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Pre-operative visceral adipose tissue radiodensity is a potentially novel prognostic biomarker for early endoscopic post-operative recurrence in Crohn’s disease

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 740-750页

作者： Phillip Gu Shishir Dube Norman Gellada So Yung Choi Susan Win Yoo Jin Lee Shaohong Yang Talin Haritunians Gil Y Melmed Eric A Vasiliauskas Niru Bonthala Gaurav Syal Andres J Yarur David Ziring Shervin Rabizadeh Phillip Fleshner Cindy Kallman Suzanne Devkota Stephan R Targan Dalin Li Dermot PB McGovern Department of Medicine Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Imaging Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Biostatistics Shared Resource Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Internal Medicine Keimyung University School of MedicineDaegu 42601South Korea Department of Medicine University of California at Los AngelesLos AngelesCA 90095United States Department of Medicine University of California at San DiegoSan DiegoCA 92093United States Department of Pediatrics Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Surgery Cedars-Sinai Medical CenterLos AngelesCA 90048United States

BACKGROUND Evidence suggests inflammatory mesenteric fat is involved in post-operative recurrence(POR)of Crohn’s disease(CD).However,its prognostic value is INTRODUCTION Crohn’s disease(CD)is a debilitating chronic immune-mediated inflammatory disease(IMID)of the gastrointestinal tract that is increasing in incidence and prevalence globally[1].CD patients often undergo surgery for disease-related complic-ations and/or medically refractory ***,surgery is not curative,and many patients develop post-operative recurrence(POR)of CD with a significant proportion eventually requiring additional *** advances in early detection and therapeutics,the contemporary 10-year risk of surgery has improved from 50%to 26%,but the risk of recurrent surgery has remained unchanged at 30%,suggesting a need to improve post-operative management strategies[2].Presently,there are two accepted strategies to mitigate POR,but each have potential ***,patients start early post-operative pharmacologic prophylaxis within 4-6 wk after *** strategy can potentially overtreat a subset of patient who may not develop long-term disease recurrence off ***,these patients are at risk of medication-related adverse events and the direct and indirect costs associated with therapy with little or no benefit[3].The second strategy is performing early colonoscopy within 6-12 months after surgery and escalating therapy based on FOOTNOTES Author contributions:Gu P is the guarantor of the article and was involved in concept and design,data collection,statistical analysis,drafting of manuscript,and final approval of manuscript;Dube S and Choi SY were involved in statistical analysis,drafting of the manuscript,and final approval of manuscript;Gellada N,Win S,Lee YJ and Yang S were involved in the data collection,drafting of the manuscript,and final approval of manuscript;Haritunians T and Li D were involved in data analysis and interpretation,drafting

关键词： Crohn’s disease Surgery Visceral adipose tissue Mesenteric adipose tissue Creeping fat Computed tomography

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Impact of an oligosaccharide-based polymer on the metabolic profiles and microbial ecology of weanling pigs experimentally infected with a pathogenic ***

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Journal of Animal Science and Biotechnology 2024年第2期15卷 749-764页

作者： Kwangwook Kim Cynthia Jinno Xunde Li David Bravo Eric Cox Peng Ji Yanhong Liu Department of Animal Science University of CaliforniaDavisCA 95616USA Department of Animal Science Michigan State UniversityEast LansingMI 48824USA cedars-sinai Medical Center Los AngelesCA 90084USA School of Veterinary Medicine University of CaliforniaDavisCA 95616USA Pancosma|ADM 1180 RolleSwitzerland Nutreco Exploration NutrecoThe Netherlands Department of Virology Parasitology and ImmunologyGhent University9000 GhentBelgium Department of Nutrition University of CaliforniaDavisCA 95616USA

Background Our previous study has reported that supplementation of oligosaccharide-based polymer enhances gut health and disease resistance of pigs infected with enterotoxigenic ***(ETEC)F18 in a manner similar to *** objective of this study was to investigate the impacts of oligosaccharide-based polymer or antibiotic on the host metabolic profiles and colon microbiota of weaned pigs experimentally infected with ETEC *** Multivariate analysis highlighted the differences in the metabolic profiles of serum and colon digesta which were predominantly found between pigs supplemented with oligosaccharide-based polymer and *** relative abundance of metabolic markers of immune responses and nutrient metabolisms,such as amino acids and carbohydrates,were significantly differentiated between the oligosaccharide-based polymer and antibiotic groups(q2.0).In addition,pigs in antibiotic had a reduced(P<0.05)relative abundance of Lachnospiraceae and Lactobacillaceae,whereas had greater(P<0.05)Clostridiaceae and Streptococcaceae in the colon digesta on d 11 post-inoculation(PI)compared with d 5 *** The impact of oligosaccharide-based polymer on the metabolic and microbial profiles of pigs is not fully understood,and further exploration is ***,current research suggest that various mechanisms are involved in the enhanced disease resistance and performance in ETEC-challenged pigs by supplementing this polymer.

