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A model for the control of DNA integrity by the sperm nuclear matrix

Asian Journal of Andrology 2015年第4期17卷 610-615页

作者： Joanna E Gawecka Jordi Ribas-Maynou Jordi Benet W Steven Ward Clinical and Translational Research Program Universityof Hawaii Cancer Center Honolulu HI USA cell biologyunit Cell Biology Phisiology and Immunology DepartmentMedicine Faculty Universitat Autonoma de Barcelona08193 Bellaterra Spain Center of Male Infertility andAnalysis de Barcelona Edifici Eureka PBM5 Parc deRecerca de la UAB Campus de la UAB 08193 BellaterraSpain Institute for Biogenesis Research Departmentof Anatomy Biochemistry and Physiology Honolulu HIUSA Department of Obstetrics Gynecology and Women'sHealth John A. Burns School of Medicine University ofHawaii at Manoa. Honolulu. HI 96822. USA.

The highly condensed chromatin of mammalian spermatozoa is usually considered to be biologically inert before fertilization. However, we have demonstrated that even in this compacted state, sperm chromatin is subject to degradation at open configurations associated with the nuclear matrix through a process we have termed sperm chromatin fragmentation （SCF）. ＂[his suggests that a mechanism exists to monitor the health of spermatozoa during transit through the male reproductive tract and to destroy the genome of defective sperm cells. The site of DNA damage in SCF, the matrix attachment sites, are the same that we hypothesize initiate DNA synthesis in the zygote. When sperm that have damaged DNA are injected into the oocyte, the newly created zygote responds by delaying DNA synthesis in the male pronudeus and, if the damage is severe enough, arresting the embryo＇s development. Here we present a model for paternal DNA regulation by the nuclear matrix that begins during sperm maturation and continues through early embryonic development.

关键词： DNA mammalian spermatozoa

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