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Layout Planning technology of cellular Manufacturing System Based on Process Interconnection Analysis

Chinese Journal of Mechanical Engineering 2011年第6期24卷 1035-1044页

作者： CHEN Huawei WANG Aimin NING Ruxin SHAO Canxia Digital Design and Manufacturing Laboratory Beijing Institute of TechnologyBeijing 100081China

With sustaining change of production mode,layout planning is no longer a thing built once for *** layout(CL) is becoming a hotspot in the research field of manufacturing system *** researches on layout planning are mainly concentrating on aspects of layout arithmetic,style and evaluation,*** seldom efforts are paid to CL and its specific problems as cell formation(CF),equipment sharing and CL *** problem analyzing of layout in cellular manufacturing system(CMS),research approach of cell formation,interactive layout and layout analysis threaded with process interconnection relationship(PIR) is *** key technologies in CL like CF technology based on similarity analysis of part processes,interactive visual layout technology,layout evaluation technology founded on PIR analysis and algorithm of cell equipment sharing are put *** the background of one enterprise which encounters problems of low utility of key equipments and disperse material logistic,an example of four-cell layout is *** CL adjustment and analysis results show that equipment with high level of sharing degree should be disposed around the boundary of its main cell,and be near to other sharing cells as possible; process route should be centralized by all means,so equipment adjustment is to be implemented along direction that route intersection can be decreased; giving consideration to the existence of discrete cell,logistic route and its density should be centralized to cells *** proposed research can help improve equipment utility and material logistic efficiency of CL,and can be popularized to other application availably.

关键词： cellular manufacturing system, layout planning process interconnection relationship cell formation equipment sharing interactive layout

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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan Sun Lingyun Nie Jing Zhang Xue Fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

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Single-Bit Comparator in Quantum-Dot cellular Automata (QCA) technology Using Novel QCAXNOR Gates

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Journal of Electronic Science and technology 2021年第3期19卷 263-273页

作者： Ali Hussien Majeed Mohd Shamian Zainal Esam Alkaldy Danial Md.NorNor Department of Electrical Engineering University of KufaNajaf 54003 Department of Electrical Engineering technology Universiti Tun Hussein Onn MalaysiaParit Raja 86400

To fill the continuous needs for faster processing elements with less power consumption causes large pressure on the complementary metal oxide semiconductor(CMOS)technology *** scaling scenario is not an option nowadays and other technologies need to be *** quantum-dot cellular automata(QCA)technology is one of the important emerging nanotechnologies that have attracted much researchers’attention in recent *** technology has many interesting features,such as high speed,low power consumption,and small *** features make it an appropriate alternative to the CMOS *** paper suggests three novel structures of XNOR gates in the QCA *** presented structures do not follow the conventional approaches to the logic gates design but depend on the inherent capabilities of the new *** proposed structures are used as the main building blocks for a single-bit *** resulted circuits are simulated for the verification purpose and then compared with existing counterparts in the *** comparison results are encouraging to append the proposed structures to the library of QCA gates.

关键词： Nanotechnology quantum-dot cellular automata(QCA) QCA comparator XNOR gate XOR gate

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Antihydatic and immunomodulatory effects of Punica granatum peel aqueous extract in a murine model of echinococcosis

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Asian Pacific Journal of Tropical Medicine 2016年第3期9卷 208-216页

作者： Moussa Labsi Lila Khelifi Dalila Mezioug Imene Soufli Chafia Touil-Boukoffa Laboratory of cellular and Molecular Biology Department of BiologyUniversity of Sciences and Technology Houari Boumediene

Objective: To investigate the effect of pomegranate peel aqueous extract (PGE) on the development of secondary experimental echinococcosis and on the viability of Echinococcus granulosus protoscoleces, and the immunomodulatory properties of PGE. Methods: Swiss mice were inoculated intraperitoneally with viable protoscoleces. Then, PGE was orally administered daily during cystic echinococcosis development. Cyst development and hepatic damage were macroscopically and histologically analyzed. The production of nitric oxide and TNF-alpha was assessed in plasma and the hepatic expression of iNOS, TNF-alpha, NF-kappa B and CD68 was examined. Moreover, protoscoleces were cultured and treated with different concentrations of PGE. Results: It was observed that in vitro treatment of protoscoleces caused a significant decrease in viability in a PGE-dose-dependent manner. In vivo, after treatment of cystic echinococcosis infected mice with PGE, a significant decrease in nitric oxide levels (P<0.000 1) and TNF-alpha levels (P<0.001) was observed. This decline was strongly related to the inhibition of cyst development (rate of hydatid cyst growth inhibition=63.08%) and a decrease in CD68 expression in both the pericystic layer of hepatic hydatid cysts and liver tissue (P<0.000 1). A significant diminution of iNOS, TNF-alpha and NF-kappa B expression was also observed in liver tissue of treated mice (P<0.000 I). Conclusions: Our results indicate an antihydatic scolicidal effect and immunomodulatory properties of PGE, suggesting its potential therapeutic role against Echinococcus granulosus infection.