关键词： Carbadox Colon microbiota Enterotoxigenic E.coli F18 Metabolomics Oligosaccharide-based polymer Weaned pigs

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Pan-cancer analysis of RNA 5-methylcytosine reader (ALYREF)

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Oncology Research 2024年第3期32卷 503-515页

作者： XING YE ZHOUTING TUO KAI CHEN RUICHENG WU JIE WANG QINGXIN YU LUXIA YE AKIRA MIYAMOTO KOO HAN YOO CHI ZHANG WURAN WEI DENGXIONG LI DECHAO FENG Samuel Oschin Comprehensive Cancer institute Department of MedicineDepartment of Biomedical SciencesCedars-Sinai Medical CenterLos AngelesCA90048USA Department of Urology The Second Afiliated Hospital of Anhui Medical UniversityHefei230601China Department of Urology Institute of UrologyWest China HospitalSichuan UniversityChengdu610041China Department of Pathology Ningbo Diagnostic Pathology Center Ningbo315021China Department of Public Research Platfom Taizhou Hospital of Zhejiang Province Afliated to Wenzhou Medical UniversityLinhai317000China Department of Rehabilitation West Kyushu UniversityKanzaki shi842-8585Japan Department of Urology Kyung Hee UniversitySeoul446701South Korea Department of Rehabilitation The Afliated Hospital of Southwest Medical UniversityLuwzhou646000China

The incre asing interest in RNA modifications has signifcantly advanced epigenomic and epitranscriptomic *** study focuses on the immuno oncological impact of ALYREF in human cancer through a pan-cancer analysis,enhancing understanding of this gene's role in *** observed differential ALYREF expression between tumor and normal samples,correl ating strongly with prognosis in various cancers,particularly kidney renal papillary cell carcinoma(KIRP)and liver hepatocellular carcinoma(LIHC).ALYREF showed a negative correlation with most tumor-infitrating cells in lung squamous cell carcinoma(LUSC)and lymphoid neoplasm difuse large B-cell lymphoma(DLBC),while positive correlations were noted in IIHC,kidney chromophobe(KICH),mesothelioma(MESO),KIRP,pheochromocytoma and paraganglioma(PARD),and glioma(GBMLGG).Aditionally,ALYREF expression was closely associated with tumor heterogeneity,stemness indices,and a high mutation rate in TP53 across these *** conclusion,ALYREF may serve as an oncogenic biomarker in numerous cancers,meriting further research attention.

关键词： Pan-cancer RNA 5-methylcytosine ALYREF Immwno-oncological efects

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MitraClip:a novel percutaneous approach to mitral valve repair

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第8期12卷 633-637页

作者： Hasan JILAIHAWI Asma HUSSAINI Saibal KAR Cardiovascular Interventional Center Heart InstituteCedars-Sinai Medical Center

As life expectancy increases,valvular heart disease is becoming more *** of heart disease and primarily valvular heart disease is expected to represent a significant proportion of healthcare provided to the elderly *** years have brought a progression of surgical treatments toward less invasive *** has given rise to percutaneous approaches for the correction of valvular heart *** mitral valve repair using the MitraClip system (Abbott Vascular,Santa Clara,CA,USA) creates a double orifice and has been successfully used in selected patients with mitral *** review the rationale,procedural aspects,and clinical data thus far available for the MitraClip approach to mitral regurgitation.

关键词： MitraClip Mitral valve Mitral regurgitation

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Cardiac BIN1(cBIN1) is a regulator of cardiac contractile function and an emerging biomarker of heart muscle health

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Science China(Life Sciences) 2017年第3期60卷 257-263页

作者： Kang Zhou Tingting Hong Department of Cardiovascular Surgery 2nd XiangYa HospitalCentral South University cedars-sinai heart institute Cedars-Sinai Medical Center Departments of Medicine Cedars-Sinai Medical Center and UCLA

