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Role of genetics in prediction of disease course and response to therapy

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World Journal of Gastroenterology 2010年第21期16卷 2609-2615页

作者： Severine Vermeire Gert Van Assche Paul Rutgeerts Department of Gastroenterology University Hospital Gasthuisberg and Catholic University LeuvenB-3000 LeuvenBelgium

The clinical course of Crohn's disease and ulcerative colitis is highly variable between patients,and this has therapeutic implications.A number of clinical features have been identified,which predict a mild or more severe ***,several of these are subjective and/or not persistent over *** the progress in genetics research in inflammatory bowel disease(IBD),genetic markers are increasingly being proposed to improve stratification of *** have the major advantage of being stable over time and not prone to subjective ***,none of the genetic variants associated with particular outcomes have shown sufficient sensitivity or specificity to have been implemented in daily *** the same line of thinking,pharmacogenetics or the study of association between variability in drug response and genetic variation has also received more attention as part of the endeavor for personalized *** ultimate goal in this area of medicine is to adapt medication to a patient's specific genetic background and therefore improve on efficacy and safety *** pharmacogenetic studies have been performed for all classes of drugs applied in IBD,few have generated consistent findings or have been *** only genetic test approved for clinical practice is thiopurine S-methyltransferase testing prior to starting treatment with thiopurine *** other reported associations have suffered from lack of confirmation or still need replication ***,the importance and necessity of pharmacogenetic studies will increase further as more therapeutic classes are being developed.

关键词： Genetics Inflammatory bowel diseases Pharmacogenetics

Anti-oxidation actions of curcumin in two forms of bed rest:oxidative stress serum and salivary markers

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Asian Pacific Journal of Tropical Medicine 2010年第8期3卷 651-654页

作者： Balwant Rai Jasdeep Kaur Maria Catalina Oral Imaging Center School of DentistryOral Pathology and Maxillofacial SurgeryCatholic University LeuvenLeuvenBelgium Forensic Odontology Section School of DentistryOral Pathology and Maxillofacial SurgeryCatholic University LeuvenLeuvenBelgium SSA-NASA JPL Solar System Ambassador NASAUSA

Objective:To determine the preventive effects of curcumin on peroxidative damage under two bed rest ***:20 healthy male(10 with curcumin and 10 without curcumin ) volunteers were *** were studied before,during,and just on bed rest conditions at -6°head-down-tilt(HDT) bed rest and bed rest position(BD) for 10 *** measured the salivary and serum oxidative markers such as Malonaldehyde,8-hydroxydeoxyguanosine, vitamin C and E just before HDT & *** HDT & BD experiment,and in course time of recovery with curcumin and without curcumin ***:The values of serum and salivary vitamin C & E showed statistically significant decrease in both bed rest conditions as compared to those of the conditions before and during the recovery ***,these levels were not significantly lowered in curcumin groups in contrast to the groups without curcumin (P>0.05).MDA and 8-OHdG levels showed significant increase in simulating microgravity and zero gravity conditions as compared to those before and in the recovery ***,these levels were lower in curcumin groups in contrast to the groups without curcumin(P<0.05).Serum and salivary correlation analysis revealed a strong and highly significant correlation for MDA. vitamin C & E and 8 dihydro-2 deoxyguanosine(8-OHdG) in the conditions before,during and in the recovery periods in both bed rest *** saliva collection is easy and noninvasive, measurements of salivary marker levels may prove to be useful in the space research. Conclusions:Curcumin prevents peroxidative damage in both bed rest *** study is required on antioxidation actions of curcumin in space microgravity conditions.

关键词： Curcumin Serum Saliva Oxidative stress Bed rest position Space microgravity

Experimental investigation of railway train-induced vibrations of surrounding ground and a nearby multi-story building

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Earthquake Engineering and Engineering Vibration 2009年第1期8卷 137-148页

作者： Xia He Chen Jianguo Wei Pengbo Xia Chaoyi G. De Roeck G. Degrande School of Civil Engineering Beijing Jiaotong University Beijing 100044 China Department of Civil Engineering Catholic University of Leuven B-3001 Heverlee Belgium

In this paper, a field experiment was carried out to study train-induced environmental vibrations. During the field experiment, velocity responses were measured at different locations of a six-story masonry structure near the Beijing- Guangzhou Railway and along a small road adjacent to the building. The results show that the velocity response levels of the environmental ground and the building floors increase with train speed, and attenuate with the distance to the railway track. Heavier freight trains induce greater vibrations than lighter passenger trains. In the multi-story building, the lateral velocity levels increase monotonically with floor elevation, while the vertical ones increase with floor elevation in a fluctuating manner. The indoor floor vibrations are much lower than the outdoor ground vibrations. The lateral vibration of the building along the direction of weak structural stiffness is greater than along the direction with stronger stiffness. A larger room produces greater floor vibrations than the staircase at the same elevation, and the vibration at the center of a room is greater than at its corner. The vibrations of the building were compared with the Federal Transportation Railroad Administration （FTA） criteria for acceptable ground-borne vibrations expressed in terms ofrms velocity levels in decibels. The results show that the train-induced building vibrations are serious, and some exceed the allowance given in relevant criterion.