关键词： Pomegranate peel aqueous extract Tumor necrosis factor-alpha iNOS Nuclear factor-kappa B

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Development of planar patch clamp technology and its application in the analysis of cellular electrophysiology

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Progress in Natural Science:Materials International 2009年第2期19卷 153-160页

作者： Peihua Chena,Wei Zhang a,Jun Zhou a,Ping Wang a,Lidan Xiaob,Mo Yang b a Biosensor National Special Laboratory,Key Laboratory of Biomedical Engineering of Education Ministry,Department of Biomedical Engineering,Zhejiang University,Hangzhou 310027,China b Department of Health technology and Informatics,The Hong Kong Polytechnic University,Hung Hom,Kowloon,Hong Kong,China Biosensor National Special Laboratory Key Laboratory of Biomedical Engineering of Education Ministry Department of Biomedical Engineering Zhejiang University Hangzhou 310027 China Department of Health technology and Informatics The Hong Kong Polytechnic University Hung Hom Kowloon Hong Kong China

A patch clamp chip,as a novel cell-based chip for electrophysiological recordings,has many prominent advantages such as high res-olution,accuracy,high throughput and automation. It can be used to perform multivariate and real-time measurements of cell networks in situ. Therefore,this technology will dramatically promote the research on ionic channels,neuronal networks and the application of this technology in drug screening. This paper reviews the development of planar patch clamp technology and its applications in detail. The latest progress in the research of taste cells electrophysiology and taste transduction is also presented. Finally,this paper analyzes the methodology of neural chips. Based on the current research of our laboratory,the prospective applications of a patch clamp chip in the research of taste sensation and transduction mechanisms at molecular and cellular levels are discussed.

关键词： Patch clamp chip cellular electrophysiology Taste Taste cell Taste transduction

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Mechanism by which Rab5 promotes regeneration and functional recovery of zebrafish Mauthner axons

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Neural Regeneration Research 2025年第6期20卷 1816-1824页

作者： Jiantao Cui Yueru Shen Zheng Song Dinggang Fan Bing Hu Center for Advanced Interdisciplinary Science and Biomedicine of IHM Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina

Rab5 is a GTPase protein that is involved in intracellular membrane trafficking. It functions by binding to various effector proteins and regulating cellular responses, including the formation of transport vesicles and their fusion with the cellular membrane. Rab5 has been reported to play an important role in the development of the zebrafish embryo;however, its role in axonal regeneration in the central nervous system remains unclear. In this study, we established a zebrafish Mauthner cell model of axonal injury using single-cell electroporation and two-photon axotomy techniques. We found that overexpression of Rab5 in single Mauthner cells promoted marked axonal regeneration and increased the number of intra-axonal transport vesicles. In contrast, treatment of zebrafish larvae with the Rab kinase inhibitor CID-1067700markedly inhibited axonal regeneration in Mauthner cells. We also found that Rab5 activated phosphatidylinositol 3-kinase(PI3K) during axonal repair of Mauthner cells and promoted the recovery of zebrafish locomotor function. Additionally, rapamycin, an inhibitor of the mechanistic target of rapamycin downstream of PI3K, markedly hindered axonal regeneration. These findings suggest that Rab5 promotes the axonal regeneration of injured zebrafish Mauthner cells by activating the PI3K signaling pathway.

关键词： axonal regeneration Mauthner cell nerve regeneration Rab5 zebrafish

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Using a 3-D multicellular simulation of spinal cord injury with live cell imaging to study the neural immune barrier to nanoparticle uptake

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Nano Research 2016年第8期9卷 2384-2397页

作者： Alan P. Weightman Stuart I. Jenkins Divya M. Chari cellular and Neural Engineering Group Institute for Science and Technology in Medicine Huxley Building Keele University Keele ST55BG UK

Development of nanoparticle （NP） based therapies to promote regeneration in sites of central nervous system （CNS; i.e, brain and spinal cord） pathology relies critically on the availability of experimental models that offer biologically valid predictions of NP fate in vivo. However, there is a major lack of biological models that mimic the pathological complexity of target neural sites in vivo, particularly the responses of resident neural immune cells to NPs. Here, we have utilised a previously developed in vitro model of traumatic spinal cord injury （based on 3-D organotypic slice arrays） with dynamic time lapse imaging to reveal in real-time the acute cellular fate of NPs within injury foci. We demonstrate the utility of our model in revealing the well documented phenomenon of avid NP sequestration by the intrinsic immune cells of the CNS （the microglia）. Such immune sequestration is a known translational barrier to the use of NP-based therapeutics for neurological injury. Accordingly, we suggest that the utility of our model in mimicking microglial sequestration behaviours offers a valuable investigative tool to evaluate strategies to overcome this cellular response within a simple and biologically relevant experimental system, whilst reducing the use of live animal neurological injury models for such studies.