In recent decades,a cardiomyocyte membrane scaffolding protein bridging integrator 1(BIN1) has emerged as a critical multifunctional regulator of transverse-tubule(t-tubule) function and calcium signaling in *** by a single gene with 20 exons that are alternatively spliced,more than ten BIN1 protein isoforms are expressed with tissue and disease *** recently discovered cardiac alternatively spliced isoform BIN1(cBIN1 or BIN1 +13 + 17)plays a crucial role in organizing membrane microfolds within cardiac *** cBIN1-induced microfolds form functional dyad microdomains by trafficking L-type calcium channels(LTCC) to t-tubule membrane and recruiting ryanodine receptors(RyR) to junctional sarcoplasmic reticulum *** cBIN1 is transcriptionally reduced as occurs in heart failure,cBIN1-microfolds are disrupted and fail to form LTCC and RyR *** a result,impaired dyad formation limits excitation-contraction coupling thus cardiac contractility,and accumulation of orphaned leaky RyRs outside of dyads increases ventricular *** myocardial BIN1 in heart failure is also detectable at the blood level,and plasma BIN1 level predicts heart failure progression and future arrhythmias in cardiomyopathy *** we will review the recent progress in BIN1-related cardiomyocyte biology studies and discuss the diagnostic and predictive values of cBIN1 in future clinical use.

关键词：收缩功能生物标志物心脏 ryanodine受体心肌收缩力选择性剪接健康肌肉

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Optimizing 6-mercaptopurine and azathioprine therapy in the management of inflammatory bowel disease

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World Journal of Gastroenterology 2011年第37期17卷 4166-4173页

作者： Kara Bradford David Q Shih Department of Medicine Cedars Sinai Medical Center Inflammatory Bowel and Immunobiology Research institute Cedars-Sinai Medical Center

The thiopurine drugs,6-mercaptopurine(6-MP) and azathioprine,are efficacious in the arsenal of inflammatory bowel disease(IBD) *** reports indicate that 6-thioguanine nucleotide(6-TGN) levels correlate with therapeutic efficacy,whereas high 6-methylmercaptopurine(6-MMP) levels are associated with hepatotoxicity and *** to their complex metabolism,there is wide individual variation in patient response therein,both in achieving therapeutic drug levels as well as in developing adverse *** strategies to optimize 6-TGN while minimizing 6-MMP levels have been adopted to administer the thiopurine class of drugs to patients who otherwise would not tolerate these drugs due to *** this report,we will review different approaches to administer the thiopurine medications,including the administration of 6-mercaptopurine in those unsuccessfully treated with azathioprine;coadministration of thiopurine with allopurinol;co-administration of thiopurine with anti-tumor necrosis factor α;6-TGN administration;desensitization trials;and split dosing of 6-MP.

关键词：巯基嘌呤治疗药物管理优化硫唑嘌呤炎症鸟嘌呤核苷酸肿瘤坏死因子肠

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Andropause and the development of cardiovascular disease presentationmore than an epi-phenomenon

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Journal of Geriatric Cardiology 2011年第1期8卷 35-43页

作者： Emst R. Schwarz Anita Phan Robert D. Willix Jr cedars sinai heart institute Cedars Sinai Medical Center 8700 Beverly Boulevard Suite 6215 Los Angeles CA 90048 USA Cenegenics Medical Institute 851 Rampart Blvd. Las Vegas NV 89145 USA

Andropause 指男荷尔蒙的概括衰落，包括在中年、老化的人的睾丸激素和 dehydroepiandrosterone。在荷尔蒙的这衰落在身体作文与象消沉，性欲的损失，性机能障碍，和变化那样的变化被联系了。老化与许多伴随物被联系了疾病，特别地心血... 详细信息

Andropause 指男荷尔蒙的概括衰落，包括在中年、老化的人的睾丸激素和 dehydroepiandrosterone。在荷尔蒙的这衰落在身体作文与象消沉，性欲的损失，性机能障碍，和变化那样的变化被联系了。老化与许多伴随物被联系了疾病，特别地心血管的疾病，并且尽管 andropause 被相关到老化，在雄激素的减小和象动脉粥样硬化和心失败那样的长期的疾病的发展之间的一种原因的关系一直不是还信服地建立了。在另一方面，增加数据出现了那在心血管的疾病前进上揭示了雄激素的底层的效果。作为一个例子，睾丸激素的底层被连接了到冠的动脉疾病的更高的发生。被用于 andropausal 人减轻男经绝期的症状的荷尔蒙代替治疗是否能停止心血管的疾病的前进，仍然保持争论地讨论了，首先由于设计得好的、使随机化的控制试用的缺乏。至少为症状改进，在 andropausal 人的雄激素代替治疗的使用可以临床上被显示，并且与适当管理并且列在后面在上面可以证明关于在更高的年龄的心血管的健康的完整的保藏有益。

关键词：心血管疾病男性雄激素替代疗法 EPI 动脉粥样硬化冠状动脉疾病随机对照试验雄性激素

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Genetic associations with adverse events from anti-tumor necrosis factor therapy in inflammatory bowel disease patients

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World Journal of Gastroenterology 2017年第40期23卷 7265-7273页