关键词： train building ground environmental vibration field experiment

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基于文化景观的旅游化讨论(英文)

资源科学 2009年第6期31卷 934-941页

作者： Myriam Jansen-Verbeke catholic univ.rsity leuven

文化景观在建立和吸引新的和多样化的旅游市场方面确实可以发挥重要作用,这个观点促使地方当局鼓励当地管理人员和企业家进一步探索和发展该地区的旅游潜力。从旅游的角度看,这个新"产品"的主要兴趣点是文化和自然风光、期望和经验以及... 详细信息

文化景观在建立和吸引新的和多样化的旅游市场方面确实可以发挥重要作用,这个观点促使地方当局鼓励当地管理人员和企业家进一步探索和发展该地区的旅游潜力。从旅游的角度看,这个新"产品"的主要兴趣点是文化和自然风光、期望和经验以及保护传统和注入创新的经济活动之间的关系。在各种景观中引入新的职能也导致当地人和游客的象征性价值的改变。这一区域性做法的一个主要假设在于文化和自然资源的共生和保护是加强区域特征的关键因素。本文讨论的重点是对改变文化景观这一不可逆转的旅游化过程的解释。了解这一转变过程对于规划和设计可持续的旅游目的地,以及最重要的制定有效的管理工具是必要的。文化景观向旅游景观的转变需要深刻地了解当地情况和外部影响,尤其是对资产的现实评估。在这个过程中,当地利益相关者之间的协商并达成一致意见是理想情况,但很难实现。其中,教育水平的差异、金融参与的多少、所有制形式、传统习惯以及最重要的遗产地原真文化都可能产生价值和期望的分歧。对文化遗产的价值进行再评估,可以促使对本土文化的认同,并激励公众的文化创新意识和行为,同时,再评估可以增强当地社区的自豪感和责任感。旅游和遗产,无论在哪,无论强调哪一方面,无可置疑的是文化景观受到了旅游的冲击。随着旅游的发展,决策者和旅游业者也逐渐意识到这点。然而,文化景观在文化旅游发展、促进当地经济增长方面具有重要作用,但也受到一定条件的限制,如协调保护和开发之间的矛盾。总之,教科书中没有每一个景点发展旅游的直接影响和间接影响的描述,也没有"最好"的遗产管理的蓝本。今后这一领域研究的首要任务是深入探讨和分析从文化景观向旅游景观、从生产景观向休闲景观、从一个综合性景观向旅游功能型景观转变过程中的各个方面及其驱动因素。这种跨学科的研究方法开辟了旅游学研究的广括前景,这是其优势,但另一方面,由于这种方法带来了各种各样的观点,这无疑也是其最大的弱点。还有一些概念存在争议,比如文化景观,至今也没有关于遗产资源及其连贯性的定义,甚至没有未来休闲景观和旅游景观的最佳发展模式。因此,本文的讨论不能作出确定的结论。

关键词：文化景观遗产旅游化

地方身份的重要性及其对于遗产保护的支撑作用:以比利时根特城市核心区工业化前的邻里关系为例(英文)

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资源科学 2009年第6期31卷 926-933页

作者： Dominique Vanneste catholic univ.rsity of leuven (K.U.leuven)

遗产包括代际之间物质和非物质的交流,各个群体和团体随着其所处环境、与自然界的相互关系和历史条件的变化不断使这种代代相传的物质的和非物质的遗产得到保护和创新,同时使他们自己具有一种认同感和历史感,从而促进了文化多样性,激发... 详细信息

遗产包括代际之间物质和非物质的交流,各个群体和团体随着其所处环境、与自然界的相互关系和历史条件的变化不断使这种代代相传的物质的和非物质的遗产得到保护和创新,同时使他们自己具有一种认同感和历史感,从而促进了文化多样性,激发人类的创造力。但是目前这种交流的客观事实或性质以及历史维度在遗产保护中并没有给予足够的重视。本文针对遗产在当地社区身份中的重要性,以及地方身份是否在当地居民中产生了对遗产保护的积极性等问题进行了探讨,调查了遗产及其保护是否以及如何成为社区复兴、保护意识、社区建设及公众参与的一个组成部分。因此,当地居民的态度及其期望是非常关键的因素。本文对在比利时弗兰德地区根特城市核心区工业化前的邻里关系进行了考察,并进行了大量的参与式图片调查。尽管其历史渊源相当独特,但当地居民反对退化和支持保护的动机却具有更加普遍的价值。

关键词：遗产地方身份地方意识复兴/保护比利时

High-sensitivity phase imaging eddy current magneto-optical system for carbon fiber reinforced polymers detection

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Journal of Electronic Science and Technology 2023年第4期21卷 48-59页