关键词： organotypic slice culture microglia immune barrier corticosteroid dexamethasone time lapse microscopy

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Caffeic acid and quercetin exert caspases-independent apoptotic effects on Leishmania major promastigotes, and reactivate the death of infected phagocytes derived from BALB/c mice

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Asian Pacific Journal of Tropical Biomedicine 2017年第4期7卷 321-331页

作者： Radia Belkhelfa-Slimani Bahia Djerdjouri Laboratory of cellular and Molecular Biology Faculty of Biological SciencesUniversity of Sciences and Technology Houari BoumedieneAlgiersAlgeria

Objective: To investigate the leishmanicidal effects of two antioxidants, caffeic acid and quercetin on Leishmania major(***) promastigotes in vitro, and their immunomodulatory effects on infected phagocytes derived from susceptible BALB/c ***: Caffeic acid and quercetin-induced cell death was examined by Pi-Hoechst double staining of *** promastigotes and MTT assay, in the presence or absence of protease inhibitors in *** acid or quercetin were administered subcutaneously to BALB/c mice infected with *** promastigotes through a dorsal air *** oxide and superoxide anion production by phagocytes infiltrating the air pouch and the expression of inducible nitric oxide synthase(i NOS), tumor necrosis factor alpha(TNF-a) and nuclear factor kappa B in the air pouch membrane were therefore evaluated using appropriate ***: Caffeic acid and quercetin displayed a dose-dependent cytotoxic effect against *** promastigotes, and induced cell death via caspases-independent *** vivo, *** promastigotes inoculation into air pouch cavity of BALB/c mice leads to a sequential influx of neutrophils(hours), followed by macrophages(days).Results showed that *** delayed apoptosis of infected neutrophils and macrophages by the cleavage of the nuclear factor kappa B p65^(RelA) subunit, and persisted by inhibiting TNF-a and i NOS expression and reactive oxygen species *** acid or quercetin restored reactive oxygen species production and TNF-a-induced i NOS activity, and abrogate apoptosis delay of infected ***: The leishmanicidal effect of caffeic acid and quercetin on promastigotes and amastigotes, as well as reactivation of infected phagocytes apoptosis, suggested a potential therapeutic role against cutaneous leishmaniasis.

关键词： Apoptosis Leishmania major Phagocytes iNOS NF-kB TNF-a

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Natural product based novel small molecules with promising neurotrophic,neurogenic and anti-neuroinflammatory actions can be developed as stroke therapeutics

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Neural Regeneration Research 2016年第6期11卷 916-917页

作者： Priya Jhelum R.Gajendra Reddy Arvind Kumar Sumana Chakravarty Chemical Biology CSIR-Indian Institute of Chemical TechnologyHyderabadIndia CSIR-Centre for cellular and Molecular Biology HyderabadIndia

Stroke is the world’s second leading cause of death and a major cause of adult *** the different kinds of stroke,ischemic stroke is the most widely prevalent type,causing high morbidity and mortality worldwide（Mosko... 详细信息

关键词： neurotrophic neurogenic disability deprivation neurological neurotrophin nutrients hippocampal mortality regeneration

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In vitro anti-hydatic and immunomodulatory effects of ginger and [6]-gingerol

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Asian Pacific Journal of Tropical Medicine 2016年第8期9卷 727-734页

作者： Manel Amri Chafia Touil-Boukoffa University of Sciences and technology Houari Boumediene Faculty of Biological Science Laboratory of Cellular and Molecular Biology Team‘Cytokines and NO Synthases'

Objective: To study in vitro anti-hydatic and immunomodulatory effects of ginger and [6]-gingerol as an alternative therapy for Cystic echinococcosis. Methods: Effect of a commonly used herbal product and ginger(Zingiber officinale) towards protoscoleces(PSC) and cyst wall in vitro was studied. The effect of [6]-gingerol, and the pungent constituent of ginger, was also evaluated on PSC culture. Furthermore, the activity of both extracts in association with interferon-gamma(IFN-γ) on PSC co-cultured with mononuclear cells of hydatic patients was evaluated. The nitric oxide(NO) production was measured in each co-culture. Results: Ginger exhibited a concentration- and time-dependent cytotoxic effect against PSC and cyst wall. Interestingly, ginger was more effective than the [6]-gingerol. Moreover, additional parasitic effect between extracts and IFN-γ are also observed in co-cultures. Furthermore, both extracts attenuated the NO production elicited by this infection or by the IFN-γ. Conclusions: Ginger has an important anti-hydatic effect in vitro. This effect is amplified in the presence of IFN-γ. Moreover, this herbal product may protect against host's cell death by reducing the high levels of NO. Ginger may act, at least, through the [6]-gingerol. All our data suggest the promising use of ginger in the treatment of Echinococcus granulosus infection.

关键词： Ginger -gingerol Echinococcosis Cytotoxic activity Nitric oxide

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