multi-dimensional anti-counterfeiting display has been explored with *** work provides an effective strategy for regulating PUCL and also provides more opportunities for the development of polarization display optical encoding,anti-counterfeiting,and integrated optical devices.

关键词： Polarization upconversion luminescence Degree of polarization Population density of excited state Number of upconversion photons Polarization anti-counterfeitingdisplay

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