作者： Jiang-Shan Ai Quan Zhou Yi-Ping Liang Chun-Rui Feng Bing Long Li-Bing Bai Yong-Gang Wang Chao Ren School of Automation Engineering University of Electronic Science and Technology of ChinaChengdu611731China Department of Mechanical Engineering Catholic University of LeuvenLeuven3001Belgium Chengdu Aircraft Industry Company Ltd. Chengdu610091China

This paper proposed a high-sensitivity phase imaging eddy current magneto-optical (PI-ECMO) system for carbon fiber reinforced polymer (CFRP) defect detection. In contrast to other eddy current-based detection systems, the proposed system employs a fixed position excitation coil while enabling the detection point to move within the detection region. This configuration effectively mitigates the interference caused by the lift-off effect, which is commonly observed in systems with moving excitation coils. Correspondingly, the relationship between the defect characteristics (orientation and position) and the surface vertical magnetic field distribution (amplitude and phase) is studied in detail by theoretical analysis and numerical simulations. Experiments conducted on woven CFRP plates demonstrate that the designed PI-ECMO system is capable of effectively detecting both surface and internal cracks, as well as impact defects. The excitation current is significantly reduced compared with traditional eddy current magneto-optical (ECMO) systems.

关键词： Carbon fiber reinforced polymers Defect detection Eddy current magneto-optical Nondestructive testing Phase imaging

The Logical Style of Confucius' Analects

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Frontiers of Philosophy in China 2020年第2期15卷 167-197页

作者： Thierry Lucas Institute of Superior Philosophy Catholic University of LeuvenB-1348Louvain-la-NeuveBelgium

Considered from a logical point of view,Confucius'Analects contain many implicit forms of reasoning and *** is shown first by analyzing the phenomenon of parallelism:direct parallelism is often a way of hinting at a general assertion,whereas anti-parallelism hides dilemmas,generalizations and modal notions of"moral preference."The Analects also have various types of conditionals,ranging from material implications,to modalized implications,and counterfactual conditionals,which are the germs of implicit reasoning,concluding with a moral *** are particularly abundant and a presentation of three examples suggests that,beyond their explicative role,they also involve moral *** implicit logic of The Analects requires an active,albeit unconscious participation of the reader,which could be an important element in explaining the enduring influence of the text.

关键词： logical analysis argumentation Confucius'Analects parallelism conditionals analogies

Structural and functional aspects of the liver and liver sinusoidal cells in relation to colon carcinoma metastasis

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World Journal of Gastroenterology 2005年第33期11卷 5095-5102页

作者： Katrien Vekemans Filip Braet Centre of Experimental Surgery and Anaesthesia Abdominal Transplant Surgery Department Catholic University of Leuven (KUL)Herestraat 49 3000 Leuven Belgium Australian Key Centre for Microscopy and Microanalysis Electron Microscopy Unit The University of SydneySydney 2006NSWAustralia

Nowadays, liver metastasis remains difficult to cure. When tumor cells escape and arrive in the liver sinusoids, they encounter the local defense mechanism specific to the liver. The sinusoidal cells have been widely described in physiologic conditions and in relation to metastasis during the past 30 years. This paper provides an “overview” of how these cells function in health and in diseases such as

关键词： Metastasis Liver Colon carcinoma Sinusoidalcells Kupffer cells Liver sinusoidal endothelial cells Hepatic NK cells

The role of radiation therapy and particle therapy in renal cell carcinoma: current evidence and future perspectives

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 775-784页

作者： Charlien Berghen Maarten Albersen Robin De Roover Kato Rans Benoit Beuselinck KarelDecaestecker Kenneth Poels Francois-Xavier Otte Steven Joniau Karin Haustermans Gert De Meerleer Department of Radiation Oncology University Hospitals LeuvenLeuven 3000Belgium Department of Urology University Hospitals LeuvenLeuven 3000Belgium Department of General Medical Oncology University Hospitals LeuvenLeuven Cancer Instituteand Laboratory of experimental OncologyDepartment of OncologyCatholic University LeuvenLeuven 3000Belgium Department of Urology Ghent University HospitalLeuven 3000Belgium Department of Radiation Oncology Institut Jules BordetBrussels 1000Belgium

For both primary and metastatic renal cell carcinoma(RCC),treatment with stereotactic body radiotherapy(SBRT)has found its way into clinical *** a non-invasive outpatient procedure,SBRT requires only a few visits to the radiation department and may be of interest for the elderly or,in the case of primary RCC,for patients who are not considered surgical candidates due to technical limitations,medical comorbidities,or in the event that the maintenance of kidney function is *** the treatment landscape of oligometastatic RCC,SBRT shows promise in eradicating metastatic disease and delaying the initiation of systemic *** advancements in the planning and administration of radiation treatment and improvements in movement management allow irradiating the tumor and/or metastatic lesions with very high doses in few fractions while maximally sparing the surrounding organs at risk,thus minimizing *** that context,the increasing availability of particle therapy,such as proton beam radiotherapy or carbon ion radiotherapy,could further optimize the delivery of radiation treatment in order to reduce toxicity and improve outcome.

关键词： Particle therapy proton therapy carbon ion radiation therapy