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New aspects of a small GTPase RAB35 in brain development and function

Neural Regeneration Research 2025年第7期20卷 1971-1980页

作者： Ikuko Maejima Ken Sato laboratory of Molecular Traffic Institute for Molecular and Cellular RegulationGunma UniversityMaebashiJapan

In eukaryotic cells,organelles in the secretory,lysosomal,and endocytic pathways actively exchange biological materials with each other through intracellular membrane trafficking,which is the process of transporting the cargo of proteins,lipids,and other molecules to appropriate compartments via transport vesicles or *** processes are strictly regulated by various small GTPases such as the RAS-like in rat brain(RAB)protein family,which is the largest subfamily of the RAS *** of membrane trafficking affects tissue homeostasis and leads to a wide range of diseases,including neurological disorders and neurodegenerative ***,it is important to understand the physiological and pathological roles of RAB proteins in brain ***35,a member of the RAB family,is an evolutionarily conserved protein in metazoans.A wide range of studies using cultured mammalian cells and model organisms have revealed that RAB35 mediates various processes such as cytokinesis,endocytic recycling,actin bundling,and cell ***35 is also involved in neurite outgrowth and turnover of synaptic *** generated brain-specific Rab35 knockout mice to study the physiological roles of RAB35 in brain development and *** mice exhibited defects in anxiety-related behaviors and spatial ***,RAB35 is required for the precise positioning of pyramidal neurons during hippocampal development,and thereby for normal hippocampal *** contrast,layer formation in the cerebral cortex occurred superficially,even in the absence of RAB35,suggesting a predominant role for RAB35 in hippocampal development rather than in cerebral cortex *** studies have suggested an association between RAB35 and neurodegenerative diseases,including Parkinson's disease and Alzheimer's *** this review,we provide an overview of the current understanding of subcellular functions of *** also provide insights into the phys

关键词： endocytosis endosomes hippocampal development neurodegenerative diseases RAB35

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Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics

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Neural Regeneration Research 2025年第11期20卷 3179-3192页

作者： Pieter-Jan Serneels Julie D.De Schutter Lies De Groef Lieve Moons Steven Bergmans KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

Decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and ***,recent studies employing single-cell RNA sequencing techniques have uncovered novel cell states,prompting a revision of the existing *** forward,the oligodendroglial lineage should be delineated into five distinct cell states:oligodendrocyte precursor cells,committed oligodendrocyte precursor cells,newly formed oligodendrocytes,myelin-forming oligodendrocytes,and mature *** new classification system enables a deeper understanding of the oligodendroglia in both physiological and pathological *** this uniform terminology will facilitate comparison and integration of data across ***,including the consolidation of findings from various demyelinating models,is essential to better understand the pathogenesis of demyelinating ***,comparing injury models across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome remyelination ***,by standardizing terminology and synthesizing data from diverse studies across different animal models,we can enhance our understanding of myelin pathology in central nervous system disorders such as multiple sclerosis,Alzheimer's disease,and amyotrophic lateral sclerosis,all of which involve oligodendroglial and myelin dysfunction.

关键词： animal models demyelination fish mammals multiple sclerosis myelin neurodegeneration oligodendrocytes oligodendroglial lineage remyelination

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Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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Neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-Núñez María Fernanda González Ana María Avalos Lisette Leyton cellular communication laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3K/AKT/connexin 43,and Notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

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Calcium channels caught in peripheral glia’s tug-of-war on axon regeneration in Drosophila

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Neural Regeneration Research 2025年第2期20卷 475-476页

作者： Jackson Powell Tobias Steinschaden Rose Horowitz Yuanquan Song Raymond G.Perelman Center for cellular and Molecular Therapeutics The Children’s Hospital of PhiladelphiaPhiladelphiaPAUSA The Neuroscience Graduate Group University of PennsylvaniaPhiladelphiaPAUSA Department of Pathology and laboratory Medicine University of PennsylvaniaPhiladelphiaPAUSA Medical University of Vienna Center for Brain ResearchDepartment of NeuroimmunologyViennaAustria

Neural damage or degeneration is at the crux of many diseases,and treatment of these diseases will require the development of therapeutics to enhance and guide neural *** intrinsic and extrinsic factors dictate a neuron’s ability to regenerate,and the combination of these factors results in the great regenerative capacity of the peripheral nervous system(PNS)and the poor regenerative capacity of the central nervous system(CNS)following *** the core of a neuron’s function is its ability to relay electrochemical signals,and a neuron’s excitability is a key factor in its ability to *** works have focused on the changes in neuronal electrophysiological properties,firing patterns,and ion flux after injury,which differentially activate signaling pathways at the core of *** role of glia in neuron regeneration has long been studied.