作者： Daniel Lew Soon Man Yoon Xiaofei Yan Lori Robbins Talin Haritunians Zhenqiu Liu Dalin Li Dermot PB McGovern Department of Medicine Cedars-Sinai Medical Center F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research institute Cedars-Sinai Medical Center Department of Gastroenterology Cedars-Sinai Medical Center

AIM To study the type and frequency of adverse events associated with anti-tumor necrosis factor(TNF)therapy and evaluate for any serologic and genetic *** This study was a retrospective review of patients attending the inflammatory bowel disease(IBD) centers at cedars-sinai IBD Center from 2005-2016. Adverse events were identified via chart review. IBD serologies were measured by ELISA. DNA samples were genotyped at cedars-sinai using Illumina Infinium Immunochipv1 array per manufacturer's protocol. SNPs underwent methodological review and were evaluated using several SNP statistic parameters to ensure optimal allele-calling. Standard and rigorous QC criteria were applied to the genetic data, which was generated using immunochip. Genetic association was assessed by logistic regression after correcting for population *** Altogether we identified 1258 IBD subjects exposed to anti-TNF agents in whom Immunochip data were available. 269/1258 patients(21%) were found to have adverse events to an anti-TNF-α agent that required the therapy to be discontinued. 25% of women compared to 17% of men experienced an adverse event. All adverse events resolved after discontinuing the antiTNF agent. In total: n = 66(5%) infusion reactions; n = 49(4%) allergic/serum sickness reactions; n = 19(1.5%) lupus-like reactions, n = 52(4%) rash, n = 18(1.4%) infections. In Crohn's disease, Ig A ASCA(P = 0.04) and Ig G-ASCA(P = 0.02) levels were also lower in patients with any adverse events, and anti-I2 level in ulcerative colitis was significantly associated with infusion reactions(P = 0.008). The logistic regression/human annotation and network analyses performed on the Immunochip data implicated the following five signaling pathways: JAK-STAT(Janus Kinase-signal transducer and activator of transcription), measles, IBD, cytokine-cytokine receptor interaction, and toxoplasmosis for any adverse event. CONCLUSION Our study shows 1 in 5 IBD patients experience an

关键词： Genetic associations Inflammatory bowel disease Anti-tumor necrosis factor Adverse events

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Predictors of re-hospitalization in patients with chronic heart failure

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World Journal of Cardiology 2012年第2期4卷 23-30页

作者： Melody Zaya Anita Phan Ernst R Schwarz cedars-sinai heart institute Cedars-Sinai Medical Center

heart failure (HF) is a chronic, progressive illness that is highly prevalent in the United States and worldwide. This morbid illness carries a very poor prognosis, and leads to frequent hospitalizations. Repeat hospitalization in HF is both largely burdensome to the patient and the healthcare system, as it is one of the most costly medical diagnoses among Medicare recipients. For years, investigators have strived to determine methods to reduce hospitalization rates of HF patients. Despite such efforts, recent reports indicate that rehospitalization rates remain persistently high, without any improvement over the past several years and thus, this topic clearly needs aggressive attention. We performed a key-word search of the literature for relevant citations. Published articles, limited to English abstracts indexed primarily in the PubMed database through the year 2011, were reviewed. This article discusses various clinical parameters, serum biomarkers, hemodynamic parameters, and psychosocial factors that have been reviewed in the literature as predictors of re-hospitalization of HF patients. With this information, ourhope is that the future holds better risk-stratification models that will allow providers to identify high-risk patients, and better customize effective interventions according to the needs of each individual HF patient.

关键词： heart failure Readmission Predictors Rehospitalization Chronic heart failure Hospitalization

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Genomic instability as a major mechanism for acquired resistance to EGFR tyrosine kinase inhibitors in cancer

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Protein & Cell 2022年第2期13卷 82-89页

作者： Bing Liu Daniela Duenas Li Zheng Karen Reckamp Binghui Shen Department of Cancer Genetics and Epigenetics Beckman Research Institute of City of Hope1500 East Duarte RoadDuarteCA 91010USA Division of Medical Oncology Cedars-Sinai Medical Center8700 Beverly BlvdWest HollywoodCA 90048USA

The mutation-mediated overexpression of epidermal growth factor receptor tyrosine kinase(EGFR TK)and its activation play an important role in the cellular proliferation and epithelial tumorigenesis.A series of inhibitors targeting the intracellular tyrosine kinase(TK)domain of EGFR have been developed and applied to clinical *** these inhibitors safely and effectively restrain tumor cell proliferation and prolong survival in some patients,acquired resistance ultimately *** mutations contribute to druginduced cancer-cell resistance.

关键词： cancer resistance clinical

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