关键词： degeneration firing system

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Syndecans in Alzheimer's disease:pathogenetic mechanisms and potential therapeutic targets

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Neural Regeneration Research 2025年第9期20卷 2594-2595页

作者： Carmela Rita Balistreri Roberto Monastero cellular Molecular and Clinical Pathological LaboratoryDepartment of BiomedicineNeuroscience and Advanced Diagnostics(Bi.N.D.)University of PalermoPalermoItaly Memory and Parkinson’s disease Center Policlinico“Paolo Giaccone”PalermoDepartment of BiomedicineNeuroscience and Advanced Diagnostics(Bi.N.D.)University of PalermoVia La Loggia 1PalermoItaly

With increasing age,humans become more susceptible to the onset of neurodegenerative diseases(NDs),and among these,Alzheimer's disease(AD)is the most frequent(Nicoletti et al.,2023).NDs are primarily characterized by neuronal loss and atrophy,but also by lesions involving the cerebral and/or cardiovascular system(Balistreri,2021).Lesions such as macroinfa rcts,microinfarcts,hemorrhages,white matter lesions,atherosclerosis,and arteriolosclerosis have also been significantly described in the preclinical stages of cognitive impairment characterizing NDs(Mariani et al.,2007).

关键词： Alzheimer cardiovascular

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Quantum private query: A new kind of practical quantum cryptographic protocol

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Science China(Physics,Mechanics & Astronomy) 2019年第7期62卷 10-21页

作者： Fei Gao SuJuan Qin Wei Huang QiaoYan Wen State Key laboratory of Networking and Switching Technology Beijing University of Posts and Telecommunications Science and Technology on communication Security laboratory Institute of Southwestern Communication State Key laboratory of Cryptology

This research aims to review the developments in the field of quantum private query(QPQ), a type of practical quantum cryptographic protocol. The primary protocol, as proposed by Jacobi et al., and the improvements in the protocol are ***, the advancements made in sability, theoretical security, and practical security are summarized. Additionally, we describe two new results concerning QPQ security. We emphasize that a procedure to detect outside adversaries is necessary for QPQ, as well as for other quantum secure computation protocols, and then briefly propose such a strategy. Furthermore, we show that the shift-and-addition or low-shift-and-addition technique can be used to obtain a secure real-world implementation of QPQ, where a weak coherent source is used instead of an ideal single-photon source.

关键词： quantum cryptography quantum private query quantum secure multiparty computation quantum oblivious key transfer quantum key distribution

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Hybrid inter-cell interference management for ultra-dense heterogeneous network in 5G

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Science China(Information Sciences) 2016年第8期59卷 180-192页

作者： Chen HUANG Qianbin CHEN Lun TANG Key laboratory of Mobile communication Technology School of Communication and Information EngineeringChongqing University of Posts and Telecommunications

The Ultra-dense Heterogeneous Network(Het Net), which consists of macro-cells and pico-cells, has been recognized as a key technique to improve network performance. However, the increasing number of pico-cells also causes severe interference including inter-cell interference and intra-cell interference. Therefore, interference management has become an important issue in ultra-dense Het Nets, and the traditional enhanced inter-cell interference coordination(e ICIC) scheme is no longer fit for the high density of small cells. In this paper, a hybrid interference management method based on dynamic e ICIC and coordinated multi-point transmission(Co MP) is proposed. Firstly, a virtual cell is established based on the characteristics of ultra dense Het ***, a novel joint dynamic e ICIC scheme combined with multi-user beamforming is deployed to eliminate the inter-cell interference, and improve the throughput of virtual cell significantly without sharp decrease of throughput of macro-cell. Furthermore, a virtual cell based joint transmission scheme is deployed with a power control algorithm, which can obviously increase the spectrum efficiency of virtual cell edge. Simulation results verify that the proposed scheme can achieve better spectrum efficiency both at macro-cell and virtual cell edges,and the network throughput is also improved.

关键词： interference management coordinated multi-point transmission ultra dense network almost blank subframe spectrum efficiency

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Practical continuous-variable quantum key distribution with feasible optimization parameters

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Science China(Information Sciences) 2023年第8期66卷 80-91页

作者： Li MA Jie YANG Tao ZHANG Yun SHAO Jinlu LIU Yujie LUO Heng WANG Wei HUANG Fan FAN Chuang ZHOU Liangliang ZHANG Shuai ZHANG Yichen ZHANG Yang LI Bingjie XU Science and Technology on communication Security laboratory Institute of Southwestern Communication State Key laboratory of Information Photonics and Optical communications Beijing University of Posts and Telecommunications

Continuous-variable quantum key distribution(CV-QKD) offers an approach to achieve a potential high secret key rate(SKR) in metropolitan areas. There are several challenges in developing a practical CV-QKD system from the laboratory to the real world. One of the most significant points is that it is really hard to adapt different practical optical fiber conditions for CV-QKD systems with unified hardware. Thus,how to improve the performance of practical CV-QKD systems in the field without modification of the hardware is very important. Here, a systematic optimization method, combining the modulation variance and error correction matrix optimization, is proposed to improve the performance of a practical CV-QKD system with a restricted capacity of postprocessing. The effect of restricted postprocessing capacity on the SKR is modeled as a nonlinear programming problem with modulation variance as an optimization parameter,and the selection of an optimal error correction matrix is studied under the same scheme. The results show that the SKR of a CV-QKD system can be improved by 24% and 200% compared with previous frequently used optimization methods theoretically with a transmission distance of 50 km. Furthermore, the experimental results verify the feasibility and robustness of the proposed method, where the achieved optimal SKR achieved practically deviates <1.6% from the theoretical optimal value. Our results pave the way to deploy high-performance CV-QKD in the real world.

关键词： continuous-variable quantum key distribution post-processing optimization secret key rate

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Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology,cognition,and behavior in APP/PS1 mice

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Neural Regeneration Research 2025年第2期20卷 533-547页

作者： Yanli Zhang Tian Li Jie Miao Zhina Zhang Mingxuan Yang Zhuoran Wang Bo Yang Jiawei Zhang Haiting Li Qiang Su Junhong Guo Department of Neurology First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Neurology Sixth Hospital of Shanxi Medical University(General Hospital of Tisco)TaiyuanShanxi ProvinceChina Department of Physiology Key Laboratory of Cellular PhysiologyMinistry of EducationShanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Hernia and Abdominal Wall Surgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of laboratory Medicine of Fenyang College Shanxi Medical UniversityFenyangShanxi ProvinceChina

In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial ***,the functional role of GGT5 in the development of Alzheimer’s disease remains *** study aimed to explore the effect of GGT5 on cognitive function and brain pathology in an APP/PS1 mouse model of Alzheimer’s disease,as well as the underlying *** observed a significant reduction in GGT5 expression in two in vitro models of Alzheimer’s disease(Aβ_(1-42)-treated hCMEC/D3 and bEnd.3 cells),as well as in the APP/PS1 mouse ***,injection of APP/PS1 mice with an adeno-associated virus encoding GGT5 enhanced hippocampal synaptic plasticity and mitigated cognitive ***,increasing GGT5 expression in cerebrovascular endothelial cells reduced levels of both soluble and insoluble amyloid-βin the brains of APP/PS1 *** effect may be attributable to inhibition of the expression ofβ-site APP cleaving enzyme 1,which is mediated by nuclear factor-kappa *** findings demonstrate that GGT5 expression in cerebrovascular endothelial cells is inversely associated with Alzheimer’s disease pathogenesis,and that GGT5 upregulation mitigates cognitive deficits in APP/PS1 *** findings suggest that GGT5 expression in cerebrovascular endothelial cells is a potential therapeutic target and biomarker for Alzheimer’s disease.

关键词： Alzheimer’s disease amyloid-β APP/PS1 mice cerebrovascular endothelial cells cognitive deficits gamma-glutamyl transferase 5 neurovascular unit nuclear factor‐kappa B synaptic plasticity β-site APP cleaving enzyme 1

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BER analysis of STBC hybrid carrier system based on WFRFT with frequency domain equalization

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Science China(Information Sciences) 2018年第8期61卷 147-159页

作者： Zhenduo WANG Lin MEI Xuejun SHA Naitong ZHANG communication Research Center Harbin Institute of Technology Science and Technology on Information Transmission and Dissemination in communication Networks laboratory

The inherent characteristic of hybrid carrier(HC) scheme based on the weighted-type fractional Fourier transform(WFRFT) is revealed. The proposed linear combination of single carrier(SC) and multicarrier’s(MC) characteristics is helpful to balance the conflicting requirements and achieve the comparative analysis of SC/MC. As an example, analytical SER/BER expressions of HC system with zero forcing(ZF)and minimum mean square error(MMSE) equalization are derived. In addition, the derived BER expressions are extended to multi-input systems. A unified framework of space time block code(STBC) HC scheme is proposed with two WFRFT modules at the transmitter or receiver, where STBC-SC and STBC-MC systems are the special cases of the novel structure.

关键词： single carrier multi-carrier weighted-type fractional Fourier transform hybrid carrier zero forcing minimum mean square error space time block code

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